Structure-based design and experimental engineering of a plant virus nanoparticle for the presentation of immunogenic epitopes and as a drug carrier

Journal of Biomolecular Structure and Dynamics

Volumn 32, Issue 4, 2014, Pages 630-647

  Arcangeli, Caterina ^a   Circelli, Patrizia ^a   Donini, Marcello ^a   Aljabali, Alaa A A ^b,c   Benvenuto, Eugenio ^a   Lomonossoff, George P ^b   Marusic, Carla ^a  

^a ENEA   (Italy)

^b JOHN INNES CENTRE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Homology modeling; molecular dynamics; nanomedicine; plant derived vaccine; viral nanoparticles

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG CARRIER; MONOCLONAL ANTIBODY 2F5; NANOPARTICLE;

ARTICHOKE MOTTLED CRINKLE VIRUS; ARTICLE; CHIMERA; COMPUTER MODEL; CONTROLLED STUDY; DRUG SAFETY; DRUG STRUCTURE; EPITOPE MAPPING; GENE INSERTION; GENE STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOGENICITY; MOLECULAR DYNAMICS; NONHUMAN; PLANT VIRUS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; TOMBUSVIRUS; VACCINATION; VIRAL GENE DELIVERY SYSTEM; VIRUS CAPSID; VIRUS LIKE AGENT;

AMINO ACID SEQUENCE; DRUG CARRIERS; DRUG DESIGN; EPITOPES; GENETIC ENGINEERING; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NANOPARTICLES; PLANT VIRUSES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 84892992911     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2013.785920     Document Type: Article

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