Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK

Biochemical Pharmacology

Volumn 87, Issue 3, 2014, Pages 489-501

  Schmuhl, Ellen ^a   Ramer, Robert ^a   Salamon, Achim ^a   Peters, Kirsten ^a   Hinz, Burkhard ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Cannabidiol; Cannabinoid receptors; Differentiation; Mesenchymal stem cells; Migration

Indexed keywords

6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CANNABIDIOL; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 55; MESSENGER RNA; OSTEOGENIC PROTEIN 1; PROTEIN P42; PROTEIN P44; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ADIPOSE DERIVED STEM CELL; ARTICLE; BONE REGENERATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CELL STIMULATION; CELL VIABILITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEALING; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYMAL STEM CELL; MINERALIZATION; OSTEOBLAST; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TISSUE REGENERATION; UPREGULATION; WOUND HEALING;

(4-[3-(4-IODOPHENYL)-2-(4-NITROPHENYL)-2H-5-TETRAZOLIO]-1.6-BENZENE DISULFONATE); (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A-,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,-D]PYRAN, SELECTIVE CB(2) AGONIST; 1,3-DIMETHOXY-5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]BENZENE, SELECTIVE GPR55 ANTAGONIST; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE, INHIBITOR OF P42/44 MAPK ACTIVATION; 2-(4-MORPHOLINYL)-8-PHENYL-1(4H)-BENZOPYRAN-4-ONE HYDROCHLORIDE, UPSTREAM INHIBITOR OF AKT; 4-AMINO-5-(4-CHLOROPHENYL)-7-(DIMETHYLETHYL)PYRAZOLO[3,4-D]PYRIMIDINE, KINASE INHIBITOR, UPSTREAM INHIBITOR OF FAK; 5-METHYL-4-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL, SELECTIVE GPR55 AGONIST; ALKALINE PHOSPHATASE; ALP; AM-251; AM-630; CANNABIDIOL; CANNABINOID RECEPTOR 1; CANNABINOID RECEPTOR 2; CANNABINOID RECEPTORS; CB(1); CB(2); DIFFERENTIATION; FAK; FOCAL ADHESION KINASE; G PROTEIN-COUPLED RECEPTOR 55; GPR55; JWH-133; LY-294.002; MAPK; MESENCHYMAL STEM CELLS; MIGRATION; MITOGEN-ACTIVATED PROTEIN KINASE; MSCS; O-1602; O-1918; PD98059; PHOSPHATIDYLINOSITOL 3-KINASE; PI3K; PKB; PP2; PROTEIN KINASE B/AKT; REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION; RT-PCR; SARCOMA KINASE; SCR KINASE; TRANSIENT RECEPTOR POTENTIAL VANILLOID 1; TRPV1; WST-1; [(6-IODO-2-METHYL-1-[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL) (4-METHOXYPHENYL)METHANONE], SELECTIVE CB(2) RECEPTOR ANTAGONIST; [N-(PIPERIDIN-1-YL)-5-(4-IODOPHENYL)-1-(2,4-DICHLOROPHENYL)-4-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE], SELECTIVE CB(1) RECEPTOR ANTAGONIST;

CANNABIDIOL; CANNABINOIDS; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; CYCLOHEXANES; FLAVONOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INDOLES; MESENCHYMAL STROMAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OSTEOBLASTS; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; RESORCINOLS;

EID: 84892913775     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.11.016     Document Type: Article

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