Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva)

European Journal of Pharmacology

Volumn 722, Issue 1, 2014, Pages 2-12

  Darmani, Nissar A ^a   Zhong, Weixia ^a   Chebolu, Seetha ^a   Vaezi, Mariam ^a   Alkam, Tursun ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

2 Me 5 HT; 5 HT3 receptor; Apomorphine; Cisplatin; D 2 receptor; Emesis; FPL 64176; L type calcium channel; Least shrew; M1 receptor; McN A 343; Nifedipine; NK1 receptor; Palonosetron; Quinpirole

Indexed keywords

2 METHYLSEROTONIN; 4 (2 BENZYLBENZOYL) 2,5 DIMETHYL 1H PYRROLE 3 CARBOXYLIC ACID METHYL ESTER; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; [4 [(3 CHLOROPHENYL)CARBAMOYLOXY] 2 BUTYNYL]TRIMETHYLAMMONIUM; APOMORPHINE; BACTERIAL PROTEIN; CALCIUM CHANNEL L TYPE; CISPLATIN; NIFEDIPINE; PALONOSETRON; QUINPIROLE; SEROTONIN; VIRUS PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIEMETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; FEMALE; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; SHREW; VOMITING;

ANIMALS; ANTIEMETICS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DRUG SYNERGISM; FEMALE; ISOQUINOLINES; MALE; NIFEDIPINE; PYRROLES; QUINUCLIDINES; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS; SHREWS; VOMITING;

EID: 84892868249     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.052     Document Type: Article

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