Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism

Neurochemistry International

Volumn 41, Issue 6, 2002, Pages 399-407

  Ono, Takeshi ^a   Inoue, Makoto ^a   Harunor Rashid, M ^a   Sumikawa, Koji ^a   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Opioid receptor (MOP R); Morphine; Nociception; Substance P

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ANTISENSE OLIGODEOXYNUCLEOTIDE; CALCIUM CHELATING AGENT; CAPSAICIN; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLORNITHYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; DIPHENHYDRAMINE; EGTAZIC ACID; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; HISTAMINE H1 RECEPTOR ANTAGONIST; INOSITOL DERIVATIVE; MORPHINE; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; NALOXONE; NEUROKININ 1 RECEPTOR ANTAGONIST; PERTUSSIS TOXIN; PHOSPHOLIPASE C INHIBITOR; SUBSTANCE P; THAPSIGARGIN; UNCLASSIFIED DRUG; XESTOSPONGIN C;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MEDIATOR RELEASE; MEMBRANE PERMEABILITY; MOUSE; NERVE ENDING; NERVE FIBER C; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE; SIGNAL TRANSDUCTION;

ANALGESICS, OPIOID; ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; HINDLIMB; MALE; MICE; MORPHINE; MUSCLE CONTRACTION; NOCICEPTORS; PERTUSSIS TOXIN; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION; SUBSTANCE P;

EID: 0036883619     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00047-5     Document Type: Article

References (34)

1. Andoh T., Nagasawa T., Satoh M., Kuraishi Y. Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J. Pharmacol. Exp. Ther. 86:1998;1140-1145.
2. Barke K.E., Hough L.B. Opiates, mast cells and histamine release. Life Sci. 53:1993;1391-1399.
3. Bleasdale J.E., Thakur N.R., Gremban R.S., Bundy G.L., Fitzpatrick F.A., Smith R.J., Bunting S. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J. Pharmacol. Exp. Ther. 255:1990;756-768.
4. Borsook, D., LeBel, A.A., McPeek, B., 1995. The Massachusetts General Hospital Handbook of Pain Management. Lippincott-Raven Publishers Inc., Philadelphia.
5. Dubuisson D., Dennis S.G. The formalin test: a quantitative study of morphine, meperidine, and brain stem stimulation in rats and cats. Pain. 4:1977;161-174.
6. Friedman J.D., Dello Buono F.A. Opioid antagonists in the treatment of opioid-induced constipation and pruritus. Ann. Pharmacother. 35:2001;85-91.
7. Gafny J., Munsch J.A., Lam T.H., Catlin M.C., Costa L.G., Moleinski T.F., Pessah I.N. Xestospongines: potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron. 19:1997;723-733.
8. Hagermark O., Hokfel T., Pernow B. Flare and itch induced by substance P in human skin. J. Invest. Dermatol. 71:1978;233-235.
9. Harry V.E., Alice R.J., Neil C.M. Selective release of histamine from rat mast cells by several drugs. J. Pharmacol. Exp. Ther. 175:1970;627-631.
10. Hermens J.M., Ebertz J.M., Hanifin J.M., Hirshman C.A. Comparison of histamine release in human skin mast cells induced by morphine, fentanyl, and oxymorphine. Anesthesiology. 62:1985;124-129.
11. Inoue, M., Ueda, H., 2000. Protein kinase C-mediated acute tolerance to peripheral μ-opioid analgesia in the bradykinin nociception test in mice. J. Pharmacol. Exp. Ther. 293, 662-669.
12. Inoue M., Tokuyama S., Nakayamada H., Ueda H. In vivo signal transduction of tetrodotoxin sensitive nociceptive responses by substance P given into the plantar of the mouse hind limb. Cell. Mol. Neurobiol. 18:1998a;555-561.
13. Inoue M., Kobayashi M., Kozaki S., Zimmer A., Ueda H. Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve ending in mice. Proc. Natl. Acad. Sci. U.S.A. 95:1998;10949-10953.
14. Inoue M., Shimohira I., Yoshida A., Zimmer A., Takeshima H., Sakurada T., Ueda H. Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. J. Pharmacol. Exp. Ther. 175:1999;627-631.
15. Kobayashi M., Miyamoto T., Aoki S., Murakami N., Kitagawa I., In Y., Ishida T. Isomerization of dimeric 2.9-disubstituted 1-oxa-quinolizidine alkaloids and structural revision of araguspongines B and Isolated from a marine sponge of xestospongia SP. Heterocycles. 47:1998;195-203.
16. Levy J.H., Brister N.W., Shearin A., Ziegler J. Jr., Hug C.C., Adelsen D.M., Walker B.F. Wheal and flare responses to opioids in human. Anesthesiology. 70:1989;756-760.
17. Martin H.A., Basbaum A.I., Kwiat G.C., Goetzl E.J., Levine J.D. Leukotriene and prostaglandin sensitization of cutaneous high-threshold C-and A-delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience. 22:1987;651-659.
18. McCarson K.E., Krause J.E. The neurokinin 1 receptor antagonist LY306, 740 blocks nociception-induced increases in dorsal horn neurokinin 1 receptor gene expression. Mol. Pharmacol. 50:1996;1189-1199.
19. Murray C.W., Cowan A., Larson A.A. Neurokinin and NMDA antagonista1s (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 44:1991;179-185.
20. Ohkubo T., Shibata M., Takahashi H., Inoki R. Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord. J. Pharmacol. Exp. Ther. 252:1990;1261-1268.
21. Singh P.P., Junnarkar A.Y., Rao C.S., Varma R.K., Schridhar D.R. Acetic acid and phenylquinone writhing test: a critical study in mice. Methods Find. Exp. Clin. Pharmacol. 5:1983;601-606.
22. Snider R.M., Constantine J.W., Lowe J.A., Longo K.P., Lebel W.S., Woody H.A., Drozda S.E., Desai M.C., Vinick E.J., Spencer R.W.et al. A potent non-peptide antagonist of the substance P (NK1) receptor. Science. 251:1991;435-437.
23. Takemura, H., Hughes, A.R., Thastrup, O., Putney, Jr., J.W., 1989. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. J. Biol. Chem. 264, 12266-12271.
24. Tausk F., Undem B. Exogenous but endogenous substance P releases histamine from isolated human skin fragments. Neuropeptides. 29:1995;351-355.
25. Thomas, D.A., Williams, G.M., Iwata, K., Kenshalo, Jr., D.R., Dubner, R., 1993. Multiple effects of morphine on facial scratching in monkeys. Anesth. Analg. 77, 933-935.
26. Ueda H., Miyamae T., Hayashi C., Watanabe S., Fukushima N., Sasaki Y., Iwamura T., Misu Y. Protein kinase C involvement in homologous desensitization of delta-opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes. J. Neurosci. 15:1995a;7485-7499.
27. i1 in Xenopus oocytes. Mol. Brain Res. 31:1995;166-170.
28. Ueda H., Tamura S., Fukushima N., Katada T., Ui M., Satoh M. Inositol 1,4,5-trisphosphate-gated calcium transport through plasma membranes in nerve terminals. J. Neurosci. 16:1996;2891-2900.
29. Ueda H. In vivo molecular signal transduction of peripheral mechanisms of pain. Jpn. J. Pharmacol. 79:1999;263-268.
30. 2+ influx. Mol. Pharmacol. 57:2000;108-115.
31. Ueda H., Inoue M., Matsumoto T. Protein kinase C-mediated inhibition of μ-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral μ-agonist analgesia. J. Neurosci. 21:2001;2967-2973.
32. Wu Y.L., Pei G., Fan G.H. Inhibition of phospholipase C blocks opioid receptor mediated activation of Gi proteins. Neuroreport. 9:1998;99-103.
33. Yuan C.S., Foss J.F., O'Connor M., Osinski J., Roizen M.F., Moss J. Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine. Drug Alcohol Depend. 52:1998;161-165.
34. Zimmermann H. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.