Cisplatin causes over-expression of tachykinin NK1 receptors and increases ERK1/2- and PKA-phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 161-169

  Darmani, Nissar A ^a   Dey, Dilip ^a   Chebolu, Seetha ^a   Amos, Barry ^a   Kandpal, Raj ^a   Alkam, Tursun ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

5 HT3 receptor; Brainstem; Cisplatin; Delayed; Emesis; ERK1 2; Immediate; Intestine; Least shrew; NK 1 receptor; PKA Intestine; Substance P

Indexed keywords

CISPLATIN; COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NK1 RECEPTOR; SUBSTANCE P; TACHYKININ RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; CRYPTOTIS PARVA; ENZYME PHOSPHORYLATION; FEMALE; GENE OVEREXPRESSION; INTESTINE; MALE; MOLECULAR CLONING; NK1 RECEPTOR GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SHREW; SIGNAL TRANSDUCTION; SUBSTANCE P GENE; VOMITING;

ANIMALS; BRAIN STEM; CISPLATIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN KINASES; RATS; RECEPTORS, NEUROKININ-1; RECEPTORS, SEROTONIN; RNA, MESSENGER; SHREWS; SIGNAL TRANSDUCTION; SUBSTANCE P; VOMITING;

EID: 84871926995     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.09.008     Document Type: Article

References (35)

1. T. Adayev, B. Ranasinghe, and P. Banerjee Transmembrane signaling in the brain by serotonin, a key regulator of physiology and emotion Biosci. Rep. 25 2005 363 385 (Pubitemid 41712664)
2. 1 receptor in nausea and emesis F.B. Hofmann, Handbook of Experimental Pharmacology 2004 Springer-Verlag Berlin 359 440
3. K.C. Appell, B.J. Fragale, J. Loscig, S. Singh, and B.E. Tomczuk Antagonists that demonstrate species differences in neurokinin-1 receptors Mol. Pharmacol. 41 1992 772 778 (Pubitemid 23021468)
4. M.E. Cvijic, W.L. Yang, and K.V. Chin Cisplatin resistance in cyclic AMP-dependent protein kinase mutants Pharmacol. Ther. 78 1998 115 128 (Pubitemid 28202387)
5. 3 receptor antagonists prevent cisplatin-induced emesis in Cryptotis parva:: a new experimental model of emesis J. Neural. Transm. 105 1998 1143 1154 (Pubitemid 29017396)
6. 1-receptor antagonists in the least shrew (Cryptotis parvaparva) Pharmacol. Biochem. Behav. 99 2011 573 579
7. N.A. Darmani, J.L. Crim, J.J. Janoyan, J. Abad, and J. Ramirez A re-evaluation of the neurotransmitter basis of chemotherapy-induced immediate and delayed vomiting: evidence from the least shrew Brain Res. 1248 2009 40 58
8. N.A. Darmani, and J.C. Johnson Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis Eur. J. Pharmacol. 488 2004 201 212 (Pubitemid 38388540)
9. N.A. Darmani, and A.P. Ray Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting Chem. Rev. 109 2009 3158 3199
10. 1 receptor antagonists Brain Res. 1214 2008 58 72
11. D. Dey, J. Abad, A.P. Ray, and N.A. Darmani Differential temporal changes in brain and gut substance P mRNA expression throughout the time-course of cisplatin-induced vomiting in the least shrew (Cryptotis parva) Brain Res. 1310 2010 103 112
12. R.A. Duffy, G.B. Varty, C.A. Morgan, and J.E. Lachowicz Correlation of tachykinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists J. Pharmacol. Exp. Ther. 301 2002 536 542 (Pubitemid 34429965)
13. 1 receptors Biochem. Pharmacol. 73 2007 259 269 (Pubitemid 44855727)
14. E. George, C. Hornuss, and C.C. Apfel Tachykinin-1 and novel serotonin antagonists for postoperative and postdischarge nausea and vomiting Curr. Opin. Anaesthesiol. 23 2010 714 721
15. P.J. Hesketh, S. Van Belle, M. Aapro, F.D. Tattersall, R.J. Naylor, R. Hargreaves, A.D. Carides, J.K. Evans, and K.J. Horgan Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists Eur. J. Cancer 39 2003 1074 1080 (Pubitemid 36555864)
16. 3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret Br. J. Pharmacol. 97 1989 247 255 (Pubitemid 19113970)
17. F. Jafri, H.M. El-Shewy, M.H. Lee, M. Kelly, D.K. Luttrell, and L.M. Luttrell Constitutive ERK1/2 activation by a chimeric tachykinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor signalsome J. Biol. Chem. 281 2006 19346 19357 (Pubitemid 44035440)
18. A.P. Knox, N.L. Strominger, A.H. Battles, and D.O. Carpenter Behavioral studies of emetic sensitivity in the ferret Brain Res. Bull. 31 1993 477 484 (Pubitemid 23113182)
19. K.G. Margolis, and M.D. Gershon Neuropeptides and inflammatory bowel disease Curr. Opin. Gastroenterol. 25 2009 503 511
20. 2+ stores and extracellular influx through TRPC3 Neurochem. Int. 57 2010 923 934
21. D.L. Persons, E.M. Yazlovitskaya, W. Cui, and J.C. Pelling Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin Clin. Cancer Res. 5 1999 1007 1014 (Pubitemid 29233214)
22. Q. Qian, W. Chen, W. Yue, Z. Yang, Z. Liu, and W. Qian Antiemetic effect of Xiao-Ban-Xia-Tang, a Chinese medicinal herb recipe, on cisplatin-induced acute and delayed emesis in minks J. Ethnopharmacol. 128 2010 590 593
23. 1 receptor expression in a vomiting model of mink Chin. Med. J. (Engl.) 123 2010 478 484
24. X. Qin, C. Liu, Y. Zhou, and G. Wang Cisplatin induces programmed death-1-ligand 1(PD-L1) over-expression in hepatoma H22 cells via Erk/MAPK signaling pathway Cell. Mol. Biol. (Noisy-le-grand) 56 2010 OL1366 OL1372 Suppl
25. R.D. Ramnath, J. Sun, S. Adhikari, and M. Bhatia Effect of mitogen-activated protein kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells J. Cell. Mol. Med. 11 2007 1326 1341
26. 1 receptors reduces GR73632-induced vomiting Behav. Neurosci. 123 2009 701 706
27. J.A. Rudd, and P.L.R. Andrews Mechanisms of acute, delayed,and anticipatory emesis induced by anticancer therapies P.J. Hesketh, Management of Nausea and Vomiting in Cancer and Cancer Treatment 2005 Jones and Bartlett Sudbury, MA 15 65
28. 1 receptor antagonists Eur. J. Pharmacol. 326 1997 201 209 (Pubitemid 27214550)
29. 1 receptor in the brain: pharmacology and putative functions Eur. J. Pharmacol. 375 1999 51 60 (Pubitemid 29317592)
30. K.K. Son, and J. Rosenblatt Overexpression of protein kinase A - RIalpha reduces lipofection efficiency of cisplatin-resistant human tumor cells Cancer Lett. 165 2001 81 86 (Pubitemid 32206661)
31. 3 receptor antagonist, with a metoclopramide-containing antiemetic cocktail in the prevention of cisplatin-induced emesis Cancer 73 1994 445 454 (Pubitemid 24030627)
32. C. St Germain, N. Niknejad, L. Ma, K. Garbuio, T. Hai, and J. Dimitroulakos Cisplatin induces cytotoxicity through the mitogen-activated protein kinase pathways and activating transcription factor 3 Neoplasia 12 2010 527 538
33. 3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells J. Physiol. 586 2008 751 762 (Pubitemid 351194115)
34. H. Wang, Q. Cai, X. Zeng, D. Yu, S. Agrawal, and R. Zhang Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration Proc. Natl. Acad. Sci. USA 96 1999 13989 13994
35. Y. Yang, K. Kinoshita, K. Koyama, K. Takahashi, T. Tai, Y. Nunoura, and K. Watanabe Novel experimental model using free radical-induced emesis for surveying anti-emetic compounds from natural sources Planta Med. 65 1999 574 576 (Pubitemid 29399965)