Orexin-a hyperphagia: Hindbrain participation in consummatory feeding responses

Endocrinology

Volumn 150, Issue 3, 2009, Pages 1202-1216

  Baird, John Paul ^a   Choe, Angela ^a   Loveland, Jasmine L ^a   Beck, Janine ^a   Mahoney, Carrie E ^a   Lord, Julia S ^a   Grigg, Lindsay A ^a  

^a AMHERST COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; MELANOTAN II; OREXIN A; SUCROSE; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FOURTH VENTRICLE; BRAIN THIRD VENTRICLE; CEREBROSPINAL FLUID ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FEEDING BEHAVIOR; FOOD DEPRIVATION; FOOD INTAKE; FOREBRAIN; HYPERPHAGIA; LICKING; MALE; MEAL; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RAT; RHOMBENCEPHALON; SOLITARY TRACT NUCLEUS; WATER DEPRIVATION; ANIMAL; ANIMAL BEHAVIOR; APPETITE; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; EATING; INFUSION PUMP; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TASTE;

ANIMALS; APPETITE; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEEDING BEHAVIOR; HYPERPHAGIA; INFUSION PUMPS; INJECTIONS, INTRAVENTRICULAR; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RHOMBENCEPHALON; TASTE;

EID: 67649861799     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0293     Document Type: Article

References (78)

1. Kunii K, Yamanaka A, Nambu T, Matsuzaki I, Goto K, Sakurai T 1999 Orexins/hypocretins regulate drinking behaviour. Brain Res 842:256-261
2. Krowicki ZK, Burmeister MA, Berthoud HR, Scullion RT, Fuchs K, Hornby PJ 2002 Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function. Am J Physiol Gastrointest Liver Physiol 283:G465-G472
3. Miyasaka K, Masuda M, Kanai S, Sato N, Kurosawa M, Funakoshi A 2002 Central orexin-A stimulates pancreatic exocrine secretion via the vagus. Pancreas 25:400-404
4. Rodgers RJ, Ishii Y, Halford JC, Blundell JE 2002 Orexins and appetite regulation. Neuropeptides 36:303-325
5. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M 1998 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:1, page following 696
6. Thorpe AJ,ClearyJP,Levine AS, Kotz CM 2005 Centrally administered orexin A increases motivation for sweet pellets in rats. Psychopharmacology (Berl) 182:75-83
7. Harris GC, Wimmer M, Aston-Jones G 2005 A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437:556-559
8. Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, Arch JR, Blundell JE 2000 Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats. Regul Pept 96:71-84
9. Furudono Y, Ando C, Yamamoto C, Kobashi M, Yamamoto T 2006 Involvement of specific orexigenic neuropeptides in sweetener-induced overconsumption in rats. Behav Brain Res 175:241-248
10. Ida T, Nakahara K, Katayama T, Murakami N, Nakazato M 1999 Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res 821:526-529
11. Zheng H, Patterson LM, Berthoud HR 2005 Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function. J Comp Neurol 485:127-142
12. Zheng H, Patterson LM, Berthoud HR 2007 Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 27:11075-11082
13. Schneider ER, Rada P, Darby RD, Leibowitz SF, Hoebel BG 2007 Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin. Alcohol Clin Exp Res 31:1858-1865
14. Haynes AC, Jackson B, Overend P, Buckingham RE, Wilson S, Tadayyon M, Arch JR 1999 Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 20:1099-1105
15. Benoit SC, Clegg DJ, Woods SC, Seeley RJ 2005 The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides. Peptides 26:751-757
16. BackbergM, Hervieu G, WilsonS,Meister B 2002 Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur JNeurosci 15:315-328
17. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS 1998 Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996-10015
18. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, Sawchenko PE 1992 The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 319:218-245
19. Zamir N, Skofitsch G, Bannon MJ, Jacobowitz DM 1986 Melanin-concentrating hormone: unique peptide neuronal system in the rat brain and pituitary gland. Proc Natl Acad Sci USA 83:1528-1531
20. Zamir N, Skofitsch G, Jacobowitz DM 1986 Distribution of immunoreactive melanin-concentrating hormone in the central nervous system of the rat. Brain Res 373:240-245
21. Clegg DJ, Air EL, Benoit SC, Sakai RS, Seeley RJ, Woods SC 2003 Intraven-tricular melanin-concentrating hormone stimulates water intake independent of food intake. Am J Physiol Regul Integr Comp Physiol 284:R494-R499
22. Saper CB, Chou TC, Elmquist JK 2002 The need to feed: homeostatic and hedonic control of eating. Neuron 36:199-211
23. Sahu A 1998 Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology 139:4739-4742
24. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671
25. Zheng H, Patterson LM, Morrison C, Banfield BW, Randall JA, Browning KN, Travagli RA, Berthoud HR 2005 Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance. Neuroscience 135:611-625
26. Morton GJ, Schwartz MW 2001 The NPY/AgRP neuron and energy homeostasis. Int J Obes Relat Metab Disord 25(Suppl 5):S56-S62
27. Guan JL, Saotome T, Wang QP, Funahashi H, Hori T, Tanaka S, Shioda S 2001 Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus. Neuroreport 12:547-551
28. Powis JE, Bains JS, Ferguson AV 1998 Leptin depolarizes rat hypothalamic paraventricular nucleus neurons. Am J Physiol 274:R1468-R1472
29. Jobst EE, Enriori PJ, Cowley MA 2004 The electrophysiology of feeding circuits. Trends Endocrinol Metab 15:488-499
30. 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hy-pothalamus. Eur J Neurosci 19:1524-1534
31. Dube MG, Kalra SP, Kalra PS 1999 Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 842:473-477
32. Baird JP, Rios C, Loveland JL, Beck J, Tran A, Mahoney CE 2008 Effects of hindbrain melanin-concentrating hormone and neuropeptide Y administration on licking for water, saccharin, and sucrose solutions. Am JPhysiol Regul Integr Comp Physiol 294:R329-R343
33. Trivedi P, YuH, MacNeil DJ, Van der Ploeg LH, GuanXM1998 Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438:71-75
34. Lu XY, Bagnol D, Burke S, Akil H, Watson SJ 2000 Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm Behav 37:335-344
35. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK 2001 Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435:6-25
36. Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K 1999 Distribution of orexin neurons in the adult rat brain. Brain Res 827:243-260
37. Rogers RC, McCannMJ1993 Intramedullaryconnections ofthe gastric region in the solitarynucleus: a biocytin histochemical tracing studyin the rat. JAuton Nerv Syst 42:119-130
38. Yang B, Ferguson AV 2002 Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance. J Neurosci 22:6303-6308
39. Ritter RC, Slusser PG, Stone S 1981 Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451-452
40. Baird JP, Gray NE, Fischer SG 2006 Effects of neuropeptide Y on feeding microstructure: dissociation of appetitive and consummatory actions. Behav Neurosci 120:937-951
41. Baird JP, Rios C, Gray NE, Walsh CE, Fischer SG, Pecora AL 2006 Effects of melanin-concentrating hormone on licking microstructure and brief-access taste responses. Am J Physiol Regul Integr Comp Physiol 291:R1265-R1274
42. Davis JD, Levine MW 1977 A model for the control of ingestion. Psychol Rev 84:379-412
43. Davis JD 1998 A model for the control of ingestion: 20 years later. Prog Psychobiol Physiol Psychol 17:127-173
44. Spector AC, Klumpp PA, Kaplan JM 1998 Analytical issues in the evaluation of food deprivation and sucrose concentration effects on the microstructure of licking behavior in the rat. Behav Neurosci 112:678-694
45. Spector AC, St John SJ 1998 Role of taste in the microstructure of quinine ingestion by rats. Am J Physiol 274:R1687-R1703
46. Baird JP, St John SJ, Nguyen EA 2005 Temporal and qualitative dynamics of conditioned taste aversion processing: combined generalization testing and licking microstructure analysis. Behav Neurosci 119:983-1003
47. Kaplan JM, Baird JP, Grill HJ 2001 Dissociation of licking and volume intake controls in rats ingesting glucose and maltodextrin. Behav Neurosci 115:188-195
48. Davis JD 1996 Deterministic and probabilistic control of the behavior of rats ingesting liquid diets. Am J Physiol 270:R793-R800
49. Edwards GL, Ritter RC 1981 Ablation of the area postrema causes exaggerated consumption of preferred foods in the rat. Brain Res 216:265-276
50. Edmonds BK, Edwards GL 1998 Dorsomedial hindbrain participation in glucoprivic feeding response to 2DG but not 2DG-induced hyperglycemia or activation of the HPA axis. Brain Res 801:21-28
51. Edwards GL, Ritter RC 1986 Area postrema lesions: cause of overingestion is not altered visceral nerve function. Am J Physiol 251:R575-R581
52. FlynnFW, Grill HJ1988 Intraoral intake and taste reactivity responses elicited by sucrose and sodium chloride in chronic decerebrate rats. Behav Neurosci 102:934-941
53. Mileykovskiy BY, Kiyashchenko LI, Siegel JM 2005 Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46:787-798
54. Glendinning JI, Chyou S, Lin I, Onishi M, Patel P, Zheng KH 2005 Initial licking responses of mice to sweeteners: effects of tas1r3 polymorphisms. Chem Senses 30:601-614
55. Hsiao S, Fan RJ1993 Additivity of taste-specific effects of sucrose and quinine: microstructural analysis of ingestive behavior in rats. Behav Neurosci 107:317-326
56. Davis JD, Smith GP, Kung TM 1994 Abdominal vagotomy alters the structure f the ingestive behavior of rats ingesting liquid diets. Behav Neurosci 108:767-779
57. Eisen S, Davis JD, Rauhofer E, Smith GP 2001 Gastric negative feedback produced by volume and nutrient during a meal in rats. Am J Physiol Regul Integr Comp Physiol 281:R1201-R1214
58. Davis JD, Smith GP, Sayler JL 1997 Reduction of in take in the rat due to gastric filling. Am J Physiol 272:R1599-R1605
59. Davis JD, Smith GP, Kung TM 1995 Abdominal vagotomy attenuates the in hibiting effect of mannitol on the ingestive behavior of rats. Behav Neurosci 109:161-167
60. Schwartz GJ, Salorio CF, Skoglund C, Moran TH 1999 Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression. Am J Physiol 276:R1623-R1629
61. Ishii Y, Blundell JE,Halford JC, Upton N, Porter R, Johns A, Rodgers RJ 2004 Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats. Physiol Behav 81:129-140
62. Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, Arch JR, Upton N, Porter RA, Johns A, Blundell JE 2001 SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur J Neurosci 13:1444-1452
63. Ono K, Kai A, Honda E, Inenaga K 2008 Hypocretin-1/orexin-A activates subfornical organ neurons of rats. Neuroreport 19:69-73
64. Berthoud HR, Patterson LM, Sutton GM, Morrison C, Zheng H 2005 Orexin inputs to caudal raphe neurons involved in thermal, cardiovascular, and gastrointestinal regulation. Histochem Cell Biol 123:147-156]
65. Davis SF, Williams KW, Xu W, Glatzer NR, Smith BN 2003 Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation. J Neurosci 23:3844-3854
66. Yamada H, Takahashi N, Tanno S, Nagamine M, Takakusaki K, Okumura T 2005 A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats. Neurosci Lett 376:137-142
67. Takahashi N, Okumura T, Yamada H, Kohgo Y 1999 Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophys Res Commun 254:623-627
68. Guan JL, Wang QP, Kageyama H, Kita T, Takenoya F, Hori T, Shioda S 2005 Characterization of orexin Aimmuno reactivity in the rat area postrema. Regul Pept 129:17-23
69. Faulconbridge LF, Cummings DE, Kaplan JM, Grill HJ 2003 Hyperphagic effects of brainstem ghrelin administration. Diabetes 52:2260-2265
70. Zheng H, Patterson LM, Phifer CB, Berthoud HR 2005 Brain stem melano-cortinergic modulation of meal size and identification of hypothalamic POMC projections. Am J Physiol Regul Integr Comp Physiol 289:R247-R258
71. Grill HJ, Norgren R 1978 Neurological tests and behavioral deficits in chronic thalamic and chronic decerebrate rats. Brain Res 143:299-312
72. Nosaka S 1984 Solitary nucleus neurons transmitting vagal visceral input to the forebrain via a direct pathway in rats. Exp Neurol 85:493-505
73. Sawchenko PE, Swanson LW 1982 The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Res 257:275-325
74. Grill HJ, Kaplan JM 2002 The neuroanatomical axis for control of energy balance. Front Neuroendocrinol 23:2-40
75. von Monakow C 1914 Die Lokalisationin Grosshirnrinde und der Abbau der Function durch Korticale herde. Wiesbaden, Germany: J.F. Bergmann
76. Williams DL, Grill HJ, Weiss SM, Baird JP, Kaplan JM 2002 Behavioralprocesses underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the rat. Psychopharmacology (Berl) 161:47-53
77. Clegg DJ, Air EL, Woods SC, Seeley RJ 2002 Eating elicited by orexin-A, but not melanin-concentrating hormone, is opioid mediated. Endocrinology 143:2995-3000
78. Sahu A 2002 Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats. Brain Res 944:232-238