Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat

Neuroscience

Volumn 210, Issue , 2012, Pages 243-248

  Choi, D L ^a   Davis, J F ^a   Magrisso, I J ^b   Fitzgerald, M E ^a   Lipton, J W ^c   Benoit, S C ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Dopamine; Hedonic feeding; Orexin; Paraventricular thalamus

Indexed keywords

DOPAMINE; OREXIN; OREXIN 1 RECEPTOR; OREXIN A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; FEEDING BEHAVIOR; GENETIC MANIPULATION; LIMBIC SYSTEM; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; RAT; REWARD; SIGNAL TRANSDUCTION;

ANIMALS; DOPAMINE; FEEDING BEHAVIOR; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOTOR ACTIVITY; NEUROPEPTIDES; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, LONG-EVANS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84861202388     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.02.036     Document Type: Article

References (22)

1. Aston-Jones G., Smith R.J., Moorman D.E., et al. Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology 2009, 56(Suppl 1):112-121.
2. Borgland S.L., Chang S.J., Bowers M.S., et al. Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J Neurosci 2009, 29(36):11215-11225.
3. Boutrel B., Cannella N., de Lecea L. The role of hypocretin in driving arousal and goal-oriented behaviors. Brain Res 2010, 1314:103-111.
4. Cason A.M., Smith R.J., Tahsili-Fahadan P., et al. Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol Behav 2010, 100(5):419-428.
5. Choi D.L., Davis J.F., Fitzgerald M.E., et al. The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats. Neuroscience 2010, 167(1):11-20.
6. Hamlin A.S., Clemens K.J., Choi E.A., et al. Paraventricular thalamus mediates context-induced reinstatement (renewal) of extinguished reward seeking. Eur J Neurosci 2009, 29(4):802-812.
7. Harris G.C., Wimmer M., Randall-Thompson J.F., et al. Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward. Behav Brain Res 2007, 183(1):43-51.
8. Huang H., Ghosh P., van den Pol A.N. Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal. J Neurophysiol 2006, 95(3):1656-1668.
9. Jones M.W., Kilpatrick I.C., Phillipson O.T. Regulation of dopamine function in the nucleus accumbens of the rat by the thalamic paraventricular nucleus and adjacent midline nuclei. Exp Brain Res 1989, 76(3):572-580.
10. Kelley A.E., Baldo B.A., et al. A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward. J Comp Neurol 2005, 493(1):72-85.
11. Kirouac G.J., Parsons M.P., Li S. Orexin (hypocretin) innervation of the paraventricular nucleus of the thalamus. Brain Res 2005, 1059(2):179-188.
12. Li Y., Li S., Sui N., et al. Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats. Pharmacol Biochem Behav 2009, 93(4):506-514.
13. Li Y., Li S., Wei C., et al. Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus. Pharmacol Biochem Behav 2010, 95(1):121-128.
14. Li Y., Li S., Wei C., et al. Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats. Psychopharmacol (Berl) 2010, 212(2):251-265.
15. Li Y., Wang H., Qi K., et al. Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal. Physiol Behav 2011, 102(1):42-50.
16. Narita M., Nagumo Y., Hashimoto S., et al. Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 2006, 26(2):398-405.
17. Parsons M.P., Li S., Kirouac G.J. Functional and anatomical connection between the paraventricular nucleus of the thalamus and dopamine fibers of the nucleus accumbens. J Comp Neurol 2007, 500(6):1050-1063.
18. Peyron C., Tighe D.K., van den Pol A.N., et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998, 18(23):9996-10015.
19. Pinto A., Jankowski M., Sesack S.R. Projections from the paraventricular nucleus of the thalamus to the rat prefrontal cortex and nucleus accumbens shell: ultrastructural characteristics and spatial relationships with dopamine afferents. J Comp Neurol 2003, 459(2):142-155.
20. Sakurai T., Mieda M., Tsujino N. The orexin system: roles in sleep/wake regulation. Ann N Y Acad Sci 2010, 1200:149-161.
21. Schultz W. Dopamine neurons and their role in reward mechanisms. Curr Opin Neurobiol 1997, 7(2):191-197.
22. Zheng H., Patterson L.M., Berthoud H.R. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 2007, 27(41):11075-11082.