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Volumn 44, Issue 2, 2014, Pages 184-196

Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma

Author keywords

Asthma; Severe asthma; TLR5; TLR7

Indexed keywords

BUDESONIDE; PREDNISOLONE; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7;

EID: 84892749900     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12176     Document Type: Article
Times cited : (44)

References (52)
  • 1
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 2008; 8:183-92.
    • (2008) Nat Rev Immunol , vol.8 , pp. 183-192
    • Barnes, P.J.1
  • 3
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: the evolution from clinical to molecular approaches
    • Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012; 18:716-25.
    • (2012) Nat Med , vol.18 , pp. 716-725
    • Wenzel, S.E.1
  • 4
    • 79551505136 scopus 로고    scopus 로고
    • Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome
    • Lotvall J, Akdis CA, Bacharier LB et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011; 127:355-60.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 355-360
    • Lotvall, J.1    Akdis, C.A.2    Bacharier, L.B.3
  • 5
    • 84860666096 scopus 로고    scopus 로고
    • Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment
    • Holt PG, Sly PD. Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med 2012; 18:726-35.
    • (2012) Nat Med , vol.18 , pp. 726-735
    • Holt, P.G.1    Sly, P.D.2
  • 6
    • 84874733216 scopus 로고    scopus 로고
    • Microbes and mucosal immune responses in asthma
    • Hansel TT, Johnston SL, Openshaw PJ. Microbes and mucosal immune responses in asthma. Lancet 2013; 381:861-73.
    • (2013) Lancet , vol.381 , pp. 861-873
    • Hansel, T.T.1    Johnston, S.L.2    Openshaw, P.J.3
  • 7
    • 79956303498 scopus 로고    scopus 로고
    • Regulation of the antimicrobial response by NLR proteins
    • Elinav E, Strowig T, Henao-Mejia J, Flavell RA. Regulation of the antimicrobial response by NLR proteins. Immunity 2011; 34:665-79.
    • (2011) Immunity , vol.34 , pp. 665-679
    • Elinav, E.1    Strowig, T.2    Henao-Mejia, J.3    Flavell, R.A.4
  • 9
    • 84860691114 scopus 로고    scopus 로고
    • The airway epithelium in asthma
    • Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med 2012; 18:684-92.
    • (2012) Nat Med , vol.18 , pp. 684-692
    • Lambrecht, B.N.1    Hammad, H.2
  • 10
    • 0032556660 scopus 로고    scopus 로고
    • Respiratory tract viral infections in inner-city asthmatic adults
    • Atmar RL, Guy E, Guntupalli KK et al. Respiratory tract viral infections in inner-city asthmatic adults. Arch Intern Med 1998; 158:2453-9.
    • (1998) Arch Intern Med , vol.158 , pp. 2453-2459
    • Atmar, R.L.1    Guy, E.2    Guntupalli, K.K.3
  • 11
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303:1529-31.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 12
    • 10144222913 scopus 로고    scopus 로고
    • The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis
    • Johnston SL, Pattemore PK, Sanderson G et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 1996; 154(3 Pt 1):654-60.
    • (1996) Am J Respir Crit Care Med , vol.154 , Issue.3 PART 1 , pp. 654-660
    • Johnston, S.L.1    Pattemore, P.K.2    Sanderson, G.3
  • 13
    • 1842631428 scopus 로고    scopus 로고
    • Recognition of single-stranded RNA viruses by toll-like receptor 7
    • Lund JM, Alexopoulou L, Sato A et al. Recognition of single-stranded RNA viruses by toll-like receptor 7. Proc Natl Acad Sci USA 2004; 101:5598-603.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5598-5603
    • Lund, J.M.1    Alexopoulou, L.2    Sato, A.3
  • 14
    • 57149098273 scopus 로고    scopus 로고
    • Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders
    • Moller-Larsen S, Nyegaard M, Haagerup A, Vestbo J, Kruse TA, Borglum AD. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax 2008; 63:1064-9.
    • (2008) Thorax , vol.63 , pp. 1064-1069
    • Moller-Larsen, S.1    Nyegaard, M.2    Haagerup, A.3    Vestbo, J.4    Kruse, T.A.5    Borglum, A.D.6
  • 16
    • 84859904767 scopus 로고    scopus 로고
    • Upping the antedrug: is a novel anti-inflammatory toll-like receptor 7 agonist also a bronchodilator?
    • Kaufman EH, Jacoby DB. Upping the antedrug: is a novel anti-inflammatory toll-like receptor 7 agonist also a bronchodilator? Br J Pharmacol 2012; 166:569-72.
    • (2012) Br J Pharmacol , vol.166 , pp. 569-572
    • Kaufman, E.H.1    Jacoby, D.B.2
  • 18
    • 84869746281 scopus 로고    scopus 로고
    • Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist
    • Matsui H, Tomizawa H, Eiho K et al. Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist. J Immunol 2012; 189:5194-205.
    • (2012) J Immunol , vol.189 , pp. 5194-5205
    • Matsui, H.1    Tomizawa, H.2    Eiho, K.3
  • 19
    • 79551468701 scopus 로고    scopus 로고
    • Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs
    • Kaufman EH, Fryer AD, Jacoby DB. Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs. J Allergy Clin Immunol 2011; 127:462-9.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 462-469
    • Kaufman, E.H.1    Fryer, A.D.2    Jacoby, D.B.3
  • 20
    • 58549116357 scopus 로고    scopus 로고
    • Imiquimod, a toll-like receptor 7 ligand, inhibits airway remodelling in a murine model of chronic asthma
    • Du Q, Zhou LF, Chen Z, Gu XY, Huang M, Yin KS. Imiquimod, a toll-like receptor 7 ligand, inhibits airway remodelling in a murine model of chronic asthma. Clin Exp Pharmacol Physiol 2009; 36:43-8.
    • (2009) Clin Exp Pharmacol Physiol , vol.36 , pp. 43-48
    • Du, Q.1    Zhou, L.F.2    Chen, Z.3    Gu, X.Y.4    Huang, M.5    Yin, K.S.6
  • 21
    • 84862564782 scopus 로고    scopus 로고
    • Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis
    • Greiff L, Cervin A, Ahlstrom-Emanuelsson C et al. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res 2012; 13:53.
    • (2012) Respir Res , vol.13 , pp. 53
    • Greiff, L.1    Cervin, A.2    Ahlstrom-Emanuelsson, C.3
  • 22
    • 77954754177 scopus 로고    scopus 로고
    • Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma
    • Xirakia C, Koltsida O, Stavropoulos A et al. Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma. Am J Respir Crit Care Med 2010; 181:1207-16.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1207-1216
    • Xirakia, C.1    Koltsida, O.2    Stavropoulos, A.3
  • 23
    • 34547849745 scopus 로고    scopus 로고
    • Role of toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts
    • Chignard M, Balloy V, Sallenave JM, Si-Tahar M. Role of toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts. Clin Immunol 2007; 124:238-43.
    • (2007) Clin Immunol , vol.124 , pp. 238-243
    • Chignard, M.1    Balloy, V.2    Sallenave, J.M.3    Si-Tahar, M.4
  • 24
    • 84857133495 scopus 로고    scopus 로고
    • Toll-like receptor 5 (TLR5), IL-1beta secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing
    • Descamps D, Le Gars M, Balloy V et al. Toll-like receptor 5 (TLR5), IL-1beta secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing. Proc Natl Acad Sci USA 2012; 5:1619-24.
    • (2012) Proc Natl Acad Sci USA , vol.5 , pp. 1619-1624
    • Descamps, D.1    Le Gars, M.2    Balloy, V.3
  • 25
    • 33747769371 scopus 로고    scopus 로고
    • Involvement of toll-like receptor 5 in the recognition of flagellated bacteria
    • Feuillet V, Medjane S, Mondor I et al. Involvement of toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci USA 2006; 103:12487-92.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12487-12492
    • Feuillet, V.1    Medjane, S.2    Mondor, I.3
  • 26
    • 70350244436 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells
    • Raoust E, Balloy V, Garcia-Verdugo I, Touqui L, Ramphal R, Chignard M. Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells. PLoS ONE 2009; 4:e7259.
    • (2009) PLoS ONE , vol.4
    • Raoust, E.1    Balloy, V.2    Garcia-Verdugo, I.3    Touqui, L.4    Ramphal, R.5    Chignard, M.6
  • 27
    • 84869209695 scopus 로고    scopus 로고
    • The toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens
    • Wilson RH, Maruoka S, Whitehead GS et al. The toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens. Nat Med 2012; 18:1705-10.
    • (2012) Nat Med , vol.18 , pp. 1705-1710
    • Wilson, R.H.1    Maruoka, S.2    Whitehead, G.S.3
  • 28
    • 35648997996 scopus 로고    scopus 로고
    • Part III: Location of asthma inflammation and the distal airways: clinical implications
    • Kraft M. Part III: Location of asthma inflammation and the distal airways: clinical implications. Curr Med Res Opin 2007; 23(Suppl 3):S21-7.
    • (2007) Curr Med Res Opin , vol.23 , Issue.SUPPL 3
    • Kraft, M.1
  • 30
    • 0023567409 scopus 로고
    • This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986
    • Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
    • Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis 1987;136:225-44.
    • (1987) Am Rev Respir Dis , vol.136 , pp. 225-244
  • 31
    • 34748839579 scopus 로고    scopus 로고
    • Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperresponsiveness
    • Tufvesson E, Aronsson D, Ankerst J, George SC, Bjermer L. Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperresponsiveness. Respir Med 2007; 101:2321-6.
    • (2007) Respir Med , vol.101 , pp. 2321-2326
    • Tufvesson, E.1    Aronsson, D.2    Ankerst, J.3    George, S.C.4    Bjermer, L.5
  • 32
    • 70449730854 scopus 로고    scopus 로고
    • Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia
    • Barajon I, Serrao G, Arnaboldi F et al. Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia. J Histochem Cytochem 2009; 57:1013-23.
    • (2009) J Histochem Cytochem , vol.57 , pp. 1013-1023
    • Barajon, I.1    Serrao, G.2    Arnaboldi, F.3
  • 33
    • 37349032870 scopus 로고    scopus 로고
    • Glial toll-like receptor signaling in central nervous system infection and autoimmunity
    • Carpentier PA, Duncan DS, Miller SD. Glial toll-like receptor signaling in central nervous system infection and autoimmunity. Brain Behav Immun 2008; 22:140-7.
    • (2008) Brain Behav Immun , vol.22 , pp. 140-147
    • Carpentier, P.A.1    Duncan, D.S.2    Miller, S.D.3
  • 36
    • 80053289161 scopus 로고    scopus 로고
    • Toll like receptors in diseases of the lung
    • Kovach MA, Standiford TJ. Toll like receptors in diseases of the lung. Int Immunopharmacol 2011; 11:1399-406.
    • (2011) Int Immunopharmacol , vol.11 , pp. 1399-1406
    • Kovach, M.A.1    Standiford, T.J.2
  • 37
    • 4944240246 scopus 로고    scopus 로고
    • Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
    • Homma T, Kato A, Hashimoto N et al. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol 2004; 31:463-9.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 463-469
    • Homma, T.1    Kato, A.2    Hashimoto, N.3
  • 38
    • 26944454482 scopus 로고    scopus 로고
    • Glucocorticoids suppress inflammation but spare innate immune responses in airway epithelium
    • Schleimer RP. Glucocorticoids suppress inflammation but spare innate immune responses in airway epithelium. Proc Am Thorac Soc 2004; 1:222-30.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 222-230
    • Schleimer, R.P.1
  • 39
    • 38349190718 scopus 로고    scopus 로고
    • Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke
    • MacRedmond RE, Greene CM, Dorscheid DR, McElvaney NG, O'Neill SJ. Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir Res 2007; 8:84.
    • (2007) Respir Res , vol.8 , pp. 84
    • MacRedmond, R.E.1    Greene, C.M.2    Dorscheid, D.R.3    McElvaney, N.G.4    O'Neill, S.J.5
  • 40
    • 84865385470 scopus 로고    scopus 로고
    • Altered regulation of toll-like receptor responses impairs antibacterial immunity in the allergic lung
    • Habibzay M, Saldana JI, Goulding J, Lloyd CM, Hussell T. Altered regulation of toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol 2012; 5:524-34.
    • (2012) Mucosal Immunol , vol.5 , pp. 524-534
    • Habibzay, M.1    Saldana, J.I.2    Goulding, J.3    Lloyd, C.M.4    Hussell, T.5
  • 41
    • 27644482903 scopus 로고    scopus 로고
    • Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: a longitudinal analysis
    • Pasternack R, Huhtala H, Karjalainen J. Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: a longitudinal analysis. J Allergy Clin Immunol 2005; 116:1123-8.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 1123-1128
    • Pasternack, R.1    Huhtala, H.2    Karjalainen, J.3
  • 42
    • 77954366848 scopus 로고    scopus 로고
    • Infections and asthma: new insights into old ideas
    • Sevin CM, Peebles RS Jr. Infections and asthma: new insights into old ideas. Clin Exp Allergy 2010; 40:1142-54.
    • (2010) Clin Exp Allergy , vol.40 , pp. 1142-1154
    • Sevin, C.M.1    Peebles Jr, R.S.2
  • 43
    • 84880830083 scopus 로고    scopus 로고
    • Viral and bacterial infection in acute asthma & chronic obstructive pulmonary disease increases the risk of readmission
    • Wark P, Tooze M, Powell H, Parsons K. Viral and bacterial infection in acute asthma & chronic obstructive pulmonary disease increases the risk of readmission. Respirology 2013;18:996-1002.
    • (2013) Respirology , vol.18 , pp. 996-1002
    • Wark, P.1    Tooze, M.2    Powell, H.3    Parsons, K.4
  • 45
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: the role of microglia in toll-like receptor-mediated neuronal injury
    • Lehnardt S. Innate immunity and neuroinflammation in the CNS: the role of microglia in toll-like receptor-mediated neuronal injury. Glia 2010; 58:253-63.
    • (2010) Glia , vol.58 , pp. 253-263
    • Lehnardt, S.1
  • 46
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 2001; 167:1882-5.
    • (2001) J Immunol , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 47
    • 2342535902 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5
    • Adamo R, Sokol S, Soong G, Gomez MI, Prince A. Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5. Am J Respir Cell Mol Biol 2004; 30:627-34.
    • (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 627-634
    • Adamo, R.1    Sokol, S.2    Soong, G.3    Gomez, M.I.4    Prince, A.5
  • 48
    • 84857670611 scopus 로고    scopus 로고
    • The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems
    • Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C. The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS ONE 2012; 7:e32125.
    • (2012) PLoS ONE , vol.7
    • Chuquimia, O.D.1    Petursdottir, D.H.2    Rahman, M.J.3    Hartl, K.4    Singh, M.5    Fernandez, C.6
  • 49
    • 37849187487 scopus 로고    scopus 로고
    • Stimulation of mast cells via FcvarepsilonR1 and TLR2: the type of ligand determines the outcome
    • Fehrenbach K, Port F, Grochowy G et al. Stimulation of mast cells via FcvarepsilonR1 and TLR2: the type of ligand determines the outcome. Mol Immunol 2007; 44:2087-94.
    • (2007) Mol Immunol , vol.44 , pp. 2087-2094
    • Fehrenbach, K.1    Port, F.2    Grochowy, G.3
  • 50
    • 79951955543 scopus 로고    scopus 로고
    • Activation of the PI3K pathway increases TLR-induced TNF-alpha and IL-6 but reduces IL-1beta production in mast cells
    • Hochdorfer T, Kuhny M, Zorn CN et al. Activation of the PI3K pathway increases TLR-induced TNF-alpha and IL-6 but reduces IL-1beta production in mast cells. Cell Signal 2011; 23:866-75.
    • (2011) Cell Signal , vol.23 , pp. 866-875
    • Hochdorfer, T.1    Kuhny, M.2    Zorn, C.N.3
  • 51
    • 77956366626 scopus 로고    scopus 로고
    • The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
    • Lambrecht BN, Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. Lancet 2010; 376:835-43.
    • (2010) Lancet , vol.376 , pp. 835-843
    • Lambrecht, B.N.1    Hammad, H.2
  • 52
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N, Ho S, Antonenko S et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001; 194:863-9.
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3


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