Investigation into mixing capability and solid dispersion preparation using the DSM Xplore Pharma Micro Extruder

Journal of Pharmacy and Pharmacology

Volumn 66, Issue 2, 2014, Pages 218-231

  Sakai, Toshiro ^a   Thommes, Markus ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

dispersive mixing; distributive mixing; formulation screening; melt extrusion; small scale extruder; solid dispersion

Indexed keywords

CARBAMAZEPINE; GRISEOFULVIN; IBUPROFEN; MACROGOL; MICROCRYSTALLINE CELLULOSE; NICOTINAMIDE; POLOXAMER; POLY(METHYL METHACRYLATE); POVIDONE; SODIUM CHLORIDE;

ARTICLE; BASE PAIRING; COMPLEX FORMATION; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG FORMULATION; DRUG MIXTURE; DRUG SCREENING; DRUG SOLUBILITY; ELECTRIC CURRENT; EXTRUDER; INFRARED SPECTROSCOPY; MACHINE; PARTICLE SIZE; PELLET EXTRUSION; POWER SUPPLY; PRECIPITATION; SOLID DISPERSION; SUSPENSION; TEMPERATURE MEASUREMENT; X RAY DIFFRACTION;

DISPERSIVE MIXING; DISTRIBUTIVE MIXING; FORMULATION SCREENING; MELT EXTRUSION; SMALL SCALE EXTRUDER; SOLID DISPERSION;

CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; FREEZING; HOT TEMPERATURE; HUMANS; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POLYETHYLENE GLYCOLS; POLYVINYLS; PYRROLIDINES; SODIUM CHLORIDE; SOLUTIONS; VINYL COMPOUNDS;

EID: 84892737821     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12085     Document Type: Article

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