Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers

Drug Development and Industrial Pharmacy

Volumn 34, Issue 1, 2008, Pages 95-106

  Patterson, James E ^a,b   James, Michael B ^b   Forster, Angus H ^b   Rades, Thomas ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Carbamazepine; Dipyridamole; Melt extrusion; PVP VA copolymer and physical stability; Spray drying

Indexed keywords

CARBAMAZEPINE; COPOLYMER; DIPYRIDAMOLE; GLASS; POLYVINYLPYRROLIDONE VINYL ACETATE 37 COPOLYMER; POLYVINYLPYRROLIDONE VINYL ACETATE 64 COPOLYMER; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; GRAVIMETRY; HYDROGEN BOND; HYDROPHILICITY; INFRARED SPECTROSCOPY; MICROSCOPY; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; SPECTROSCOPY; SPRAY DRYING; THERMOGRAVIMETRY; X RAY POWDER DIFFRACTION;

CARBAMAZEPINE; DIPYRIDAMOLE; DRUG STABILITY; PYRROLIDINES; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; VINYL COMPOUNDS;

EID: 38549138908     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040701484627     Document Type: Article

References (22)

1. Amidon, G. L., Lennernas, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12, 413-420.
2. Beten, D. B., & Moes, A. J. (1994). Controlled release coevaporates of dipyridamole prepared with acrylic polymers. International Journal of Pharmaceutics, 103, 243-251.
3. Bhandari, B. (2004). Glass transition relation to stickiness during spray drying. St. Lucia: University of Queensland.
4. Buhler, V. (2001). Kollidon. Polyvinylpyrrolidone for the pharmaceutical industry, BASF.
5. Chokshi, R. J., Sandhu, H. K., Iyer, R.M., Shah, N. H., Malick, A. W., & Zia, H. (2005). Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion processs as a means to manufacture solid-dispersion/solution. Journal of Pharmaceutical Sciences, 94, 2463-2474.
6. Ford (1986). The current status of solid-dispersions. Pharmaceutica Acta Helvetiae, 61, 69-88.
7. Forster, A., Hempenstall, J., Tucker, I., & Rades, T. (2001). Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis. International Journal of Pharmaceutics, 226, 147-161.
8. Gordon, M., & Taylor, J. (1952). Journal of Applied Chemistry, 2, 493.
9. Krahn, F.U., & Mielck, J.B. (1987). Relations between several polymorphic forms and dihydrate of carbamazepine. Pharmaceutica Acta Helvetiae, 62, 247-254.
10. Kuhnert-Brandstatter, M., & Wurian, I. (1982). Thermoanalytische und IR-spektroskopische Untersuchungen an enantiotrop polymorphen arzneistoffen. Scientia Pharmaceutica, 50, 3-11.
11. Moneghini, M., Voinovich, D., Princivalle, F., & Magarotto, L. (2000). Formulation and evaluation of vinylpyrrolidone/vinylacetate copolymer microspheres with carbamazepine. Pharmaceutical Development and Technology, 5, 347-353.
12. Najib, N. M., Suleiman, M., & Malakh, A. (1986). Characteristics of the in vitro release of ibuprofen from polyvinylpyrrolidone solid-dispersions. International Journal of Pharmaceutics, 32, 229-236.
13. Ohara, T., Kitamura, S., Kitagawa, T., & Terada, K. (2005). Dissolution mechanism of poorly water-soluble drug from extended release solid-dispersion system with ethylcellulose and hydroxypropylmethylcellulose. International Journal of Pharmaceutics, 302, 95-102.
14. Patterson, J., James, M., Forster, A., Lancaster, R., Butler, J., & Rades, T. (2005). The influence of thermal and mechanical preparative techniques on the amorphous state of four poorly soluble compounds. Journal of Pharmaceutical Sciences, 94, 1998-2012.
15. Patterson, J., James, M., Forster, A., Lancaster, R., Butler, J., & Rades, T. (2007). Preparation of glass solutions of three water soluble drugs by spray drying, melt extrusion and ball milling. International Journal of Pharmaceutics, 336, 22-34.
16. Patterson, J., James, M., Forster, A., & Rades, T. (2003). The use of Raman Microscopy, MTDSC, and high speed DSC to determine homogeneity of carbamazepine solid-dispersion. Poster Presentation: AAPS Annual Meeting. Salt Lake City, Utah, USA Oct 2003. AAPS PharmSci, 5, Abstract M1233.
17. Simonelli, A.P., Mehta, S.C., & Higuchi, W. I. (1969). Journal of Pharmaceutical Sciences, 58, 538-548.
18. Verreck, G., Six, K., Van den Mooter, G., Baert, L., Peeters, J., & Brewster, M. E. (2003). Characterization of solid-dispersions of itraconazole and hydroxypropylmethylcellulose prepared by melt extrusion - Part I. International Journal of Pharmaceutics, 251, 165-174.
19. Vojnovic, D., Rubessa, F., Bogataj, M., & Mrhar, A. (1993). Formulation and evaluation of VP-VA copolymer microspheres with Griseofulvin. Journal of Microencapsulation, 10, 89-99.
20. Yoshioka, M., Hancock, B. C., & Zografi, G. (1994). Crystallization of Indomethacin from the amorphous state below and above its glass transition temperature. Journal of Pharmaceutical Sciences, 83, 1700-1705.
21. Zhang, F., & McGinity, J. (2000). Properties of hot melt extruded theophylline tablets containing poly(vinyl acetate). Drug Development and Industrial Pharmacy, 26, 931-942.
22. Zingone, G., & Rubessa, F. (1994). Release of Carbamazepine from solid-dispersions with PVP/VA copolymer. S.T.P.Pharma Sciences, 4, 122-127.