Soulamarin Isolated from Calophyllum brasiliense (Clusiaceae) Induces Plasma Membrane Permeabilization of Trypanosoma cruzi and Mytochondrial Dysfunction

PLoS Neglected Tropical Diseases

Volumn 7, Issue 12, 2013, Pages

  Rea, Alexandre ^a   Tempone, Andre G ^b   Pinto, Erika G ^b,c   Mesquita, Juliana T ^b   Rodrigues, Eliana ^a   Silva, Luciana Grus M ^a   Sartorelli, Patricia ^a   Lago, João Henrique G ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO ADOLFO LUTZ   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BENZNIDAZOLE; COUMARIN; OLIGOMYCIN; PLANT MEDICINAL PRODUCT; REACTIVE OXYGEN METABOLITE; SOULAMARIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHAGAS DISEASE; CLUSIACEAE; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FLUORESCENCE MICROSCOPY; HEMOLYSIS; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PLANT STEM; PLASMA MEMBRANE PERMEABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROFLUOROMETRY; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; ANTIPROTOZOAL AGENTS; CALOPHYLLUM; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; COUMARINS; ERYTHROCYTES; MACROPHAGES, PERITONEAL; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; MITOCHONDRIA; PLANT BARK; PLANT EXTRACTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPANOSOMA CRUZI;

EID: 84892719802     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002556     Document Type: Article

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