Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

Parasitology Research

Volumn 106, Issue 5, 2010, Pages 1245-1248

  Grecco, Simone S ^a   Reimão, Juliana Q ^b   Tempone, Andre G ^b   Sartorelli, Patricia ^a   Romoff, Paulete ^c   Ferreira, Marcelo J P ^c   Fávero, Oriana A ^c   Lago, Joao H G ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO ADOLFO LUTZ   (Brazil)

^c MACKENZIE PRESBYTERIAN UNIVERSITY   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

5,6,7 TRIHYDROXY 4' METHOXYFLAVANONE; BACCHARIS RETUSA EXTRACT; BENZNIDAZOLE; DICHLOROMETHANE; FLAVANONE DERIVATIVE; HERBACEOUS AGENT; MEGLUMINE ANTIMONATE; METHANOL; PENTAMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; ASTERACEAE; BACCHARIS RETUSA; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IC 50; LEISHMANIA; LEISHMANIA BRAZILIENSIS; LEISHMANIA CHAGASI; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; SOLVENT EXTRACTION; SYRIAN HAMSTER; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPROTOZOAL AGENTS; BACCHARIS; BRAZIL; CELLS, CULTURED; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; FLAVANONES; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA; MACACA MULATTA; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MONOCYTES; PLANT EXTRACTS; PLANT LEAVES; TRYPANOSOMA CRUZI;

ASTERACEAE; BACCHARIS; LEISHMANIA SP.; RETUSA; TRYPANOSOMA CRUZI;

EID: 77953286008     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-010-1771-8     Document Type: Article

References (20)

1. Agrawal PK (1989) Carbon-13 NMR of flavonoids. Elsevier Science, Amsterdam
2. Balaña-Fouce R, Reguera RM, Cubría C, Ordóñez D (1998) The pharmacology of Leishmaniasis. Gen Pharm 30:435-443 (Pubitemid 28102818)
3. Chappuis F, Sundar S, Hailu A, Ghalib H, Rijal S, Peeling RW et al (2007) Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol 5:873-882 (Pubitemid 47578388)
4. da Silva Filho AA, Resende DO, Fukui MJ, Santos FF, Pauletti PM, Cunha WR, Silva ML, Gregório LE, Bastos JK, Nanayakkara NP (2009) In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D.C (Asteraceae). Fitoterapia 80:478-482
5. Danelutte AP, Lago JHG, Young MCM, Kato MJ (2003) Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth. Phytochemistry 64:555-559
6. Lane JE, Ribeiro-Rodrigues R, Suarez CC, Bogitsh BJ, Jones MM, Singh PK, Carter CE (1996) In vitro trypanocidal activity of tetraethylthiuram disulfide and sodium diethylamine-N-carbodithioate on Trypanosoma cruzi. Am Soc Trop Med Hyg 55:263-266
7. Marín C, Boutaleb-Charki S, Díaz JG, Huertas O, Rosales MJ, Pérez-Cordon G, Guitierrez-Sánchez R, Sánchez-Moreno M (2009) Antileishmaniasis activity of flavonoids from Consolida oliveriana. J Nat Prod 72:1069-1074
8. Matoussi N, Ameur HB, Amor SB, Fitouri Z, Becher SB (2007) Cardiotoxicity of n-methyl-glucamine antimoniate (Glucantime) - a case report. Med Mal Infect 37:S257-S259
9. Mortara RA, Andreoli WK, Fernandes MC, da Silva CV, Fernandes AB, L'Abbate C, da Silva S (2008) Host cell actin remodeling in response to Trypanosoma cruzi: trypomastigote versus amastigote entry. Subcell Biochem 47:101-109
10. Muzitano MF, Falcão CA, Cruz EA, Bergonzi MC, Bilia AR, Vincieri FF, Rossi-Bergmann B, Costa SS (2009) Oral metabolism and efficacy of Kalanchoe pinnata flavonoids in a murine model of cutaneous leishmaniasis. Planta Med 75:307-311
11. Ribeiro A, Piló-Veloso D, Romanha AJ, Zani CL (1997) Trypanocidal flavonoids from Trixis vauthieri. J Nat Prod 60:836-841
12. Sartorelli P, Andrade SP, Melhem MS, Prado FO, Tempone AG (2007) Isolation of antileishmanial sterol from the fruits of Cassia fistula using bioguided fractionation. Phytother Res 7:644-647
13. Silva CF, Batista MM, Mota RA, De Souza EM, Stephens CE, Boykin DW, Soeiro MN (2007) Activity of "reversed" diamidines against Trypanosoma cruzi in vitro. Biochem Pharmacol 73:1939-1946
14. Singh S, Sivakumar R (2004) Challenges and new discoveries in the treatment of leishmaniasis. J Infect Chemother 10:307-315
15. Tada H, Shiho O, Kuroshima K, Koyama M, Tsukamoto K (1986) An improved colorimetric assay for interleukin 2. J Immunol Methods 93:157-165
16. Tempone AG, Perez D, Rath S, Vilarinho AL, Mortara RA, de Andrade HF Jr (2004) Targeting Leishmania (L.) chagasi amastigotes through macrophage scavenger receptors: the use of drugs entrapped in liposomes containing phosphatidylserine. J Antimicrob Chemother 54:60-68
17. Tempone AG, Sartorelli P, Fernandes F, Mady C (2007) Natural toxins to antitrypanosomal drugs: an overview of new drug prototypes for American trypanosomiasis. Cardiovasc Hematol Agents Med Chem 5:222-235
18. Tempone AG, Sartorelli P, Teixeira D, Prado FO, Calixto IA, Lorenzi H, Melhem MS (2008) Brazilian flora extracts as source of novel antileishmanial and antifungal compounds. Mem Inst Oswaldo Cruz 103:443-449
19. Trouiller P, Torreele E, Olliaro P, White N, Foster S, Wirth D, Pecoul B (2001) Drugs for neglected diseases: a failure of the market and a public health failure? Trop Med Int Health 6:945-951
20. Verdi LG, Brighente IMC, Pizzolatti MG (2005) Gênero Baccharis (Asteraceae): aspectos químicos, econômicos e biológicos. Quím Nova 28:85-94