Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi

Experimental Parasitology

Volumn 127, Issue 2, 2011, Pages 429-435

  De Souza, E M ^a   da Silva, P B ^a   Nefertiti, A S G ^a   Ismail, M A ^b   Arafa, R K ^b   Tao, B ^b   Nixon Smith, C K ^b   Boykin, D W ^b   Soeiro, M N C ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Aromatic amidine; Trypanocidal activity; Trypanosoma cruzi

Indexed keywords

5,5' [1,4 PHENYLENEBISO(OXY)] DI(2 AMIDINO)PYRIDINE; AMIDINE; BENZNIDAZOLE; CRYSTAL VIOLET; DB 1283; DB 820D; DB 829C; DIAMIDINE DERIVATIVE; N [4 (PICOLINIMIDAMIDO)BENZYL] 3 [4 (PICOLINIMIDAMIDO)PHENYL]ACRYLAMIDE; N,N' 4,4' (1,4 PHENYLENE) BIS(OXY) BIS(4,1 PHENYLENE) BIS(4 TERT BUTYLBENZIMIDAMIDE); UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; LD 50; NONHUMAN; PRIORITY JOURNAL; PROTIST LIFE CYCLE STAGE; TRYPANOSOMA CRUZI;

AMIDINES; ANIMALS; CHAGAS DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; LETHAL DOSE 50; MICE; MYOCYTES, CARDIAC; PARASITEMIA; PENTAMIDINE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

MAMMALIA; TRYPANOSOMA CRUZI;

EID: 78751601288     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.10.010     Document Type: Article

References (30)

1. Batista D.G., Pacheco M.G., Kumar A., Branowska D., Ismail M.A., Hu L., Boykin D.W., Soeiro M.N. Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi. Parasitology 2010, 137:251-259.
2. Batista D.G.J., Batista M.M., Oliveira G.M., Borges P., Lannes-Vieira J., Britto C.C., Junqueira A., Lima M.M., Romanha A.J., Sales Junior P.A., Stephens C.E., Boykin D.B., Soeiro M.N.C. Arylimidamide DB766: a potential chemotherapeutic candidate for chagas disease treatment. Antimicrobial Agents and Chemoterapy 2010, 54:2940-2952.
3. Chiari E., Oliveira A.B., Prado M.A., Alves R.J., Galvão L.M., Araújo F.G. Potential use of WR6026 as prophylaxis against transfusion-transmitted American trypanosomiasis. Antimicrobial Agents and Chemoterapy 1996, 40:613-615.
4. Coura J.R., Albajar Viñas P. Chagas disease: a new worldwide challenge. Nature 2010, 465:S6-S7.
5. Coura J.R., Dias J.C. Epidemiology, control and surveillance of Chagas disease: 100 years after its discovery. Memórias do Instituto Oswaldo Cruz 2009, 1:31-40.
6. Daliry A., Da Silva P.B., Da Silva C.F., Batista M.M., De Castro S.L., Tidwell R.R., Soeiro M.N.C. In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi. Journal of Antimicrobial Chemotherapy 2009, 64:747-750.
7. De Souza E.M., Lansiaux A., Bailly C., Wilson W.D., Hu Q., Boykin D.W., Batista M.M., Araújo-Jorge T.C., Soeiro M.N.C. Phenyl substitution of furamidine markedly potentiates its antiparasitic activity against Trypanosoma cruzi and Leishmania amazonensis. Biochemical Pharmacology 2004, 68:593-600.
8. De Souza E.M., Melo G., Boykin D.W., Wilson W.D., Hu Q., Soeiro M.N.C. Tripanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. Journal Antimicrobial Chemotherapy 2006, 58:610-614.
9. De Souza W. From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality. Kinetoplastid Biology Disease 2002, 1:3.
10. Dias J.C. Elimination of Chagas disease transmission: perspectives. Memórias do Instituto Oswaldo Cruz 2009, 1:41-45.
11. Docampo R., Moreno S.N., Gadelha F.R., de Souza W., Cruz F.S. Prevention of Chagas' disease resulting from blood transfusion by treatment of blood: toxicity and mode of action of gentian violet. Biomed Environ Sci 1988, 1:406-413.
12. Hernández-Becerril N., Mejía A.M., Ballinas-Verdugo M.A., Garza-Murillo V., Manilla-Toquero E., López R., Trevethan S., Cardenas M., Reyes P.A., Hirayama K., Monteón V.M. Blood transfusion and iatrogenic risks in Mexico City. Anti-Trypanosoma cruzi seroprevalence in 43,048 blood donors, evaluation of parasitemia, and electrocardiogram findings in seropositive. Memórias do Instituto Oswaldo Cruz 2005, 100:111-116.
13. Ismail M.A., Brun R., Easterbrook J.D., Tanious F.A., Wilson W.D., Boykin D.W. Synthesis and antiprotozoal activity of aza-analogues of furamidine. Journal of Medicinal Chemistry 2003, 46:4761-4769.
14. Lannes-Vieira J., Silverio J.C., Pereira I.R., Vinagre N.F., Carvalho C.M., Paiva C.N., da Silva A.A. Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true. Memórias do Instituto Oswaldo Cruz 2009, 1:226-235.
15. McKerrow J.H., Doyle P.S., Engel J.C., Podust L.M., Robertson S.A., Ferreira R., Saxton T., Arkin M., Kerr I.D., Brinen L.S., Craik C.S. Two approaches to discovering and developing new drugs for Chagas disease. Memórias do Instituto Oswaldo Cruz 2009, 104:263-269.
16. Meirelles M.N., Chiari E., de Souza W. Interaction of bloodstream, tissue culture-derived and axenic culture-derived trypomastigotes of Trypanosoma cruzi with macrophages. Acta Tropical 1982, 39:195-203.
17. Meirelles M.N.L., Araújo-Jorge T.C., Miranda C.F., De Souza W., Barbosa H.S. Interaction of Trypanosoma cruzi with heart muscle cells: ultrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in in vitro. European Journal of Cell Biology 1986, 41:198-206.
18. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation in cytotoxicity assays. Journal of Immunological Methods 1983, 65:55-63.
19. Pacheco M.G.O., Silva C.F., De Souza E.M., Batista M.M., Silva P.B., Kumar A., Stephens C.E., Boykin D.W., Soeiro M.N.C. Trypanosoma cruzi: activity of heterocyclic cationic molecules in vitro. Experimental Parasitology 2009, 123:73-80.
20. Rocha M.O., Teixeira M.M., Ribeiro A.L. An update on the management of Chagas cardiomyopathy. Expert Review of Anti-infective Therapy 2007, 5:727-743.
21. Romanha A.J., Castro S.L., Soeiro M.N.C., Lannes-Vieira J., Ribeiro I., Talvani A., Bourdin B., Blum B., Olivieri B., Zani C., Spadafora C., Chiari E., Chatelain E., Chaves G., Calzada J.E., Bustamante J.M., Freitas-Junior L.H., Romero L.I., Bahia M.T., Lotrowska M., Soares M., Andrade S.G., Armstrong T., Degrave W., Andrade Z.A. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Memórias do Instituto Oswaldo Cruz 2010, 105:233-238.
22. Silva C.F., Meuser M.B., De Souza E.M., Meirelles M.N., Stephens C.E., Som P., Boykin D.W., Soeiro M.N. Cellular effects of reversed amidines on Trypanosoma cruzi. Antimicrobial Agents Chemotherapy 2007, 51:3803-3809.
23. Soeiro M.N., de Castro S.L. Trypanosoma cruzi targets for new chemotherapeutic approaches. Expert Opinion Therapeutic Targets 2009, 13:105-121.
24. Soeiro M.N., de Castro S.L., de Souza E.M., Batista D.G., Silva C.F., Boykin D.W. Diamidine activity against trypanosomes: the state of the art. Current Molecular Pharmacology 2008, 1:151-161.
25. Stephens C.E., Tanious F., Kim S., Wilson W.D., Schell W.A., Perfect J.R., Franzblau S.G., Boykin D.W. Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents. Journal of Medicinal Chemistry 2001, 44:1741-1748.
26. Urbina J.A. Ergosterol biosynthesis and drug development for Chagas disease. Memórias do Instituto Oswaldo Cruz 2009, 104:311-318.
27. Urbina J.A. Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches. Acta Tropica 2010, 115:55-68.
28. Wang M.Z., Zhu X., Srivastava A., Liu Q., Sweat J.M., Pandharkar T., Stephens C.E., Riccio E., Parman T., Munde M., Mandal S., Madhubala R., Tidwell R.R., Wilson W.D., Boykin D.W., Hall J.E., Kyle D.E., Werbovetz K.A. Novel Arylimidamides for the Treatment of Visceral Leishmaniasis. Antimicrobial Agents Chemotherapy 2010, 54:2507-2516.
29. Wenzler T., Boykin D.W., Ismail M.A., Hall J.E., Tidwell R.R., Brun R. New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial Agents Chemotherapy 2009, 53:4185-4192.
30. Werbovetz K. Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. Current Opinion Investigational Drugs 2006, 7:147-157.