Global axonal transport rates are unaltered in htau mice in vivo

Journal of Alzheimer's Disease

Volumn 37, Issue 3, 2013, Pages 579-586

  Yuan, Aidong ^a,b,d   Kumar, Asok ^a,b   Sasaki, Takahiro ^a   Duff, Karen ^c   Nixon, Ralph A ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Columbia University ^*  (United States)

^d NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Alzheimer's disease; fast axonal transport; neurofilament; slow axonal transport; tau; tauopathy

Indexed keywords

NEUROFILAMENT PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IN VIVO STUDY; MOUSE; NERVE FIBER; NERVE FIBER TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RETINA GANGLION CELL; TAUOPATHY; TRANSPORT KINETICS;

ANIMALS; AXONAL TRANSPORT; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RETINAL GANGLION CELLS; TAU PROTEINS; TIME FACTORS;

EID: 84892690719     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130671     Document Type: Article

References (37)

1. Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8, 663-672.
2. Avila J, deBarreda EG, Pallas-Bazarra N, Hernandez F (2013) Tau and neuron aging. Aging Dis 4, 23-28.
3. Kanai Y, Takemura R, Oshima T, Mori H, Ihara Y, Yanagi-sawa M, Masaki T, Hirokawa N (1989) Expressionofmultiple tau isoforms and microtubule bundle formation in fibrob-lasts transfected with a single tau cDNA. J Cell Biol 109, 1173-1184.
4. Caceres A, Kosik KS (1990) Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons. Nature 343, 461-463.
5. Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Neuronal loss correlates with but exceeds neurofibrillary tanglesin Alzheimer's disease. Ann Neurol 41, 17-24.
6. Ghoshal N, Garcia-Sierra F, Wuu J, Leurgans S, Bennett DA, Berry RW, Binder LI (2002) Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease. Exp Neurol 177, 475-493.
7. Khatoon S, Grundke-Iqbal I, Iqbal K (1992) Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem 59, 750-753.
8. Ksiezak-Reding H, Binder LI, Yen SH (1988) Immunochemi-cal and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1. J Biol Chem 263, 7948-7953.
9. Sergeant N, Buee L (2011) Tau pathology. In Cytoskeleton of the Nervous System, Yuan A, Nixon RA, eds. Springer, New York, pp. 83-132.
10. Vershinin M, Carter BC, Razafsky DS, King SJ, Gross SP (2007) Multiple-motor based transport and its regulation by tau. Proc Natl Acad Sci USA 104, 87-92.
11. Millecamps S, Julien JP (2013) Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci 14, 161-176.
12. Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156, 1051-1063.
13. Morfini G, Pigino G, Mizuno N, Kikkawa M, Brady ST (2007) Tau binding to microtubules does not directly affect microtubule-based vesicle motility. J Neurosci Res 85, 2620-2630.
14. Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA (2008) Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci 28, 1682-1687.
15. LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, Brady ST (2009) The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity. J Neurosci Res 87, 440-451.
16. Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI (2011) Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci 31, 9858-9868.
17. Duff K, Knight H, Refolo LM, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goedert M, Burki K, Davies P (2000) Characterization of pathology in trans-genic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis 7, 87-98.
18. Andorfer C, Kress Y, Espinoza M, de Silva R, Tucker KL, Barde YA, Duff K, Davies P (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86, 582-590.
19. Tucker KL, Meyer M, Barde YA (2001) Neurotrophins are required for nerve growth during development. Nat Neurosci 4, 29-37.
20. Yuan A, Rao MV, Kumar A, Julien JP, Nixon RA (2003) Neurofilament transport in vivo minimally requires hetero-oligomer formation. J Neurosci 23, 9452-9458.
21. Yuan A, Rao MV, Sasaki T, Chen Y, Kumar A, Veeranna, Liem RK, Eyer J, Peterson AC, Julien JP, Nixon RA (2006) Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J Neurosci 26, 10006-10019.
22. Mercken M, Fischer I, Kosik KS, Nixon RA (1995) Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: Evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci 15, 8259-8267.
23. Andorfer C, Acker CM, Kress Y, Hof PR, Duff K, Davies P (2005) Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 25, 5446-5454.
24. Uboga NV, Price JL (2000) Formation of diffuse and fibril-lar tangles in aging and early Alzheimer's disease. Neurobiol Aging 21, 1-10.
25. Hess DT, Slater TM, Wilson MC, Skene JH (1992) The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS. J Neurosci 12, 4634-4641.
26. Kimura T, Yamashita S, Fukuda T, Park JM, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, Takashima A (2007) Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. EMBO J 26, 5143-5152.
27. Smith KD, Peethumnongsin E, Lin H, Zheng H, Pautler RG (2010) Increased human wildtype tau attenuates axonal transport deficits caused by loss of APP in mouse models. Magn Reson Insights 4, 11-18.
28. Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow E (1998) Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer's disease. J Cell Biol 143, 777-794.
29. Zhang B, Higuchi M, Yoshiyama Y, Ishihara T, Forman MS, Martinez D, Joyce S, Trojanowski JQ, Lee VM (2004) Retarded axonal transport of R406W mutant tau in trans-genic mice with a neurodegenerative tauopathy. J Neurosci 24, 4657-4667.
30. Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Tro-janowski JQ, Lee VM (1999) Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24, 751-762.
31. Zhang B, Maiti A, Shively S, Lakhani F, McDonald-Jones G, Bruce J, Lee EB, Xie SX, Joyce S, Li C, Toleikis PM, Lee VM, Trojanowski JQ (2005) Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc Natl Acad Sci USA 102, 227-231.
32. Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soini-nen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei JJ (2006) Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiol Dis 22, 657-668.
33. de la Monte SM, Ganju N, Feroz N, Luong T, Banerjee K, Cannon J, Wands JR (2000) Oxygen free radical injury is sufficientto cause some Alzheimer-type molecular abnormalities in human CNS neuronal cells. J Alzheimers Dis 2, 261-281.
34. Utton MA, Connell J, Asuni AA, van Slegtenhorst M, Hutton M, de Silva R, Lees AJ, Miller CC, Anderton BH (2002) The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons. J Neurosci 22, 6394-6400.
35. Li W, Hoffman PN, Stirling W, Price DL, Lee MK (2004) Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations. J Neurochem 88, 401-410.
36. Malik B, Nirmalananthan N, Bilsland LG, La Spada AR, Hanna MG, Schiavo G, Gallo JM, Greensmith L (2011) Absence of disturbed axonal transport in spinal and bulbar muscular atrophy. Hum Mol Genet 20, 1776-1786.
37. Feany MB, La Spada AR (2003) Polyglutamines stop traffic: Axonal transport as a common target in neurodegenerative diseases. Neuron 40, 1-2.