Tau and neuron aging

Aging and Disease

Volumn 4, Issue 1, 2013, Pages 23-28

  Avila, Jesus ^a,b   de Barreda, Elena Gomez ^a,b   Pallas Bazarra, Noemi ^a,b   Hernandez, Felix ^a,b  

^a CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

Alzheimer disease; Posttranslational modifications; Tau isoforms

Indexed keywords

ANIMALIA; MAMMALIA;

EID: 84888033945     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Review

References (64)

1. Neve RL, Harris P, Kosik KS, Kurnit DM and Donlon TA (1986). Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Brain Res, 387: 271-280
2. Caffrey TM and Wade-Martins R (2012). The role of MAPT sequence variation in mechanisms of disease susceptibility. Biochem Soc Trans, 40: 687-692
3. Rovelet-Lecrux A and Campion D (2012). Copy number variations involving the microtubule-associated protein tau in human diseases. Biochem Soc Trans, 40: 672-676
4. Himmler A (1989). Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family. Mol Cell Biol, 9: 1389-1396
5. Himmler A, Drechsel D, Kirschner MW and Martin DW, Jr. (1989). Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol, 9: 1381-1388
6. Lee G, Cowan N and Kirschner M (1988). The primary structure and heterogeneity of tau protein from mouse brain. Science, 239: 285-288
7. Weingarten MD, Lockwood AH, Hwo SY and Kirschner MW (1975). A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A, 72: 1858-1862
8. Drubin DG and Kirschner MW (1986). Tau protein function in living cells. J Cell Biol, 103: 2739-2746
9. Caceres A and Kosik KS (1990). Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons. Nature, 343: 461-463
10. Brandt R and Lee G (1993). Functional organization of microtubule-associated protein tau. Identification of regions which affect microtubule growth, nucleation, and bundle formation in vitro. J Biol Chem, 268: 3414-3419
11. Panda D, Goode BL, Feinstein SC and Wilson L (1995). Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau. Biochemistry, 34: 11117-11127
12. Hinrichs MH, Jalal A, Brenner B, Mandelkow E, Kumar S and Scholz T (2012). Tau protein diffuses along the microtubule lattice. J Biol Chem
13. Couchie D and Nunez J (1985). Immunological characterization of microtubule-associated proteins specific for the immature brain. FEBS Lett, 188: 331-335
14. Dixit R, Ross JL, Goldman YE and Holzbaur EL (2008). Differential regulation of dynein and kinesin motor proteins by tau. Science, 319: 1086-1089
15. Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B and Mandelkow E (1998). Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J Cell Biol, 143: 777-794
16. Yuan A, Kumar A, Peterhoff C, Duff K and Nixon RA (2008). Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci, 28: 1682-1687
17. Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA and Avila J (2009). Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem, 109: 1756-1766
18. Ding H, Dolan PJ and Johnson GV (2008). Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem, 106: 2119-2130
19. Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wolfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E and Gotz J (2010). Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell, 142: 387-397
20. Manczak M and Reddy PH (2012). Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet, 21: 2538-2547
21. DuBoff B, Gotz J and Feany MB (2012). Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron, 75: 618-632
22. Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, Sato-Yoshitake R, Takei Y, Noda T and Hirokawa N (1994). Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature, 369: 488-491
23. Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI and Vitek MP (2001). Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci, 114: 1179-1187
24. Ikegami S, Harada A and Hirokawa N (2000). Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice. Neurosci Lett, 279: 129-132
25. Barreda EG and Avila J (2011). Tau regulates the subcellular localization of calmodulin. Biochem Biophys Res Commun, 408: 500-504
26. Goedert M, Spillantini MG, Potier MC, Ulrich J and Crowther RA (1989). Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J, 8: 393-399
27. Avila J, Lucas JJ, Perez M and Hernandez F (2004). Role of tau protein in both physiological and pathological conditions. Physiol Rev, 84: 361-384
28. Fuster-Matanzo A, de Barreda EG, Dawson HN, Vitek MP, Avila J and Hernandez F (2009). Function of tau protein in adult newborn neurons. FEBS Lett, 583: 3063-3068
29. Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG and Smith MA (1997). 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem, 68: 2092-2097
30. Yan SD, Chen X, Schmidt AM, Brett J, Godman G, Zou YS, Scott CW, Caputo C, Frappier T, Smith MA and et al. (1994). Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci U S A, 91: 7787-7791
31. Ledesma MD, Bonay P, Colaco C and Avila J (1994). Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem, 269: 21614-21619
32. Perez M, Cuadros R, Smith MA, Perry G and Avila J (2000). Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal. FEBS Lett, 486: 270-274
33. Reynolds MR, Lukas TJ, Berry RW and Binder LI (2006). Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms. Biochemistry, 45: 4314-4326
34. Swerdlow RH (2011). Brain aging, Alzheimer's disease, and mitochondria. Biochim Biophys Acta, 1812: 1630-1639
35. Lee VM, Goedert M and Trojanowski JQ (2001). Neurodegenerative tauopathies. Annu Rev Neurosci, 24: 1121-1159
36. Wang Y and Mandelkow E (2012). Degradation of tau protein by autophagy and proteasomal pathways. Biochem Soc Trans, 40: 644-652
37. Koren J, 3rd, Jinwal UK, Lee DC, Jones JR, Shults CL, Johnson AG, Anderson LJ and Dickey CA (2009). Chaperone signalling complexes in Alzheimer's disease. J Cell Mol Med, 13: 619-630
38. Voss K, Combs B, Patterson KR, Binder LI and Gamblin TC (2012). Hsp70 alters tau function and aggregation in an isoform specific manner. Biochemistry, 51: 888-898
39. Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ and Lee VM (2011). The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun, 2: 252
40. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M and Gan L (2010). Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron, 67: 953-966
41. Hanger DP, Anderton BH and Noble W (2009). Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol Med, 15: 112-119
42. Alonso AC, Grundke-Iqbal I and Iqbal K (1996). Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med, 2: 783-787
43. Townsend M, Mehta T and Selkoe DJ (2007). Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem, 282: 33305-33312
44. Tackenberg C and Brandt R (2009). Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau. J Neurosci, 29: 14439-14450
45. Magdesian MH, Carvalho MM, Mendes FA, Saraiva LM, Juliano MA, Juliano L, Garcia-Abreu J and Ferreira ST (2008). Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem, 283: 9359-9368
46. Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M and Ikeuchi T (2012). Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-beta at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3beta Signaling Pathway. J Biol Chem, 287: 35222-35233
47. Mena R, Edwards PC, Harrington CR, Mukaetova-Ladinska EB and Wischik CM (1996). Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease. Acta Neuropathol, 91: 633-641
48. Avila J (2010). Alzheimer disease: Caspases first. Nat Rev Neurol, 6: 587-588
49. Gomez de Barreda E, Perez M, Gomez Ramos P, de Cristobal J, Martin-Maestro P, Moran A, Dawson HN, Vitek MP, Lucas JJ, Hernandez F and Avila J (2010). Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis, 37: 622-629
50. Rapoport M, Dawson HN, Binder LI, Vitek MP and Ferreira A (2002). Tau is essential to beta -amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A, 99: 6364-6369
51. Gotz J, Chen F, van Dorpe J and Nitsch RM (2001). Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science, 293: 1491-1495
52. Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M and Ashe KH (2005). Tau suppression in a neurodegenerative mouse model improves memory function. Science, 309: 476-481
53. Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Ronicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU and Bloom GS (2012). Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta. Nature, 485: 651-655
54. Zhong Q, Congdon EE, Nagaraja HN and Kuret J (2012). Tau isoform composition influences rate and extent of filament formation. J Biol Chem, 287: 20711-20719
55. Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BX, Adlard PA, Cherny RA, Lam LQ, Roberts BR, Volitakis I, Egan GF, McLean CA, Cappai R, Duce JA and Bush AI (2012). Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med, 18: 291-295
56. Gomez-Ramos A, Diaz-Hernandez M, Cuadros R, Hernandez F and Avila J (2006). Extracellular tau is toxic to neuronal cells. FEBS Lett, 580: 4842-4850
57. Gomez-Ramos A, Diaz-Hernandez M, Rubio A, Miras-Portugal MT and Avila J (2008). Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Mol Cell Neurosci, 37: 673-681
58. Diaz-Hernandez M, Gomez-Ramos A, Rubio A, Gomez-Villafuertes R, Naranjo JR, Miras-Portugal MT and Avila J (2010). Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau. J Biol Chem, 285: 32539-32548
59. Gomez-Ramos A, Diaz-Hernandez M, Rubio A, Diaz-Hernandez JI, Miras-Portugal MT and Avila J (2009). Characteristics and consequences of muscarinic receptor activation by tau protein. Eur Neuropsychopharmacol, 19: 708-717
60. Frost B, Jacks RL and Diamond MI (2009). Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem, 284: 12845-12852
61. Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M and Tolnay M (2009). Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol, 11: 909-913
62. de Calignon A, Polydoro M, Suarez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL and Hyman BT (2012). Propagation of tau pathology in a model of early Alzheimer's disease. Neuron, 73: 685-697
63. Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C and Duff K (2012). Trans-synaptic spread of tau pathology in vivo. PLoS One, 7: e31302
64. Saman S, Kim W, Raya M, Visnick Y, Miro S, Jackson B, McKee AC, Alvarez VE, Lee NC and Hall GF (2012). Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem, 287: 3842-3849