Reprogramming of bone marrow-derived mesenchymal stem cells into functional insulin-producing cells by chemical regimen

American Journal of Stem Cells

Volumn 1, Issue 2, 2012, Pages 128-137

  Wang, Qiwei ^a   Ye, Lingling ^a   Liu, Hong ^a   Liu, Xingmao ^a   Li, Shichong ^a   Chen, Zhaolie ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

Bone marrow; Insulin producing cells; Mesenchymal stem cells; Reprogramming

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ACTIVIN A; BETA1 INTEGRIN; C PEPTIDE; ENDOGLIN; EXENDIN 4; GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 3BETA; HERMES ANTIGEN; INSULIN; INSULIN 1; MATRIGEL; NICOTINAMIDE; RETINOIC ACID; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; HYPERGLYCEMIA; IMMUNOCYTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; PANCREAS ISLET CELL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 84892680563     PISSN: None     EISSN: 21604150     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Atkinson MA and Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001; 358: 221-229.
2. Knight RJ, Lawless A, Patel SJ and Gaber AO. Simultaneous kidney-pancreas transplantation for end-stage renal disease patients with insulin-dependent diabetes and detectable Cpeptide. Transplant Proc 2010; 42: 4195-4196.
3. Valdes-Gonzalez R, Rodriguez-Ventura AL, White DJ, Bracho-Blanchet E, Castillo A, Ramirez-Gonzalez B, Lopez-Santos MG, Leon-Mancilla BH and Dorantes LM. Long-term follow-up of patients with type 1 diabetes transplanted with neonatal pig islets. Clin Exp Immunol 2010; 162: 537-542.
4. Ludwig B, Ludwig S, Steffen A, Saeger HD and Bornstein SR. Islet versus pancreas transplantation in type 1 diabetes: competitive or complementary? Curr Diab Rep 2010; 10: 506-511.
5. Han DJ and Sutherland DE. Pancreas transplantation. Gut Liver 2011; 4: 450-465.
6. Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R and McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001; 292: 1389-1394.
7. Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorechi KL and Tzukerman M. Insulin production by human embryonic stem cells. Diabetes 2001; 50: 1691-1697.
8. Soria B, Roche E, Berná G, León-Quinto T, Reig JA and Martín F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000; 49: 157-162.
9. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL and Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci USA 2009; 106: 15768-15773.
10. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A and O'Neil JJ. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 2000; 97: 7999-8004.
11. Yang L, Li S, Hatch H, Ahrens K, Cornelius JG, Petersen BE and Peck AB. In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA 2002; 99: 8078-8083.
12. Yoshida S, Ishikawa F, Kawano N, Shimoda K, Nagafuchi S, Shimoda S, Yasukawa M, Kanemaru T, Ishibashi H, Shultz LD and Harada M. Human cord blood-derived cells generate insulin-producing cells in vivo. Stem Cells 2005; 23: 1409-1416.
13. Hori Y, Gu X, Xie X and Kim SK. Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med 2005; 2: 347-356.
14. Oh SH, Muzzonigro TM, Bae SH, LaPlante JM, Hatch HM and Petersen BE. Adult bone marrow-derived cells transdifferentiating into insulinproducing cells for the treatment of type I diabetes. Lab Invest 2004; 84: 607-617.
15. Ma K, Fox L, Shi G, Shen J, Liu Q, Pappas JD, Cheng J and Qu T. Generation of neural stem cell-like cells from bone marrow-derived human mesenchymal stem cells. Neurol Res 2011; 33: 1083-1093.
16. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA and Verfaillie CM. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-49.
17. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-74.
18. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147.
19. Wang QW, Chen ZL and Piao YJ. Mesenchymal Stem Cells Differentiate into Tenocytes by Bone Morphogenetic Protein (BMP) 12 Gene Transfer. J Biosci Bioeng 2005; 100: 418-422.
20. Wan SY, Zhang TF and Ding Y. Galectin-3 enhances proliferation and angiogenesis of endothelial cells differentiated from bone marrow mesenchymal stem cells. Transplant Proc 2011; 43: 3933-3938.
21. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK and Baetge EE. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006; 24: 1392-1401.
22. Shi Y, Hou L, Tang F, Jiang W, Wang P, Ding M and Deng H. Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid. Stem Cells 2005; 23: 656-662.
23. Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB and Cornelius JG. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 2000; 6: 278-282.
24. Suzuki A, Nakauchi H and Taniguchi H. Glucagon-like peptide1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc Natl Acad Sci USA 2003; 100: 5034-5039.
25. Tang DQ, Cao LZ, Burkhardt BR, Xia CQ, Litherland SA, Atkinson MA and Yang LJ. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004; 53: 1721-1732.
26. Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE and Scott EW. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002; 416: 542-545.
27. Lechner A, Yang YG, Blacken RA, Wang L, Nolan A.L and Habener JF. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 2004; 53: 616-623.
28. Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B, Thyssen S, Gray DA and Bhatia M. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 2003; 21: 763-770.
29. Ianus A, Holz GG, Theise ND and Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003; 111: 843-850.
30. Kumar M, Jordan N, Melton D and Grapin-Botton A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol 2003; 259: 109-122.
31. Kubo A, Shinozaki K, Shannon JM, Kouskoff V, Kennedy M, Woo S, Fehling HJ and Keller G. Development of definitive endoderm from embryonic stem cells in culture. Development 2004; 131: 1651-1662.
32. Florio P, Luisi S, Marchetti P, Lupi R, Cobellis L, Falaschi C, Sugino H, Navalesi R, Genazzani AR and Petraglia F. Activin A stimulates insulin secretion in cultured human pancreatic islets. J Endocrinol Invest 2000; 23: 231-234.
33. Li L, Yi Z, Seno M and Kojima I. Activin A and betacellulin: effect on regeneration of pancreatic β-cells in neonatal streptozotocin-treated rats. Diabetes 2004; 53: 608-615.
34. Maden M. Role and distribution of retinoic acid during CNS development. Int Rev Cytol 2001; 209: 1-77.
35. Stafford D and Prince VE. Retinoic acid signal ing is required for a critical early step in Zebrafish pancreatic development. Curr Biol 2002; 12: 1215-1220.
36. Moriya N, Komazaki S, Takahashi S, Yokota C and Asashima M. In vitro pancreas formation from Xenopus ectoderm treated with activin and retinoic acid. Dev Growth Differ 2000; 42: 593-602.
37. Soria B. In-vitro differentiation of pancreatic beta-cells. Differentiation 2001; 68: 205-219.
38. Bonner-Weir S, Deery D, Leahy JL and Weir GC. Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion. Diabetes 1989; 38: 49-53.
39. Zalzman M, Gupta S, Giri RK, Berkovich I, Sappal BS, Karnieli O, Zern MA, Fleischer N and Efrat S. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA 2003; 100: 7253-7258.
40. Gao R, Ustinov J, Pulkkinen MA, Lundin K, Korsgren O and Otonkoski T. Characterization of endocrineprogenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 2003; 52: 2007-2015.
41. Gotherstrom C, Ringden O, Tammik C, Zetterberg E, Westgren M and Le Blanc K. Immunologic properties of human fetal mesenchymal stem cells. Am J Obstet Gynecol 2004; 190: 239-245