Human cord blood-derived cells generate insulin-producing cells in vivo

Stem Cells

Volumn 23, Issue 9, 2005, Pages 1409-1416

  Yoshida, Shuro ^a   Ishikawa, Fumihiko ^a   Kawano, Noriaki ^a   Shimoda, Kazuya ^a   Nagafuchi, Seiho ^a   Shimoda, Shinji ^a   Yasukawa, Masaki ^b   Kanemaru, Takaaki ^c   Ishibashi, Hiromi ^d   Shultz, Leonard D ^e   Harada, Mine ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^e JACKSON LABORATORY   (United States)

Author keywords

Human cord blood; Insulin; Neonate; Pancreas

Indexed keywords

BETA 2 MICROGLOBULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DIABETES MELLITUS; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC TRANSCRIPTION; HISTOCOMPATIBILITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INSULIN SYNTHESIS; MONONUCLEAR CELL; MOUSE; NONHUMAN; PANCREAS; REACTION ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; T LYMPHOCYTE; UMBILICAL CORD BLOOD; XENOGRAFT;

ANIMALS; BONE MARROW CELLS; CORD BLOOD STEM CELL TRANSPLANTATION; FETAL BLOOD; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INSULIN; ISLETS OF LANGERHANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED NOD; MICE, SCID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS;

MURINAE;

EID: 27144462791     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2005-0079     Document Type: Article

References (43)

1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001;414:782-787.
2. Hussain MA, Theise ND. Stem-cell therapy for diabetes mellitus. Lancet 2004;364:203-205.
3. Kelly WD, Lillehei RC, Merkel FK et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 1967;61:827-837.
4. Hakim NS. Pancreatic transplantation for patients with type 1 diabetes. Transplant Proc 2003;35:2801-2802.
5. Moskalewski S. Isolation and Culture of the Islets of Langerhans of the Guinea Pig. Gen Comp Endocrinol 1965;44:342-353.
6. Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 1967;16:35-39.
7. Weir GC, Bonner-Weir S. Scientific and political impediments to successful islet transplantation. Diabetes 1997;46:1247-1256.
8. Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-238.
9. Soria B, Roche E, Berna G et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000;49:157-162.
10. Lumelsky N, Blondel O, Laeng P et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001;292:1389-1394.
11. Assady S, Maor G, Amit M et al. Insulin production by human embryonic stem cells. Diabetes 2001;50:1691-1697.
12. Segev H, Fishman B, Ziskind A et al. Differentiation of human embryonic stem cells into insulin-producing clusters. STEM CELLS 2004;22:265-274.
13. Hori Y, Rulifson IC, Tsai BC et al. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 2002;99:16105-16110.
14. Blyszczuk P, Czyz J, Kania G et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci U S A 2003;100:998-1003.
15. Rajagopal J, Anderson WJ, Kume S et al. Insulin staining of ES cell progeny from insulin uptake. Science 2003;299:363.
16. Hansson M, Tonning A, Frandsen U et al. Artifactual insulin release from differentiated embryonic stem cells. Diabetes 2004;53:2603-2609.
17. Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from humanblastocysts. Science 1998;282:1145-1147.
18. Petersen BE, Bowen WC, Patrene KD et al. Bone marrow as a potential source of hepatic oval cells. Science 1999;284:1168-1170.
19. Krause DS, Theise ND, Collector MI et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377.
20. Lagasse E, Connors H, Al-Dhalimy M et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-1234.
21. Ianus A, Holz GG, Theise ND et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-850.
22. Hess D, Li L, Martin M et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 2003;21:763-770.
23. Terada N, Hamazaki T, Oka M et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002;416:542-545.
24. Ying QL, Nichols J, Evans EP et al. Changing potency by spontaneous fusion. Nature 2002;416:545-548.
25. Vassilopoulos G, Wang PR, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature 2003;422:901-904.
26. Wang X, Willenbring H, Akkari Y et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003;422:897-901.
27. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003;425:968-973.
28. + T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 1997;158:3578-3586.
29. Greiner DL, Hesselton RA, Shultz LD. SCID mouse models of human stem cell engraftment. STEM CELLS 1998;16:166-177.
30. + cells regenerate gastrointestinal epithelial cells. FASEB J 2004;18:1958-1960.
31. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003;102:3483-3493.
32. Pessina A, Eletti B, Croera C et al. Pancreas developing markers expressed on human mononucleated umbilical cord blood cells. Biochem Biophys Res Commun 2004;323:315-322.
33. Ishikawa F, Livingston AG, Wingard JR et al. An assay for long-term engrafting human hematopoietic cells based on newborn NOD/SCID/beta2- microglobulin(null) mice. Exp Hematol 2002;30:488-494.
34. Ishikawa F, Drake CJ, Yang S et al. Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann N Y Acad Sci 2003;996:174-185.
35. -. Leukemia 2003;17:960-964.
36. Hesselton RM, Greiner DL, Mordes JP et al. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis 1995;172:974-982.
37. Kodama S, Kuhtreiber W, Fujimura S et al. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 2003;302:1223-1227.
38. Choi JB, Uchino H, Azuma K et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003;46:1366-1374.
39. Lechner A, Yang YG, Blacken RA et al. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 2004;53:616-623.
40. Mathews V, Hanson PT, Ford E et al. Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes 2004;53:91-98.
41. D'Ippolito G, Diabira S, Howard GA et al. Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci 2004;117:2971-2981.
42. Oh SH, Muzzonigro TM, Bae SH et al. Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 2004;84:607-617.
43. Tang DQ, Cao LZ, Burkhardt BR et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004;53:1721-1732.