The dry skin cycle

Cosmetic Formulation of Skin Care Products

Volumn , Issue , 2005, Pages 79-114

  Matts, Paul J ^a   Rawlings, Anthony V ^b  

^a Rusham Park Technical Center   (United Kingdom)

^b AVR Consulting Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84892674325     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (144)

1. Rawlings AV, Scott IR, Harding CR, Bowser PA. Stratum corneum moisturization at the molecular level. J Invest Dermatol 1994; 103:731-740.
2. Rawlings AV, Matts PJ. Stratum corneum at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol 2005; 124:1099-1110.
3. Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol Ther 2004; 17:43-18.
4. Rawlings AV. Skin waxes: their composition, properties, structures and biological significance. In: Hamilton RJ, ed. Waxes: Chemistry, Molecular Biology and Functions. New York: The Oily Press, 1994:221-256. Chapter 6.
5. Harding CR, Watkinson A, Rawlings AV. Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci 2000; 22:21-52.
6. Rawlings AV, Harding CR, Watkinson, Scott IR. Dry and xerotic skin conditions. In: Leyden JJ, Rawlings AV, eds. Skin Moisturization. New York NY: Marcel Dekker 2002:119-143.
7. Warner RR, Lilly NA. Correlation of water content with ultrastructure in the stratum corneum. In: Elsner P, Berardesca E, Maibach HI, eds. Bioengineering of the Skin: Water and the Stratum Corneum. Boca Raton: CRC Press Inc, 1994:3-12.
8. Blank IH. Factors which influence the water content of the stratum corneum. J Invest Dermatol 1952; 18:433-440.
9. Pfeiffer S, Vielhaber G, Vietzke JP, Wittern KP, Hintze U, Wepf R. High-pressure freezing provides new information on human epidermis: simultaneous protein antigen and lamellar lipid structure preservation. Study on human epidermis by cryoimmobilization. J Invest Dermatol 2000; 114:1030-1038.
10. Norlen L. Skin barrier structure and function: the single gel phase model. J Invest Dermatol 2001; 117:830-836.
11. Norlen L, Al-Amoudi A. Stratum corneum keratin structure, function, and formation: the cubic rod-packing and membrane templating model. J Invest Dermatol 2004; 123:715-732.
12. Bouwstra JA, de GraaffA, Gooris GS, Nijsse J, Wiechers JW, van Aelst AC. Water distribution and related morphology in human stratum corneum at different hydration levels. J Invest Dermatol 2003; 120:750-758.
13. Richter T, Peuckert C, Sattler M, et al. Dead but highly dynamic-the stratum corneum is divided into three hydration zones. Skin Pharmacol Physiol 2004; 17:246-257.
14. Downing DT, Stewart ME. Epidermal composition. In: Loden M, Maibach HI, eds. Dry Skin and Moisturizers Chemistry and Function, 2000:13-26.
15. Motta SM, Monti M, Sesana S, et al. Ceramide composition of psoriatic scale. Biochem Biophys Acta 1993; 1182:147-151.
16. Oku H, Mimura K, Tokitsu Y, Onaga K, Iwasaki H, Chinen I. Biased distribution of the branched-chain fatty acids in ceramides of vernix caseosa. Lipids 2000; 35:373-381.
17. Chopart M, Castiel-Higounenc I, Arbey E, Schmidt R. A new type of covalently bound ceramide in human epithelium. Stratum Corneum 2001; III.
18. Hamanaka S, Hara M, Nishio H, Otsuk F, Suzuki A, Uchida Y. Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. J Invest Dermatol 2002; 119:416-423.
19. Pilgram GSK, Engelsma-van Pelt AM, Bouwstra JA, Koerten HK. Electron diffraction provides new information on human stratum corneum lipid organisation studied in relation to depth and temperature. J Invest Dermatol 1999; 113:403-409.
20. Brancaleon L, Bamberg MP, Sakamaki T, Kollias N. Attenuated total reflection-fourier transform infrared spectroscopy as a possible method to investigate biophysical parameters of stratum corneum in vivo. J Invest Dermatol 2001; 116:380-386.
21. Bouwstra J, Pilgram G, Gooris G, Koerten H, Ponec M. New aspects of the skin barrier organization. Skin Pharm Appl Skin Physiol 2001; 14:52-62.
22. Bouwstra J, Gooris GS, Dubbelaar FER, Ponec M. Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide 1. J Invest Dermatol 2002; 118:606-617.
23. Rawlings AV, Watkinson A, Rogers J, et al. Abnormalities in stratum corneum structure lipid composition and desmosome degradation in soap-induced winter xerosis. J Soc Cosmet Chem 1994; 45:203-220.
24. Warner RR, Boissy YL. Effect of moisturizing products on the structure of lipids in the outer stratum corneum of humans. In: Loden M, Maibach HI, eds. Dry Skin and Moisturisers. Boca Raton: CRC Press Inc, 2000:349-372.
25. Berry N, Charmeil C, Gouion C, et al. A clinical, biometrological and ultrastructural study of xerotic skin. Int J Cosmet Sci 1999; 21:241-249.
26. Serre G, Mils V, Haftek M, et al. Identification of late differentiation antigens of human cornified epithelia, expressed in re-organized desmosomes and bound to cross-linked envelope. J Invest Dermatol 1991; 97:1061-1072.
27. Lundstorm A, Egelud T. Cell shedding from human plantar skin in vitro: evidence that two different types of protein structures are degraded by a chymotrypsin-like enzyme. Arch Dermatol Res 1990; 282:237-243.
28. Suzuki Y, Nomura J, Koyama J, Horii T. The role of proteases in stratum corneum: involvement in stratum corneum desquamation. Arch Dermatol Res 1994; 286:249-253.
29. Horikoshi T, Igarashi S, Uchiwa H, Brysk H, Brysk MM. Role of endogenous cathepsin D-like and chymotrypsin-like proteolysis in human epidermal desquamation. Br J Dermatol 1999; 141:453-459.
30. Horikoshi T, Arany I, Rajaraman S, et al. Isoforms of cathepsin D human epidermal differentiation. Biochimie 1998; 80:605-612.
31. Watkinson A. Stratum corneum thiol protease (SCTP): a novel cysteine protease of late epidermal differentiation. Arch Dermatol Res 1999; 291:260-268.
32. Bernard D, et al. Analysis of proteins with caseinolytic activity in a human SC extract revealed a yet unidentified cysteine protease and identified the so called 'SC thiol protease' as Cathepsin L2. J Invest Dermatol 2003; 120:592-600.
33. Caubet C, et al. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family. J Invest Dermatol 2004; 122:1235-1244.
34. Bernard D, Mehul B, Delattre C, Simonetti L, Thomas-Collignon A, Schmidt R. Purification and characterization of the endoglycosidase heparanase 1 from human plantar stratum corneum: a key enzyme in epidermal physiology. J Invest Dermatol 2001; 117:1266-1273.
35. Simon M, Jonca N, Guerrin M, et al. Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation. J Bio Chem 2001; 276:20292-20299.
36. Sondell B, Thornell LE, Stigbrand T, Egelrud T. Immunolocalization of SCCE in human skin. Histo Cytom 1994; 42:459-465.
37. Watkinson A, Smith C, Coan P, Wiedow O. The role of Pro-SCCE and SCCE in desquamation. 21st IFSCC Congress 2000; 16-25.
38. Igarashi S, Takizawa T, Yasuda Y, et al. Cathepsin D, degrades desmosomes during epidermal desquamation. Brit J Dermatol 2004;151:355.
39. Ishida-Yamamoto A, Simon M, Kishibe M, et al. Epidermal lamellar granules transport different cargoes as distinct aggregates. J Invest Dermatol 2004; 122:1145-1153.
40. Watkinson A, Harding C, Moore A, Coan P. Water modulation of stratum corneum chymotryptic enzyme activity and desquamation. Arch Dermatol Res 2001; 293:470-476.
41. Komatsu N, Takata M, Otsuki N, et al. Elevated stratum corneum hydrolytic activity in netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. J Invest Dermatol 2002; 118:436-443.
42. Franzke CW, Baici A, Bartels J, Christophers E, Wiedow O. Antileukoprotease inhibits stratum corneum chymotryptic enzyme. J Biol Chem 1996; 271:21886-21890.
43. Brattsand M, Stefansson K, Lundh C, Haasum Y, Egelrud T. A proteolytic cascade of kallikreins in the stratum corneum. J Invest Dermatol 2005; 124:198-203.
44. Watkinson A, Harding CR, Rawlings AV. The cornified envelope: its role on stratum corneum structure and maturation. In: Leyden JJ, Rawlings AV, eds. Skin Moisturization. New York NY: Marcel Dekker 2002:95-117.
45. Candi E, et al. Transglutaminase cross linking properties of the small proline rich 1 family of cornified envelope proteins. J Biol Chem 1999; 274:7226-7237.
46. Kim IG, Gorman JJ, Park SC, Chung SI, Steinert PM. The deduced sequence of the novel protransglutaminase-E (TGase 3) of human and mouse. J Biol Chem 1993; 268:12682-12690.
47. Nemes Z, Marekov LN, Steinert PM. Involucrin cross linking by transglutaminase 1. J Biol Chem 1999; 274:11013-11021.
48. Cabral A, Voskamp P, Cleton-Jansen M, et al. Structural organisation and regulation of the small proline rich family of cornified envelope precursors suggest a role in adaptive barrier function. J Biol Chem 1923; 26:19231-19237.
49. Mils V, Vincent C, Croute F, Serre G. The expression of desmosomal and corneodesmosomal antigens shows specific variations during the terminal differentiation of epidermis and hair follicle epithelia. J Histochem Cytochem 1992; 40:1329-1337.
50. Harding CR, Long S, Richardson J, et al. The cornified cell envelope: an important marker of stratum corneum maturation in healthy and dry skin. Int J Cosmet Sci 2003; 25:1-11.
51. Hirao T, Denda M, Takahashi M. Identification of immature cornfield envelopes in the barrier-impaired epidermis by characterization of their hydrophobicity and antigenicities of the components. Exp Dermatol 2001; 10:35-44.
52. Kashibuchi N, Hirai Y, O'Goshi K, Tagami H. Three-dimensional analyses of individual corneocytes with atomic force microscope: morphological changes related to age, location and to the pathologic skin conditions. Skin Res Technol 2002; 8:203-211.
53. Jokura Y, Ishikawa S, Tokuda H, et al. Molecular analysis of elastic properties of the stratum corneum by solid-state C-13-nuclear magnetic resonance spectroscopy. J Invest Dermatol 1995; 104:806.
54. Mechin MC, Enji M, Nachat R, et al. The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities & subcellular locations. CMLS DO1 2005;1-12.
55. Sakai S, Yasuda R, Sayo T, et al. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol 2000; 114:1184.
56. Fluhr JW, Mao-Qiang M, Brown BE, et al. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (Asebia) mice. J Invest Dermatol 2003; 120:728.
57. Choi EH, Man MQ, Wang F, et al. Is endogenous glycerol a determinant of stratum corneum hydration in humans. J Invest Dermatol 2005;1-6.
58. Nakagawa N, et al. Relationship between NMF (potassium and lactate) content and the physical properties of the stratum corneum in healthy subjects. J Invest Dermatol 2004; 122:755.
59. Fluhr JW, et al. Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. J Invest Dermatol 2001; 117:44.
60. Krein PM, Kermici M. Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum- an unexpected role for urocanic acid. J Invest Dermatol 2000; 115:414.
61. Caspers PJ, Lucassen GW, Carter EA, Bruining HA, Puppels GJ. In vivo confocal raman microspectroscopy of the skin: non-invasive determination of molecular concentration profiles. J Invest Dermatol 2001; 116:434-442.
62. Rogers J, Harding CR, Mayo A, Banks J, Rawlings AV. Stratum corneums lipids: the effect of ageing and the seasons. Arch Dermatol Res 1996; 288:765-770.
63. Meldrum H. The characteristic decrease in scalp stratum corneum lipids in dandruffis reversed by use of a ZnPTO containing shampoo. IFSCC Mag 2003; 6:3-6.
64. Declercq L, Muizzuddin N, Hellemans L, et al. Adaptation response in human skin barrier to a hot and dry environment. J Invest Dermatol 2002; 119:716.
65. Denda M, Sato J, Masuda Y, et al. Exposure to a dry environment enhances epidermal permeability barrier function. J Invest Dermatol 1998; 111:858-863.
66. Sato J, Denda M, Chang S, et al. Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. J Invest Dermatol 2002; 119:900-904.
67. Chou TC, Lin KH, Wang SM, et al. Transepidermal water loss & skin capacitance alterations among workers in an u;tra-low humidity environment. Arch Dermatol Res 2005; 296:489-495.
68. Katagiri C, Sato J, Nomura J, et al. Changes in environmental humidity affect the waterholding capacity of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice. J Dermatol Sci 2003; 31:29-35.
69. Denda M, Sato J, Tsuchiya T, Elias PM, Feingold KR. Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication for seasonal exacerbation of inflammatory dermatoses. J Invest Dermatol 1988; 111:873-878.
70. Ashida Y, Ogo M, Denda M. Epidermal interleukin-1 generation is amplified at low humidity: implications for the pathogenesis of inflammatory dermatoses. Br J Dermatol 2001; 144:238-243.
71. Ashida Y, Denda M. Dry environment increases mast cell number and histamine content in dermis in hairless mice. Br J Dermatol 2003; 149:240-247.
72. Simon M, Bernard D, Minondo AM, et al. Persistence of both peripheral and non-peripheral corneodesmosomes in the upper stratum corneum of winter xerosis skin versus only peripheral in normal skin. J Invest Dermatol 2001; 116:23-30.
73. Long S, Banks J, Watkinson A, Harding C, Rawlings AV. Desmocollins: a key marker for desmosome processing in stratum corneum. J Invest Dermatol 1996; 106:872.
74. Van Overloop L, Declercq L, Maes D. Visual scaling of human skin correlates to decreased ceramide levels and decreased stratum corneum protease activity. J Invest Dermatol 2001; 117:811.
75. Kawai E, Kohno Y, Ogawa K, et al. Can inorganic powders provide any biological benefit in stratum corneum while residing on the skin surface. 22nd IFSCC Congress Edinburgh P10, 2002.
76. Fulmer AW, Kramer GJ. Stratum corneum lipid abnormalities in surfactant-induced scaly skin. J Invest Dermatol 1986; 86:598-602.
77. Saint-Leger D, Francois AM, Leveque JL, Stoudemayer TJ, Kligman AM, Grove G. Stratum corneum lipids in skin xerosis. Dermatologica 1989; 178:151-155.
78. Chopart M, Castiel-Higounenc C, Arbey E. Quantitative analysis of ceramides in stratum corneum of normal and dry skin. Stratum Corneum 2001; III.
79. Imokawa G. Ceramides as natural moisturizing factors and their efficacy in dry skin. In: Leyden JJ, ed. Skin Moisturization. New York NY: Marcel Dekker 2002:267-302.
80. Schreiner V, Gooris GS, Pfeiffer S, et al. Barrier characteristics of different human skin types investigated with x-ray diffraction, lipid analysis and electron microscopy imaging. J Invest Dermatol 2000; 114:600-654.
81. Tezuka T. Electron microscopical changes in xerotic senilis epidermis. Its abnormal membrane coating granule formation. Dermatologica 1983; 166:57.
82. Matts PJ, Goodyer E. A new instrument to measure the mechanical properties of human skin in vivo. J Cosmet Sci 1998; 49:321-333.
83. Matts PJ. In: Elsner P, Beradesca E, Wilhem KP, Maibach HI, eds. Hardware and Measurement Principles: the Gas-Bearing Electrodynamometer and Linear Skin Rheometer, in Bioengineering of the Skin: Skin Biomechanics. Boca Raton: CRC Press, 2002.
84. Cooper ER, Missel PJ, Hannon DP, Albright GB. Mechanical properties of dry, normal and glycerol-treated skin as measured by the gas-bearing electrodynamometer. J Cosmet Sci 1985; 36:335-348.
85. Christensen MS, Hargens CW, III, Nacht S, Gans EH. Viscoelastic properties of intact human skin: instrumentation, hydration effects, and the contribution of the stratum corneum. J Invest Dermatol 1977; 69:282-286.
86. Denda M, Wood LC, Emami S, et al. The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss. Arch Dermatol Res 1996; 288:230-238.
87. Kikuchi K, Kobayashi H, Hirao T, Ito A, Takahashi H, Tagami H. Improvement of mild inflammatory changes of the facial skin induced by winter environment with daily applications of a moisturizing cream. A half-side test of biophysical skin parameters, cytokine expression pattern and the formation of cornified envelope. Dermatology 2003; 207:269-275.
88. Terui T, Hirao T, Sato Y, et al. A increased ration of interleukin-1 receptor antagonist to interleukin-1 in inflammatory skin diseases. Exp Dermatol 1998; 7:327-334.
89. Proksch E, Jensen J, Elias PM. Skin lipids and epidermal differentiation in atopic dermatitis. Clin Dermatol 2003; 21:134-144.
90. Proksch E, Feingold KR, Man MQ, Elias PM. Barrier function regulates epidermal DNA synthesis. J Clin Invest 1991; 87:1668-1673.
91. Angel P, Szabowski A. Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin. Biochem Pharmacol 2002; 64:949-956.
92. Rawlings AV, Canestrari DA, Dobkowski B. Moisturizer technology versus clinical performance. Dermatol Ther 2004; 17:49-56.
93. Mattai J, Froebe CL, Rhein LD, et al. Prevention of model stratum corneum lipid phase transitions in vitro bu cosmetic additives. J Soc Cosmet Chem 1993; 44:89-100.
94. Rawlings AV, Watkinson A, Hope J, Sabin C, Harding R. The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch Dermatol Res 1995; 287:457-464.
95. Hirao T, Takahashi M, Kikuchi K, et al. A novel non-invasive evaluation method of cornified envelope maturation in the stratum corneum provides new insight for skincare cosmetics. 22nd IFSCC Congress, Edinburgh. P51, (2002).
96. Fluhr JW, Gloor M, Lehmann L, et al. Glycerol accelerates recovery of barrier function in vivo. Acta Derm Venereol 1999; 79:418-421.
97. Rattner H. Dermatologic uses of urea. Acta Derm Venereol 1943; 37:155-165.
98. Fredrikkson T, Gip L. Urea creams in the treatment of dry skin & hand dermatitis. Int J Dermatol 1990; 14:442-444.
99. McCallion R, Po AL. Modelling TEWL under steady state conditions & relative humidities. Int J Pharm 1994; 105:103-112.
100. Loden M. Urea containing moisturisers influence barrier properties of normal skin. Arch Dermatol Res 1996; 288:103-107.
101. Pigatto PD, Bigardi AS, Cannistraci C, et al. 10% urea cream for atopic dermatitis. J Dermatol Treat 1996; 7:171-175.
102. Scott IR, Harding CR. A filasggrin analogue to increase natural moisturising factor synthesis in skin. Dermatology 2000; 773:1993.
103. Kwoyo Hakko Kogyo. Pyrroliodone carboxylic acid esters compositions to prevent loss of moisture from the skin. Patent JA 4882046, 1982.
104. Org Santerre. Pyrolidone carboxylic acid sugar compounds as rehydrating ingredients in cosmetics. Patent FR 2277823, 1977.
105. Clar EJ, Foutanier A. L'acide pyrrolidone carboxylique et la peau. J Cosmet Sci 1981; 3:101-113.
106. Middelton JD, Roberts ME. Effects of a skin cream containing the sodium salts of pyrrolidone carboxylic acid on dry & flaky skin. J Soc Cosmet Chem 1978; 29:201-205.
107. Ghadially R, Halkiersorenson L, Elias PM. Effects of petrolatum on stratum corneum structure & function. J Am Acad Dermatol 1992; 26:387-396.
108. Barany E, Lindberg M, Loden M. Unexpected skin barrier influence from non-ionic emulsifiers. Int J Pharm 2000; 195:189-195.
109. Kucharekova M, Schalkwijk J, Van De Kerkhof PC, Van De Valk PG. Effect of a lipid-rich emollient. Contact Dermatitis 2002; 46:331-338.
110. De Paepe K, Roseeuw D, Rogiers V. Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids. JEADV 2002; 16:587-594.
111. Berardesca E, Barbareschi M, Veraldi S, Pimpinelli N. Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study. Contact Dermatitis 2001; 45:280-285.
112. Chamlin SL, Kao J, Frieden IJ, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002; 47:198-208.
113. Wollenweber U, Korevaar K, Rawlings AV, Schick. Application of a skin-identical lipid concentrate for enhanced skin moisturization and protection. SOFW-J 2004; 130:9.
114. Summers RS, Summers B, Chandar P, Feinberg C, Gurskey R, Rawlings AV. The effect of lipids with and without humectant on skin xerosis. J Soc Cosmet Chem 1996; 47:27-39.
115. Leveque JL, Saint-Leger D. Salicylic acid and derivatives. In: Leyden JJ, Rawlings AV, eds. Skin Moisturization. New York NY: Marcel Dekker 2002:353-364.
116. Fartasch M, Teal J, Menon GK. Mode of action of glycolic acid on human stratum corneum: ultrastructural and functional evaluation of the epidermal barrier. Arch Dermatol Res 1997; 289:404-409.
117. Bowser P, Evenson A, Rawlings AV. Cosmetic composition containing a lipid and a hydroxyl or ketcarboxylic acid. EP0587288B1.
118. Rawlings AV, Davies A, Carlomusto M, et al. Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Derm Res 1996; 288:383-390.
119. Rawlings AV, Hope J, Ackerman C, Banks J. Hydroxycaprylic acid improves stratum corneum extensibility at low relative humidity and protects desmosomes against mechanical damage. IFSCC Congress, Yokohama, 1992: P1.
120. Johnson AW. Hydroxyacids. In: Leyden AV, Rawlings JJ, eds. Skin Moisturization, 2002:323-352.
121. Berardesca E, et al. Alpha hydroxy acids modulate stratum corneum barrier function. Br J Dermatol 1997; 137:934.
122. Hanley K, Jiang Y, He SS, et al. Keratinocyte differentiation is stimulated by activators of the nuclear receptor PPAR alpha. J Invest Dermatol 1998; 110:368-375.
123. Westergaard M, Henningsen J, Svendsen ML, et al. Maodulators of keratinocyte gene expression and differentiation by PPAR selective ligand tetradecylthioacetic acid. J Invest Dermatol 2001; 116:702-712.
124. River M, Castiel I, Safonova I, Ailhaud G, Michel S. Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model. J Invest Dermatol 2000; 114:687-691.
125. Alaluf S, Barrett KE, Green MR, Ottey A, Rawlings AV. A cosmetic composition for treating aged wrinkled skin through topical application of a composition containing petroselenic acid. US6042841.
126. Alaluf S, Rawlings AV. A topical composition comprising from petroselenic acid and conjugated linoleic acid. US6423325.
127. Lee R, Paterson S, Marti V, Ginger R, Watkinson A, Rawlings AV. Peroxisome proliferator activated receptor alpha activators: Petroselenic acid as a novel skin benefit agent for antiperspirants. 22nd IFSCC Congress, Edinburgh P11 (2002).
128. Wiechers JW, Rawlings AV, Garcia C, et al. A new mechanism of action for skin whitening agents: binding to the peroxisome proliferator activated receptor. Int J Cosmet Sci 2005; 27:123-132.
129. Mao-Qiang M, Feingold KR, Elias PM. Exogenous lipids influence permeability barrier function. Arch Dermatol 1993; 129:729-738.
130. Chamlin SL, Frieden IJ, Fowler A, et al. Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol 1996; 106:1096-1101.
131. Haratake A, Ikenaga K, Katoh N, Uchiwa H, Hirano S, Yasuho H. Topical mevalonic acid stimulates de novo cholesterol biosynthesis and epidermal permeability barrier homeostasis in aged mice. J Invest Dermatol 2000; 114:247-252.
132. Rawlings AV, Davies A, Carlomusto M, et al. Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Derm Res 1996; 288:383-390.
133. Matts PJ, Oblong JE, Bissett DL. A review of the range of effects of niacinamide in human skin. IFSCC Mag 2002; 5:285-290.
134. Tanno O, Ota Y, Hikima R, Matsumoto M, Ota, M, Inoue S. An increase in Endogenous Epidermal Lipids Improves Skin Barrier Function. 20th IFSCC International Congress. P 347-358 (2000).
135. Ertel KD, Berge CA, Mercurio MG, et al. New facial moistuizer technology increase exfoliation without compromising barrier function. 58th Annual meeting of the American Academy Of Dermatology, San Francisco (2000).
136. Draelos ZD, Ertel E, Berge C, et al. A facial moisturizing product as an adjunct in the treatment of rosacea. 59th Annual meeting of the American Academy Of Dermatology, San Francisco (2001).
137. Davies A, Verdejo P, Feinberg C, Rawlings AV. Increased stratum corneum ceramide levels and improved barrier function following treatment with tetraacetylphytosphingosine. J Invest Dermatol 1996; 106:918.
138. Conti A, Rogers P, Verdejo P, Harding CR, Rawlings AV. Seasonal influences on stratum corneum ceramide 1 fatty acids and the influence of topical essential fatty acids. Int J Cos Sci 1996; 18:1-12.
139. Msika P, Piccirilli A, Chesne C. Effects of two specific lipidic ingredients on the synthesis of epidermal lipids in human skin explants in culture. 21st IFSCC Congress, Berlin. P1-5 (2000).
140. Denda M. New stategies to improve skin barrier homeostasis. Ad Drug Del Rev 2002; 54:123-130.
141. The effect of thiols on epidermal lipid biosynthesis. Zhang K, Kosturko K, Rawlings AV. Annual Meeting Of Society For Investigative Dermatology, Chicago, USA, 1995. J Invest Dermatol 1995; 104:687.
142. Uchida Y, Behne M, Quice D, et al. Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures. J Invest Dermatol 2001; 117:1307-1313.
143. Yarosh DB, Both D, Brown D. Liposomal ursolic acid (merotaine) increases ceramides and collagen in human skin. Horm Res 2000; 54:318-321.
144. Matts PJ, Gray J, Rawlings AV. In: The 'Dryskin Cycle'-A New Model of Dry Skin & Mechanisms for Intervention, Vol. 256. London: The Royal Society Of Medicine Press International congress & symposium series, 2005:1-38.