Ceramides as natural moisturizing factors and their efficacy in dry skin

Skin Moisturization

Volumn , Issue , 2002, Pages 267-302

  Imokawa, Genji ^a  

^a Kao Biological Science Laboratories   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0038292131     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (33)

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2. Imokawa G, Hattori M. A possible function of structural lipid in the water-holding properties of the stratum corneum. J Invest Dermatol 1985; 84:282–284.
3. Imokawa G. Stratum corneum moisturizing effect and intercellular lipids. Fragrance J 1987; 15:35–41.
4. Imokawa G. Intercellular Lipids of the Stratum Corneum. Gendai Hifukagaku Taikei. Nakayama Publishing, 1990; 43–53.
5. Imokawa G. Properties and function of the stratum corneum lipids and its measurement. Rinshouhifuka 1990; 44:583–588.
6. Imokawa G, Akasaki S, Kuno O, Zama M, Kawai M, Minematsu Y, Hattori M, Yoshizuka N, Kawamata A, Yano S, Takaishi N. Function of lipids on human skin. J Dis Sci Tech 1989; 10:617–641.
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8. Imokawa G. Water and the stratum corneum. In: Elsner P, Berardesca E, Maibach HI, eds. Bioengineering of Skin. Vitro and in Vivo Models. Vol 1. CRC Press, 3. 1993:23–47.
9. Imokawa G, Akasaki S, Hattori M, Yoshizuka N. Selective recovery of deranged water-holding properties by stratum corneum lipids. J. Invest. Dermatol. 1986; 87:758–761.
10. Akasaki S, Minematsu Y, Yoshizuka N, Imokawa G. The role of intercellular lipids in the water-holding properties of the stratum corneum: recovery effect on experimentally induced dry skin. Jap. J. Dermatol. 1988; 98:40–51.
11. Imokawa G. Role of stratum corneum components in their moisturizing function. Fragrance J 2000; 17:27–39.
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13. 13C-nuclear magnetic resonance spectroscopy. J Invest Dermatol 1995; 104:806–812.
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16. Imokawa G. Abe A, Higaki Y, Kawashima M, Hidano A. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J. Invest. Dermatol. 1991; 96:523–526.
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18. Imokawa G, Kawashima M. Atopic dermatitis and the stratum corneum lipids. Tokyo Tanabe Quarterly 1997; 42:41–52.
19. Murata Y, Ogata J, Higaki Y, Kawashima M, Yada Y, Higuchi K, Tsuchiya T, Kawaminami S, Imokawa G. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J. Invest Dermatol. 1996; 106:1242–1249.
20. Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G. High expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest. Dermatol. 2000; 115:406–413.
21. Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G. The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. Biochem. J. 2000; 350:747–756.
22. Okamoto R, Hara J, Kawashima M, Takagi Y, Imokawa G. Quantitative analysis of sphingosylphosphorylcholine in the stratum corneum of atopic dermatitis patients [abstract]. J Dermatol Sci 1999; 21:221.
23. Imokawa G, Akasaki S, Zama M, Minematsu Y, Kawamata A, Yano Y, Takaishi N. Selective recovery of deranged water-holding properties in the stratum corneum by synthesized pseudo-ceramide derivatives. Proc Jpn Soc Invest Dermatol 1988; 12:126–127.
24. Imokawa G, Akasaki S, Kawamata A, Yano S, Takaishi N.Water-retaining function in the stratum corneum and its recovery properties by synthetic pseudo-ceramides. J Soc Cosmet Chem 1989; 40:273–285.
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26. Imokawa G. Stratum corneum intercellular lipids: their function and application. Hifu to Biyo 1991; 23:3806–3818.
27. Imokawa G. Structure and function of intercellular lipids in the stratum corneum. Yukagaku 1995; 44:751–766.
28. Imokawa G. Moisturizers used in dermatology fields. J Clin Dermatol 1998; 56:87–96.
29. Imokawa G. Skin moisturizers: development and clinical use of ceramides. In: Loden M, ed. Dry Skin and Moisturizers. CRC Press, 1999:269–299.
30. Koizumi K, Noguchi K, Imokawa G, Etou T, Nakagawa H, Isibashi H. Clinical effects of synthetic pseudo-ceramides on the dry skin of atopic dermatitis patients [abstract]. Jpn J Dermatoallergol 1993; 2:66.
31. Mizutani J, Takahashi M, Shimizu M, Kariya N, Sato H, Imokawa G. Usage of pseudoceramide cream in atopic dry skin in comparison with 10% urea cream. Nishihihon Hifuka 2001; 63:457–461.
32. Yamanaka M, Ishikawa O, Takahashi M, Sato H, Imokawa G. Usage of pseudoceramide cream in atopic dry skin in comparison with 20% urea cream. Hifu 2001; 43:341–347.
33. Nakamura T, Honma D, Katusragi T, Sakai H, Hashimoto Y, Iizuka H. Usage of pseudoceramide cream in atopic dry skin in comparison with heparinoid cream. Nishinihon Hifu 1999; 61:671–681.