Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice

Journal of Investigative Dermatology

Volumn 114, Issue 2, 2000, Pages 247-252

  Haratake, Akinori ^a   Ikenaga, Kenji ^b   Katoh, Norito ^b   Uchiwa, Hideyo ^a   Hirano, Shinya ^b   Yasuno, Hirokazu ^b  

^a KANEBO LTD   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Acetone treatment; Aging; Cholesterol synthesis; Damaged skin; Epidermal permeability barrier; HMG CoA reductase; Homeostasis; Mevalonic acid; Transepidermal water loss

Indexed keywords

ACETONE; CERAMIDE; CHOLESTEROL; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; MEVALONOLACTONE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDERMIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN DEFECT; SKIN PERMEABILITY; SKIN WATER LOSS; STRATUM CORNEUM;

EID: 0034095787     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00875.x     Document Type: Article

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