Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine- polycarboxybetaine lipid for systemic delivery of siRNA

Journal of Controlled Release

Volumn 176, Issue 1, 2014, Pages 104-114

  Li, Yan ^a,d   Cheng, Qiang ^b   Jiang, Qian ^b   Huang, Yuanyu ^b   Liu, Hongmei ^a,d   Zhao, Yuliang ^c   Cao, Weipeng ^c   Ma, Guanghui ^a   Dai, Fengying ^a   Liang, Xingjie ^c   Liang, Zicai ^b   Zhang, Xin ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b PEKING UNIVERSITY   (China)

^c NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Cationic liposomes; Endosomal lysosomal escape; pH sensitive; Polycarboxybetaine; siRNA delivery

Indexed keywords

CATIONIC LIPOSOMES; ENDOSOMAL/LYSOSOMAL ESCAPE; PH SENSITIVE; POLYCARBOXYBETAINE; SIRNA DELIVERY;

BODY FLUIDS; COMPLEXATION; EFFICIENCY; ENCAPSULATION; ORGANIC POLLUTANTS; RNA;

POLYCHLORINATED BIPHENYLS;

APOLIPOPROTEIN B MRNA; DISTEAROYL PHOSPHOETHANOLAMINE POLYCARBOXYBETAINE LIPID; LIPOPLEX; MACROGOL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENCAPSULATION; GENE DELIVERY SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RETICULOENDOTHELIAL SYSTEM; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

CATIONIC LIPOSOMES; ENDOSOMAL/LYSOSOMAL ESCAPE; PH-SENSITIVE; POLYCARBOXYBETAINE; SIRNA DELIVERY;

ANIMALS; APOLIPOPROTEINS B; BETAINE; CELL SURVIVAL; ENDOSOMES; HELA CELLS; HUMANS; LIPOSOMES; LIVER; LUCIFERASES; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84892649983     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.12.007     Document Type: Article

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