Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-l-lysine nanocarrier to suppress prostate cancer growth in mice

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 5, 2012, Pages 521-532

  Guo, Jianfeng ^a   Cheng, Woei Ping ^b   Gu, Jingxia ^c   Ding, Caixia ^c   Qu, Xiaozhong ^c   Yang, Zhenzhong ^c   O'Driscoll, Caitriona ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^c INSTITUTE OF CHEMISTRY   (China)

Author keywords

pH induced endolysosomal escape; Poly l lysine nanocarrier; Prostate cancer; siRNA delivery

Indexed keywords

ALPHA INTERFERON; AMPHOPHILE; INTERLEUKIN 12; MESSENGER RNA; NANOCARRIER; POLYLYSINE; SMALL INTERFERING RNA; VASCULOTROPIN;

ACIDITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CELL MIGRATION; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RESPONSE; DECOMPLEXATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG STABILITY; ENDOSOME; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN BLOOD LEVEL; REPORTER GENE; SURFACE CHARGE; TUMOR XENOGRAFT; ZETA POTENTIAL;

ANIMALS; CATIONS; DOWN-REGULATION; ENDOSOMES; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GENETIC VECTORS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LYSINE; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; NANOPARTICLES; PARTICLE SIZE; POLYAMINES; POLYETHYLENE GLYCOLS; PROSTATIC NEOPLASMS; RNA, MESSENGER; RNA, SMALL INTERFERING; SURFACE-ACTIVE AGENTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84862777300     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.11.024     Document Type: Article

References (40)

1. S. Ahmad, G. Casey, P. Sweeney, M. Tangney, and G.C. O'Sullivan Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth Mol. Ther. 17 2009 1101 1108
2. S. Akhtar, and I. Benter Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity Adv. Drug Deliv. Rev. 59 2007 164 182 (Pubitemid 46773052)
3. D.S. Benoit, S.M. Henry, A.D. Shubin, A.S. Hoffman, and P.S. Stayton PH-responsive polymeric siRNA carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1 Mol. Pharm. 7 2010 442 455
4. D. Bumcrot, M. Manoharan, V. Koteliansky, and D.W.Y. Sah RNA therapeutics: a potential new class of pharmaceutical drugs Nat. Chem. Biol. 2 2006 711 719 (Pubitemid 44764213)
5. S. Carmona, M.R. Jorgensen, S. Kolli, C. Crowther, F.H. Salazar, P.L. Marion, M. Fujino, Y. Natori, M. Thanou, P. Arbuthnot, and A.D. Miller Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles Mol. Pharm. 6 2009 706 717
6. Y. Chen, X. Zhu, X. Zhang, B. Liu, and L. Huang Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy Mol. Ther. 18 2010 1650 1656
7. Y.S. Choi, J.Y. Lee, J.S. Suh, Y.M. Kwon, S.J. Lee, J.K. Chung, D.S. Lee, V.C. Yang, C.P. Chung, and Y.J. Park The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine Biomaterials 31 2010 1429 1443
8. J.P. Dassie, X.Y. Liu, G.S. Thomas, R.M. Whitaker, K.W. Thiel, K.R. Stockdale, D.K. Meyerholz, A.P. McCaffrey, J.O.I.I. McNamara, and P.H. Giangrande Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors Nat. Biotechnol. 27 2009 839 849
9. A. de Fougerolles, H.P. Vornlocher, J. Maraganore, and J. Lieberman Interfering with disease: a progress report on siRNA-based therapeutics Nat. Rev. Drug. Discov. 6 2007 443 453 (Pubitemid 47064567)
10. M. Dominska, and D.M. Dykxhoorn Breaking down the barriers: siRNA delivery and endosome escape J. Cell. Sci. 123 2010 1183 1189
11. K.L. Douglas, C.A. Piccirillo, and M. Tabrizian Cell line-dependent internalization pathways, intracellular trafficking determine transfection efficiency of nanoparticle Vectors Eur. J. Pharm. Biopharm. 68 2008 676 687 (Pubitemid 351318216)
12. M.L. Edelstein, M.R. Abedi, and J. Wixon Gene therapy clinical trials worldwide to 2007-an update J. Gene Med. 9 2007 833 842 (Pubitemid 47543250)
13. S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498 (Pubitemid 32494397)
14. J. Gu, W.-P. Cheng, J. Liu, S.Y. Lo, D. Smith, X. Qu, and Z. Yang PH-triggered reversible "stealth" polycationic micelles Biomacromolecules 9 2008 255 262 (Pubitemid 351201606)
15. J. Guo, K.A. Fisher, R. Darcy, J.F. Cryan, and C. O'Driscoll Therapeutic targeting in the silent era: advances in non-viral siRNA delivery Mol. Biosyst. 6 2010 1143 1161
16. J. Guo, L. Bourre, D.M. Soden, G.C. O'Sullivan, and C. O'Driscoll Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics Biotechnol. Adv. 29 2011 402 417
17. H. Hatakeyama, E. Ito, H. Akita, M. Oishi, Y. Nagasaki, S. Futaki, and H. Harashima A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo J. Control. Release 139 2009 127 132
18. K.A. Howard Delivery of RNA interference therapeutics using polycation-based nanoparticles Adv. Drug. Deliv. Rev. 61 2009 710 720
19. G. Jiang, K. Park, J. Kim, K.S. Kim, and S.K. Hahn Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis Mol. Pharm. 6 2009 727 737
20. S.H. Kim, J.H. Jeong, S.H. Lee, S.W. Kim, and T.G. Park PEG conjugated VEGF anti-angiogenic gene therapy J. Control. Release 116 2006 123 129 (Pubitemid 44854271)
21. S.H. Kim, J.H. Jeong, S.H. Lee, S.W. Kim, and T.G. Park Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer J. Control. Release 129 2008 107 116
22. M. Kortylewski, P. Swiderski, A. Herrmann, L. Wang, C. Kowolik, M. Kuiawski, H. Lee, A. Scuto, Y. Liu, C. Yang, J. Deng, H.S. Soifer, A. Raubitschek, S. Forman, and J.J. Rossi In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses Nat. Biotechnol. 27 2009 925 932
23. W. Li, and F.C. Szoka Jr. Lipid-based nanoparticles for nucleic acid delivery Pharm. Res. 24 2007 438 449 (Pubitemid 46295166)
24. S.D. Li, and L. Huang Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting J. Control. Release 145 2010 178 181
25. M. Meyer, C. Dohmen, A. Philipp, D. Kiener, G. Maiwald, C. Scheu, M. Ogris, and E. Wagner Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate Mol. Pharm. 6 2009 752 762
26. H. Mok, S.H. Lee, J.W. Park, and T.G. Park Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing Nat. Mater. 9 2010 272 278
27. Y.K. Oh, and T.G. Park siRNA delivery systems for cancer treatment Adv. Drug Deliv. Rev. 61 2009 850 862
28. M.J. O'Neill, J. Guo, C. Byrne, R. Darcy, and C.M. O'Driscoll Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells Int. J. Pharm. 413 2011 174 183
29. K.F. Pirollo, G. Zon, A. Rait, Q. Zhou, W. Yu, R. Hogrefe, and E.H. Chang Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery Hum. Gene. Ther. 17 2006 117 124 (Pubitemid 43100520)
30. M.A. Phillips, M.L. Gran, and N.A. Peppas Targeted nanodelivery of drugs and diagnostics Nano Today 5 2010 143 159
31. A. Santel, M. Aleku, N. Roder, K. Moper, B. Durieux, O. Janke, O. Keil, and J. Endruschat Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models Clin. Cancer Res. 16 2011 5469 5480
32. Q. Shi, A.T. Nguyen, Y. Angell, D. Deng, C.R. Na, K. Burgess, D.D. Roberts, F.C. Brunicardi, and N.S. Templeton A combinatorial approach for targeted delivery using small molecules, reversible masking to bypass nonspecific uptake in vivo Gene Ther. 17 2010 1085 1097
33. R. Siegel, E. Ward, O. Brawley, and A. Jemal Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J. Clin. 61 2011 2011 212 236
34. C.E. Thomas, A. Ehrhardt, and M.A. Kay Progress and problems with the use of viral vectors for gene therapy Nat. Rev. Genet. 4 2003 346 358 (Pubitemid 36538359)
35. M. Walsh, M. Tangney, M.J. O'Neill, J.O. Larkin, D.M. Soden, S.L. Mckenna, R. Darcy, G.C. O'Sullivan, and C.M. O'Driscoll Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-l-lysine compacted DNA: implications for cancer gene therapy Mol. Pharm. 3 2006 644 653 (Pubitemid 46087481)
36. X. Wang, R. Xu, X. Wu, D. Gillespie, R. Jensen, and Z. Lu Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice Mol. Pharm. 6 2009 738 746
37. K. Watanabe, M. Harada-Shiba, A. Suzuki, R. Gokuden, R. Kurihara, Y. Sugao, T. Mori, Y. Katayama, and T. Niidome In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia Mol. Biosyst. 5 2009 1306 1310
38. K.A. Whitehead, R. Langer, and D.G. Anderson Knocking down barriers: advances in siRNA delivery Nat. Rev. Drug Discov. 8 2009 129 138
39. X.B. Xiong, H. Uludag, and A. Lavasanifar Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery Biomaterials 30 2009 242 253
40. I. Yusuke, R. Kurihara, A. Tsuchida, M. Hasegawa, T. Nagashima, T. Mori, T. Niidome, Y. Katayama, and O. Okitsu Efficient delivery of siRNA using dendritic poly(l-lysine) for loss-of-function analysis J. Control. Release 126 2007 59 66