Endosomal escape and transfection efficiency of PEGylated cationic liposome-DNA complexes prepared with an acid-labile PEG-lipid

Biomaterials

Volumn 33, Issue 19, 2012, Pages 4928-4935

  Chan, Chia Ling ^a,b,c,d   Majzoub, Ramsey N ^a,b   Shirazi, Rahau S ^b   Ewert, Kai K ^a,b   Chen, Yen Ju ^d   Liang, Keng S ^d,e   Safinya, Cyrus R ^a,b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF PHYSICS   (Taiwan)

^d NATIONAL SYNCHROTRON RADIATION RESEARCH CENTER   (Taiwan)

^e NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

Acid labile; Cationic lipid; Gene therapy; Nonviral; PEGylation; Poly(ethylene glycol)

Indexed keywords

ACID-LABILE; CATIONIC LIPIDS; CELLULAR UPTAKE; CHARGE RATIO; ENDOSOMES; IN-VIVO; LATE ENDOSOMES; LIPID MEMBRANES; LIVE-CELL IMAGING; NON-VIRAL GENE DELIVERY; NONVIRAL; PARTICLE DISTRIBUTIONS; PEGYLATION; TRANSFECTION EFFICIENCY; VIRAL VECTORS;

EFFICIENCY; GENE THERAPY; GENE TRANSFER; LIPOSOMES; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS;

DNA;

CATIONIC LIPOSOME DNA COMPLEX; DNA; LIPOSOME; MACROGOL; POLY(ETHYLENE GLYCOL) LIPID; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL TRANSPORT; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STABILITY; DRUG SYNTHESIS; ENDOCYTOSIS; ENDOSOME; GENETIC TRANSFECTION; HYDROLYSIS; INTERNALIZATION; LIPID MEMBRANE; NONVIRAL GENE DELIVERY SYSTEM; PH; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CELL SURVIVAL; DNA; ENDOSOMES; GENE THERAPY; LIPOSOMES; MICE; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; TRANSFECTION;

EID: 84859871592     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.03.038     Document Type: Article

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