-
1
-
-
34548108138
-
Targeting virulence: A new paradigm for antimicrobial therapy
-
Clatworthy A, Pierson E, Hung D. Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol 2007;3:541-8
-
(2007)
Nat Chem Biol
, vol.3
, pp. 541-548
-
-
Clatworthy, A.1
Pierson, E.2
Hung, D.3
-
2
-
-
73649191344
-
Infective heredity of multiple drug resistance in bacteria
-
Watanabe T. Infective heredity of multiple drug resistance in bacteria. Bacteriol Rev 1963;27:87-115
-
(1963)
Bacteriol Rev
, vol.27
, pp. 87-115
-
-
Watanabe, T.1
-
3
-
-
80053937055
-
The antibiotic R&D pipeline: An update
-
Jabes D. The antibiotic R&D pipeline: an update. Curr Opin Microbiol 2011;14:564-9
-
(2011)
Curr Opin Microbiol
, vol.14
, pp. 564-569
-
-
Jabes, D.1
-
4
-
-
36749067251
-
Resistant gram-negative bacilli: A neglected healthcare crisis?
-
quiz S22
-
Lautenbach E, Polk R. Resistant gram-negative bacilli: a neglected healthcare crisis? Am J Health Syst Pharm 2007;64:S3-21.quiz S22
-
(2007)
Am J Health Syst Pharm
, vol.64
-
-
Lautenbach, E.1
Polk, R.2
-
5
-
-
84869886623
-
Antibiotics in Phase II and III clinical trials
-
Coates A, Halls G. Antibiotics in Phase II and III clinical trials. Handb Exp Pharmacol 2012;211:167-83
-
(2012)
Handb Exp Pharmacol
, vol.211
, pp. 167-183
-
-
Coates, A.1
Halls, G.2
-
6
-
-
44949215750
-
Virulence blockers as alternatives to antibiotics: Type III secretion inhibitors against Gram-negative bacteria
-
Keyser P, Elofsson M, Rosell S, Wolf-Watz H. Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria. J Intern Med 2008;264:17-29
-
(2008)
J Intern Med
, vol.264
, pp. 17-29
-
-
Keyser, P.1
Elofsson, M.2
Rosell, S.3
Wolf-Watz, H.4
-
7
-
-
39349107697
-
Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea
-
Chang J, Antonopoulos D, Kalra A, et al. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea. J Infect Dis 2008;197:435-8
-
(2008)
J Infect Dis
, vol.197
, pp. 435-438
-
-
Chang, J.1
Antonopoulos, D.2
Kalra, A.3
-
9
-
-
85003983917
-
On the acquisition of immunity against diptheria and tetanus in animals
-
Von Behring E, Kitasato S. On the acquisition of immunity against diptheria and tetanus in animals. Dtsch Med Wochensch 1890;16:1145-8
-
(1890)
Dtsch Med Wochensch
, vol.16
, pp. 1145-1148
-
-
Von Behring, E.1
Kitasato, S.2
-
10
-
-
84862556686
-
Protein export according to schedule: Architecture, assembly, and regulation of type III secretion systems from plant-and animal-pathogenic bacteria
-
Büttner D. Protein export according to schedule: architecture, assembly, and regulation of type III secretion systems from plant-and animal-pathogenic bacteria. Microbiol Mol Biol Rev 2012;76:262-310
-
(2012)
Microbiol Mol Biol Rev
, vol.76
, pp. 262-310
-
-
Büttner, D.1
-
11
-
-
33750110911
-
The type III secretion injectisome
-
Cornelis G. The type III secretion injectisome. Nat Rev Microbiol 2006;4:811-25
-
(2006)
Nat Rev Microbiol
, vol.4
, pp. 811-825
-
-
Cornelis, G.1
-
12
-
-
0035675043
-
Salmonella entry into host cells: The work in concert of type III secreted effector proteins
-
Zhou D, Galán J. Salmonella entry into host cells: the work in concert of type III secreted effector proteins. Microbes Infect Inst Pasteur 2001;3:1293-8
-
(2001)
Microbes Infect Inst Pasteur
, vol.3
, pp. 1293-1298
-
-
Zhou, D.1
Galán, J.2
-
13
-
-
0037105562
-
Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway
-
Collier-Hyams L, Zeng H, Sun J, et al. Cutting edge: salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. J Immunol Baltim Md 1950;169:2846-50
-
(1950)
J Immunol Baltim Md
, vol.169
, pp. 2846-2850
-
-
Collier-Hyams, L.1
Zeng, H.2
Sun, J.3
-
14
-
-
78049422962
-
The EspF effector, a bacterial pathogen's Swiss army knife
-
Holmes A, Mühlen S, Roe AJ, Dean P. The EspF effector, a bacterial pathogen's Swiss army knife. Infect Immun 2010;78:4445-53
-
(2010)
Infect Immun
, vol.78
, pp. 4445-4453
-
-
Holmes, A.1
Mühlen, S.2
Roe, A.J.3
Dean, P.4
-
15
-
-
25444461419
-
The shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes
-
Kim D, Lenzen G, Page A-L, et al. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc Natl Acad Sci USA 2005;102:14046-51
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14046-14051
-
-
Kim, D.1
Lenzen, G.2
Page, A.-L.3
-
16
-
-
79956211337
-
Identification of small-molecule inhibitors of Yersinia pestis type III secretion system YscN ATPase
-
Swietnicki W, Carmany D, Retford M, et al. Identification of small-molecule inhibitors of Yersinia pestis type III secretion system YscN ATPase. PLoS ONE 2011;6:e19716
-
(2011)
PLoS ONE
, vol.6
-
-
Swietnicki, W.1
Carmany, D.2
Retford, M.3
-
17
-
-
25844524137
-
Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli
-
Gauthier A, Robertson M, Lowden M, et al. Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli. Antimicrob Agents Chemother 2005;49:4101-9
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4101-4109
-
-
Gauthier, A.1
Robertson, M.2
Lowden, M.3
-
18
-
-
0031029062
-
Yersinia pestis-etiologic agent of plague
-
Perry R, Fetherston J. Yersinia pestis-etiologic agent of plague. Clin Microbiol Rev 1997;10:35-66
-
(1997)
Clin Microbiol Rev
, vol.10
, pp. 35-66
-
-
Perry, R.1
Fetherston, J.2
-
19
-
-
84867981278
-
Pathogenesis of Y. Enterocolitica and Y. Pseudotuberculosis in human yersiniosis
-
Galindo C, Rosenzweig J, Kirtley M, Chopra A. Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in human Yersiniosis. J Pathog 2011;2011:182051
-
(2011)
J Pathog
, vol.2011
, pp. 182051
-
-
Galindo, C.1
Rosenzweig, J.2
Kirtley, M.3
Chopra, A.4
-
21
-
-
69249205726
-
Addressing the global disease burden of typhoid fever
-
Bhutta Z, Threlfall J. Addressing the global disease burden of typhoid fever. JAMA J Am Med Assoc 2009;302:898-9
-
(2009)
JAMA J Am Med Assoc
, vol.302
, pp. 898-899
-
-
Bhutta, Z.1
Threlfall, J.2
-
22
-
-
73949118739
-
Molecular mechanisms of Escherichia coli pathogenicity
-
Croxen M, Finlay B. Molecular mechanisms of Escherichia coli pathogenicity. Nat Rev Microbiol 2010;8:26-38
-
(2010)
Nat Rev Microbiol
, vol.8
, pp. 26-38
-
-
Croxen, M.1
Finlay, B.2
-
23
-
-
84855471343
-
Antibiotic treatment of Escherichia coli O157 infection and the risk of hemolytic uremic syndrome, Minnesota
-
Smith K, Wilker P, Reiter P, et al. Antibiotic treatment of Escherichia coli O157 infection and the risk of hemolytic uremic syndrome, Minnesota. Pediatr Infect Dis J 2012;31:37-41
-
(2012)
Pediatr Infect Dis J
, vol.31
, pp. 37-41
-
-
Smith, K.1
Wilker, P.2
Reiter, P.3
-
24
-
-
78249251496
-
Research progress in Shigella in the postgenomic era
-
Peng J, Yang J, Jin Q. Research progress in Shigella in the postgenomic era. Sci China Life Sci 2010;53:1284-90
-
(2010)
Sci China Life Sci
, vol.53
, pp. 1284-1290
-
-
Peng, J.1
Yang, J.2
Jin, Q.3
-
25
-
-
77953292609
-
N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability
-
Grier M, Garrity-Ryan L, Bartlett V, et al. N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: in vitro anti-virulence activity and metabolic stability. Bioorg Med Chem Lett 2010;20:3380-3
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 3380-3383
-
-
Grier, M.1
Garrity-Ryan, L.2
Bartlett, V.3
-
26
-
-
77954597457
-
The type III secretion injectisome, a complex nanomachine for intracellular "toxin" delivery
-
Cornelis G. The type III secretion injectisome, a complex nanomachine for intracellular "toxin" delivery. Biol Chem 2010;391:745-51
-
(2010)
Biol Chem
, vol.391
, pp. 745-751
-
-
Cornelis, G.1
-
27
-
-
0035949491
-
Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure
-
Sekiya K, Ohishi M, Ogino T, et al. Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure. Proc Natl Acad Sci USA 2001;98:11638-43
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11638-11643
-
-
Sekiya, K.1
Ohishi, M.2
Ogino, T.3
-
28
-
-
79955838725
-
Biogenesis, regulation, and targeting of the type III secretion system
-
Izoré T, Job V, Dessen A. Biogenesis, regulation, and targeting of the type III secretion system. Struct Lond Engl 1993;19:603-12
-
(1993)
Struct Lond Engl
, vol.19
, pp. 603-612
-
-
Izoré, T.1
Job, V.2
Dessen, A.3
-
29
-
-
0034730179
-
Molecular characterization and assembly of the needle complex of the salmonella typhimurium type III protein secretion system
-
Kubori T, Sukhan A, Aizawa S, Galán J. Molecular characterization and assembly of the needle complex of the Salmonella Typhimurium type III protein secretion system. Proc Natl Acad Sci USA 2000;97:10225-30
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10225-10230
-
-
Kubori, T.1
Sukhan, A.2
Aizawa, S.3
Galán, J.4
-
30
-
-
0029787714
-
Modulation of virulence factor expression by pathogen target cell contact
-
Pettersson J, Nordfelth R, Dubinina E, et al. Modulation of virulence factor expression by pathogen target cell contact. Science 1996;273:1231-3
-
(1996)
Science
, vol.273
, pp. 1231-1233
-
-
Pettersson, J.1
Nordfelth, R.2
Dubinina, E.3
-
31
-
-
34250840609
-
YscU recognizes translocators as export substrates of the Yersinia injectisome
-
Sorg I, Wagner S, Amstutz M, et al. YscU recognizes translocators as export substrates of the Yersinia injectisome. EMBO J 2007;26:3015-24
-
(2007)
EMBO J
, vol.26
, pp. 3015-3024
-
-
Sorg, I.1
Wagner, S.2
Amstutz, M.3
-
32
-
-
20144387135
-
Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens
-
Deng W, Li Y, Hardwidge P, et al. Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens. Infect Immun 2005;73:2135-46
-
(2005)
Infect Immun
, vol.73
, pp. 2135-2146
-
-
Deng, W.1
Li, Y.2
Hardwidge, P.3
-
33
-
-
84856799133
-
Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure
-
Barta M, Guragain M, Adam P, et al. Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure. Proteins 2012;80:935-45
-
(2012)
Proteins
, vol.80
, pp. 935-945
-
-
Barta, M.1
Guragain, M.2
Adam, P.3
-
34
-
-
27144559247
-
Chaperone release and unfolding of substrates in type III secretion
-
Akeda Y, Galán J. Chaperone release and unfolding of substrates in type III secretion. Nature 2005;437:911-15
-
(2005)
Nature
, vol.437
, pp. 911-915
-
-
Akeda, Y.1
Galán, J.2
-
35
-
-
24644474725
-
Real-time imaging of type III secretion: Salmonella SipA injection into host cells
-
Schlumberger M, Müller AJ, Ehrbar K, et al. Real-time imaging of type III secretion: salmonella SipA injection into host cells. Proc Natl Acad Sci USA 2005;102:12548-53
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 12548-12553
-
-
Schlumberger, M.1
Müller, A.J.2
Ehrbar, K.3
-
36
-
-
0029948607
-
YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis
-
Andersson K, Carballeira N, Magnusson K, et al. YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis. Mol Microbiol 1996;20:1057-69
-
(1996)
Mol Microbiol
, vol.20
, pp. 1057-1069
-
-
Andersson, K.1
Carballeira, N.2
Magnusson, K.3
-
37
-
-
76449085581
-
Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV
-
Lee P-C, Stopford C, Svenson A, Rietsch A. Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV. Mol Microbiol 2010;75:924-41
-
(2010)
Mol Microbiol
, vol.75
, pp. 924-941
-
-
Lee, P.-C.1
Stopford, C.2
Svenson, A.3
Rietsch, A.4
-
38
-
-
33947249049
-
The type III secretion system needle tip complex mediates host cell sensing and translocon insertion
-
Veenendaal A, Hodgkinson J, Schwarzer L, et al. The type III secretion system needle tip complex mediates host cell sensing and translocon insertion. Mol Microbiol 2007;63:1719-30
-
(2007)
Mol Microbiol
, vol.63
, pp. 1719-1730
-
-
Veenendaal, A.1
Hodgkinson, J.2
Schwarzer, L.3
-
39
-
-
79955741104
-
Expression hierarchy in the Yersinia type III secretion system established through YopD recognition of RNA
-
Chen Y, Anderson D. Expression hierarchy in the Yersinia type III secretion system established through YopD recognition of RNA. Mol Microbiol 2011;80:966-80
-
(2011)
Mol Microbiol
, vol.80
, pp. 966-980
-
-
Chen, Y.1
Anderson, D.2
-
40
-
-
0036182095
-
YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA
-
Anderson D, Ramamurthi K, Tam C, Schneewind O. YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA. J Bacteriol 2002;184:1287-95
-
(2002)
J Bacteriol
, vol.184
, pp. 1287-1295
-
-
Anderson, D.1
Ramamurthi, K.2
Tam, C.3
Schneewind, O.4
-
41
-
-
0036838012
-
Yersinia enterocolitica type III secretion: YscM1 and yscM2 regulate yop gene expression by a posttranscriptional mechanism that targets the 5' untranslated region of yop mRNA
-
Cambronne E, Schneewind O. Yersinia enterocolitica type III secretion: yscM1 and yscM2 regulate yop gene expression by a posttranscriptional mechanism that targets the 5' untranslated region of yop mRNA. J Bacteriol 2002;184:5880-93
-
(2002)
J Bacteriol
, vol.184
, pp. 5880-5893
-
-
Cambronne, E.1
Schneewind, O.2
-
42
-
-
0037350267
-
Targeting bacterial virulence: Inhibitors of type III secretion in Yersinia
-
Kauppi A, Nordfelth R, Uvell H, et al. Targeting bacterial virulence: inhibitors of type III secretion in Yersinia. Chem Biol 2003;10:241-9
-
(2003)
Chem Biol
, vol.10
, pp. 241-249
-
-
Kauppi, A.1
Nordfelth, R.2
Uvell, H.3
-
44
-
-
53349117642
-
An inhibitor of gram-negative bacterial virulence protein secretion
-
Felise H, Nguyen H, Pfuetzner R, et al. An inhibitor of gram-negative bacterial virulence protein secretion. Cell Host Microbe 2008;4:325-36
-
(2008)
Cell Host Microbe
, vol.4
, pp. 325-336
-
-
Felise, H.1
Nguyen, H.2
Pfuetzner, R.3
-
45
-
-
0037078817
-
Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia
-
Linington R, Robertson M, Gauthier A, et al. Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia. Org Lett 2002;4:4089-92
-
(2002)
Org Lett
, vol.4
, pp. 4089-4092
-
-
Linington, R.1
Robertson, M.2
Gauthier, A.3
-
48
-
-
77953628734
-
Visible fluorescence detection of type III protein secretion from bacterial pathogens
-
Yount J, Tsou L, Dossa P, et al. Visible fluorescence detection of type III protein secretion from bacterial pathogens. J Am Chem Soc 2010;132:8244-5
-
(2010)
J Am Chem Soc
, vol.132
, pp. 8244-8245
-
-
Yount, J.1
Tsou, L.2
Dossa, P.3
-
49
-
-
77951637036
-
Imaging type-III secretion reveals dynamics and spatial segregation of Salmonella effectors
-
Van Engelenburg S, Palmer A. Imaging type-III secretion reveals dynamics and spatial segregation of Salmonella effectors. Nat Methods 2010;7:325-30
-
(2010)
Nat Methods
, vol.7
, pp. 325-330
-
-
Van Engelenburg, S.1
Palmer, A.2
-
50
-
-
44949102310
-
Quantification of real-time Salmonella effector type III secretion kinetics reveals differential secretion rates for SopE2 and SptP
-
Van Engelenburg S, Palmer A. Quantification of real-time Salmonella effector type III secretion kinetics reveals differential secretion rates for SopE2 and SptP. Chem Biol 2008;15:619-28
-
(2008)
Chem Biol
, vol.15
, pp. 619-628
-
-
Van Engelenburg, S.1
Palmer, A.2
-
52
-
-
84871737316
-
Small molecules aimed at type III secretion systems to inhibit bacterial virulence
-
Tsou L, Dossa P, Hang H. Small molecules aimed at type III secretion systems to inhibit bacterial virulence. Med Chem Comm 2013;4:68-79
-
(2013)
Med Chem Comm
, vol.4
, pp. 68-79
-
-
Tsou, L.1
Dossa, P.2
Hang, H.3
-
53
-
-
84876247610
-
Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium
-
Li J, Lv C, Sun W, et al. Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother 2013;57:2191-8
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 2191-2198
-
-
Li, J.1
Lv, C.2
Sun, W.3
-
54
-
-
79951937305
-
A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium
-
Kimura K, Iwatsuki M, Nagai T, et al. A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium. J Antibiot (Tokyo) 2011;64:197-203
-
(2011)
J Antibiot (Tokyo)
, vol.64
, pp. 197-203
-
-
Kimura, K.1
Iwatsuki, M.2
Nagai, T.3
-
55
-
-
77954514638
-
Suppression of bacterial cell-cell signalling, biofilm formation and type III secretion system by citrus flavonoids
-
Vikram A, Jayaprakasha G, Jesudhasan P, et al. Suppression of bacterial cell-cell signalling, biofilm formation and type III secretion system by citrus flavonoids. J Appl Microbiol 2010;109:515-27
-
(2010)
J Appl Microbiol
, vol.109
, pp. 515-527
-
-
Vikram, A.1
Jayaprakasha, G.2
Jesudhasan, P.3
-
58
-
-
78049444219
-
Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model
-
Garrity-Ryan L, Kim O, Balada-Llasat J-M, et al. Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model. Infect Immun 2010;78:4683-90
-
(2010)
Infect Immun
, vol.78
, pp. 4683-4690
-
-
Garrity-Ryan, L.1
Kim, O.2
Balada-Llasat, J.-M.3
-
59
-
-
0021360511
-
Synthesis and antimicrobial activity of salicylanilide derivatives. II
-
Ozawa I, Takeuchi I, Yamamoto K, et al. Synthesis and antimicrobial activity of salicylanilide derivatives. II. Chem Pharm Bull (Tokyo) 1984;32:305-12
-
(1984)
Chem Pharm Bull (Tokyo)
, vol.32
, pp. 305-312
-
-
Ozawa, I.1
Takeuchi, I.2
Yamamoto, K.3
-
60
-
-
34548569906
-
Novel anti-infection agents: Small-molecule inhibitors of bacterial transcription factors
-
Bowser T, Bartlett V, Grier M, et al. Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors. Bioorg Med Chem Lett 2007;17:5652-5
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 5652-5655
-
-
Bowser, T.1
Bartlett, V.2
Grier, M.3
-
61
-
-
70349197665
-
N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: Novel antivirulence agents
-
Kim O, Garrity-Ryan L, Bartlett V, et al. N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents. J Med Chem 2009;52:5626-34
-
(2009)
J Med Chem
, vol.52
, pp. 5626-5634
-
-
Kim, O.1
Garrity-Ryan, L.2
Bartlett, V.3
-
62
-
-
37849049329
-
Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides-potent inhibitors of type III secretion in Yersinia
-
Dahlgren M, Kauppi A, Olsson I-M, et al. Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides-potent inhibitors of type III secretion in Yersinia. J Med Chem 2007;50:6177-88
-
(2007)
J Med Chem
, vol.50
, pp. 6177-6188
-
-
Dahlgren, M.1
Kauppi, A.2
Olsson, I.-M.3
-
63
-
-
0036718795
-
AT Pases as drug targets: Learning from their structure
-
Chène P. AT Pases as drug targets: learning from their structure. Nat Rev Drug Discov 2002;1:665-73
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 665-673
-
-
Chène, P.1
-
64
-
-
33749593502
-
Inhibitors of helicobacter pylori ATPase cagalpha block CagA transport and cag virulence
-
Hilleringmann M, Pansegrau W, Doyle M, et al. Inhibitors of Helicobacter pylori ATPase Cagalpha block CagA transport and cag virulence. Microbiol Read Engl 2006;152:2919-30
-
(2006)
Microbiol Read Engl
, vol.152
, pp. 2919-2930
-
-
Hilleringmann, M.1
Pansegrau, W.2
Doyle, M.3
-
65
-
-
0033033304
-
A new pathway for the secretion of virulence factors by bacteria: The flagellar export apparatus functions as a protein-secretion system
-
Young G, Schmiel D, Miller V. A new pathway for the secretion of virulence factors by bacteria: the flagellar export apparatus functions as a protein-secretion system. Proc Natl Acad Sci USA 1999;96:6456-61
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6456-6461
-
-
Young, G.1
Schmiel, D.2
Miller, V.3
-
66
-
-
77950250064
-
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
-
Vijay-Kumar M, Aitken J, Carvalho F, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010;328:228-31
-
(2010)
Science
, vol.328
, pp. 228-231
-
-
Vijay-Kumar, M.1
Aitken, J.2
Carvalho, F.3
-
67
-
-
56749177331
-
Substituted 2-imino-5-arylidenethiazolidin-4-one inhibitors of bacterial type III secretion
-
Kline T, Felise H, Barry K, et al. Substituted 2-imino-5- arylidenethiazolidin-4-one inhibitors of bacterial type III secretion. J Med Chem 2008;51:7065-74
-
(2008)
J Med Chem
, vol.51
, pp. 7065-7074
-
-
Kline, T.1
Felise, H.2
Barry, K.3
-
68
-
-
58649103547
-
Small-molecule type III secretion system inhibitors block assembly of the Shigella type III secreton
-
Veenendaal A, Sundin C, Blocker A. Small-molecule type III secretion system inhibitors block assembly of the Shigella type III secreton. J Bacteriol 2009;191:563-70
-
(2009)
J Bacteriol
, vol.191
, pp. 563-570
-
-
Veenendaal, A.1
Sundin, C.2
Blocker, A.3
-
69
-
-
77949350020
-
Designed coiled-coil peptides inhibit the type three secretion system of enteropathogenic Escherichia coli
-
Larzábal M, Mercado E, Vilte D, et al. Designed coiled-coil peptides inhibit the type three secretion system of enteropathogenic Escherichia coli. PLoS ONE 2010;5:e9046
-
(2010)
PLoS ONE
, vol.5
-
-
Larzábal, M.1
Mercado, E.2
Vilte, D.3
-
70
-
-
84872933512
-
Effect of coiled-coil peptides on the function of the type III secretion system-dependent activity of enterohemorrhagic Escherichia coli O157:H7 and Citrobacter rodentium
-
Larzábal M, Zotta E, Ibarra C, et al. Effect of coiled-coil peptides on the function of the type III secretion system-dependent activity of enterohemorrhagic Escherichia coli O157:H7 and Citrobacter rodentium. Int J Med Microbiol IJMM 2013;303:9-15
-
(2013)
Int J Med Microbiol IJMM
, vol.303
, pp. 9-15
-
-
Larzábal, M.1
Zotta, E.2
Ibarra, C.3
-
71
-
-
22244476683
-
Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes
-
Goure J, Broz P, Attree O, et al. Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes. J Infect Dis 2005;192:218-25
-
(2005)
J Infect Dis
, vol.192
, pp. 218-225
-
-
Goure, J.1
Broz, P.2
Attree, O.3
-
72
-
-
0031750789
-
Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine
-
Heath D, Anderson G, Mauro J, et al. Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine. Vaccine 1998;16:1131-7
-
(1998)
Vaccine
, vol.16
, pp. 1131-1137
-
-
Heath, D.1
Anderson, G.2
Mauro, J.3
-
73
-
-
0032907634
-
Active and passive immunization with the Pseudomonas v antigen protects against type III intoxication and lung injury
-
Sawa T, Yahr T, Ohara M, et al. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. Nat Med 1999;5:392-8
-
(1999)
Nat Med
, vol.5
, pp. 392-398
-
-
Sawa, T.1
Yahr, T.2
Ohara, M.3
-
74
-
-
0035889948
-
Therapeutic administration of anti-PcrV F(ab')(2) in sepsis associated with Pseudomonas aeruginosa
-
Shime N, Sawa T, Fujimoto J, et al. Therapeutic administration of anti-PcrV F(ab')(2) in sepsis associated with Pseudomonas aeruginosa. J Immunol Baltim Md 1950;167:5880-6
-
(1950)
J Immunol Baltim Md
, vol.167
, pp. 5880-5886
-
-
Shime, N.1
Sawa, T.2
Fujimoto, J.3
-
75
-
-
84864289317
-
Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: A randomized, double-blind, placebo-controlled trial
-
François B, Luyt C-E, Dugard A, et al. Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: a randomized, double-blind, placebo-controlled trial. Crit Care Med 2012;40:2320-6
-
(2012)
Crit Care Med
, vol.40
, pp. 2320-2326
-
-
François, B.1
Luyt, C.-E.2
Dugard, A.3
-
78
-
-
0030701868
-
Enteropathogenic E. Coli (EPEC) transfers its receptor for intimate adherence into mammalian cells
-
Kenny B, DeVinney R, Stein M, et al. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 1997;91:511-20
-
(1997)
Cell
, vol.91
, pp. 511-520
-
-
Kenny, B.1
Devinney, R.2
Stein, M.3
-
79
-
-
0027164517
-
The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model
-
Donnenberg M, Tzipori S, McKee M, et al. The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model. J Clin Invest 1993;92:1418-24
-
(1993)
J Clin Invest
, vol.92
, pp. 1418-1424
-
-
Donnenberg, M.1
Tzipori, S.2
McKee, M.3
-
80
-
-
77955410498
-
Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis
-
Harmon D, Davis A, Castillo C, Mecsas J. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob Agents Chemother 2010;54:3241-54
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 3241-3254
-
-
Harmon, D.1
Davis, A.2
Castillo, C.3
Mecsas, J.4
-
81
-
-
0027305714
-
The yersinia pseudotuberculosis adhesin YadA mediates intimate bacterial attachment to and entry into HEp-2 cells
-
Bliska J, Copass M, Falkow S. The Yersinia pseudotuberculosis adhesin YadA mediates intimate bacterial attachment to and entry into HEp-2 cells. Infect Immun 1993;61:3914-21
-
(1993)
Infect Immun
, vol.61
, pp. 3914-3921
-
-
Bliska, J.1
Copass, M.2
Falkow, S.3
-
82
-
-
34447273555
-
Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors
-
Hudson D, Layton A, Field T, et al. Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors. Antimicrob Agents Chemother 2007;51:2631-5
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 2631-2635
-
-
Hudson, D.1
Layton, A.2
Field, T.3
-
83
-
-
34547629449
-
Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium
-
Negrea A, Bjur E, Ygberg S, et al. Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium. Antimicrob Agents Chemother 2007;51:2867-76
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 2867-2876
-
-
Negrea, A.1
Bjur, E.2
Ygberg, S.3
-
84
-
-
65549090158
-
Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells
-
Muschiol S, Normark S, Henriques-Normark B, Subtil A. Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells. BMC Microbiol 2009;9:75
-
(2009)
BMC Microbiol
, vol.9
, pp. 75
-
-
Muschiol, S.1
Normark, S.2
Henriques-Normark, B.3
Subtil, A.4
-
85
-
-
34447270306
-
Reversal of the antichlamydial activity of putative type III secretion inhibitors by iron
-
Slepenkin A, Enquist P-A, Hägglund U, et al. Reversal of the antichlamydial activity of putative type III secretion inhibitors by iron. Infect Immun 2007;75:3478-89
-
(2007)
Infect Immun
, vol.75
, pp. 3478-3489
-
-
Slepenkin, A.1
Enquist, P.-A.2
Hägglund, U.3
-
86
-
-
70349420964
-
Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7
-
Tree J, Wang D, McInally C, et al. Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7. Infect Immun 2009;77:4209-20
-
(2009)
Infect Immun
, vol.77
, pp. 4209-4220
-
-
Tree, J.1
Wang, D.2
McInally, C.3
-
87
-
-
17644371042
-
Small-molecule inhibitors specifically targeting type III secretion
-
Nordfelth R, Kauppi A, Norberg H, et al. Small-molecule inhibitors specifically targeting type III secretion. Infect Immun 2005;73:3104-14
-
(2005)
Infect Immun
, vol.73
, pp. 3104-3114
-
-
Nordfelth, R.1
Kauppi, A.2
Norberg, H.3
-
88
-
-
47249155189
-
Global regulation by horizontally transferred regulators establishes the pathogenicity of Escherichia coli
-
Abe H, Miyahara A, Oshima T, et al. Global regulation by horizontally transferred regulators establishes the pathogenicity of Escherichia coli. DNA Res Int J Rapid Publ Rep Genes Genomes 2008;15:25-38
-
(2008)
DNA Res Int J Rapid Publ Rep Genes Genomes
, vol.15
, pp. 25-38
-
-
Abe, H.1
Miyahara, A.2
Oshima, T.3
-
89
-
-
74049115090
-
Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron
-
Layton A, Hudson D, Thompson A, et al. Salicylidene acylhydrazide- mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron. FEMS Microbiol Lett 2010;302:114-22
-
(2010)
FEMS Microbiol Lett
, vol.302
, pp. 114-122
-
-
Layton, A.1
Hudson, D.2
Thompson, A.3
-
90
-
-
84862583329
-
Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds
-
Gabrielsen M, Beckham KS, Feher VA, et al. Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds. PLoS One 2012;7:e32217
-
(2012)
PLoS One
, vol.7
-
-
Gabrielsen, M.1
Beckham, K.S.2
Feher, V.A.3
-
91
-
-
80051935421
-
Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds
-
Wang D, Zetterström CE, Gabrielsen M, et al. Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. J Biol Chem 2011;286:29922-31
-
(2011)
J Biol Chem
, vol.286
, pp. 29922-29931
-
-
Wang, D.1
Zetterström, C.E.2
Gabrielsen, M.3
-
92
-
-
84871793328
-
Isolation of Salmonella mutants resistant to the inhibitory effect of Salicylidene acylhydrazides on flagella-mediated motility
-
Martinez-Argudo I, Veenendaal A, Liu X, et al. Isolation of Salmonella mutants resistant to the inhibitory effect of Salicylidene acylhydrazides on flagella-mediated motility. PloS One 2013;8:e52179
-
(2013)
PloS One
, vol.8
-
-
Martinez-Argudo, I.1
Veenendaal, A.2
Liu, X.3
-
93
-
-
33748490301
-
Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle
-
Wolf K, Betts H, Chellas-Géry B, et al. Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle. Mol Microbiol 2006;61:1543-55
-
(2006)
Mol Microbiol
, vol.61
, pp. 1543-1555
-
-
Wolf, K.1
Betts, H.2
Chellas-Géry, B.3
-
94
-
-
80053427854
-
Protection of mice from a Chlamydia trachomatis vaginal infection using a Salicylidene acylhydrazide, a potential microbicide
-
Slepenkin A, Chu H, Elofsson M, et al. Protection of mice from a Chlamydia trachomatis vaginal infection using a Salicylidene acylhydrazide, a potential microbicide. J Infect Dis 2011;204:1313-20
-
(2011)
J Infect Dis
, vol.204
, pp. 1313-1320
-
-
Slepenkin, A.1
Chu, H.2
Elofsson, M.3
-
95
-
-
84883273494
-
Mutations in hemG mediate resistance to Salicylidene acylhydrazides: A novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity
-
Engström P, Nguyen BD, Normark J, et al. Mutations in hemG mediate resistance to Salicylidene acylhydrazides: a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. J Bacteriol 2013;195:4221-30
-
(2013)
J Bacteriol
, vol.195
, pp. 4221-4230
-
-
Engström, P.1
Nguyen, B.D.2
Normark, J.3
-
97
-
-
84875126287
-
A novel human antimicrobial factor targets Pseudomonas aeruginosa through its type III secretion system
-
Mahmood F, Hakimiyan A, Jayaraman V, et al. A novel human antimicrobial factor targets Pseudomonas aeruginosa through its type III secretion system. J Med Microbiol 2013;62:531-9
-
(2013)
J Med Microbiol
, vol.62
, pp. 531-539
-
-
Mahmood, F.1
Hakimiyan, A.2
Jayaraman, V.3
-
98
-
-
78650470902
-
Emerging resistance in Gram-negative pathogens and implications for clinical practice
-
Cantón R, Lumb J. Emerging resistance in Gram-negative pathogens and implications for clinical practice. Future Microbiol 2011;6:19-22
-
(2011)
Future Microbiol
, vol.6
, pp. 19-22
-
-
Cantón, R.1
Lumb, J.2
-
99
-
-
84876840449
-
A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly
-
Bergeron J, Worrall L, Sgourakis N, et al. A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly. PLoS Pathog 2013;9:e1003307
-
(2013)
PLoS Pathog
, vol.9
-
-
Bergeron, J.1
Worrall, L.2
Sgourakis, N.3
-
100
-
-
8344258355
-
Structural insights into the assembly of the type III secretion needle complex
-
Marlovits T, Kubori T, Sukhan A, et al. Structural insights into the assembly of the type III secretion needle complex. Science 2004;306:1040-2
-
(2004)
Science
, vol.306
, pp. 1040-1042
-
-
Marlovits, T.1
Kubori, T.2
Sukhan, A.3
-
101
-
-
79952262440
-
Three-dimensional model of Salmonella's needle complex at subnanometer resolution
-
Schraidt O, Marlovits T. Three-dimensional model of Salmonella's needle complex at subnanometer resolution. Science 2011;331:1192-5
-
(2011)
Science
, vol.331
, pp. 1192-1195
-
-
Schraidt, O.1
Marlovits, T.2
-
103
-
-
84868338357
-
EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation
-
Berger C, Crepin V, Baruch K, et al. EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation. mBio 2012;3:e00317-12
-
(2012)
MBio
, vol.3
-
-
Berger, C.1
Crepin, V.2
Baruch, K.3
-
104
-
-
68249146082
-
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
-
Huang Z, Sutton S, Wallenfang A, et al. Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics. Nat Struct Mol Biol 2009;16:853-60
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 853-860
-
-
Huang, Z.1
Sutton, S.2
Wallenfang, A.3
-
105
-
-
84884702053
-
Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD
-
Heine S, Diaz-McNair J, Martinez-Becerra F, et al. Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD. Vaccine 2013;31:2919-29
-
(2013)
Vaccine
, vol.31
, pp. 2919-2929
-
-
Heine, S.1
Diaz-Mcnair, J.2
Martinez-Becerra, F.3
-
106
-
-
10744233213
-
Decreased shedding of Escherichia coli O157:H7 by cattle following vaccination with type III secreted proteins
-
Potter A, Klashinsky S, Li Y, et al. Decreased shedding of Escherichia coli O157:H7 by cattle following vaccination with type III secreted proteins. Vaccine 2004;22:362-9
-
(2004)
Vaccine
, vol.22
, pp. 362-369
-
-
Potter, A.1
Klashinsky, S.2
Li, Y.3
-
107
-
-
84941636958
-
Chapter 14 - Type 3 secretion systems
-
Donnenberg M, editor. 2nd revised edition. Academic Press, Salt Lake City, Utah. Elsevier Science & Technology Books
-
Worrall L, Bergeron J, Strynadka N. Chapter 14 - Type 3 secretion systems. In: Donnenberg M, editor. Escherichia coli: Pathotypes and principles of pathogenesis. 2nd revised edition. Academic Press, Salt Lake City, Utah. Elsevier Science & Technology Books 2013. p. 417-50
-
(2013)
Escherichia Coli: Pathotypes and Principles of Pathogenesis
, pp. 417-450
-
-
Worrall, L.1
Bergeron, J.2
Strynadka, N.3
-
108
-
-
84886692148
-
Disarming bacterial virulence through chemical inhibition of the DNA-binding domain of an AraC-like transcriptional activator
-
doi:10.1074/jbc.M113.503912
-
Yang J, Hocking DM, Cheng C, et al. Disarming bacterial virulence through chemical inhibition of the DNA-binding domain of an AraC-like transcriptional activator. J Biol Chem 2013; doi:10.1074/jbc.M113.503912
-
(2013)
J Biol Chem
-
-
Yang, J.1
Hocking, D.M.2
Cheng, C.3
|