Chaperone release and unfolding of substrates in type III secretion

Nature

Volumn 437, Issue 7060, 2005, Pages 911-915

  Akeda, Yukihiro ^a   Galán, Jorge E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELL CULTURE; VIRUSES;

BACTERIAL VIRULENCE PROTEINS; CELL CYTOPLASM; PROTEIN SECRETION SYSTEM; SUBSTRATE RECOGNITION;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; CHAPERONE; PROTEIN INVC; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

MEDICINE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SALMONELLA ENTERICA;

ANIMALIA; BACTERIA (MICROORGANISMS); SALMONELLA ENTERICA;

EID: 27144559247     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature03992     Document Type: Article

References (30)

1. Galán, J. E. & Collmer, A. Type III secretion machines: bacterial devices for protein delivery into host cells. Science 284, 1322-1328 (1999).
2. 1 ATPase family of proteins. J. Bacteriol. 176, 4501-4510 (1994).
3. Cornelis, G. R. & Van Gijsegem, F. Assembly and function of type III secretory systems. Annu. Rev. Microbiol. 54, 735-774 (2000).
4. Kubori, T. et al. Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science 280, 602-605 (1998).
5. Marlovits, T. C. et al. Structural insights into the assembly of the type III secretion needle complex. Science 306, 1040-1042 (2004).
6. Stebbins, C. E. & Galan, J. E. Priming virulence factors for delivery into the host. Nature Rev. Mol. Biol. 4, 738-743 (2003).
7. Stebbins, C. E. & Galán, J. E. Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion. Nature 414, 77-81 (2001).
8. Birtalan, S. C., Phillips, R. M. & Ghosh, P. Three-dimensional secretion signals in chaperone-effector complexes of bacterial pathogens. Mol. Cell 9, 971-980 (2002).
9. Michiels, T. & Cornelis, G. R. Secretion of hybrid proteins by the Yersinia Yop export system. J. Bacteriol. 173, 1677-1685 (1991).
10. Ramamurthi, K. S. & Schneewind, O. Substrate recognition by the Yersinia type III protein secretion machinery. Mol. Microbiol. 50, 1095-1102 (2003).
11. Lloyd, S. A., Forsberg, A., Wolf-Watz, H. & Francis, M. S. Targeting exported substrates to the Yersinia TTSS: different functions for different signals? Trends Microbiol. 9, 367-371 (2001).
12. Galán, J. E. Salmonella interaction with host cells: Type III secretion at work. Annu. Rev. Cell Dev. Biol. 17, 53-86 (2001).
13. 1 ATPase and to virulence proteins of mammalian and plant pathogens. J Bacteriol. 175, 3131-3138 (1993).
14. Pozidis, C. et al. Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerization. J Biol. Chem. 278, 25816-25824 (2003).
15. Claret, L., Calder, S. R., Higgins, M. & Hughes, C. Oligomerization and activation of the Flil ATPase central to bacterial flagellum assembly. Mol. Microbiol. 48, 1349-1355 (2003).
16. Akeda, Y. & Galan, J. E. Genetic analysis of the Salmonella enterica type III secretion-associated ATPase InvC defines discrete functional domains. J. Bacteriol. 186, 2402-2412 (2004).
17. Kaniga, K., Uralil, J., Bliska, J. B. & Galán, J. E. A secreted tyrosine phosphatase with modular effector domains encoded by the bacterial pathogen Salmonella typhimurium. Mol. Microbiol. 21, 633-641 (1996).
18. Stebbins, C. E. & Galán, J. E. Modulation of host signalling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1. Mol. Cell 6, 1449-1460 (2000).
19. Gauthier, A. & Finlay, B. B. Translocated intimin receptor and its chaperone interact with ATPase of the type III secretion apparatus of enteropathogenic Escherichia coli. J. Bacteriol. 185, 6747-6755 (2003).
20. Luo, Y. et al. Structural and biochemical characterization of the type III secretion chaperones CesT and SigE. Nature Struct. Biol. 8, 1031-1036 (2001).
21. Farr, G., Scharl, E., Schumacher, R., Sondek, S. & Horwich, A. Chaperonin-mediated folding in the eukaryotic cytosol proceeds through rounds of release of native and nonnative forms. Cell 89, 927-937 (1997).
22. Lee, S. H. & Galan, J. E. Salmonella type III secretion-associated chaperones confer secretion-pathway specificity. Mol. Microbiol. 51, 483-495 (2004).
23. Lee, V. T. & Schneewind, O. Yop fusions to tightly folded protein domains and their effects on Yersinia enterocolitica type III secretion. J. Bacteriol. 184, 3740-3745 (2002).
24. Fischer, C., Schauerte, J., Wisser, K., Steel, D. & Gafni, A. Differences in the pathways for unfolding and hydrogen exchange among mutants of Escherichia coli alkaline phosphatase. Biochim. Biophys. Acta 1545, 96-103 (2001).
25. + proteases and disassembly machines. Cell 119, 9-18 (2004).
26. Ogura, T. & Wilkinson, A. AAA+ superfamily ATPases: common structure - diverse function. Genes Cells 6, 575-597 (2001).
27. Frickey, T. & Lupas, A. Phylogenetic analysis of AAA proteins. J. Struct. Biol. 146, 2-10 (2004).
28. Dougan, D., Mogk, A., Zeth, K., Turgay, K. & Bukau, B. AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett. 529, 6-10 (2002).
29. Kaniga, K., Bossio, J. C. & Galán, J. E. The Salmonella typhimurium invasion genes invF and invG encode homologues to the PulD and AraC family of proteins. Mol. Microbiol. 13, 555-568 (1994).
30. Lara-Tejero, M. & Galán, J. E. CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity. Infect. Immun. 69, 4358-4365 (2001).