A novel human antimicrobial factor targets Pseudomonas aeruginosa through its type III secretion system

Journal of Medical Microbiology

Volumn 62, Issue PART4, 2013, Pages 531-539

  Mahmood, Fareeha ^a   Hakimiyan, Arnavaz ^b   Jayaraman, Vijayakumar ^a   Wood, Stephen ^a   Sivaramakrishnan, Gayathri ^a   Rehman, Tooba ^a   Reuhs, Bradley L ^b   Chubinskaya, Susanna ^a   Shafikhani, Sasha H ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CARTILAGE ASSOCIATED ANTIMICROBIAL FACTOR; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CARTILAGE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; MICROFLORA; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TYPE II SECRETION SYSTEM; TYPE III SECRETION SYSTEM;

ANTI-INFECTIVE AGENTS; BACTERIAL SECRETION SYSTEMS; CARTILAGE; COLONY COUNT, MICROBIAL; HUMANS; IMMUNITY, INNATE; PSEUDOMONAS AERUGINOSA;

EID: 84875126287     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.051227-0     Document Type: Article

References (57)

1. Andor, A., Trülzsch, K., Essler, M., Roggenkamp, A., Wiedemann, A., Heesemann, J. & Aepfelbacher, M. (2001). YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. Cell Microbiol 3, 301-310.
2. Beck, M. R., Dekoster, G. T., Cistola, D. P. & Goldman, W. E. (2009). NMR structure of a fungal virulence factor reveals structural homology with mammalian saposin B. Mol Microbiol 72, 344-353.
3. Black, D. S. & Bliska, J. B. (2000). The RhoGAP activity of the Yersinia cytotoxin YopE is required for antiphagocytic function and virulence. Mol Microbiol 37, 515-527.
4. Bulgin, R., Arbeloa, A., Goulding, D., Dougan, G., Crepin, V. F., Raymond, B. & Frankel, G. (2009). The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals. PLoS Pathog 5, e1000683.
5. Chuanchuen, R., Narasaki, C. T. & Schweizer, H. P. (2002). Benchtop and microcentrifuge preparation of Pseudomonas aeruginosa competent cells. Biotechniques 33, 760, 762-763.
6. Collins, D. H. & McElligott, T. F. (1960). Sulphate (35SO4) uptake by chondrocytes in relation to histological changes in osteoarthritic human articular cartilage. Ann Rheum Dis 19, 318-330.
7. Comolli, J., Hauser, A., Waite, L., Whitchurch, C., Mattick, J. & Engel, J. (1999). Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia. Infect Immun 67, 3625-3630.
8. Daas, H., Abuhmaid, F. & Zervos, M. (2009). Successful treatment of Candida parapsilosis and Pseudomonas aeruginosa infection using medical and surgical management in an injecting drug user with mitral and aortic valve endocarditis: a case report. J Med Case Reports 3, 6598.
9. de Bentzmann, S., Plotkowski, C. & Puchelle, E. (1996). Receptors in the Pseudomonas aeruginosa adherence to injured and repairing airway epithelium. Am J Respir Crit Care Med 154, S155-S162.
10. De Smet, K. & Contreras, R. (2005). Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol Lett 27, 1337-1347.
11. Devasahayam, G., Scheld, W. M. & Hoffman, P. S. (2010). Newer antibacterial drugs for a new century. Expert Opin Investig Drugs 19, 215-234.
12. Elshaier, A. M., Hakimiyan, A. A., Rappoport, L., Rueger, D. C. & Chubinskaya, S. (2009). Effect of interleukin-1b on osteogenic protein 1-induced signaling in adult human articular chondrocytes. Arthritis Rheum 60, 143-154.
13. Engel, J. N. (2003). Molecular pathogenesis of acute Pseudomonas aeruginosa infections. Severe Infections Caused by Pseudomonas aeruginosa. pp. 201-230. Edited by A. Hauser & J. Rello. New York: Kluwer Academic/Plenum Press.
14. Feltman, H., S. Khan, M. Jain, L. Peterson & A. Hauser (2001). Type III secretion genotypes of clinical and environmental Pseudomonas aeruginosa isolates. ASM abstracts, D22.
15. Feng, X., Oropeza, R. & Kenney, L. J. (2003). Dual regulation by phospho-OmpR of ssrA/B gene expression in Salmonella pathogenicity island 2. Mol Microbiol 48, 1131-1143.
16. Franchi, L., Kamada, N., Nakamura, Y., Burberry, A., Kuffa, P., Suzuki, S., Shaw, M. H., Kim, Y. G. & Núñ ez, G. (2012). NLRC4-driven production of IL-1b discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol 13, 449-456.
17. Galán, J. E. & Wolf-Watz, H. (2006). Protein delivery into eukaryotic cells by type III secretion machines. Nature 444, 567-573.
18. Garrity-Ryan, L., Kazmierczak, B., Kowal, R., Comolli, J., Hauser, A. & Engel, J. N. (2000). The arginine finger domain of ExoT contributes to actin cytoskeleton disruption and inhibition of internalization of Pseudomonas aeruginosa by epithelial cells and macrophages. Infect Immun 68, 7100-7113.
19. Garrity-Ryan, L., Shafikhani, S., Balachandran, P., Nguyen, L., Oza, J., Jakobsen, T., Sargent, J., Fang, X., Cordwell, S. & other authors (2004). The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun 72, 546-558.
20. Geiser, T. K., Kazmierczak, B. I., Garrity-Ryan, L. K., Matthay, M. A. & Engel, J. N. (2001). Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair. Cell Microbiol 3, 223-236.
21. Harder, J., Bartels, J., Christophers, E. & Schröder, J. M. (1997). A peptide antibiotic from human skin. Nature 387, 861.
22. Hauser, A. R. (2009). The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat Rev Microbiol 7, 654-665.
23. Hecht, G., Marrero, J. A., Danilkovich, A., Matkowskyj, K. A., Savkovic, S. D., Koutsouris, A. & Benya, R. V. (1999). Pathogenic Escherichia coli increase Cl-secretion from intestinal epithelia by upregulating galanin-1 receptor expression. J Clin Invest 104, 253-262.
24. Heinegard, D. (2009). Proteoglycans and more-from molecules to biology. Int J Exp Pathol 90, 575-586.
25. Jones, D. M., Sutcliffe, E. M. & Curry, A. (1991). Recovery of viable but non-culturable Campylobacter jejuni. J Gen Microbiol 137, 2477-2482.
26. Kang, P. J., Hauser, A. R., Apodaca, G., Fleiszig, S. M., Wiener-Kronish, J., Mostov, K. & Engel, J. N. (1997). Identification of Pseudomonas aeruginosa genes required for epithelial cell injury. Mol Microbiol 24, 1249-1262.
27. Keller, P. J. & Allan, B. J. (1967). The protein composition of human pancreatic juice. J Biol Chem 242, 281-287.
28. Kluh, I. (1981). Amino acid sequence of hog pancreatic a-amylase isoenzyme I. FEBS Lett 136, 231-234.
29. Koch, C. (2002). Early infection and progression of cystic fibrosis lung disease. Pediatr Pulmonol 34, 232-236.
30. Lee, V. T., Smith, R. S., Tümmler, B. & Lory, S. (2005). Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection. Infect Immun 73, 1695-1705.
31. Li, Z., Kosorok, M. R., Farrell, P. M., Laxova, A., West, S. E., Green, C. G., Collins, J., Rock, M. J. & Splaingard, M. L. (2005). Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis. JAMA 293, 581-588.
32. Lin, J. J., Wu, C. T., Hsia, S. H., Lin, K. L. & Chiu, C. H. (2009). Community-acquired Pseudomonas meningitis causes acute obstructive hydrocephalus. Childs Nerv Syst 25, 723-725.
33. Marchis-Mouren, G., Sarda, L. & Desnuelle, P. (1960). [Purification of lipase from hog pancreatic juice]. Biochim Biophys Acta 41, 358-360 (in French).
34. Maresso, A. W., Deng, Q., Pereckas, M. S., Wakim, B. T. & Barbieri, J. T. (2007). Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation. Cell Microbiol 9, 97-105.
35. Matsumoto, H. & Young, G. M. (2009). Translocated effectors of Yersinia. Curr Opin Microbiol 12, 94-100.
36. Nakatsuji, T., Kao, M. C., Zhang, L., Zouboulis, C. C., Gallo, R. L. & Huang, C. M. (2010). Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating b-defensin-2 expression. J Invest Dermatol 130, 985-994.
37. Oliver, J. D. (1995). The viable but non-culturable state in the human pathogen Vibrio vulnificus. FEMS Microbiol Lett 133, 203-208.
38. Pascual Garrido, C., Hakimiyan, A. A., Rappoport, L., Oegema, T. R., Wimmer, M. A. & Chubinskaya, S. (2009). Anti-apoptotic treatments prevent cartilage degradation after acute trauma to human ankle cartilage. Osteoarthritis Cartilage 17, 1244-1251.
39. Sato, H., Feix, J. B. & Frank, D. W. (2006). Identification of superoxide dismutase as a cofactor for the Pseudomonas type III toxin, ExoU. Biochemistry 45, 10368-10375.
40. Selvaggini, C., De Gioia, L., Cantu, L., Ghibaudi, E., Diomede, L., Passerini, F., Forloni, G., Bugiani, O., Tagliavini, F. & Salmona, M. (1993). Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein. Biochem Biophys Res Commun 194, 1380-1386.
41. Shafikhani, S. (2002). Factors affecting PCR-mediated recombination. Environ Microbiol 4, 482-486.
42. Shafikhani, S. H. & Engel, J. (2006). Pseudomonas aeruginosa type IIIsecreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps. Proc Natl Acad Sci U S A 103, 15605-15610.
43. Shafikhani, S. H., Morales, C. & Engel, J. (2008). The Pseudomonas aeruginosa type III secreted toxin ExoT is necessary and sufficient to induce apoptosis in epithelial cells. Cell Microbiol 10, 994-1007.
44. Shigemura, K., Arakawa, S., Tanaka, K. & Fujisawa, M. (2009). Clinical investigation of isolated bacteria from urinary tracts of hospitalized patients and their susceptibilities to antibiotics. J Infect Chemother 15, 18-22.
45. Sobecky, P. A., Schell, M. A., Moran, M. A. & Hodson, R. E. (1992). Adaptation of model genetically engineered microorganisms to lake water: growth rate enhancements and plasmid loss. Appl Environ Microbiol 58, 3630-3637.
46. Stavrinides, J., McCann, H. C. & Guttman, D. S. (2008). Hostpathogen interplay and the evolution of bacterial effectors. Cell Microbiol 10, 285-292.
47. Timpl, R., Johansson, S., van Delden, V., Oberbäumer, I. & Höök, M. (1983). Characterization of protease-resistant fragments of laminin mediating attachment and spreading of rat hepatocytes. J Biol Chem 258, 8922-8927.
48. Tsang, K. W. T., Rutman, A., Tanaka, E., Lund, V., Dewar, A., Cole, P. J. & Wilson, R. (1994). Interaction of Pseudomonas aeruginosa with human respiratory mucosa in vitro. Eur Respir J 7, 1746-1753.
49. Varoga, D., Pufe, T., Harder, J., Meyer-Hoffert, U., Mentlein, R., Schröder, J. M., Petersen, W. J., Tillmann, B. N., Proksch, E. & other authors (2004). Production of endogenous antibiotics in articular cartilage. Arthritis Rheum 50, 3526-3534.
50. Veesenmeyer, J. L., Hauser, A. R., Lisboa, T. & Rello, J. (2009). Pseudomonas aeruginosa virulence and therapy: evolving translational strategies. Crit Care Med 37, 1777-1786.
51. Viboud, G. I. & Bliska, J. B. (2001). A bacterial type III secretion system inhibits actin polymerization to prevent pore formation in host cell membranes. EMBO J 20, 5373-5382.
52. Viboud, G. I., Mejía, E. & Bliska, J. B. (2006). Comparison of YopE and YopT activities in counteracting host signalling responses to Yersinia pseudotuberculosis infection. Cell Microbiol 8, 1504-1515.
53. Wlodarska, M. & Finlay, B. B. (2010). Host immune response to antibiotic perturbation of the microbiota. Mucosal Immunol 3, 100-103.
54. Wu, W., Badrane, H., Arora, S., Baker, H. V. & Jin, S. (2004). MucAmediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol 186, 7575-7585.
55. Yahr, T. L. & Wolfgang, M. C. (2006). Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system. Mol Microbiol 62, 631-640.
56. Yamaguchi, T. & Yamada, H. (1991). Role of mechanical injury on airway surface in the pathogenesis of Pseudomonas aeruginosa. Am Rev Respir Dis 144, 1147-1152.
57. Zahm, J. M., Chevillard, M. & Puchelle, E. (1991). Wound repair of human surface respiratory epithelium. Am J Respir Cell Mol Biol 5, 242-248.