Salmonella entry into host cells: The work in concert of type III secreted effector proteins

Microbes and Infection

Volumn 3, Issue 14-15, 2001, Pages 1293-1298

  Zhou, Daoguo ^a   Galán, Jorge ^b  

^a PURDUE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actin cytoskeleton; Bacterial pathogenesis; Salmonella; Signal transduction; Type III secretion

Indexed keywords

ACTIN; BACTERIAL PROTEIN; PROTEIN CDC42; PROTEIN SIPA; PROTEIN SIPC; PROTEIN SOPB; PROTEIN SOPE; PROTEIN SOPE2; PROTEIN SPI 1; RAC PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DISEASE TRANSMISSION; HOST CELL; INTESTINE EPITHELIUM CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION; SALMONELLA ENTERICA; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); SALMONELLA; SALMONELLA ENTERICA;

EID: 0035675043     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(01)01489-7     Document Type: Review

References (59)

1. Summary of Notifiable Diseases, United States, 1998
2. Prevalence of salmonellae in cattle and in the environment on California dairies
3. Summary of Notifiable Diseases, United States, 1997
4. Emergence of multidrug resistant Salmonella enterica serotype typhimurium DT104 infections in the United States
5. Electron microscopic studies of experimental Salmonella infection. 1. Penetration into the intestinal epithelium by Salmonella typhimurium
6. Comparative biology of intracellular parasitism
7. Intracellular survival of wild-type Salmonella typhimurium and macrophage-sensitive mutants in diverse populations of macrophages
8. Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
9. Identification of a pathogenicity island required for Salmonella survival in host cells
10. Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium
11. Supramolecular structure of the Salmonella typhimurium type III protein secretion system
12. Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system
13. The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell
14. Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis
15. Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems
16. A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria
17. A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage
18. Salmonella typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
19. Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell
20. Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins
21. Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells
22. A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium
23. Secreted effector proteins of Salmonella dublin act in concert to induce enteritis
24. Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells
25. SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry
26. The secreted effector protein of Salmonella dublin, SopA, is translocated into eukaryotic cells and influences the induction of enteritis
27. Isolation of a temperate bacteriophage encoding the type III effector protein SopE from an epidemic Salmonella typhimurium strain
28. Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells
29. Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria
30. Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium
31. The three faces of profilin
32. Gelsolin, a multifunctional actin regulatory protein
33. Proteins of the ADF/cofilin family: Essential regulators of actin dynamics
34. Parallel actin bundles and their multiple actin-bundling proteins
35. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
36. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
37. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
38. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host-cell actin cytoskeleton rearrangements and bacterial internalization
39. SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase
40. Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells
41. Requirement of CDC42 for Salmonella-induced cytoskeletal and nuclear responses
42. A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
43. Genetic analysis of the yopE region of Yersinia spp.: Identification of a novel conserved locus, yerA, regulating yopE expression
44. Secretion of Yop proteins by Yersinia
45. Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388
46. The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription
47. Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703
48. Role of the S. typhimurium actin-binding protein SipA in bacterial internalization
49. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin
50. Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella
51. Human T cell L-plastin bundles actin filaments in a calcium-dependent manner
52. Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells
53. Inoculum composition and Salmonella pathogenicity island 1 regulate M-cell invasion and epithelial destruction by Salmonella typhimurium
54. Mutation of invH, but not stn, reduces Salmonella-induced enteritis in cattle
55. Contribution of Salmonella typhimurium virulence factors to diarrheal disease in calves
56. SspA is required for lethal Salmonella enterica serovar typhimurium infections in calves but is not essential for diarrhea
57. The early dynamic response of the calf ileal epithelium to Salmonella typhimurium
58. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
59. The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton