Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging

Age

Volumn 35, Issue 5, 2013, Pages 1881-1897

  Zemva, J ^a   Udelhoven, M ^a   Moll, L ^a,b   Freude, S ^a   Stohr O ^a   Bronneke H S ^a   Drake, R B ^a   Krone, W ^a   Schubert, M ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Brain; Diabetes; Insulin resistance; IRS2; Locomotoric activity; Mice

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 2; TRANSCRIPTION FACTOR FKHR;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL LYSATE; CONTROLLED STUDY; DIETARY INTAKE; DOWNSTREAM PROCESSING; ENERGY EXPENDITURE; ENERGY METABOLISM; FAT MASS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; LEARNING; LOCOMOTION; MALE; MEMORY; MOUSE; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T-MAZE TEST; VOLUNTARY MOVEMENT; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, SOUTHERN; BRAIN; CALORIMETRY, INDIRECT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; GLUCOSE INTOLERANCE; IMMUNOHISTOCHEMISTRY; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LOCOMOTION; MICE;

EID: 84892603420     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9491-x     Document Type: Article

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