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Volumn 35, Issue 3, 2012, Pages 341-352

IRS2 signalling is required for the development of a subset of sensory spinal neurons

Author keywords

Dorsal root ganglia; Insulin; Insulin like growth factor; Mouse; Nociceptive neurons

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; ISOLECTIN B4; NERVE GROWTH FACTOR; NEUROTROPHIN 3; PROTEIN TYROSINE KINASE A; SOMATOMEDIN C; SUBSTANCE P;

EID: 84856478857     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2011.07959.x     Document Type: Article
Times cited : (11)

References (73)
  • 1
    • 0032497842 scopus 로고    scopus 로고
    • The role of PI 3-kinase in insulin action
    • Alessi, D.R. & Downes, C.P. (1998) The role of PI 3-kinase in insulin action. Biochim. Biophys. Acta, 1436, 151-164.
    • (1998) Biochim. Biophys. Acta , vol.1436 , pp. 151-164
    • Alessi, D.R.1    Downes, C.P.2
  • 2
    • 0026691620 scopus 로고
    • Effects of astrocyte insulin and insulin-like growth factor I on the survival of motorneurons in vitro
    • Ang, L.C., Bhaumick, B., Muñoz, D.G., Sass, J. & Juurlink, B.H.J. (1992) Effects of astrocyte insulin and insulin-like growth factor I on the survival of motorneurons in vitro. J. Neurol. Sci., 109, 168-172.
    • (1992) J. Neurol. Sci. , vol.109 , pp. 168-172
    • Ang, L.C.1    Bhaumick, B.2    Muñoz, D.G.3    Sass, J.4    Juurlink, B.H.J.5
  • 3
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
    • Araki, E., Lipes, M.A., Patti, M.E., Bruning, J.C., Haag, B. III, Johnson, R.S. & Kahn, C.R. (1994) Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature, 372, 186-190.
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.A.2    Patti, M.E.3    Bruning, J.C.4    Haag III, B.5    Johnson, R.S.6    Kahn, C.R.7
  • 4
    • 0029034576 scopus 로고
    • Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons
    • Averill, S., McMahon, S.B., Clary, D.O., Reichardt, L.F. & Priestley, J.V. (1995) Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur. J. Neurosci., 7, 1484-1494.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1484-1494
    • Averill, S.1    McMahon, S.B.2    Clary, D.O.3    Reichardt, L.F.4    Priestley, J.V.5
  • 5
    • 0032522908 scopus 로고    scopus 로고
    • A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury
    • Bennett, D.L., Michael, G.J., Ramachandran, N., Munson, J.B., Averill, S., Yan, Q., McMahon, S.B. & Priestley, J.V. (1998) A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J. Neurosci., 18, 3059-3072.
    • (1998) J. Neurosci. , vol.18 , pp. 3059-3072
    • Bennett, D.L.1    Michael, G.J.2    Ramachandran, N.3    Munson, J.B.4    Averill, S.5    Yan, Q.6    McMahon, S.B.7    Priestley, J.V.8
  • 6
    • 0031418450 scopus 로고    scopus 로고
    • Diabetes-induced supression of IGF-I and its receptor mRNA levels in rat superior cervical ganglia
    • Bitar, M.S., Pilcher, C.W., Khan, I. & Waldbillig, R.J. (1997) Diabetes-induced supression of IGF-I and its receptor mRNA levels in rat superior cervical ganglia. Diabetes Res. Clin. Pract., 38, 73-80.
    • (1997) Diabetes Res. Clin. Pract. , vol.38 , pp. 73-80
    • Bitar, M.S.1    Pilcher, C.W.2    Khan, I.3    Waldbillig, R.J.4
  • 8
    • 0000854861 scopus 로고
    • Growth of a rat neuroblastoma cell line in serum-free supplemented medium
    • Bottenstein, J.E. & Sato, G.H. (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. USA, 76, 514-517.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 514-517
    • Bottenstein, J.E.1    Sato, G.H.2
  • 9
    • 0018865660 scopus 로고
    • Selective survival of neurons from chick embryo sensory ganglionic dissociates utilizing serum-free supplemented medium
    • Bottenstein, J.E., Skaper, S.D., Varon, S.S. & Sato, G.H. (1980) Selective survival of neurons from chick embryo sensory ganglionic dissociates utilizing serum-free supplemented medium. Exp. Cell Res., 125, 183-190.
    • (1980) Exp. Cell Res. , vol.125 , pp. 183-190
    • Bottenstein, J.E.1    Skaper, S.D.2    Varon, S.S.3    Sato, G.H.4
  • 11
    • 0033554302 scopus 로고    scopus 로고
    • IGF-I promotes peripheral nervous system myelination
    • Cheng, H.L., Russel, J.W. & Feldman, E.L. (1999) IGF-I promotes peripheral nervous system myelination. Ann. NY Acad. Sci., 883, 124-130.
    • (1999) Ann. NY Acad. Sci. , vol.883 , pp. 124-130
    • Cheng, H.L.1    Russel, J.W.2    Feldman, E.L.3
  • 12
    • 0037120230 scopus 로고    scopus 로고
    • Preferential expression of IGF-I in small DRG neurons and downregulation following injury
    • Craner, M.J., Klein, J.P., Black, J.A. & Waxman, S.G. (2002) Preferential expression of IGF-I in small DRG neurons and downregulation following injury. Neuroreport, 13, 1649-1652.
    • (2002) Neuroreport , vol.13 , pp. 1649-1652
    • Craner, M.J.1    Klein, J.P.2    Black, J.A.3    Waxman, S.G.4
  • 14
    • 0027330994 scopus 로고
    • p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
    • Davies, A.M., Lee, K.F. & Jaenisch, R. (1993) p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron, 11, 565-574.
    • (1993) Neuron , vol.11 , pp. 565-574
    • Davies, A.M.1    Lee, K.F.2    Jaenisch, R.3
  • 16
    • 0033956283 scopus 로고    scopus 로고
    • Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
    • Fantin, V.R., Wang, Q., Lienhard, G.E. & Keller, S.R. (2000) Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am. J. Physiol. Endocrinol. Metab., 278, E127-E133.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278
    • Fantin, V.R.1    Wang, Q.2    Lienhard, G.E.3    Keller, S.R.4
  • 18
    • 0032143396 scopus 로고    scopus 로고
    • Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo
    • Fariñas, I., Wilkinson, G.A., Backus, C., Reichardt, L.F. & Patapoutian, A. (1998) Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron, 21, 325-334.
    • (1998) Neuron , vol.21 , pp. 325-334
    • Fariñas, I.1    Wilkinson, G.A.2    Backus, C.3    Reichardt, L.F.4    Patapoutian, A.5
  • 19
    • 0030717725 scopus 로고    scopus 로고
    • Insulin-like growth factors regulate neuronal differentiation and survival
    • Feldman, E.L., Sullivan, K.A., Kim, B. & Russell, J.W. (1997) Insulin-like growth factors regulate neuronal differentiation and survival. Neurobiol. Dis., 4, 201-214.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 201-214
    • Feldman, E.L.1    Sullivan, K.A.2    Kim, B.3    Russell, J.W.4
  • 20
    • 0027502092 scopus 로고
    • Insulin and IGF-I enhance regeneration in cultured rat sensory neurons
    • Fernyhough, P., Willars, G.B., Lindsay, R.M. & Tomlinson, D.R. (1993) Insulin and IGF-I enhance regeneration in cultured rat sensory neurons. Brain Res., 607, 117-124.
    • (1993) Brain Res. , vol.607 , pp. 117-124
    • Fernyhough, P.1    Willars, G.B.2    Lindsay, R.M.3    Tomlinson, D.R.4
  • 21
    • 0034009494 scopus 로고    scopus 로고
    • In vivo survival requeriment of a subset of nodose ganglion neurons for nerve growth factor
    • Forgie, A., Kuehnel, F., Wyatt, S. & Davies, A.M. (2000) In vivo survival requeriment of a subset of nodose ganglion neurons for nerve growth factor. Eur. J. Neurosci., 12, 670-676.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 670-676
    • Forgie, A.1    Kuehnel, F.2    Wyatt, S.3    Davies, A.M.4
  • 23
    • 0032994519 scopus 로고    scopus 로고
    • IGF-I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF-I treatment
    • Gao, W.Q., Shinsky, N., Beck, G.I., Elias, K.A. & Powell-Braxton, L. (1999) IGF-I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF-I treatment. J. Neurobiol., 39, 142-152.
    • (1999) J. Neurobiol. , vol.39 , pp. 142-152
    • Gao, W.Q.1    Shinsky, N.2    Beck, G.I.3    Elias, K.A.4    Powell-Braxton, L.5
  • 25
    • 0027982013 scopus 로고
    • Elevated insulin-like growth factor (IGF) gene expression in sciatic nerves during IGF-supported nerve regeneration
    • Glazner, G.W., Morrison, A.E. & Ishii, D.N. (1994) Elevated insulin-like growth factor (IGF) gene expression in sciatic nerves during IGF-supported nerve regeneration. Brain Res. Mol. Brain Res., 25, 165-272.
    • (1994) Brain Res. Mol. Brain Res. , vol.25 , pp. 165-272
    • Glazner, G.W.1    Morrison, A.E.2    Ishii, D.N.3
  • 26
    • 80052711772 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy
    • Grote, C.W., Morris, J.K., Ryals, J.M., Geiger, P.C. & Wright, D.E. (2011) Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy. Exp. Diabetes Res., 2011, 1-12.
    • (2011) Exp. Diabetes Res. , vol.2011 , pp. 1-12
    • Grote, C.W.1    Morris, J.K.2    Ryals, J.M.3    Geiger, P.C.4    Wright, D.E.5
  • 27
    • 0021895384 scopus 로고
    • Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones
    • Harper, A.A. & Lawson, S.N. (1985) Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J. Physiol., 359, 31-46.
    • (1985) J. Physiol. , vol.359 , pp. 31-46
    • Harper, A.A.1    Lawson, S.N.2
  • 28
    • 3042692039 scopus 로고    scopus 로고
    • Control of neuronal phenotype: what targets tell the cell bodies
    • Hippenmeyer, S., Kramer, I. & Arber, S. (2004) Control of neuronal phenotype: what targets tell the cell bodies. Trends Neurosci., 27, 482-488.
    • (2004) Trends Neurosci. , vol.27 , pp. 482-488
    • Hippenmeyer, S.1    Kramer, I.2    Arber, S.3
  • 29
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: roles in neuronal development and function
    • Huang, E.J. & Reichardt, L.F. (2001) Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci., 24, 677-736.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 30
    • 0022707169 scopus 로고
    • Numbers of rat dorsal root axons and ganglion cells during postnatal development
    • Hulsebosch, C.E., Coggeshall, R.E. & Chung, K. (1986) Numbers of rat dorsal root axons and ganglion cells during postnatal development. Brain Res., 391, 5-13.
    • (1986) Brain Res. , vol.391 , pp. 5-13
    • Hulsebosch, C.E.1    Coggeshall, R.E.2    Chung, K.3
  • 31
    • 0028065228 scopus 로고
    • Role of insulin-like growth factors in peripheral nerve regeneration
    • Ishii, D.N., Glazner, G.W. & Pu, S.F. (1994) Role of insulin-like growth factors in peripheral nerve regeneration. Pharmocol. Ther., 62, 125-144.
    • (1994) Pharmocol. Ther. , vol.62 , pp. 125-144
    • Ishii, D.N.1    Glazner, G.W.2    Pu, S.F.3
  • 32
    • 0041430783 scopus 로고    scopus 로고
    • The synergistic effects of NGF and IGF-1 on neurite growth in adult sensory neurons: convergence on the PI 3-kinase pathway
    • Jones, D.M., Tucker, B.A., Rahimtula, M. & Mearow, K.M. (2003) The synergistic effects of NGF and IGF-1 on neurite growth in adult sensory neurons: convergence on the PI 3-kinase pathway. J. Neurochem., 86, 1116-1128.
    • (2003) J. Neurochem. , vol.86 , pp. 1116-1128
    • Jones, D.M.1    Tucker, B.A.2    Rahimtula, M.3    Mearow, K.M.4
  • 33
    • 0035869733 scopus 로고    scopus 로고
    • Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase
    • Kimpinski, K. & Mearow, K. (2001) Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase. J. Neurosci. Res., 63, 486-499.
    • (2001) J. Neurosci. Res. , vol.63 , pp. 486-499
    • Kimpinski, K.1    Mearow, K.2
  • 34
    • 0036867003 scopus 로고    scopus 로고
    • Sensing life: regulation of sensory neuron survival by neurotrophins
    • Kirstein, M. & Fariñas, I. (2002) Sensing life: regulation of sensory neuron survival by neurotrophins. Cell. Mol. Life Sci., 59, 1787-1802.
    • (2002) Cell. Mol. Life Sci. , vol.59 , pp. 1787-1802
    • Kirstein, M.1    Fariñas, I.2
  • 35
    • 0030995946 scopus 로고    scopus 로고
    • The 60-kDa phosphotyrosine protein in insulin-treated adipocytes in a new member of the insulin receptor substrate family
    • Lavan, B.E., Lane, W.S. & Lienhard, G.E. (1997) The 60-kDa phosphotyrosine protein in insulin-treated adipocytes in a new member of the insulin receptor substrate family. J. Biol. Chem., 272, 11439-11443.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11439-11443
    • Lavan, B.E.1    Lane, W.S.2    Lienhard, G.E.3
  • 36
    • 0018775912 scopus 로고
    • Development of mouse dorsal root ganglia: an autoradiographic and quantitative study
    • Lawson, S.N. & Biscoe, T.J. (1979) Development of mouse dorsal root ganglia: an autoradiographic and quantitative study. J. Neurocytol., 8, 265-274.
    • (1979) J. Neurocytol. , vol.8 , pp. 265-274
    • Lawson, S.N.1    Biscoe, T.J.2
  • 37
    • 0033581023 scopus 로고    scopus 로고
    • Insulin receptor substrate 3 is not essential for growth or glucose homeostasis
    • Liu, S.C., Wang, Q., Lienhard, G.E. & Keller, S.R. (1999) Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. J. Biol. Chem., 274, 18093-18099.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18093-18099
    • Liu, S.C.1    Wang, Q.2    Lienhard, G.E.3    Keller, S.R.4
  • 39
    • 0020052002 scopus 로고
    • Primary afferent units from the hairy skin of the rat hind limb
    • Lynn, B. & Carpenter, S.E. (1982) Primary afferent units from the hairy skin of the rat hind limb. Brain Res., 238, 29-43.
    • (1982) Brain Res. , vol.238 , pp. 29-43
    • Lynn, B.1    Carpenter, S.E.2
  • 40
    • 33846447430 scopus 로고    scopus 로고
    • Specification and connectivity of neuronal subtypes in the sensory lineage
    • Marmigère, F. & Ernfors, P. (2007) Specification and connectivity of neuronal subtypes in the sensory lineage. Nat. Rev. Neurosci., 8, 114-127.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 114-127
    • Marmigère, F.1    Ernfors, P.2
  • 41
    • 0028289478 scopus 로고
    • Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets
    • McMahon, S.B., Armanini, M.P., Ling, L.H. & Phillips, H.S. (1994) Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron, 12, 1161-1171.
    • (1994) Neuron , vol.12 , pp. 1161-1171
    • McMahon, S.B.1    Armanini, M.P.2    Ling, L.H.3    Phillips, H.S.4
  • 44
  • 45
    • 0022916433 scopus 로고
    • Effects of insulin, IGF-II, and NGF on neurite formation and survival in cultured sympathetic and sensory neurons
    • Recio-Pinto, E., Rechler, M.M. & Ishii, D.N. (1986) Effects of insulin, IGF-II, and NGF on neurite formation and survival in cultured sympathetic and sensory neurons. J. Neurosci., 6, 1211-1219.
    • (1986) J. Neurosci. , vol.6 , pp. 1211-1219
    • Recio-Pinto, E.1    Rechler, M.M.2    Ishii, D.N.3
  • 47
    • 0026503610 scopus 로고
    • Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development
    • Ruit, K.G., Elliott, J.L., Osborne, P.A., Yan, Q. & Snider, W.D. (1992) Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development. Neuron, 8, 573-587.
    • (1992) Neuron , vol.8 , pp. 573-587
    • Ruit, K.G.1    Elliott, J.L.2    Osborne, P.A.3    Yan, Q.4    Snider, W.D.5
  • 51
    • 0028331599 scopus 로고
    • Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
    • Smeyne, R.J., Klein, R., Schnapp, A., Long, L.K., Bryant, S., Lewin, A., Lira, S.A. & Barbacid, M. (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature, 368, 246-249.
    • (1994) Nature , vol.368 , pp. 246-249
    • Smeyne, R.J.1    Klein, R.2    Schnapp, A.3    Long, L.K.4    Bryant, S.5    Lewin, A.6    Lira, S.A.7    Barbacid, M.8
  • 52
    • 0030044429 scopus 로고    scopus 로고
    • Neurotrophins cause a new sensation
    • Snider, W.D. & Wright, D.E. (1996) Neurotrophins cause a new sensation. Neuron, 16, 229-232.
    • (1996) Neuron , vol.16 , pp. 229-232
    • Snider, W.D.1    Wright, D.E.2
  • 53
    • 0036129522 scopus 로고    scopus 로고
    • Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord
    • Sugimoto, K., Murakawa, Y. & Sima, A.A. (2002) Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord. J. Peripher. Nerv. Syst., 7, 44-53.
    • (2002) J. Peripher. Nerv. Syst. , vol.7 , pp. 44-53
    • Sugimoto, K.1    Murakawa, Y.2    Sima, A.A.3
  • 54
    • 57349124828 scopus 로고    scopus 로고
    • Insulin-like growth factors in the peripheral nervous system
    • Sullivan, K.A., Kim, B. & Feldman, E.L. (2008) Insulin-like growth factors in the peripheral nervous system. Endocrinology, 149, 5963-5971.
    • (2008) Endocrinology , vol.149 , pp. 5963-5971
    • Sullivan, K.A.1    Kim, B.2    Feldman, E.L.3
  • 58
    • 33646437269 scopus 로고    scopus 로고
    • Remote neurotrophic support of epidermal nerve fibres in experimental diabetes
    • Toth, C., Brussee, V. & Zochodne, D.W. (2006) Remote neurotrophic support of epidermal nerve fibres in experimental diabetes. Diabetologia, 49, 1081-1088.
    • (2006) Diabetologia , vol.49 , pp. 1081-1088
    • Toth, C.1    Brussee, V.2    Zochodne, D.W.3
  • 59
    • 0033988375 scopus 로고    scopus 로고
    • IRS-4 mediates protein kinase B during insulin stimulation without promoting antiapoptosis
    • Uchida, T., Myers, M.G. Jr & White, M.F. (2000) IRS-4 mediates protein kinase B during insulin stimulation without promoting antiapoptosis. Mol. Cell. Biol., 20, 126-138.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 126-138
    • Uchida, T.1    Myers Jr., M.G.2    White, M.F.3
  • 61
    • 10644268512 scopus 로고    scopus 로고
    • IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes
    • Valverde, A.M., Fabregat, I., Burks, D.J., White, M.F. & Benito, M. (2004) IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology, 40, 1285-1294.
    • (2004) Hepatology , vol.40 , pp. 1285-1294
    • Valverde, A.M.1    Fabregat, I.2    Burks, D.J.3    White, M.F.4    Benito, M.5
  • 63
    • 0036669037 scopus 로고    scopus 로고
    • Control of cell survival by IGF signalling pathways
    • Vincent, A.M. & Feldman, E.L. (2002) Control of cell survival by IGF signalling pathways. Growth Horm. IGF Res., 12, 193-197.
    • (2002) Growth Horm. IGF Res. , vol.12 , pp. 193-197
    • Vincent, A.M.1    Feldman, E.L.2
  • 64
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White, M.F. (2002) IRS proteins and the common path to diabetes. Am. J. Physiol. Endocrinol. Metab., 283, E413-E422.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • White, M.F.1
  • 65
    • 0344305782 scopus 로고    scopus 로고
    • Insulin in health and disease
    • White, M.F. (2003) Insulin in health and disease. Science, 302, 1710-1711.
    • (2003) Science , vol.302 , pp. 1710-1711
    • White, M.F.1
  • 69
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • Withers, D.J., Burks, D.J., Towery, H.H., Altamuro, S.L., Flint, C.L. & White, M.F. (1999) Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat. Genet., 23, 32-40.
    • (1999) Nat. Genet. , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 70
    • 0030856143 scopus 로고    scopus 로고
    • Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons
    • Yamada, M., Ohnishi, H., Sano, S., Nakatani, A., Ikeuchi, T. & Hatanaka, H. (1997) Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons. J. Biol. Chem., 272, 30334-30339.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30334-30339
    • Yamada, M.1    Ohnishi, H.2    Sano, S.3    Nakatani, A.4    Ikeuchi, T.5    Hatanaka, H.6
  • 72
    • 0035173792 scopus 로고    scopus 로고
    • Dos diabetes target ganglion neurons? Progressive sensory neuron involvement in long term experimental diabetes
    • Zochodne, D.W., Verge, V.M.K., Cheng, C., Sun, H. & Johnston, J. (2001) Dos diabetes target ganglion neurons? Progressive sensory neuron involvement in long term experimental diabetes. Brain, 124, 2319-2334.
    • (2001) Brain , vol.124 , pp. 2319-2334
    • Zochodne, D.W.1    Verge, V.M.K.2    Cheng, C.3    Sun, H.4    Johnston, J.5
  • 73
    • 47549101404 scopus 로고    scopus 로고
    • Neuronal targeting in diabetes mellitus: a story of sensory neurons and motor neurons
    • Zochodne, D.W., Ramji, N. & Toth, C. (2008) Neuronal targeting in diabetes mellitus: a story of sensory neurons and motor neurons. Neuroscientist, 14, 311.
    • (2008) Neuroscientist , vol.14 , pp. 311
    • Zochodne, D.W.1    Ramji, N.2    Toth, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.