Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter

Journal of Endocrinology

Volumn 204, Issue 2, 2010, Pages 199-208

  Udelhoven, Michael ^a   Pasieka, Mareike ^a   Leeser, Uschi ^a   Krone, Wilhelm ^a   Schubert, Markus ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 2; LUCIFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1;

AGING; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; DOWN REGULATION; ELECTROPHORETIC MOBILITY; FERTILITY; FOOD INTAKE; HUMAN; HUMAN CELL; MUTANT; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BINDING SITES; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; NEURONS; PROMOTER REGIONS, GENETIC; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 75149131326     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0266     Document Type: Article

References (38)

1. Bai L & Merchant JL 2001 ZBP-89 promotes growth arrest through stabilization of p53. Molecular and Cellular Biology 21 4670-4683.
2. Bai L &Merchant JL 2003 Transcription factor ZBP-89 is required for STAT1 constitutive expression. Nucleic Acids Research 31 7264-7270.
3. Bai L, Yoon SO, King PD & Merchant JL 2004 ZBP-89-induced apoptosis is p53-independent and requires JNK. Cell Death and Differentiation 11 663-673.
4. Burks DJ, Font de Mora J, Schubert M,Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL &White MF 2000 IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407 377-382.
5. Cheng PY, Kagawa N, Takahashi Y &Waterman MR 2000 Three zinc finger nuclear proteins, Sp1, Sp3, and a ZBP-89 homologue, bind to the cyclic adenosine monophosphate-responsive sequence of the bovine adrenodoxin gene and regulate transcription. Biochemistry 39 4347-4357.
6. Chupreta S, Brevig H, Bai L, Merchant JL & Iniguez-Lluhi JA 2007 Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89. Journal of Biological Chemistry 282 36155-36166.
7. Cohen E & Dillin A 2008 The insulin paradox: aging, proteotoxicity and neurodegeneration. Nature Reviews. Neuroscience 9 759-767.
8. Dignam JD, Lebovitz RM & Roeder RG 1983 Accurate transcription initiation by RNA polymerase-II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Research 11 1475-1489.
9. Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA & White MF 2008 Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metabolism 8 65-76.
10. Giannakou ME & Partridge L 2007 Role of insulin-like signalling in Drosophila lifespan. Trends in Biochemical Sciences 32 180-188.
11. Haeusler RA & Accili D 2008 The double life of Irs. Cell Metabolism 8 7-9.
12. Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H et al. 2004 SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nature Cell Biology 6 351-357.
13. Kenyon C, Chang J, Gensch E, Rudner A & Tabtiang R 1993 A C. elegans mutant that lives twice as long as wild type. Nature 366 461-464.
14. Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M et al. 2008 Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metabolism 8 49-64.
15. Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR & Lienhard GE 1997a A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. Journal of Biological Chemistry 272 21403-21407.
16. Lavan BE, Lane WS & Lienhard GE 1997b The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. Journal of Biological Chemistry 272 11439-11443.
17. Law GL, Itoh H, Law DJ, Mize GJ, Merchant JL & Morris DR 1998 Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter. Journal of Biological Chemistry 273 19955-19964.
18. Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y & White MF 2004 Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. Journal of Clinical Investigation 114 908-916.
19. Merchant JL, Du M & Todisco A 1999 SP1 phosphorylation by ERK2 stimulates DNA binding. Biochemical and Biophysical Research Communications 254 454-461.
20. Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A et al. 2006 TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nature Medicine 12 107-113.
21. Pessin JE & Saltiel AR 2000 Signaling pathways in insulin action: molecular targets of insulin resistance. Journal of Clinical Investigation 106 165-169.
22. Pfaffl MW 2001 A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 29 e45.
23. Remington MC, Tarle SA, Simon B & Merchant JL 1997 ZBP-89, a Kruppel-type zinc finger protein, inhibits cell proliferation. Biochemical and Biophysical Research Communications 237 230-234.
24. Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR & de la Monte SM 2005 Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. Journal of Alzheimer's Disease 8 247-268.
25. SchubertM, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P,Warot XM, Rio C et al. 2003 Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. Journal of Neuroscience 23 7084-7092.
26. Shimano H 2007 SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling. Journal of Molecular Medicine 85 437-444.
27. Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR & de la Monte SM 2005 Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? Journal of Alzheimer's Disease 7 63-80.
28. Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ & White MF 1991 Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352 73-77.
29. Sun XJ,Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH & White MF 1995 Role of IRS-2 in insulin and cytokine signalling. Nature 377 173-177.
30. Taguchi A, Wartschow LM & White MF 2007 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317 369-372.
31. Thimmarayappa J, Sun J, Schultz LE, Dejkhamron P, Lu C, Giallongo A, Merchant JL & Menon RK 2006 Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor, ZBP-89. Molecular Endocrinology 20 2747-2760.
32. Thirone AC, Huang C & Klip A 2006 Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends in Endocrinology and Metabolism 17 72-78.
33. Wang Y, Kobori JA & Hood L 1993 The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression. Molecular and Cellular Biology 13 5691-5701.
34. White MF 2003 Insulin signaling in health and disease. Science 302 1710-1711.
35. Wieczorek E, Lin Z, Perkins EB, Law DJ, Merchant JL & Zehner ZE 2000 The zinc finger repressor, ZBP-89, binds to the silencer element of the human vimentin gene and complexes with the transcriptional activator, Sp1. Journal of Biological Chemistry 275 12879-12888.
36. Withers DJ, Burks DJ, Towery HH, Altamuro S, Flint C & White MF 1999 Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nature Genetics 23 32-40.
37. Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS & Goldstein JL 2001 Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. PNAS 98 3756-3761.
38. Zhang X, Diab IH & Zehner ZE 2003 ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. Nucleic Acids Research 31 2900-2914.