-
1
-
-
33744981148
-
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
-
Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, Mattson MP. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med 12: 621-623, 2006.
-
(2006)
Nat Med
, vol.12
, pp. 621-623
-
-
Arumugam, T.V.1
Chan, S.L.2
Jo, D.G.3
Yilmaz, G.4
Tang, S.C.5
Cheng, A.6
Gleichmann, M.7
Okun, E.8
Dixit, V.D.9
Chigurupati, S.10
Mughal, M.R.11
Ouyang, X.12
Miele, L.13
Magnus, T.14
Poosala, S.15
Granger, D.N.16
Mattson, M.P.17
-
2
-
-
16244419725
-
Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway
-
Bridgewater DJ, Ho J, Sauro V, Matsell DG. Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway. Kidney Int 67: 1308-1314, 2005.
-
(2005)
Kidney Int
, vol.67
, pp. 1308-1314
-
-
Bridgewater, D.J.1
Ho, J.2
Sauro, V.3
Matsell, D.G.4
-
3
-
-
77951138485
-
Study of protein profiling of human urine in diabetic hypertensive nephropathy versus normal healthy controls
-
Butt A, Riaz S. Study of protein profiling of human urine in diabetic hypertensive nephropathy versus normal healthy controls. Diabetes Tech-nol Ther 12: 379-386, 2010.
-
(2010)
Diabetes Tech-nol Ther
, vol.12
, pp. 379-386
-
-
Butt, A.1
Riaz, S.2
-
4
-
-
33947312487
-
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
-
Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 134: 801-811, 2007.
-
(2007)
Development
, vol.134
, pp. 801-811
-
-
Cheng, H.T.1
Kim, M.2
Valerius, M.T.3
Surendran, K.4
Schuster-Gossler, K.5
Gossler, A.6
McMahon, A.P.7
Kopan, R.8
-
5
-
-
77954668887
-
Angiogenesis inhibitors: Current strategies and future prospects
-
Cook KM, Figg WD. Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin 60: 222-243, 2010.
-
(2010)
CA Cancer J Clin
, vol.60
, pp. 222-243
-
-
Cook, K.M.1
Figg, W.D.2
-
6
-
-
78649814383
-
Erythropoietin prevents reactive oxygen species generation and renal tubular cell apoptosis at high glucose level
-
Dang J, Jia R, Tu Y, Xiao S, Ding G. Erythropoietin prevents reactive oxygen species generation and renal tubular cell apoptosis at high glucose level. Biomed Pharmacother 64: 681-685, 2010.
-
(2010)
Biomed Pharmacother
, vol.64
, pp. 681-685
-
-
Dang, J.1
Jia, R.2
Tu, Y.3
Xiao, S.4
Ding, G.5
-
7
-
-
77954351997
-
Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer
-
Dong Y, Li A, Wang J, Weber JD, Michel LS. Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer. Cancer Res 70: 5465-5474, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 5465-5474
-
-
Dong, Y.1
Li, A.2
Wang, J.3
Weber, J.D.4
Michel, L.S.5
-
8
-
-
77950292495
-
Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model
-
Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res 70: 2476-2484, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 2476-2484
-
-
Efferson, C.L.1
Winkelmann, C.T.2
Ware, C.3
Sullivan, T.4
Giampaoli, S.5
Tammam, J.6
Patel, S.7
Mesiti, G.8
Reilly, J.F.9
Gibson, R.E.10
Buser, C.11
Yeatman, T.12
Coppola, D.13
Winter, C.14
Clark, E.A.15
Draetta, G.F.16
Strack, P.R.17
Majumder, P.K.18
-
9
-
-
57149084692
-
Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway
-
Graziani I, Eliasz S, De Marco MA, Chen Y, Pass HI, De May RM, Strack PR, Miele L, Bocchetta M. Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway. Cancer Res 68: 9678-9685, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 9678-9685
-
-
Graziani, I.1
Eliasz, S.2
de Marco, M.A.3
Chen, Y.4
Pass, H.I.5
de May, R.M.6
Strack, P.R.7
Miele, L.8
Bocchetta, M.9
-
10
-
-
79951722518
-
PI3K/Akt pathway mediates high glucose-induced lipogenesis and extracellular matrix accumulation in HKC cells through regulation of SREBP-1 and TGF-fj1
-
Hao J, Liu S, Zhao S, Liu Q, Lv X, Chen H, Niu Y, Duan H. PI3K/Akt pathway mediates high glucose-induced lipogenesis and extracellular matrix accumulation in HKC cells through regulation of SREBP-1 and TGF-fj1. Histochem Cell Biol 135: 173-181, 2011.
-
(2011)
Histochem Cell Biol
, vol.135
, pp. 173-181
-
-
Hao, J.1
Liu, S.2
Zhao, S.3
Liu, Q.4
Lv, X.5
Chen, H.6
Niu, Y.7
Duan, H.8
-
11
-
-
84856735270
-
Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway
-
Huang KF, Zhang GD, Huang YQ, Diao Y. Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. lnt Immunopharmacol 12: 334-341, 2012.
-
(2012)
Lnt Immunopharmacol
, vol.12
, pp. 334-341
-
-
Huang, K.F.1
Zhang, G.D.2
Huang, Y.Q.3
Diao, Y.4
-
12
-
-
80053188650
-
Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation
-
Ji X, Wang Z, Geamanu A, Sarkar FH, Gupta SV. Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. J Cell Biochem 112: 2773-2783, 2011.
-
(2011)
J Cell Biochem
, vol.112
, pp. 2773-2783
-
-
Ji, X.1
Wang, Z.2
Geamanu, A.3
Sarkar, F.H.4
Gupta, S.V.5
-
13
-
-
38349113170
-
Transforming growth factor-fj (TGF-fj1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression
-
Kennard S, Liu H, Lilly B. Transforming growth factor-fj (TGF-fj1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression. J Biol Chem 283: 1324-1333, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 1324-1333
-
-
Kennard, S.1
Liu, H.2
Lilly, B.3
-
14
-
-
82855177408
-
Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose
-
Kim KM, Kim YS, Jung DH, Lee J, Kim JS. Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose. Exp Cell Res 318: 152-159, 2012.
-
(2012)
Exp Cell Res
, vol.318
, pp. 152-159
-
-
Kim, K.M.1
Kim, Y.S.2
Jung, D.H.3
Lee, J.4
Kim, J.S.5
-
15
-
-
33645569518
-
Redox dependence of glomerular epithelial cell hypertrophy in response to glucose
-
Kim NH, Rincon-Choles H, Bhandari B, Choudhury GG, Abboud HE, Gorin Y. Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. Am J Physiol Renal Physiol 290: F741-F751, 2006.
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
Kim, N.H.1
Rincon-Choles, H.2
Bhandari, B.3
Choudhury, G.G.4
Abboud, H.E.5
Gorin, Y.6
-
16
-
-
73949113574
-
Notch-1 inhibition by withaferin-A: A therapeutic target against colon carcinogen-esis
-
Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C. Notch-1 inhibition by withaferin-A: a therapeutic target against colon carcinogen-esis. Mol Cancer Ther 9: 202-210, 2010.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 202-210
-
-
Koduru, S.1
Kumar, R.2
Srinivasan, S.3
Evers, M.B.4
Damodaran, C.5
-
17
-
-
79960034970
-
Cannabinoid receptor 1 mediates high glucose-induced apoptosis via endoplasmic reticulum stress in primary cultured rat mesangial cells
-
Lim JC, Lim SK, Park MJ, Kim GY, Han HJ, Park SH. Cannabinoid receptor 1 mediates high glucose-induced apoptosis via endoplasmic reticulum stress in primary cultured rat mesangial cells. Am J Physiol Renal Physiol 301: F179-F188, 2011.
-
(2011)
Am J Physiol Renal Physiol
, vol.301
-
-
Lim, J.C.1
Lim, S.K.2
Park, M.J.3
Kim, G.Y.4
Han, H.J.5
Park, S.H.6
-
18
-
-
77955366446
-
Modulation of notch-1 signaling alleviates vascular endo-thelial growth factor-mediated diabetic nephropathy
-
Lin CL, Wang FS, Hsu YC, Chen CN, Tseng MJ, Saleem MA, Chang PJ, Wang JY. Modulation of notch-1 signaling alleviates vascular endo-thelial growth factor-mediated diabetic nephropathy. Diabetes 59: 1915-1925, 2010.
-
(2010)
Diabetes
, vol.59
, pp. 1915-1925
-
-
Lin, C.L.1
Wang, F.S.2
Hsu, Y.C.3
Chen, C.N.4
Tseng, M.J.5
Saleem, M.A.6
Chang, P.J.7
Wang, J.Y.8
-
19
-
-
84864970762
-
Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism
-
Liu W, Zhang Y, Hao J, Liu S, Liu Q, Zhao S, Shi Y, Duan H. Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism. J Cell Biochem 113: 3186-3196, 2012.
-
(2012)
J Cell Biochem
, vol.113
, pp. 3186-3196
-
-
Liu, W.1
Zhang, Y.2
Hao, J.3
Liu, S.4
Liu, Q.5
Zhao, S.6
Shi, Y.7
Duan, H.8
-
20
-
-
33845609555
-
Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1
-
Liu ZJ, Xiao M, Balint K, Soma A, Pinnix CC, Capobianco AJ, Velazquez OC, Herlyn M. Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB J 20: 1009-1011, 2006.
-
(2006)
FASEB J
, vol.20
, pp. 1009-1011
-
-
Liu, Z.J.1
Xiao, M.2
Balint, K.3
Soma, A.4
Pinnix, C.C.5
Capobianco, A.J.6
Velazquez, O.C.7
Herlyn, M.8
-
21
-
-
43149102480
-
Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis
-
Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S, Los M. Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. J Cell Sci 121: 979-988, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 979-988
-
-
Maddika, S.1
Ande, S.R.2
Wiechec, E.3
Hansen, L.L.4
Wesselborg, S.5
Los, M.6
-
22
-
-
0037230145
-
Notch signaling in kidney development
-
McCright B. Notch signaling in kidney development. Curr Opin Nephrol Hypertens 12: 5-10, 2003.
-
(2003)
Curr Opin Nephrol Hypertens
, vol.12
, pp. 5-10
-
-
McCright, B.1
-
24
-
-
33847403486
-
Notch signaling is necessary for epithelial growth arrest by TGF-fj
-
Niimi H, Pardali K, Vanlandewijck M, Heldin CH, Moustakas A. Notch signaling is necessary for epithelial growth arrest by TGF-fj. J Cell Biol 176: 695-707, 2007.
-
(2007)
J Cell Biol
, vol.176
, pp. 695-707
-
-
Niimi, H.1
Pardali, K.2
Vanlandewijck, M.3
Heldin, C.H.4
Moustakas, A.5
-
25
-
-
40449112321
-
The Notch pathway in podocytes plays a role in the development of glomerular disease
-
Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med 14: 290-298, 2008.
-
(2008)
Nat Med
, vol.14
, pp. 290-298
-
-
Niranjan, T.1
Bielesz, B.2
Gruenwald, A.3
Ponda, M.P.4
Kopp, J.B.5
Thomas, D.B.6
Susztak, K.7
-
26
-
-
79954546899
-
High glucose concentration affects the oxidant-antioxidant balance in cultured mouse podocytes
-
Piwkowska A, Rogacka D, Audzeyenka I, Jankowski M, Angielski S. High glucose concentration affects the oxidant-antioxidant balance in cultured mouse podocytes. J Cell Biochem 112: 1661-1672, 2011.
-
(2011)
J Cell Biochem
, vol.112
, pp. 1661-1672
-
-
Piwkowska, A.1
Rogacka, D.2
Audzeyenka, I.3
Jankowski, M.4
Angielski, S.5
-
27
-
-
47249124118
-
Notch-1 regulates transcription of the epidermal growth factor receptor through p53
-
Purow BW, Sundaresan TK, Burdick MJ, Kefas BA, Comeau LD, Hawkinson MP, Su Q, Kotliarov Y, Lee J, Zhang W, Fine HA. Notch-1 regulates transcription of the epidermal growth factor receptor through p53. Carcinogenesis 29: 918-925, 2008.
-
(2008)
Carcinogenesis
, vol.29
, pp. 918-925
-
-
Purow, B.W.1
Sundaresan, T.K.2
Burdick, M.J.3
Kefas, B.A.4
Comeau, L.D.5
Hawkinson, M.P.6
Su, Q.7
Kotliarov, Y.8
Lee, J.9
Zhang, W.10
Fine, H.A.11
-
28
-
-
74049097246
-
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy
-
Rane MJ, Song Y, Jin S, Barati MT, Wu R, Kausar H, Tan Y, Wang Y, Zhou G, Klein JB, Li X, Cai L. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol 298: F49-F61, 2010.
-
(2010)
Am J Physiol Renal Physiol
, vol.298
-
-
Rane, M.J.1
Song, Y.2
Jin, S.3
Barati, M.T.4
Wu, R.5
Kausar, H.6
Tan, Y.7
Wang, Y.8
Zhou, G.9
Klein, J.B.10
Li, X.11
Cai, L.12
-
29
-
-
70350243048
-
PI3K signaling in lymphocyte migration
-
Saudemont A, Colucci F. PI3K signaling in lymphocyte migration. Cell Cycle 8: 3307-3310, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 3307-3310
-
-
Saudemont, A.1
Colucci, F.2
-
30
-
-
69949093640
-
15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inacti-vation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity
-
Shin SW, Seo CY, Han H, Han JY, Jeong JS, Kwak JY, Park JI. 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inacti-vation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. Clin Cancer Res 15: 5414-5425, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5414-5425
-
-
Shin, S.W.1
Seo, C.Y.2
Han, H.3
Han, J.Y.4
Jeong, J.S.5
Kwak, J.Y.6
Park, J.I.7
-
31
-
-
48049124597
-
Ectopic Notch activation in developing podocytes causes glomerulosclerosis
-
Waters AM, Wu MY, Onay T, Scutaru J, Liu J, Lobe CG, Quaggin SE, Piscione TD. Ectopic Notch activation in developing podocytes causes glomerulosclerosis. J Am Soc Nephrol 19: 1139-1157, 2008.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 1139-1157
-
-
Waters, A.M.1
Wu, M.Y.2
Onay, T.3
Scutaru, J.4
Liu, J.5
Lobe, C.G.6
Quaggin, S.E.7
Piscione, T.D.8
-
32
-
-
69449104272
-
EGFR-PLC-y1 signaling mediates high glucose-induced PKC|31-Akt activation and collagen I upregulation in mesangial cells
-
Wu D, Peng F, Zhang B, Ingram AJ, Kelly DJ, Gilbert RE, Gao B, Kumar S, Krepinsky JC. EGFR-PLC-y1 signaling mediates high glucose-induced PKC|31-Akt activation and collagen I upregulation in mesangial cells. Am J Physiol Renal Physiol 297: F822-F834, 2009.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
-
-
Wu, D.1
Peng, F.2
Zhang, B.3
Ingram, A.J.4
Kelly, D.J.5
Gilbert, R.E.6
Gao, B.7
Kumar, S.8
Krepinsky, J.C.9
-
33
-
-
59449105533
-
1,25-Dihydroxyvitamin D3 prevents puromycin aminonucleo-side-induced apoptosis of glomerular podocytes by activating the phos-phatidylinositol 3-kinase/Akt-signaling pathway
-
Xiao H, Shi W, Liu S, Wang W, Zhang B, Zhang Y, Xu L, Liang X, Liang Y. 1,25-Dihydroxyvitamin D3 prevents puromycin aminonucleo-side-induced apoptosis of glomerular podocytes by activating the phos-phatidylinositol 3-kinase/Akt-signaling pathway. Am J Nephrol 30: 34-43, 2009.
-
(2009)
Am J Nephrol
, vol.30
, pp. 34-43
-
-
Xiao, H.1
Shi, W.2
Liu, S.3
Wang, W.4
Zhang, B.5
Zhang, Y.6
Xu, L.7
Liang, X.8
Liang, Y.9
-
34
-
-
73949154866
-
DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis
-
Xie D, Gore C, Zhou J, Pong RC, Zhang H, Yu L, Vessella RL, Min W, Hsieh JT. DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci USA 106: 19878-19883, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 19878-19883
-
-
Xie, D.1
Gore, C.2
Zhou, J.3
Pong, R.C.4
Zhang, H.5
Yu, L.6
Vessella, R.L.7
Min, W.8
Hsieh, J.T.9
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