PI3K/Akt pathway mediates high glucose-induced lipogenesis and extracellular matrix accumulation in HKC cells through regulation of SREBP-1 and TGF-β1

Histochemistry and Cell Biology

Volumn 135, Issue 2, 2011, Pages 173-181

  Hao, Jun ^a   Liu, Shuxia ^a   Zhao, Song ^a   Liu, Qingjuan ^a   Lv, Xin ^a   Chen, Huan ^a   Niu, Yunyi ^a   Duan, Huijun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Extracellular matrix; High glucose; Lipogenesis; PI3K Akt; SREBP 1; TGF 1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FAT DROPLET; GLUCOSE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL LINE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LIPID METABOLISM; LIPID STORAGE; LIPID TRANSPORT; LIPOGENESIS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

CELL LINE; CHROMONES; EXTRACELLULAR MATRIX; GLUCOSE; HUMANS; KIDNEY TUBULES, PROXIMAL; LIPOGENESIS; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79951722518     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-011-0777-3     Document Type: Article

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