Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism

Journal of Cellular Biochemistry

Volumn 113, Issue 10, 2012, Pages 3186-3196

  Liu, Wei ^a   Zhang, Yue ^a   Hao, Jun ^a   Liu, Shuxia ^a   Liu, Qingjuan ^a   Zhao, Song ^a   Shi, Yonghong ^a   Duan, Huijun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; cyclin dependent kinase 5; high glucose; Nestin; podocyte

Indexed keywords

CASPASE 3; CYCLIN DEPENDENT KINASE 5; GLUCOSE; NESTIN; PROTEIN BAX; PROTEIN P35;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; CYTOSKELETON; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RNA INTERFERENCE;

ANIMALS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; CULTURE MEDIA; CYCLIN-DEPENDENT KINASE 5; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; MICE; MICRORNAS; NERVE TISSUE PROTEINS; PHOSPHOTRANSFERASES; PODOCYTES; RNA INTERFERENCE; RNA, MESSENGER; TIME FACTORS; TRANSFECTION;

EID: 84864970762     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24195     Document Type: Article

References (41)

1. Bijian K, Takano T, Papillon J, Le Berre L, Michaud JL, Kennedy CR, Cybulsky AV,. 2005. Actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells. Am J Physiol Renal Physiol 289: F1313-F1323.
2. Chen J, Boyle S, Zhao M, Su W, Takahashi K, Davis L, Decaestecker M, Takahashi T, Breyer MD, Hao CM,. 2006. Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J Am Soc Nephrol 17: 1283-1291.
3. Dalla Vestra M, Masiero A, Roiter AM, Saller A, Crepaldi G, Fioretto P,. 2003. Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes. Diabetes 52: 1031-1035.
4. de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, Shahinfar S, Snapinn S, Cooper ME, Mitch WE, Brenner BM,. 2004. Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL. Kidney Int 65: 2309-2320.
5. Dhavan R, Tsai LH,. 2001. A decade of CDK5. Nat Rev Mol Cell Biol 2: 749-759.
6. Dinsdale D, Lee JC, Dewson G, Cohen GM, Peter ME,. 2004. Intermediate filaments control the intracellular distribution of caspases during apoptosis. Am J Pathol 164: 395-407.
7. Griffin SV, Hiromura K, Pippin J, Petermann AT, Blonski MJ, Krofft R, Takahashi S, Kulkarni AB, Shankland SJ,. 2004. Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. Am J Pathol 165: 1175-1185.
8. He FF, Zhang C, Chen S, Deng BQ, Wang H, Shao N, Tian XJ, Fang Z, Sun XF, Liu JS, Zhu ZH, Meng XF,. 2011. Role of CD2-associated protein in albumin overload-induced apoptosis in podocytes. Cell Biol Int 35: 827-834.
9. Huang YL, Wu CM, Shi GY, Wu GC, Lee H, Jiang MJ, Wu HL, Yang HY,. 2009. Nestin serves as a prosurvival determinant that is linked to the cytoprotective effect of epidermal growth factor in rat vascular smooth muscle cells. J Biochem 146: 307-315.
10. Hunziker E, Stein M,. 2000. Nestin-expressing cells in the pancreatic islets of Langerhans. Biochem Biophys Res Commun 271: 116-119.
11. Kachinsky AM, Dominov JA, Miller JB,. 1994. Myogenesis and the intermediate filament protein, nestin. Dev Biol 165: 216-228.
12. Kachinsky AM, Dominov JA, Miller JB,. 1995. Intermediate filaments in cardiac myogenesis: Nestin in the developing mouse heart. J Histochem Cytochem 43: 843-847.
13. Kriz W, Gretz N, Lemley KV,. 1998. Progression of glomerular diseases: Is the podocyte the culprit? Kidney Int 54: 687-697.
14. Lendahl U, Zimmerman LB, McKay RD,. 1990. CNS stem cells express a new class of intermediate filament protein. Cell 60: 585-595.
15. Li L, Mignone J, Yang M, Matic M, Penman S, Enikolopov G, Hoffman RM,. 2003. Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci USA 100: 9958-9961.
16. Li JJ, Kwak SJ, Jung DS, Kim JJ, Yoo TH, Ryu DR, Han SH, Choi HY, Lee JE, Moon SJ, Kim DK, Han DS, Kang SW,. 2007. Podocyte biology in diabetic nephropathy. Kidney Int Suppl 106: S36-S42.
17. Marceau N, Schutte B, Gilbert S, Loranger A, Henfling ME, Broers JL, Mathew J, Ramaekers FC,. 2007. Dual roles of intermediate filaments in apoptosis. Exp Cell Res 313: 2265-2281.
18. Meyer TW, Bennett PH, Nelson RG,. 1999. Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria. Diabetologia 42: 1341-1344.
19. Mundel P, Reiser J, Zúñiga Mejía Borja A, Pavenstädt H, Davidson GR, Kriz W, Zeller R,. 1997. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236: 248-258.
20. Paglini G, Cáceres A,. 2001. The role of the Cdk5-p35 kinase in neuronal development. Eur J Biochem 268: 1528-1533.
21. Pagtalunan ME, Miller PL, Jumping-Eagle S, Nelson RG, Myers BD, Rennke HG, Coplon NS, Sun L, Meyer TW,. 1997. Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 99: 342-348.
22. Peters I, Tossidou I, Achenbach J, Woroniecki R, Mengel M, Park JK, Paschy M, de Groot K, Haller H, Schiffer M,. 2006. IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. J Am Soc Nephrol 17: 1644-1656.
23. Reed JC,. 2006. Proapoptotic multidomain Bcl-2/Bax-family proteins: Mechanisms, physiological roles, and therapeutic opportunities. Cell Death Differ 13: 1378-1386.
24. Riedl E, Pfister F, Braunagel M, Brinkkötter P, Sternik P, Deinzer M, Bakker SJ, Henning RH, van den Born J, Krämer BK, Navis G, Hammes HP, Yard B, Koeppel H,. 2011. Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats. Cell Physiol Biochem 28: 279-288.
25. Rosales JL, Lee KY,. 2006. Extraneuronal roles of cyclin-dependent kinase 5. Bioessays 28: 1023-1034.
26. Sahlgren CM, Mikhailov A, Vaittinen S, Pallari HM, Kalimo H, Pant HC, Eriksson JE,. 2003. Cdk5 regulates the organization of Nestin and its association with p35. Mol Cell Biol 23: 5090-5106.
27. Sahlgren CM, Pallari HM, He T, Chou YH, Goldman RD, Eriksson JE,. 2006. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J 25: 4808-4819.
28. Schwartz MM, Evans J, Bain R, Korbet SM,. 1999. Focal segmental glomerulosclerosis: Prognostic implications of the cellular lesion. J Am Soc Nephrol 10: 1900-1907.
29. Sharma MR, Tuszynski GP, Sharma MC,. 2004. Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J Cell Biochem 91 (2): 398-409.
30. Steffes MW, Schmidt D, McCrery R, Basgen JM,. 2001. Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int 59: 2104-2113.
31. Su W, Chen J, Yang H, You L, Xu L, Wang X, Li R, Gao L, Gu Y, Lin S, Xu H, Breyer MD, Hao CM,. 2007. Expression of nestin in the podocytes of normal and diseased human kidneys. Am J Physiol Regul Integr Comp Physiol 292: R1761-R1767.
32. Susztak K, Raff AC, Schiffer M, Böttinger EP,. 2006. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55: 225-233.
33. Townson DH, Putnam AN, Sullivan BT, Guo L, Irving-Rodgers HF,. 2010. Expression and distribution of cytokeratin 8/18 intermediate filaments in bovine antral follicles and corpus luteum: An intrinsic mechanism of resistance to apoptosis? Histol Histopathol 25: 889-900.
34. Toyoda M, Najafian B, Kim Y, Caramori ML, Mauer M,. 2007. Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes 56: 2155-2160.
35. Uchugonova A, Duong J, Zhang N, König K, Hoffman RM,. 2011. The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle. J Cell Biochem 112: 2046-2050.
36. Verzola D, Gandolfo MT, Ferrario F, Rastaldi MP, Villaggio B, Gianiorio F, Giannoni M, Rimoldi L, Lauria F, Miji M, Deferrari G, Garibotto G,. 2007. Apoptosis in the kidneys of patients with type II diabetic nephropathy. Kidney Int 72: 1262-1272.
37. Vogel MW,. 2002. Cell death, Bcl-2, Bax, and the cerebellum. Cerebellum 1: 277-287.
38. Weishaupt JH, Neusch C, Bähr M,. 2003. Cyclin-dependent kinase 5 (CDK5) and neuronal cell death. Cell Tissue Res 312: 1-8.
39. Wen D, You L, Zhang Q, Zhang L, Gu Y, Hao CM, Chen J,. 2011. Upregulation of nestin protects podocytes from apoptosis induced by puromycin aminonucleoside. Am J Nephrol 34: 423-434.
40. Wolf G, Chen S, Ziyadeh FN,. 2005. From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy. Diabetes 54: 1626-1634.
41. Yang Y, Guo L, Blattner SM, Mundel P, Kretzler M, Wu C,. 2005. Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival. J Am Soc Nephrol 16: 1966-1976.