EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells

American Journal of Physiology - Renal Physiology

Volumn 297, Issue 3, 2009, Pages

  Wu, D ^a   Peng, F ^a   Zhang, B ^a   Ingram, A J ^a   Kelly, D J ^b   Gilbert, R E ^c   Gao, B ^a   Kumar, S ^a   Krepinsky, J C ^a,d  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d ST JOSEPH S HOSPITAL   (Canada)

Author keywords

Diabetic nephropathy; Epidermal growth factor receptor; Extracellular matrix

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; COLLAGEN TYPE 1; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE; MANNITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; EGFR PROTEIN, RAT; ENZYME INHIBITOR; ESTRANE DERIVATIVE; PHOSPHOLIPASE C GAMMA; TYRPHOSTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; GLOMERULUS; IMMUNOPRECIPITATION; KIDNEY CORTEX; MALE; MESANGIUM CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; COLLAGEN TYPE I; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTRENES; FEMALE; MALE; MESANGIAL CELLS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; TYRPHOSTINS; UP-REGULATION;

EID: 69449104272     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00054.2009     Document Type: Article

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