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Volumn 8, Issue 12, 2013, Pages

Isolation and characterisation of a recombinant antibody fragment that binds NCAM1-expressing intervertebral disc cells

Author keywords

[No Author keywords available]

Indexed keywords

NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE 1; RECOMBINANT ANTIBODY; RECOMBINANT NERVE CELL ADHESION MOLECULE 1 IMMUNOGLOBULIN 1 DOMAIN SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

EID: 84892556123     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083678     Document Type: Article
Times cited : (10)

References (50)
  • 1
    • 85012556391 scopus 로고    scopus 로고
    • Degeneration of intervertebral discs: Current understanding of cellular and molecular events, and implications for novel therapies
    • Freemont TJ, LeMaitre C, Watkins A, Hoyland JA (2001) Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies. Expert Rev Mol Med 2001: 1-10
    • (2001) Expert Rev Mol Med , vol.2001 , pp. 1-10
    • Freemont, T.J.1    LeMaitre, C.2    Watkins, A.3    Hoyland, J.A.4
  • 2
    • 33645241455 scopus 로고    scopus 로고
    • European guidelines for prevention in low back pain: November 2004 chapter 2
    • doi:10.1007/s00586-006-1070-3. PubMed: 16550446
    • Burton AK, Balagué F, Cardon G, Eriksen HR, Henrotin Y et al. (2006) European guidelines for prevention in low back pain: November 2004 chapter 2. Eur Spine J 15: S136-S168. doi:10.1007/s00586-006-1070-3. PubMed: 16550446.
    • (2006) Eur Spine J , vol.15
    • Burton, A.K.1    Balagué, F.2    Cardon, G.3    Eriksen, H.R.4    Henrotin, Y.5
  • 3
    • 0023888488 scopus 로고
    • Lumbar disc degeneration: Correlation with age, sex, and spine level in 600 autopsy specimens
    • PubMed: 3406837
    • Miller JA, Schmatz C, Schultz AB (1988) Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine (Phila Pa 1976) 13: 173-178. PubMed: 3406837.
    • (1988) Spine (Phila Pa 1976) , vol.13 , pp. 173-178
    • Miller, J.A.1    Schmatz, C.2    Schultz, A.B.3
  • 4
    • 0036894572 scopus 로고    scopus 로고
    • Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science
    • PubMed: 12461389
    • Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF et al. (2002) Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine (Phila Pa 1976) 27: 2631-2644. PubMed: 12461389.
    • (2002) Spine (Phila Pa 1976) , vol.27 , pp. 2631-2644
    • Boos, N.1    Weissbach, S.2    Rohrbach, H.3    Weiler, C.4    Spratt, K.F.5
  • 5
    • 0038300772 scopus 로고    scopus 로고
    • Degeneration of the intervertebral disc
    • doi:10.1186/ar629. PubMed: 12723977
    • Urban JP, Roberts S (2003) Degeneration of the intervertebral disc. Arthritis Res Ther 5: 120-130. doi:10.1186/ar629. PubMed: 12723977.
    • (2003) Arthritis Res Ther , vol.5 , pp. 120-130
    • Urban, J.P.1    Roberts, S.2
  • 6
    • 84867990014 scopus 로고    scopus 로고
    • Diversity of intervertebral disc cells: Phenotype and function
    • doi:10.1111/j.1469-7580.2012.01521.x. PubMed: 22686699
    • Pattappa G, Li Z, Peroglio M, Wismer N, Alini M et al. (2012) Diversity of intervertebral disc cells: phenotype and function. J Anat 221: 480-496. doi:10.1111/j.1469-7580.2012.01521.x. PubMed: 22686699.
    • (2012) J Anat , vol.221 , pp. 480-496
    • Pattappa, G.1    Li, Z.2    Peroglio, M.3    Wismer, N.4    Alini, M.5
  • 7
    • 14844362345 scopus 로고    scopus 로고
    • Biology of intervertebral disc aging and degeneration: Involvement of the extracellular matrix
    • PubMed: 15564918
    • Roughley PJ (2004) Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine (Phila Pa 1976) 29: 2691-2699. PubMed: 15564918.
    • (2004) Spine (Phila Pa 1976) , vol.29 , pp. 2691-2699
    • Roughley, P.J.1
  • 8
    • 0034879644 scopus 로고    scopus 로고
    • Height of lumbar discs measured from radiographs compared with degeneration and height classified from MR images
    • doi:10.1007/s003300000556. PubMed: 11218025
    • Frobin W, Brinckmann P, Kramer M, Hartwig E (2001) Height of lumbar discs measured from radiographs compared with degeneration and height classified from MR images. Eur Radiol 11: 263-269. doi:10.1007/s003300000556. PubMed: 11218025.
    • (2001) Eur Radiol , vol.11 , pp. 263-269
    • Frobin, W.1    Brinckmann, P.2    Kramer, M.3    Hartwig, E.4
  • 9
    • 0019799162 scopus 로고
    • Biochemical changes in intervertebral disc degeneration
    • doi:10.1016/0304-4165(81)90476-1. PubMed: 7225426
    • Lyons G, Eisenstein SM, Sweet MB (1981) Biochemical changes in intervertebral disc degeneration. Biochim Biophys Acta 673: 443-453. doi:10.1016/0304-4165(81)90476-1. PubMed: 7225426.
    • (1981) Biochim Biophys Acta , vol.673 , pp. 443-453
    • Lyons, G.1    Eisenstein, S.M.2    Sweet, M.B.3
  • 10
    • 80053578695 scopus 로고    scopus 로고
    • Intervertebral disc degeneration and emerging biologic treatments
    • PubMed: 21885700
    • Kepler CK, Anderson DG, Tannoury C, Ponnappan RK (2011) Intervertebral disc degeneration and emerging biologic treatments. J Am Acad Orthop Surg 19: 543-553. PubMed: 21885700.
    • (2011) J Am Acad Orthop Surg , vol.19 , pp. 543-553
    • Kepler, C.K.1    Anderson, D.G.2    Tannoury, C.3    Ponnappan, R.K.4
  • 11
    • 84856778594 scopus 로고    scopus 로고
    • Adjacent-level biomechanics after single versus multilevel cervical spine fusion
    • doi:10.3171/2011.10.SPINE11116. PubMed: 22136389
    • Prasarn ML, Baria D, Milne E, Latta L, Sukovich W (2012) Adjacent-level biomechanics after single versus multilevel cervical spine fusion. J Neurosurg Spine 16: 172-177. doi:10.3171/2011.10.SPINE11116. PubMed: 22136389.
    • (2012) J Neurosurg Spine , vol.16 , pp. 172-177
    • Prasarn, M.L.1    Baria, D.2    Milne, E.3    Latta, L.4    Sukovich, W.5
  • 12
    • 48749093464 scopus 로고    scopus 로고
    • Adipose-derived stem cell therapy for intervertebral disc regeneration: An in vitro reconstructed tissue in alginate capsules
    • doi:10.1089/ten.tea.2007.0330. PubMed: 18593270
    • Gaetani P, Torre ML, Klinger M, Faustini M, Crovato F et al. (2008) Adipose-derived stem cell therapy for intervertebral disc regeneration: an in vitro reconstructed tissue in alginate capsules. Tissue Eng Part A 14: 1415-1423. doi:10.1089/ten.tea.2007.0330. PubMed: 18593270.
    • (2008) Tissue Eng Part A , vol.14 , pp. 1415-1423
    • Gaetani, P.1    Torre, M.L.2    Klinger, M.3    Faustini, M.4    Crovato, F.5
  • 13
    • 84861671921 scopus 로고    scopus 로고
    • Composite hydrogels for nucleus pulposus tissue engineering
    • doi:10.1016/j.jmbbm.2011.10.003. PubMed: 22658151
    • Strange DGT, Oyen ML (2012) Composite hydrogels for nucleus pulposus tissue engineering. J Mech Behav Biomed Mater 11: 16-26. doi:10.1016/j.jmbbm. 2011.10.003. PubMed: 22658151.
    • (2012) J Mech Behav Biomed Mater , vol.11 , pp. 16-26
    • Strange, D.G.T.1    Oyen, M.L.2
  • 14
    • 36249008658 scopus 로고    scopus 로고
    • An injectable cross-linked scaffold for nucleus pulposus regeneration
    • doi:10.1016/j.biomaterials.2007.10.009. PubMed: 17959242
    • Halloran DO, Grad S, Stoddart M, Dockery P, Alini M et al. (2008) An injectable cross-linked scaffold for nucleus pulposus regeneration. Biomaterials 29: 438-447. doi:10.1016/j.biomaterials.2007.10.009. PubMed: 17959242.
    • (2008) Biomaterials , vol.29 , pp. 438-447
    • Halloran, D.O.1    Grad, S.2    Stoddart, M.3    Dockery, P.4    Alini, M.5
  • 15
    • 79951576907 scopus 로고    scopus 로고
    • An injectable vehicle for nucleus pulposus cell-based therapy
    • doi:10.1016/j.biomaterials.2011.01.018. PubMed: 21276612
    • Collin EC, Grad S, Zeugolis DI, Vinatier CS, Clouet JR et al. (2011) An injectable vehicle for nucleus pulposus cell-based therapy. Biomaterials 32: 2862-2870. doi:10.1016/j.biomaterials.2011.01.018. PubMed: 21276612.
    • (2011) Biomaterials , vol.32 , pp. 2862-2870
    • Collin, E.C.1    Grad, S.2    Zeugolis, D.I.3    Vinatier, C.S.4    Clouet, J.R.5
  • 16
    • 35348971546 scopus 로고    scopus 로고
    • Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels
    • doi: 10.1016/j.biomaterials.2007.09.018. PubMed: 17920676
    • Richardson SM, Hughes N, Hunt JA, Freemont AJ, Hoyland JA (2008) Human mesenchymal stem cell differentiation to NP-like cells in chitosan- glycerophosphate hydrogels. Biomaterials 29: 85-93. doi: 10.1016/j.biomaterials. 2007.09.018. PubMed: 17920676.
    • (2008) Biomaterials , vol.29 , pp. 85-93
    • Richardson, S.M.1    Hughes, N.2    Hunt, J.A.3    Freemont, A.J.4    Hoyland, J.A.5
  • 17
    • 0042975394 scopus 로고    scopus 로고
    • The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro
    • PubMed: 12923462
    • Tim Yoon S, Su Kim K, Li J, Soo Park J, Akamaru T et al. (2003) The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. Spine (Phila Pa 1976) 28: 1773-1780. PubMed: 12923462.
    • (2003) Spine (Phila Pa 1976) , vol.28 , pp. 1773-1780
    • Tim Yoon, S.1    Su Kim, K.2    Li, J.3    Soo Park, J.4    Akamaru, T.5
  • 18
    • 84859119714 scopus 로고    scopus 로고
    • In vivo targeting and imaging of tumor vasculature with radiolabeled, antibodyconjugated nanographene
    • doi:10.1021/nn204625e. PubMed: 22339280
    • Hong H, Yang K, Zhang Y, Engle JW, Feng L et al. (2012) In vivo targeting and imaging of tumor vasculature with radiolabeled, antibodyconjugated nanographene. ACS Nano 6: 2361-2370. doi:10.1021/nn204625e. PubMed: 22339280.
    • (2012) ACS Nano , vol.6 , pp. 2361-2370
    • Hong, H.1    Yang, K.2    Zhang, Y.3    Engle, J.W.4    Feng, L.5
  • 19
    • 72449163929 scopus 로고    scopus 로고
    • Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro - A quantitative study
    • doi:10.1016/j.jconrel.2009.09.008. PubMed: 19766679
    • Asgeirsdóttir SA, Talman EG, de Graaf IA, Kamps JA, Satchell SC et al. (2010) Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro - a quantitative study. J Control Release 141: 241-251. doi:10.1016/j.jconrel.2009.09.008. PubMed: 19766679.
    • (2010) J Control Release , vol.141 , pp. 241-251
    • Asgeirsdóttir, S.A.1    Talman, E.G.2    De Graaf, I.A.3    Kamps, J.A.4    Satchell, S.C.5
  • 20
    • 84874912368 scopus 로고    scopus 로고
    • Antibody immobilization on solid surfaces: Methods and applications
    • T Syed Cambridge, (UK): The Royal Society of Chemistry
    • Hu X, O'Connor IB, Wall JG (2012) Antibody immobilization on solid surfaces: methods and applications. In: T Syed. Biological Interactions with Surface Charge in Biomaterials. Cambridge, (UK): The Royal Society of Chemistry. pp. 90-104.
    • (2012) Biological Interactions with Surface Charge in Biomaterials , pp. 90-104
    • Hu, X.1    O'Connor, I.B.2    Wall, J.G.3
  • 21
    • 0025226085 scopus 로고
    • Phage antibodies: Filamentous phage displaying antibody variable domains
    • doi:10.1038/348552a0. PubMed: 2247164
    • McCafferty J, Griffiths AD, Winter G, Chiswell DJ (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348: 552-554. doi:10.1038/348552a0. PubMed: 2247164.
    • (1990) Nature , vol.348 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 22
    • 0032434753 scopus 로고    scopus 로고
    • The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system
    • doi:10.1016/S0531-5565(98)00040-0. PubMed: 9951628
    • Rønn LC, Hartz BP, Bock E (1998) The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system. Exp Gerontol 33: 853-864. doi:10.1016/S0531-5565(98)00040-0. PubMed: 9951628.
    • (1998) Exp Gerontol , vol.33 , pp. 853-864
    • Rønn, L.C.1    Hartz, B.P.2    Bock, E.3
  • 23
    • 67651151247 scopus 로고    scopus 로고
    • Differential phenotype of intervertebral disc cells: Microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus
    • PubMed: 19525835
    • Sakai D, Nakai T, Mochida J, Alini M, Grad S (2009) Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus. Spine (Phila Pa 1976) 34: 1448-1456. PubMed: 19525835.
    • (2009) Spine (Phila Pa 1976) , vol.34 , pp. 1448-1456
    • Sakai, D.1    Nakai, T.2    Mochida, J.3    Alini, M.4    Grad, S.5
  • 24
    • 76549130659 scopus 로고    scopus 로고
    • Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: Potential associations with aging and degeneration
    • doi:10.1016/j.joca.2009.09.009. PubMed: 19833252
    • Rutges J, Creemers LB, Dhert W, Milz S, Sakai D et al. (2010) Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration. Osteoarthritis Cartilage 18: 416-423. doi:10.1016/j.joca.2009.09. 009. PubMed: 19833252.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 416-423
    • Rutges, J.1    Creemers, L.B.2    Dhert, W.3    Milz, S.4    Sakai, D.5
  • 25
    • 60549116209 scopus 로고    scopus 로고
    • A compact phage display human scFv library for selection of antibodies to a wide variety of antigens
    • doi: 10.1186/1472-6750-9-6. PubMed: 19175944
    • Pansri P, Jaruseranee N, Rangnoi K, Kristensen P, Yamabhai M (2009) A compact phage display human scFv library for selection of antibodies to a wide variety of antigens. BMC Biotechnol 9: 6. doi: 10.1186/1472-6750-9-6. PubMed: 19175944.
    • (2009) BMC Biotechnol , vol.9 , pp. 6
    • Pansri, P.1    Jaruseranee, N.2    Rangnoi, K.3    Kristensen, P.4    Yamabhai, M.5
  • 26
    • 0029980152 scopus 로고    scopus 로고
    • The three-dimensional structure of the first domain of neural cell adhesion molecule
    • doi:10.1038/nsb0796-581. PubMed: 8673600
    • Thomsen NK, Soroka V, Jensen PH, Berezin V, Kiselyov VV et al. (1996) The three-dimensional structure of the first domain of neural cell adhesion molecule. Nat Struct Biol 3: 581-585. doi:10.1038/nsb0796-581. PubMed: 8673600.
    • (1996) Nat Struct Biol , vol.3 , pp. 581-585
    • Thomsen, N.K.1    Soroka, V.2    Jensen, P.H.3    Berezin, V.4    Kiselyov, V.V.5
  • 27
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
    • doi:10.1002/elps.1150181505. PubMed: 9504803
    • Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18: 2714-2723. doi:10.1002/elps.1150181505. PubMed: 9504803.
    • (1997) Electrophoresis , vol.18 , pp. 2714-2723
    • Guex, N.1    Peitsch, M.C.2
  • 28
    • 0037255597 scopus 로고    scopus 로고
    • Overview of tag protein fusions: From molecular and biochemical fundamentals to commercial systems
    • PubMed: 12536251
    • Terpe K (2003) Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems. Appl Microbiol Biotechnol 60: 523-533. PubMed: 12536251.
    • (2003) Appl Microbiol Biotechnol , vol.60 , pp. 523-533
    • Terpe, K.1
  • 29
    • 14844294424 scopus 로고    scopus 로고
    • Protein production by auto-induction in high density shaking cultures
    • doi:10.1016/j.pep.2005.01.016. PubMed: 15915565
    • Studier FW (2005) Protein production by auto-induction in high density shaking cultures. Protein Expr Purif 41: 207-234. doi:10.1016/j.pep.2005.01.016. PubMed: 15915565.
    • (2005) Protein Expr Purif , vol.41 , pp. 207-234
    • Studier, F.W.1
  • 30
    • 84872578197 scopus 로고    scopus 로고
    • Covalent and oriented immobilization of scFv antibody fragments via an engineered glycan moiety
    • doi:10.1021/bm301518p. PubMed: 23215344
    • Hu X, Hortigüela MJ, Robin S, Lin H, Li Y et al. (2013) Covalent and oriented immobilization of scFv antibody fragments via an engineered glycan moiety. Biomacromolecules 14: 153-159. doi:10.1021/bm301518p. PubMed: 23215344.
    • (2013) Biomacromolecules , vol.14 , pp. 153-159
    • Hu, X.1    Hortigüela, M.J.2    Robin, S.3    Lin, H.4    Li, Y.5
  • 31
    • 33845957062 scopus 로고    scopus 로고
    • Optimisation of production of a domoic acid-binding scFv antibody fragment in Escherichia coli using molecular chaperones and functional immobilisation on a mesoporous silicate support
    • doi:10.1016/j.pep.2006.08.009. PubMed: 17005419
    • Hu X, O'Hara L, White S, Magner E, Kane M et al. (2007) Optimisation of production of a domoic acid-binding scFv antibody fragment in Escherichia coli using molecular chaperones and functional immobilisation on a mesoporous silicate support. Protein Expr Purif 52: 194-201. doi:10.1016/j.pep.2006.08.009. PubMed: 17005419.
    • (2007) Protein Expr Purif , vol.52 , pp. 194-201
    • Hu, X.1    O'Hara, L.2    White, S.3    Magner, E.4    Kane, M.5
  • 32
    • 84875771762 scopus 로고    scopus 로고
    • Improved detection of domoic acid using covalently immobilised antibody fragments
    • doi:10.3390/md11030881. PubMed: 23493076
    • Hortigüela MW, Wall JG (2013) Improved detection of domoic acid using covalently immobilised antibody fragments. Mar Drugs 11: 881-895. doi:10.3390/md11030881. PubMed: 23493076.
    • (2013) Mar Drugs , vol.11 , pp. 881-895
    • Hortigüela, M.W.1    Wall, J.G.2
  • 33
    • 25644448227 scopus 로고    scopus 로고
    • Cloning, expression and characterisation of a single-chain Fv antibody fragment against domoic acid in Escherichia coli
    • doi:10.1016/j.jbiotec.2005.05.018. PubMed: 16019098
    • Hu X, O'Dwyer R, Wall JG (2005) Cloning, expression and characterisation of a single-chain Fv antibody fragment against domoic acid in Escherichia coli. J Biotechnol 120: 38-45. doi:10.1016/j.jbiotec.2005.05.018. PubMed: 16019098.
    • (2005) J Biotechnol , vol.120 , pp. 38-45
    • Hu, X.1    O'Dwyer, R.2    Wall, J.G.3
  • 34
    • 0036691789 scopus 로고    scopus 로고
    • Isolation of a novel Thermus thermophilus metal efflux protein that improves Escherichia coli growth under stress conditions
    • doi:10.1007/s00792-001-0257-0. PubMed: 12215815
    • Spada S, Pembroke JT, Wall JG (2002) Isolation of a novel Thermus thermophilus metal efflux protein that improves Escherichia coli growth under stress conditions. Extremophiles 6: 301-308. doi:10.1007/s00792-001-0257-0. PubMed: 12215815.
    • (2002) Extremophiles , vol.6 , pp. 301-308
    • Spada, S.1    Pembroke, J.T.2    Wall, J.G.3
  • 35
    • 84876514809 scopus 로고    scopus 로고
    • GDNF gene delivery via a 2-(dimethylamino)ethyl methacrylate based cyclized knot polymer for neuronal cell applications
    • doi:10.1021/cn4000023. PubMed: 23391146
    • Newland B, Abu-Rub M, Naughton M, Zheng Y, Pinoncely AV et al. (2013) GDNF gene delivery via a 2-(dimethylamino)ethyl methacrylate based cyclized knot polymer for neuronal cell applications. ACS Chem Neurosci 4: 540-546. doi:10.1021/cn4000023. PubMed: 23391146.
    • (2013) ACS Chem Neurosci , vol.4 , pp. 540-546
    • Newland, B.1    Abu-Rub, M.2    Naughton, M.3    Zheng, Y.4    Pinoncely, A.V.5
  • 36
    • 70350568907 scopus 로고    scopus 로고
    • Engineering of cysteine residues leads to improved production of a human dipeptidase enzyme in E. coli
    • doi:10.1007/s12010-008-8379-9. PubMed: 18931951
    • O'Dwyer R, Razzaque R, Hu X, Hollingshead SK, Wall JG (2009) Engineering of cysteine residues leads to improved production of a human dipeptidase enzyme in E. coli. Appl Biochem Biotechnol 159: 178-190. doi:10.1007/s12010-008-8379-9. PubMed: 18931951.
    • (2009) Appl Biochem Biotechnol , vol.159 , pp. 178-190
    • O'Dwyer, R.1    Razzaque, R.2    Hu, X.3    Hollingshead, S.K.4    Wall, J.G.5
  • 37
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
    • doi:10.1093/nar/25.17.3389. PubMed: 9254694
    • Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402. doi:10.1093/nar/25.17.3389. PubMed: 9254694.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3389-3402
    • Altschul, S.F.1    Madden, T.L.2    Schäffer, A.A.3    Zhang, J.4    Zhang, Z.5
  • 38
    • 84871794357 scopus 로고    scopus 로고
    • Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
    • doi: 10.1038/ncomms2226. PubMed: 23232394
    • Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S et al. (2012) Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun 3: 1264. doi: 10.1038/ncomms2226. PubMed: 23232394.
    • (2012) Nat Commun , vol.3 , pp. 1264
    • Sakai, D.1    Nakamura, Y.2    Nakai, T.3    Mishima, T.4    Kato, S.5
  • 39
    • 35848965890 scopus 로고    scopus 로고
    • Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: Implications for anular repair
    • PubMed: 17978648
    • Zhang Y, Anderson DG, Phillips FM, Thonar EJ, He TC et al. (2007) Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair. Spine (Phila Pa 1976) 32: 2515-2520. PubMed: 17978648.
    • (2007) Spine (Phila Pa 1976) , vol.32 , pp. 2515-2520
    • Zhang, Y.1    Anderson, D.G.2    Phillips, F.M.3    Thonar, E.J.4    He, T.C.5
  • 40
    • 84870507478 scopus 로고    scopus 로고
    • Hydrogel-based platforms for the regeneration of osteochondral tissue and intervertebral disc
    • doi:10.3390/polym4031590
    • Guarino V, Gloria A, Raucci MG, Ambrosio L (2012) Hydrogel-based platforms for the regeneration of osteochondral tissue and intervertebral disc. Polymers 4: 1590-1612. doi:10.3390/polym4031590.
    • (2012) Polymers , vol.4 , pp. 1590-1612
    • Guarino, V.1    Gloria, A.2    Raucci, M.G.3    Ambrosio, L.4
  • 41
    • 84892500092 scopus 로고    scopus 로고
    • Development of a whole disc organ culture system to study human intervertebral disc
    • doi:10.1055/s-0028-1100919. PubMed: 23637672
    • Parolin M, Gawri R, Mwale F, Steffen T, Roughley P et al. (2010) Development of a whole disc organ culture system to study human intervertebral disc. Evid Based Spine Care J 1: 67-68. doi:10.1055/s-0028-1100919. PubMed: 23637672.
    • (2010) Evid Based Spine Care J , vol.1 , pp. 67-68
    • Parolin, M.1    Gawri, R.2    Mwale, F.3    Steffen, T.4    Roughley, P.5
  • 42
    • 77956419226 scopus 로고    scopus 로고
    • The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates
    • doi:10.1097/BRS.0b013e3181c48019. PubMed: 20395884
    • Illien-Jünger S, Gantenbein-Ritter B, Grad S, Lezuo P, Ferguson SJ et al. (2010) The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates. Spine 35: 1744-1752. doi:10.1097/BRS.0b013e3181c48019. PubMed: 20395884.
    • (2010) Spine , vol.35 , pp. 1744-1752
    • Illien-Jünger, S.1    Gantenbein-Ritter, B.2    Grad, S.3    Lezuo, P.4    Ferguson, S.J.5
  • 43
    • 33749614883 scopus 로고    scopus 로고
    • Adsorption and activity of a domoic acid binding antibody fragment on mesoporous silicates
    • doi:10.1021/jp062423e. PubMed: 16970501
    • Hu X, Spada S, White S, Hudson S, Magner E et al. (2006) Adsorption and activity of a domoic acid binding antibody fragment on mesoporous silicates. J Phys Chem B 110: 18703-18709. doi:10.1021/jp062423e. PubMed: 16970501.
    • (2006) J Phys Chem B , vol.110 , pp. 18703-18709
    • Hu, X.1    Spada, S.2    White, S.3    Hudson, S.4    Magner, E.5
  • 44
    • 0029449604 scopus 로고
    • Expression and purification strategies for the production of single-chain antibody and T-cell receptor fragments in E. coli
    • doi:10.1007/BF02779017. PubMed: 8680930
    • Molloy PE, Graham BM, Cupit PM, Grant SD, Porter AJ et al. (1995) Expression and purification strategies for the production of single-chain antibody and T-cell receptor fragments in E. coli. Mol Biotechnol 4: 239-245. doi:10.1007/BF02779017. PubMed: 8680930.
    • (1995) Mol Biotechnol , vol.4 , pp. 239-245
    • Molloy, P.E.1    Graham, B.M.2    Cupit, P.M.3    Grant, S.D.4    Porter, A.J.5
  • 45
    • 0031017853 scopus 로고    scopus 로고
    • Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A
    • doi:10.1016/S0022-1759(96)00215-3. PubMed: 9032407
    • Jendeberg L, Nilsson P, Larsson A, Denker P, Uhlén M et al. (1997) Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A. J Immunol Methods 201: 25-34. doi:10.1016/S0022-1759(96)00215-3. PubMed: 9032407.
    • (1997) J Immunol Methods , vol.201 , pp. 25-34
    • Jendeberg, L.1    Nilsson, P.2    Larsson, A.3    Denker, P.4    Uhlén, M.5
  • 47
    • 84892493938 scopus 로고    scopus 로고
    • Affinity maturation of an epidermal growth factor receptor targeting human monoclonal antibody ER414 by CDR mutation
    • doi:10.4110/in.2012.12.4.155. PubMed: 23091439
    • Chang KH, Kim MS, Hong GW, Seo MS, Shin YN et al. (2012) Affinity maturation of an epidermal growth factor receptor targeting human monoclonal antibody ER414 by CDR mutation. Immune Netw 12: 155-164. doi:10.4110/in.2012.12. 4.155. PubMed: 23091439.
    • (2012) Immune Netw , vol.12 , pp. 155-164
    • Chang, K.H.1    Kim, M.S.2    Hong, G.W.3    Seo, M.S.4    Shin, Y.N.5
  • 48
    • 82455163775 scopus 로고    scopus 로고
    • Identification of cell surface specific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase 12 varies with age and degeneration
    • doi: 10.1002/art.30607. PubMed: 22127705
    • Power KA, Grad S, Rutges JP, Creemers LB, van Rijen MHP et al. (2011) Identification of cell surface specific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase 12 varies with age and degeneration. Arthritis Rheum 63: 3876-3886. doi: 10.1002/art.30607. PubMed: 22127705.
    • (2011) Arthritis Rheum , vol.63 , pp. 3876-3886
    • Power, K.A.1    Grad, S.2    Rutges, J.P.3    Creemers, L.B.4    Van Rijen, M.H.P.5
  • 49
    • 79959855408 scopus 로고    scopus 로고
    • Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration
    • doi:10.1016/j.yexmp.2011.06.001. PubMed: 21689646
    • Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Zinchenko N et al. (2011) Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration. Exp Mol Pathol 91: 534-539. doi:10.1016/j.yexmp.2011.06.001. PubMed: 21689646.
    • (2011) Exp Mol Pathol , vol.91 , pp. 534-539
    • Gruber, H.E.1    Hoelscher, G.L.2    Ingram, J.A.3    Bethea, S.4    Zinchenko, N.5
  • 50
    • 84872070771 scopus 로고    scopus 로고
    • Challenges and strategies in the repair of ruptured annulus fibrosus
    • PubMed: 23283636
    • Guterl CC, See EY, Blanquer SB, Pandit A, Ferguson SJ et al. (2013) Challenges and strategies in the repair of ruptured annulus fibrosus. Eur Cell Mater 25: 1-21. PubMed: 23283636.
    • (2013) Eur Cell Mater , vol.25 , pp. 1-21
    • Guterl, C.C.1    See, E.Y.2    Blanquer, S.B.3    Pandit, A.4    Ferguson, S.J.5


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