Crystal Structure of a Human Autoimmune Complex between IgM Rheumatoid Factor RF61 and IgG1 Fc Reveals a Novel Epitope and Evidence for Affinity Maturation

Journal of Molecular Biology

Volumn 368, Issue 5, 2007, Pages 1321-1331

  Duquerroy, Stephane ^a,b,c   Stura, Enrico A ^d   Bressanelli, Stéphane ^a   Fabiane, Stella M ^e   Vaney, Marie C ^a   Beale, Dennis ^f   Hamon, Maureen ^f   Casali, Paolo ^g   Rey, Felix A ^a,b   Sutton, Brian J ^e   Taussig, Michael J ^f  

^a INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d CEA SACLAY   (France)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f BABRAHAM INSTITUTE   (United Kingdom)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

autoantibody; autoantigen; autoimmunity; rheumatoid factor; X ray crystallography

Indexed keywords

ARGININE; GLUTAMINE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; RHEUMATOID FACTOR; RHEUMATOID FACTOR RF61; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROPHILICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

EID: 34247246737     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.02.085     Document Type: Article

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