Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality

Human Molecular Genetics

Volumn 23, Issue 3, 2014, Pages 693-705

  Ma, Aiping ^a,d   Wang, Lianmei ^a,b   Gao, Yunzhou ^c   Chang, Zai ^e   Peng, Haiyong ^b   Zeng, Ni ^a   Gui, Yao Song ^a   Tian, Xinlun ^a   Li, Xue ^a   Cai, Baiqiang ^a   Zhang, Hongbing ^a,b   Xu, Kai Feng ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b Postdoctoral Research Station Institute of Basic Medicine Sciences CAMS and PUMC   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^d THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^e TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; TUBEROUS SCLEROSIS COMPLEX 1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLEEDING; CARDIOVASCULAR MALFORMATION; CELL JUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; GENE; GENE INACTIVATION; HEART VENTRICLE WALL; IMMUNOHISTOCHEMISTRY; LETHALITY; MITOCHONDRION; MORPHOLOGY; MOUSE; NERVE SPROUTING; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; SKIN EDEMA; VASCULAR ENDOTHELIUM; YOLK SAC;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ENDOTHELIAL CELLS; FEMALE; FETAL DEATH; HOMOZYGOTE; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MITOCHONDRIA; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS; YOLK SAC;

EID: 84892461290     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt456     Document Type: Article

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