Paracrine modulation of heart cell function by endothelial cells

Cardiovascular Research

Volumn 31, Issue 6, 1996, Pages 847-867

  Shah, Ajay M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Arterial tone; Endothelium; Myocadial contraction; Myocardial function; Paracrine modulation

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; CALCIUM; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN 1; KININASE; NATRIURETIC FACTOR; NITRIC OXIDE; PROSTANOID;

ARTERY TONE; ENDOTHELIUM CELL; ENZYME ACTIVITY; HEART CONTRACTION; HEART FUNCTION; HUMAN; PRIORITY JOURNAL; REVIEW; STARLING LAW;

ANIMALS; ATRIAL NATRIURETIC FACTOR; ENDOTHELINS; ENDOTHELIUM, VASCULAR; HEART; HEART DISEASES; HUMANS; MYOCARDIAL CONTRACTION; NITRIC OXIDE; RATS; RENIN-ANGIOTENSIN SYSTEM;

EID: 0029940216     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/0008-6363(96)00025-9     Document Type: Review

References (224)

1. Brutsaert DL, Meulemans AL, Sipido KR, Sys SU. Effects of damaging the endocardial surface on the mechanical performance of isolated cardiac muscle. Circ Res 1988;62:358-66.
2. Shah AM, Brutsaert DL, Meulemans AL, Andries LJ, Capron M. Eosinophils from hypereosinophilic patients damage endocardium of isolated feline heart muscle preparations. Circulation 1990;81:1081-8.
3. Andries LJ, Meulemans AL, Brutsaert DL. Ultrasound as a novel method for selective damage of endocardial endothelium. Am J Physiol 1991;261:H1636-42.
4. Gillebert TC, De Hert SG, Andries LJ, Jagenau AH, Brutsaert DL. Intracavitary ultrasound impairs left ventricular performance: presumed role of endocardial endothelium. Am J Physiol 1992;263:H857-65.
5. Fort S, Lewis MJ, Shah AM. The role of endocardial endothelium in the modulation of myocardial contraction in the isolated whole heart. Cardioscience 1993;4:217-23.
6. Shah AM, Meulemans AL, Brutsaert DL. Myocardial inotropic responses to aggregating platelets and modulation by the endocardium. Circulation 1989;79:1315-23.
7. Shah AM, Andries LJ, Meulemans AL, Brutsaert DL. Endocardium modulates myocardial inotropic response to 5-hydroxytryptamine. Am J Physiol 1989;257:H1790-7.
8. 1-adrenoceptor agonist in mammalian heart. J Mol Cell Cardiol 1990;22:667-85.
9. Li K, Stewart DJ, Rouleau JL. Myocardial contractile actions of endothelin-1 in rat and rabbit papillary muscles. Circ Res 1991;69:301-12.
10. Smith JA, Shah AM, Lewis MJ. Factors released from the endocardium of the ferret and pig modulate myocardial contraction. J Physiol 1991;439:1-14.
11. Ramaciotti C, Sharkey A, McClellan G, Winegrad S. Endothelial cells regulate cardiac contractility. Proc Natl Acad Sci USA 1992;89:4033-6.
12. Paulus WJ, Vantrimpont PJ, Shah AM. Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in man. Circulation 1994;89:2070-8.
13. Paulus WJ, Vantrimpont PJ, Shah AM. Paracrine coronary endothelial control of left ventricular function in humans. Circulation 1995;92:2119-26.
14. Brutsaert DL, Andries LJ. The endocardial endothelium. Am J Physiol 1992;263:H985-1002.
15. Mebazaa A, Wetzel R, Cherian M, Abraham M. Comparison between endocardial and great vessel endothelial cells: morphology, growth and prostaglandin release. Am J Physiol 1995;268:H250-9.
16. Manabe K, Ito H, Matsuda H, Noma A. Hyperpolarization induced by vasoactive substances in intact guinea-pig endocardial endothelial cells. J Physiol 1995;484.1:25-40.
17. Manabe K, Ito H, Noma A, Shibata Y. Classification of ion channels in the luminal and abluminal membranes of guinea-pig endocardial endothelial cells. J Physiol 1995;484.1:41-52.
18. Page E, Upshaw-Earley J, Goings G. Permeability of rat atrial endocardium, epicardium, and myocardium to large molecules. Stretch-dependent effects. Circ Res 1992;71:159-73.
19. Marron K, Wharton J, Sheppard MN, et al. Human endocardial innervation and its relationship to the endothelium: an immunohistochemical, histochemical, and quantitative study. Cardiovasc Res 1994;28:1490-9.
20. Shah AM, Shattock MJ, Lewis MJ. Action potential duration and endocardial modulation of myocardial contraction. Cardiovasc Res 1992;26:376-8.
21. Shah AM. Modulation of myocardial contractile function by endothelium. In: Haunso S, Kjeldsen K, eds. Proceedings of the International Society for Heart Research European Section Meeting. Monduzzi Editore, Bologna, 1994, pp. 53-60.
22. Rüegg JC. Towards a molecular understanding of contractility. Cardioscience 1990;1:163-7.
23. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992;6:3051-64.
24. Schmidt HHHW, Lohmann SM, Walter U. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochim Biophys Acta 1993;1178:153-75.
25. 2+-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992;105:575-80.
26. Klimaschewski L, Kummer W, Mayer B, et al. Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart. Circ Res 1992;71:1533-7.
27. Wildhirt SM, Dudek RR, Suzuki H, Pinto V, Narayan KS, Bing RJ. Immunohistochemistry in the identification of nitric oxide synthase isoenzymes in myocardial infarction. Cardiovasc Res 1995;29:526-31.
28. Shah AM, Lewis MJ, Henderson AH. Effects of 8-bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle. J Mol Cell Cardiol 1990;23:55-64.
29. Grocott-Mason R, Fort S, Lewis MJ, Shah AM. Myocardial relaxant effect of exogenous nitric oxide in the isolated ejecting heart. Am J Physiol 1994;266:H1699-705.
30. Grocott-Mason RM, Anning PB, Evans H, Lewis MJ, Shah AM. Modulation of left ventricular relaxation in isolated ejecting heart by endogenous nitric oxide. Am J Physiol 1994;267:H1804-13.
31. Shah AM, Spurgeon H, Sollott SJ, Talo A, Lakatta EG. 8-bromo cyclic GMP reduces the myofilament response to calcium in intact cardiac myocytes. Circ Res 1994;74:970-8.
32. Pfitzer G, Rüegg JC, Flockerzi V, Hofmann F. cGMP-dependent protein kinase decreases calcium sensitivity of skinned cardiac fibers. FEBS Lett 1982;149:171-5.
33. Hajjar RJ, Gwathmey JK. Effect of cyclic GMP in human myocardium: role of cAMP/cGMP balance (abstract). J Am Coll Cardiol 1995, 25:414A.
34. Lakatta EG, Sollott SJ, Janczewski AM, et al. Mechanisms of relaxation: perspectives from studies in single cardiac cells. In: Lorell BH, Grossman W, eds. Diastolic Relaxation of the Heart. Kluwer Academic Publishers, Boston, 1994, pp. 149-65.
35. Balligand JL, Kelly RA, Marsden PA, Smith TW, Michel T. Control of cardiac muscle function by an endogenous nitric oxide signalling system. Proc Natl Acad Sci USA 1993;90:347-51.
36. Balligand JL, Kobzik L, Han X, Kaye DM, et al. Nitric oxide-dependent parasympathetic signalling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem 1995;270:14582-6.
37. Kobzik L, Reid MB, Bredt DS, Stamler JS. Nitric oxide in skeletal muscle. Nature 1994;372:546-8.
38. Hare JM, Keaney JF, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Role of nitric oxide in parasympathetic modulation of β-adrenergic myocardial contractility in dogs. J Clin Invest 1995;95:360-6.
39. Han X, Shimoni Y, Giles WR. An obligatory role for nitric oxide in autonomic control of mammalian heart rate. J Physiol 1994;476.2:309-14.
40. Roberts AB, Vodovotz Y, Roche NS, Sporn MB, Nathan CF. Role of nitric oxide in antagonistic effects of transforming growth factor-β and interleukin-1β on the beating rate of cultured cardiac myocytes. Mol Endocrinol 1992;6:1921-30.
41. Shindo T, Ikeda U, Ohkawa F, et al. Nitric oxide synthesis in rat cardiac myocytes and fibroblasts. Life Sci 1994;55:1101-8.
42. ++-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular myocytes. J Pharmacol Exp Ther 1993;266:919-25.
43. Wahler GM, Dollinger S. Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase. Am J Physiol 1995;268:C45-54.
44. 2+ current. J Biol Chem 1994;268:26286-95.
45. Kirstein M, Rivet-Bastide M, Hatem S, Bénardeau A, Mercadier JJ, Fischmeister R. Nitric oxide regulates the calcium current in isolated human atrial myocytes. J Clin Invest 1995;95:794-802.
46. Mohan P, Sys SU, Brutsaert DL. Nitric oxide donors induce a positive inotropic effect mediated by cGMP in isolated cardiac muscle without endothelium (abstract). Eur Heart J 1994;15(abstr. suppl.):114.
47. Kojda G, Kottenberg K, Nix P, Schluter KD, Piper HM. Opposite responses of rat cardiac myocytes to different nitrovasodilators (abstract). Circulation 1994;90:I-592.
48. Brady AJB, Warren JB, Poole-Wilson PA, Williams TJ, Harding SE. Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol 1993;265:H176-82.
49. Lincoln TM, Cornwell TL. Intracellular cyclic GMP receptor proteins. FASEB J 1993;7:328-38.
50. Clemo HF, Baumgarten CM. Atrial natriuretic factor decreases cell volume of rabbit atrial and ventricular myocytes. Am J Physiol 1991;260:C681-90.
51. 4-induced cardiac hypertrophy. Am J Physiol 1995;268:H686-91.
52. Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science 1993;258:1898-902.
53. Shen W, Xu X, Ochoa M, Zhao G, Wolin MS, Hintze TH. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ Res 1994;75:1086-95.
54. Schweizer M, Richter C. Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension. Biochem Biophys Res Commun 1994;204:169-75.
55. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620-4.
56. Pryor WA, Squadrito GL. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 1995;268:L699-722.
57. Lamontagne D, Pohl U, Busse R. Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ Res 1992;70:123-30.
58. Hutcheson IR, Griffith TM. Release of endothelium-derived relaxing factor is modulated both by frequency and amplitude of pulsatile flow. Am J Physiol 1991;261:H257-62.
59. Wang J, Wolin MS, Hintze TH. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ Res 1993;73:829-38.
60. Winlaw DS, Smythe GA, Keogh AM, Schyvens CG, Spratt PM, Macdonald PS. Increased nitric oxide production in heart failure. Lancet 1994;344:373-4.
61. Lorell BH. Left ventricular hypertrophy: the consequences for diastole. In: WH Gaasch, MM LeWinter, eds. Left Ventricular Diastolic Dysfunction and Heart Failure. Lea & Febiger, Malvern, 1994, pp. 345-53.
62. Hausdorf G, Banner NR, Mitchell A, Khagani A, Martin M, Yacoub M. Diastolic function after cardiac and heart-lung transplantation. Br Heart J 1989;62:123-32.
63. McDonald KM, Francis GS, Matthews J, Hunter DW, Cohn JN. Chronic oral nitrate therapy prevents long-term ventricular remodelling in the dog. J Am Coll Cardiol 1993;21:514-22.
64. Shah AM, Silverman HS, Griffith EJ, Spurgeon HA, Lakatta EG. Cyclic GMP prevents delayed relaxation at reoxygenation following brief hypoxia in isolated cardiac myocytes. Am J Physiol 1995;268:H2396-404.
65. Hasebe N, Shen YT, Vatner SF. Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs. Circulation 1993;88:2862-71.
66. Ehring T, Baumgart D, Krajcar M, Hümmelgen M, Kompa S, Heusch G. Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide. Circulation 1994;90:1368-85.
67. Schluter KD, Weber M, Schraven E, Piper HM. NO donor SIN-1 protects against reoxygenation-induced cardiomyocyte injury by a dual action. Am J Physiol 1994;267:H1461-6.
68. Pinsky DJ, Oz MC, Koga S, et al. Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway. J Clin Invest 1994;93:2291-7.
69. Vegh A, Szekeres L, Parratt J. Preconditioning of the ischaemic myocardium; involvement of the L-arginine nitric oxide pathway. Br J Pharmacol 1992;107:648-52.
70. Patel VC, Yellon DM, Singh KJ, Neild GH, Woolfson RG. Inhibition of nitric oxide limits infarct size in the in situ rabbit heart. Biochem Biophys Res Commun 1993;194:234-8.
71. G-nitro-l-arginine improves myocardial function following ischaemia/reperfusion in isolated perfused rat heart. J Mol Cell Cardiol 1995;27:419-26.
72. Brady AJB, Poole-Wilson PA, Harding SE, Warren JB. Nitric oxide within cardiac myocytes reduces their contractility in endotoxaemia. Am J Physiol 1992;263:H1963-6.
73. Evans HG, Lewis MJ, Shah AM. Interleukin-1β modulates myocardial contraction via dexamethasone-sensitive production of nitric oxide. Cardiovasc Res 1993;27:1486-90.
74. Balligand JL, Ungureanu D, Kelly RA, et al. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest 1993;91:2314-9.
75. i and cell contraction in cultured chick ventricular myocytes. Circ Res 1994;75:285-95.
76. Schulz R, Panas DL, Catena R, Moncada S, Olley PM, Lopaschuk GD. The role of nitric oxide in cardiac depression induced by interleukin-1β and tumour necrosis factor-α. Br J Pharmacol 1995;114:27-34.
77. Lancaster JR, Langrehr JM, Bergonia HA, Murase N, Simmons RL, Hoffman RA. EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. J Biol Chem 1992;267:10994-8.
78. Yang X, Chowdhury N, Cai B, et al. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Invest 1994;94:714-21.
79. Tsujino M, Hirata Y, Imai T, et al. Induction of nitric oxide synthase gene by interleukin-1β in cultured rat cardiocytes. Circulation 1994;90:375-83.
80. Balligand JL, Ungureanu-Longrois D, Simmons WW, et al. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. J Biol Chem 1994;269:27580-8.
81. Morris SM, Billiar TR. New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol 1994;266:E829-39.
82. Balligand JL, Ungureanu-Longrois D, Simmons WW, et al. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1β and IFN-γ. Am J Physiol 1995;268:H1293-303.
83. Smith JA, Radomski MW, Schulz R, Moncada S, Lewis MJ. Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase. Br J Pharmacol 1993;108:1107-1110.
84. De Beider AJ, Radomski MW, Why HJF, et al. Nitric oxide synthase in human myocardium. Lancet 1993;341:84-5.
85. Decking UKM, Flesche CW, Gödecke A, Schrader J. Endotoxin-induced contractile dysfunction in guinea pig hearts is not mediated by nitric oxide. Am J Physiol 1995;268:H2460-5.
86. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992;257:387-9.
87. Karupiah G, Xie Q, Buller RML, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science 1993;261:1445-8.
88. Aitken K, Peninger J, Mak T, et al. Increased susceptibility to Coxsackie viral myocarditis in IRF-1 transgenic knockout mice (abstract). Circulation 1994;90:I-139.
89. Paul M, Bachmann J, Ganten D. The tissue renin-angiotensin systems in cardiovascular disease. Trends Cardiovasc Med 1992;2:94-9.
90. Linz W, Wiemer G, Gohlke P, Unger T, Schölkens BA. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol Rev 1995;47:25-49.
91. Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. J Clin Invest 1990;86:1913-20.
92. Urata H, Healy B, Stewart RW, Bumpus FM, Husain A. Angiotensin II-forming pathways in normal and failing human hearts. Circ Res 1990;66:883-90.
93. Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 1990;265:22348-57.
94. Kinoshita A, Urata H, Bumpus FM, Husain A. Measurement of angiotensin I converting enzyme inhibition in the heart. Circ Res 1993;73:51-60.
95. Baumgarten C, Linz W, Kunkel G, Scholkens B, Wiemer G. Ramiprilat increases bradykinin outflow from isolated hearts of rat. Br J Pharmacol 1993;108:293-5.
96. Hecker M, Porsti I, Bara A, Busse R. Potentiation by ACE inhibitors of the dilator response to bradykinin in the coronary microcirculation: interaction at the receptor level. Br J Pharmacol 1994;111:238-44.
97. Lang D, Shah AM, Lewis MJ. Angiotensin converting enzyme (ACE) activity: aortic and endocardial endothelium compared. Endothelium 1996;4:51-61.
98. Katwa LC, Ratajska A, Cleutjens JPM, et al. Angiotensin converting enzyme and kininase-II-like activities in cultured valvular interstitial cells of the rat heart. Cardiovasc Res 1995;29:57-64.
99. Busse R, Lamontagne D. Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting enzyme in human endothelial cells. Naunyn-Schmiedberg's Arch Pharmacol 1991;344:126-9.
100. Cambien F, Poirier O, Lecerf L, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992;359:641-4.
101. Swedburg K, Held P, Kjekshus J, Rasmussen K, Ryden L, Wedel H. On behalf of the CONSENSUS II study group. Effects of early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative North Scandinavian Enalapril Survival Study II (CONSENSUS II). N Engl J Med 1992;327:678-84.
102. The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992;327:685-91.
103. The AIRE Study Investigators. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 1993;342:821-28.
104. ISIS Collaborative Group. A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 1995;345:669-85.
105. 1 receptor subtype. Circ Res 1993;73:413-23.
106. Neyses L, Vetter H. Action of atrial natriuretic peptide and angiotensin II on the myocardium: studies in isolated rat ventricular cardiomyocytes. Biochem Biophys Res Commun 1989;163:1435-43.
107. Meulemans AL, Andries LJ, Brutsaert DL. Does endocardial endothelium mediate positive inotropic response to angiotensin I and angiotensin II? Circ Res 1990;66:1591-601.
108. Holubarsch C, Hasenfuss G, Schmidt-Schweda S, et al. Angiotensin I and II exert inotropic effects in atrial but not ventricular human myocardium. Circulation 1993;88:1228-37.
109. Moravec CS, Schluchter MD, Paranandi L, et al. Inotropic effects of angiotensin II on human cardiac muscle in vitro. Circulation 1990;82:1973-84.
110. 2+ channel current by angiotensin II in rabbit ventricular myocytes. Circ Res 1994;75:1121-5.
111. 2+ and pH in isolated beating rabbit hearts and myocytes loaded with the indicator indo-1. J Physiol 1994;480.2:203-15.
112. Matsui H, Barry WH, Livsey C, Spitzer KW. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res 1995;29:215-21.
113. 2+ current in sinoatrial node cells of rabbits. Am J Physiol 1995;268:H1053-60.
114. Pelc L, Gross G, Warltier D. Mechanism of coronary vasodilation produced by bradykinin. Circulation 1991;83:2048-56.
115. Yang S, Cheek DJ, Westfall DP, Buxton ILO. Purinergic axis in cardiac blood vessels. Agonist-mediated release of ATP from cardiac endothelial cells. Circ Res 1994;74:401-7.
116. Anning PB, Grocott-Mason RM, Lewis MJ, Shah AM. Enhancement of left ventricular relaxation in the isolated heart by an angiotensin converting-enzyme inhibitor. Circulation 1995;92: 2660-5.
117. Haber H, Powers E, Gimple L, et al. Intracoronary angiotensin-converting enzyme inhibition improves diastolic function in patients with hypertensive left ventricular hypertrophy. Circulation 1994;89:2616-25.
118. Friedrich S, Lorell B, Rousseau M, et al. Intracardiac angiotensin-converting enzyme inhibition improves diastolic function in patients with left ventricular hypertrophy due to aortic stenosis. Circulation 1994;90:2761-71.
119. Foult JM, Tavolaro O, Antony I, Nitenberg A. Direct myocardial and coronary effects of enalaprilat in patients with dilated cardiomyopathy: assessment by a bilateral intracoronary infusion technique. Circulation 1988;77:337-44.
120. 2 receptors in adult myocardium and neonatal rat cardiomyocytes. Circ Res 1995;76:773-80.
121. 2-bradykinin receptor antagonist HOE140 abolishes the antihypertrophic effect of ramipril. Br J Pharmacol 1992;105:771-2.
122. McDonald KM, Mock J, D'Aloia A, et al. Bradykinin antagonism inhibits the antigrowth effect of converting enzyme inhibition in the dog myocardium after discrete transmural myocardial necrosis. Circulation 1995;91:2043-8.
123. Kangawa K, Matsuo H. Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide. Biochem Biophys Res Commun 1984;118:131-9.
124. Sudoh T, Kangawa K, Minamino N, Matsuo H. A new natriuretic peptide in porcine brain. Nature 1988;332:78-81.
125. Sudoh T, Minamino N, Kangawa K, Matsuo H. C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 1990;168:863-70.
126. Minamino N, Makino Y, Tateyama H, Kangawa K, Matsuo H. Characterization of immunoreactive human C-type natriuretic peptide in brain and heart. Biochem Biophys Res Commun 1991;179:535-42.
127. 2+-ATPase gene. Circ Res 1992;71:9-17.
128. Stingo AJ, Clavell AL, Heublein DM, Wei CM, Pittelkow MR, Burnett JC. Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Physiol 1992;263:H1318-21.
129. Suga S, Nakao K, Itoh H, et al. Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-β. J Clin Invest 1992;90:1145-9.
130. Brandt RR, Heublein DM, Mattingly MT, Pittelkow MR, Burnett JC. Presence and secretion of atrial natriuretic peptide from cultured human aortic endothelial cells. Am J Physiol 1995;268:H921-5.
131. Claycombe KJ, Lee DW, Miller HA. Proportions of rat ANP-secreting cells that are cardiomyocytes and that synthesize the hormone. Am J Physiol 1995;268:H265-70.
132. Fukuda Y, Hirata Y, Yoshimi H, Kojima T, Kobayashi Y, Yanagisawa M, Masaki T. Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes. Biochem Biophys Res Commun 1988;155:167-72.
133. Suzuki E, Hirata Y, Kohmoto O, et al. Cellular mechanisms for synthesis and secretion of atrial natriuretic peptide and brain natriuretic peptide in cultured rat atrial cells. Circ Res 1992;71:1039-48.
134. Lew RA, Baertschi AJ. Endothelial cells stimulate ANF secretion from atrial myocytes in co-culture. Biochem Biophys Res Commun 1989;163:701-9.
135. Lew RA, Baertschi AJ. Endothelium-dependent ANF secretion in vitro. Am J Physiol 1992;263:H1071-7.
136. Suga S, Nakao K, Hosoda K, et al. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 1992;130:229-39.
137. Hu RM, Levin ER, Pedram A, Frank HJL. Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. J Biol Chem 1992;267:17384-9.
138. Kohno M, Horio T, Yokokawa K, Kurihara N, Takeda T. C-type natriuretic peptide inhibits thrombin- and angiotensin II-stimulated endothelin release via cyclic guanosine 3′,5′-monophosphate. Hypertension 1992;19:320-5.
139. Rutherford RAD, Wharton J, Gordon L, Moscoso G, Yacoub MH, Polak JM. Endocardial localization and characterization of natriuretic peptide binding sites in human fetal and adult heart. Eur J Pharmacol 1992;212:1-7.
140. Meulemans AL, Sipido KR, Sys SU, Brutsaert DL. Atriopeptin III induces early relaxation of isolated mammalian papillary muscle. Circ Res 1988;62:1171-4.
141. Vaxelaire JF, Laurent S, Lacolley P, Briand V, Schmitt H, Michel JB. Atrial natriuretic peptide decreases contractility of cultured chick ventricular cells. Life Sci 1989;45:41-8.
142. McCall D, Fried TA. Effect of atriopeptin II on Ca influx, contractile behavior and cyclic nucleotide content of cultured neonatal rat myocardial cells. J Mol Cell Cardiol 1990;22:201-12.
143. + current in fetal single ventricular cells. J Mol Cell Cardiol 1993;25:1305-16.
144. Cramb G, Banks R, Rugg EL, Aiton JF. Actions of atrial natriuretic peptide (ANP) on cyclic nucleotide concentrations and phosphatidylinositol turnover in ventricular myocytes. Biochem Biophys Res Commun 1987;148:962-70.
145. Anand-Srivastava MB, Cantin M. Atrial natriuretic factor receptors are negatively coupled to adenylate cyclase in cultured atrial and ventricular cardiocytes. Biochem Biophys Res Commun 1986;138:427-36.
146. 2+ channel activity by human natriuretic peptide in rabbit heart cells. Br J Pharmacol 1995;114;1076-82.
147. + current in human atrial cells. Pflügers Arch 1992;421:486-91.
148. Gisbert MP, Fischmeister R. Atrial natriuretic factor regulates the calcium current in frog isolated cardiac cells. Circ Res 1988;62:660-7.
149. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by endothelial cells. Nature 1988;332:411-5.
150. Rubanyi GM, Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 1994;46:325-415.
151. Nishida M, Springhorn JP, Kelly RA, Smith TW. Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture. J Clin Invest 1993;91:1934-41.
152. Mebazaa A, Mayoux E, Maeda K, Lakatta EG, Robotham JL, Shah AM. Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin. Am J Physiol 1993;265:H1841-6.
153. Siney L, Lewis MJ. Nitric oxide modulates endothelin release from porcine cultured endocardial endothelium. Endothelium 1994;2:169-75.
154. Suzuki T, Kumazaki T, Mitsui Y. Endothelin 1 is produced and secreted by neonatal rat cardiac myocytes in vitro. Biochem Biophys Res Commun 1993;191:823-30.
155. Tonnessen T, Giaid A, Saleh D, Naess PA, Yanagisawa M, Christensen G. Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia. Circ Res 1995;76:767-72.
156. Eid H, Kuroski de Bold M, Chen JH, de Bold AJ. Epicardial mesothelial cells synthesize and release endothelin. J Cardiovasc Pharmacol 1994;24:715-20.
157. Chua BHL, Chua CC, Diglio CA, Siu BB. Regulation of endothelin-1 mRNA by angiotensin II in rat heart endothelial cells. Biochim Biophys Acta 1993;1178:201-6.
158. Ito H, Hirata Y, Adachi S, et al. Endothelin-1 is an autocrine/paracrine factor in mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 1993;92:398-403.
159. Hirata Y, Fukuda Y, Yoshimi H, Emori T, Shichiri M, Marumo F. Specific receptor for endothelin in cultured rat cardiocytes. Biochem Biophys Res Commun 1989;160:1438-44.
160. Ono K, Eto K, Sakomoto A, et al. Negative chronotropic effect of endothelin 1 mediated through ETA receptor in guinea pig atria. Circ Res 1995;76:284-92.
161. Moody CJ, Dashwood MR, Sykes RM, et al. Functional and autoradiographic evidence for endothelin 1 receptors on human and rat cardiac myocytes. Comparison with single smooth muscle cells. Circ Res 1990;67:764-9.
162. Molenaar P, O'Reilly G, Sharkey A, et al. Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium. Circ Res 1993;72:526-38.
163. Hilal-Dandan R, Urasawa K, Brunton LL. Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes. J Biol Chem 1992;267:10620-4.
164. Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive inotropic effect of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol 1988;255:H970-3.
165. Hu JR, Von Harsdorf R, Lang RE. Endothelin has potent inotropic effects in rat atria. Eur J Pharmacol 1988;158:275-8.
166. Shah AM, Lewis MJ, Henderson AH. Inotropic effects of endothelin in ferret ventricular myocardium. Eur J Pharmacol 1989;163:365-7.
167. 2+ responsiveness in aequorin-loaded ferret myocardium. Circ Res 1991;69:582-9.
168. Takanashi M, Endoh M. Characterization of the positive inotropic effect of endothelin on mammalian ventricular myocardium. Am J Physiol 1991;261:H611-9.
169. Moravec CS, Reynolds EE, Stewart RW, Bond M. Endothelin is a positive inotropic agent in human and rat heart in vitro. Biochem Biophys Res Commun 1989;159:14-18.
170. Vigne P, Breittmayer JP, Frelin C. Thapsigargin, a new inotropic agent, antagonizes action of endothelin-1 in rat atrial cells. Am J Physiol 1992;263:H1689-94.
171. Kelly RA, Eid H, Kramer BK, et al. Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway. J Clin Invest 1990;86:1164-71.
172. 2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes. J Physiol 1992;448:729-47.
173. Furukawa T, Ito H, Nitta J, et al. Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes. Circ Res 1992;71:1242-53.
174. + exchanger. Circ Res 1990;68:269-79.
175. Wang J, Flemal K, Morgan JP. Endothelin-1 enhances cross-bridge function of ferret myocardium: role of second messengers. Am J Physiol 1993;265:H2168-74.
176. 2+ transient and contractility in ferret myocardium. Circ Res 1992;71:631-9.
177. Shah AM, Mebazaa A, Lakatta EG. Factors released by endothelial cells modulate cardiac diastolic tone (abstract). Circulation 1993;88:I-86.
178. + current in atrial cells. Circ Res 1991;69:250-5.
179. Ono K, Tsujimoto G, Sakomoto A, et al. Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents. Nature 1994;370:301-4.
180. James AF, Xie LH, Fujitani Y, Hayashi S, Horie M. Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1. Nature 1994;370:297-300.
181. Wagner OF, Christ G, Wojta J, et al. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 1992;267:16066-8.
182. McClellan G, Weisberg A, Rose D, Winegrad S. Endothelial cell storage and release of endothelin as a cardioregulatory mechanism. Circ Res 1994;70:787-803.
183. Evans HG, Lewis MJ, Shah AM. Modulation of myocardial relaxation by basal release of endothelin from endocardial endothelium. Cardiovasc Res 1994;28:1694-9.
184. 2+ responsiveness in aequorin-loaded ferret myocardium. Cire Res 1992;70:754-760.
185. McClellan G, Weisberg A, Winegrad S. Endothelin regulation of cardiac contractility in absence of added endothelin. Am J Physiol 1995;268:H1621-7.
186. Prendergast BP, Anning PB, Lewis MJ, Shah AM. Endogenous endothelin modulates left ventricular relaxation in the isolated heart (abstract). Br Heart J 1995;73:P46.
187. Teerlink JR, Carteaux JP, Sprecher U, Lüffler BM, Clozel M, Clozel JP. Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs. Am J Physiol 1995;268:H432-40.
188. Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A. Contribution of endogenous endothelin to extension of myocardial infarct size in rats. Circ Res 1991;69:370-7.
189. De Keulenaer GW, Andries LJ, Sys SU, Brutsaert DL. Endothelin-mediated positive inotropic effect induced by reactive oxygen species in isolated cardiac muscle. Circ Res 1995;76:878-84.
190. 125I]endothelin-1 binding to rat cardiac membranes. J Cardiovasc Pharmacol 1990;15:436-43.
191. Wang QD, Hemsén A, Li XS, Lundberg JM, Uriuda Y, Pernow J. Local overflow and enhanced tissue content of endothelin following myocardial ischaemia and reperfusion in the pig: modulation by L-arginine. Cardiovasc Res 1995;29:44-9.
192. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. Circ Res 1994;75:369-78.
193. Hayashida W, Donckier J, Van Mechelen H, Stoleru L, Pouleur H. Endothelin-1 exacerbates diastolic stunning in conscious dogs. Am J Physiol 1993;265:H1688-95.
194. Grover GJ, Dzwonczyk S, Parham CS. The endothelin-1 receptor antagonist BQ123 reduces infarct size in a canine model of coronary occlusion and reperfusion. Cardiovasc Res 1993;27:1613-8.
195. Han H, Neubauer S, Braeker B, Ertl G. Endothelin-1 contributes to ischemia/reperfusion injury in isolated rat heart - attenuation of ischemic injury by the endothelin-1 antagonists BQ123 and BQ610. J Mol Cell Cardiol 1995;27:761-6.
196. Shubeita HE, McDonough PM, Harris AN, et al. Endothelin induction of inositol phosholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. J Biol Chem 1990;265:13809-17.
197. Bogoyevitch MA, Glennon PE, Sugden PH. Endothelin 1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes. FEBS Lett 1993;317:271-5.
198. Ito H, Hiroe M, Hirata Y, et al. Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload. Circulation 1994;89:2198-203.
199. Dusting GJ, MacDonald PS. Prostacyclin and vascular function: implications for hypertension and atherosclerosis. Pharmacol Ther 1990;323-44.
200. 2. J Mol Cell Cardiol 1993;25:245-8.
201. Mullane KM, Fornabiaio D. Thromboxane synthetase inhibitors reduce infarct size by a platelet-dependent, aspirin-sensitive mechanism. Circ Res 1988;62:668-78.
202. Farber NE, Pieper GM, Thomas JP, Gross GJ. Beneficial effects of iloprost in the stunned canine myocardium. Circ Res 1988;62:204-15.
203. Schrör K, Hohfeld T. Inotropic effects of eicosanoids. Basic Res Cardiol 1992;87:2-11.
204. Fassina G, Tessari F, Dorigo P. Positive inotropic effect of a stable analogue of PGI2 in isolated guinea pig atria. Mechanism of action. Pharmacol Res Commun 1983;15:735-49.
205. 2+ exchange in isolated myocardial muscle cells. Prostaglandins Leukotr Med 1983;12:305-14.
206. Couttenye MM, De Clerck NM, Herman AG, Brutsaert DL. Effects of prostacyclin on contractile properties of isolated mammalian cardiac muscle. J Cardiovasc Pharmacol 1985;9:971-6.
207. Liang BT. Adenosine receptors and cardiovascular function. Trends Cardiovasc Med 1992;2:100-8.
208. Burnstock G. Vascular control by purines with emphasis on the coronary system. Eur Heart J 1989;10(suppl. F):15-21.
209. 2b receptors in cultured fetal chick heart cells. Circ Res 1995;76:242-51.
210. Downey JM, Liu GS, Thornton JD. Adenosine and the anti-infarct effects of preconditioning. Cardiovasc Res 1993;27:3-8.
211. Anning P, Grocott-Mason R, Lewis MJ, Shah AM. Adenylpurines contribute to the myocardial relaxant effects of bradykinin in the intact heart (abstract). Br Heart J 1994;71 (suppl.):P48.
212. Danziger RS, Raffaeli S, Moreno-Sanchez R, et al. Extracellular ATP has a potent effect to enhance cytosolic calcium and contractility in single ventricular myocytes. Cell Calcium 1988;9:193-9.
213. Scamps F, Legssyer A, Mayoux E, Vassort G. The mechanism of positive inotropy induced by adenosine triphosphate in rat heart. Circ Res 1990;67:1007-16.
214. Legssyer A, Pogglioli J, Renard D, Vassort G. ATP and other adenosine compounds increase mechanical activity and inositol trisphosphate production in rat heart. J Physiol 1988;401:185-99.
215. Shah AM, Mebazaa A, Wetzel RC, Lakatta EG. Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells. Circulation 1994;89:2492-7.
216. Ramaciotti C, McClellan G, Sharkey A, Rose D, Wiseberg A, Winegrad S. Cardiac endothelial cells modulate contractility of rat heart in response to oxygen tension and coronary flow. Circ Res 1993;72:1044-64.
217. McClellan G, Wiseberg A, Kato NS, Ramaciotti C, Sharkey A, Winegrad S. Contractile proteins in myocardial cells are regulated by factor(s) released by blood vessels. Circ Res 1992;70:787-803.
218. Pepper CB, Lang D, Lewis MJ, Shah AM. Endothelial inhibition of myofilament calcium response in intact cardiac myocytes. Am J Physiol 1995;269:H1538-44.
219. McClellan G, Wiseberg A, Lin LE, Rose D, Ramaciotti C, Winegrad S. Endothelial cells are required for the cAMP regulation of cardiac contractile proteins. Proc Natl Acad Sci USA 1993;90:2885-9.
220. 2+-independent inhibition of actomyosin crossbridge cycling in cardiac myocytes by endothelial cell factors in response to hypoxia (abstract). J Physiol 1994;475.P:80P.
221. Ross J. Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 1991;83:1076-83.
222. Nishida M, Carley WW, Gerritsen ME, Ellingsen O, Kelly RA, Smith TW. Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am J Physiol 1993;264:H639-52.
223. Lakatta EG. Length modulation of muscle performance. Frank-Starling law of the heart. In: Fozzard HA, ed. The Heart and Cardiovascular System. Raven Press, New York, 1992, pp. 1325-51.
224. Shah AM, Prendergast B, Grocott-Mason RM, Lewis MJ, Paulus WJ. The influence of endothelium-derived nitric oxide on myocardial contractile function. Int J Cardiol 1995;50:225-31.