The purinergic P2×7 receptor is expressed on monocytes in Behçet's disease and is modulated by TNF-α

European Journal of Immunology

Volumn 44, Issue 1, 2014, Pages 227-238

  Castrichini, Monica ^a   Lazzerini, Pietro Enea ^a   Gamberucci, Alessandra ^a   Capecchi, Pier Leopoldo ^a   Franceschini, Rossella ^a   Natale, Mariarita ^a   Hammoud, Mohamed ^a   Moramarco, Antonio ^a   Zimbone, Stefania ^a   Gianchecchi, Elena ^a,b   Montilli, Cinzia ^a   Ricci, Gianluca ^a   Selvi, Enrico ^a   Cantarini, Luca ^a   Galeazzi, Mauro ^a   Laghi Pasini, Franco ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Beh et's disease; IL 1 ; Monocytes; P2 7 receptor; TNF

Indexed keywords

2' 3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BEHCET DISEASE; CALCIUM TRANSPORT; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; INNATE IMMUNITY; ION PERMEABILITY; MALE; MIDDLE AGED; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

BEHÇET'S DISEASE; IL-1Β; MONOCYTES; P2 × 7 RECEPTOR; TNF-Α;

ADENOSINE TRIPHOSPHATE; ADULT; BEHCET SYNDROME; BIOLOGICAL TRANSPORT, ACTIVE; CALCIUM; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1BETA; ION TRANSPORT; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MONOCYTES; PLATELET AGGREGATION INHIBITORS; PURINERGIC P2X RECEPTOR AGONISTS; RECEPTORS, PURINERGIC P2X7; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84892457590     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343353     Document Type: Article

References (42)

1. Di Virgilio, F., Liaisons dangereuses: P2×7 and the inflammosoma. Trends. Pharmacol. Sci. 2007. 28: 465-472.
2. Martinon, F. and Tschopp, J., Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004. 117: 561-574.
3. Lachmann, H. J., Quartier, P., So, A. and Hawkins, P. N., The emerging role of interleukin-1β in autoinflammatory diseases. Arthritis Rheum. 2011. 63: 314-324.
4. Galeazzi, M., Gasbarrini, G., Ghirardello, A., Grandemange, S., Hoffman, H. M., Manna, R., Podswiadek, M. et al., Autoinflammatory syndromes. Clin. Exp. Rheumatol. 2006. 24: S79-S85.
5. Dinarello, C. A., Blocking interleukin-1β in acute and chronic autoinflammatory diseases. J. Intern. Med. 2011. 269: 16-28.
6. Mendes, D., Correia, M., Barbero, M., Vaio, T., Mota, M., Gonçalves, O. and Valente, J., Behçet's disease - a contemporary review. J. Autoimmun. 2009. 32: 178-188.
7. Direskeneli, H., Autoimmunity vs autoinflammation in Behcet's disease: do we oversimplify a complex disorder? Rheumatology 2006. 45: 1461-1465.
8. Yosipovitch, G., Shohat, B., Bshara, J., Wysenbeek, A. and Weinberger, A., Elevated serum interleukin 1 receptors and interleukin 1β in patients with Behçet's disease: correlations with disease activity and severity. Isr. J. Med. Sci. 1995. 31: 345-348.
9. Pay, S., Erdem, H., Pekel, A., Simsek, I., Musabak, U., Sengul, A. and Dinc, A., Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behcet's disease. Does interleukin-1β play a major role in Behçet's synovitis? Rheumatol. Int. 2006. 26: 608-613.
10. Botsios, C., Sfriso, P., Furlan, A., Punzi, L. and Dinarello, C. A., Resistant Behçet's disease responsive to anakinra. Ann. Intern. Med. 2008. 149: 284-286.
11. Bilginer, Y., Ayaz, N. A. and Ozen, S., Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behçet's disease. Clin. Rheumatol. 2010. 29: 209-210.
12. Arida, A., Fragiadaki, K., Giavri, E. and Sfikakis, P. P., Anti-TNF- agents for Behçet's disease: analysis of published data on 369 patients. Semin. Arthritis Rheum. 2011. 41: 61-70.
13. Evereklioglu, C., Er, H., Türköz, Y. and Cekmen, M., Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease. Mediators Inflamm. 2002. 11: 87-93.
14. Düzgün, N., Ayaşlioǧlu, E., Tutkak, H. and Aydintuǧ, O. T., Cytokine inhibitors: soluble tumor necrosis factor receptor 1 and interleukin-1 receptor antagonist in Behçet's disease. Rheumatol. Int. 2005. 25: 1-5.
15. Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E. et al., The P2×7 receptor: a key player in IL-1 processing and release. J. Immunol. 2006. 176: 3877-3883.
16. Rossi, L., Salvestrini, V., Ferrari, D., Di Virgilio, F. and Lemoli, R. M., The sixth sense: hematopoietic stem cells detect danger through purinergic signaling. Blood 2012. 120: 2365-2375.
17. Caporali, F., Capecchi, P. L., Gamberucci, A., Lazzerini, P. E., Pompella, G., Natale, M., Lorenzini, S. et al., Human rheumatoid synoviocytes express functional P2×7 receptors. J. Mol. Med. 2008. 86: 937-949.
18. Al-Shukaili, A., Al-Kaabi, J. and Hassan, B., A comparative study of interleukin-1beta production and p2×7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls. Inflammation 2008. 31: 84-90.
19. Portales-Cervantes, L., Niño-Moreno, P., Doníz-Padilla, L., Baranda-Candido, L., García-Hernández, M., Salgado-Bustamante, M., González-Amaro, R. et al., Expression and function of the P2X(7) purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis. Hum. Immunol. 2010. 71: 818-825.
20. Al-Shukaili, A., Al-Kaabi, J., Hassan, B., Al-Araimi, T., Al-Tobi, M., Al-Kindi, M., Al-Maniri, A. et al., P2×7 receptor gene polymorphism analysis in rheumatoid arthritis. Int. J. Immunogenet. 2011. 38: 389-396.
21. Matute, C., Torre, I., Pérez-Cerdá, F., Pérez-Samartín, A., Alberdi, E., Etxebarria, E., Arranz, A. M. et al., P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. J. Neurosci. 2007. 27: 9525-9533.
22. Oyanguren-Desez, O., Rodríguez-Antigüedad, A., Villoslada, P., Domercq, M., Alberdi, E. and Matute, C., Gain-of-function of P2×7 receptor gene variants in multiple sclerosis. Cell Calcium 2011. 50: 468-472.
23. Caragnano, M., Tortorella, P., Bergami, A., Ruggieri, M., Livrea, P., Specchio, L. M., Martino, G. et al., Monocytes P2×7 purinergic receptor is modulated by glatiramer acetate in multiple sclerosis. J. Neuroimmunol. 2012. 245: 93-97.
24. Cesaro, A., Brest, P., Hofman, V., Hébuterne, X., Wildman, S., Ferrua, B., Marchetti, S. et al., Amplification loop of the inflammatory process is induced by P2×7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration. Am. J. Physiol. Gastrointest. Liver Physiol. 2010. 299: G32-G42.
25. Gulbransen, B. D., Bashashati, M., Hirota, S. A., Gui, X., Roberts, J. A., MacDonald, J. A., Muruve, D. A. et al., Activation of neuronal P2×7 receptor-pannexin-1 mediates death of enteric neurons during colitis. Nat. Med. 2012. 18: 600-604.
26. Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H. et al., Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2×7 purinoceptors. Nat. Commun. 2012. 3: 1034-1045.
27. Gudipaty, L., Humphreys, B. D., Buell, G. and Dubyak, G. R., Regulation of P2×7 nucleotide receptor function in human monocytes by extracellular ions and receptor density. Am. J. Physiol. Cell. Physiol. 2001. 280: C943-C953.
28. Costa-Junior, H. M., Sarmento Vieira, F. and Coutinho-Silva, R., C terminus of the P2×7 receptor: treasure hunting. Purinergic Signal. 2011. 7: 7-19.
29. Jindrichova, M., Kuzyk, P., Li, S, Stojilkovic, S. S. and Zemkova, H., Conserved ectodomain cysteines are essential for rat P2×7 receptor trafficking. Purinergic Signal. 2012. 8: 317-325.
30. Gu, B. J., Zhang, W. Y., Bendall, L. J., Chessell, I. P., Buell, G. N. and Wiley, J. S., Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors. Am. J. Physiol. Cell. Physiol. 2000. 279: C1189-C1197.
31. Sun, C., Chu, J., Singh, S. and Salter, R. D., Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function. Purinergic Signal. 2010. 6: 31-45.
32. Bradley, H. J., Baldwin, J. M., Goli, G. R., Johnson, B., Zou, J., Sivaprasadarao, A., Baldwin, S. A. et al., Residues 155 and 348 contribute to the determination of P2×7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms. J. Biol. Chem. 2011. 286: 8176-8187.
33. Turan, B., Gallati, H., Erdi, H., Gürler, A., Michel, B. A. and Villiger, P. M., Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Behçet's disease; soluble TNF-R-75 as a biological marker of disease activity. J. Rheumatol. 1997. 24: 128-132.
34. Baud, V. and Karin, M., Signal transduction by tumor necrosis factor and its relatives. Trends Cell. Biol. 2001. 11: 372-377.
35. McInnes, I. B. and Schett, G., Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 2007. 7: 429-442.
36. Brown, S. J. and Mayer, L., The immune response in inflammatory bowel disease. Am. J. Gastroenterol. 2007. 102: 2058-2069.
37. Santos Lacomba, M., Marcos Martín, C., Gallardo Galera, J. M., Gómez Vidal, M. A., Collantes Estévez, E., Ramírez Chamond, R. and Omar, M., Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis. Ophthalmic Res. 2001. 33: 251-255.
38. Yarilina, A., Park-Min, K. H., Antoniv, T., Hu, X. and Ivashkiv, L. B., TNF-activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes. Nat. Immunol. 2008. 9: 378-387.
39. Saklatvala, J., Dean, J. and Clark, A., Control of the expression of inflammatory response genes. Biochem. Soc. Symp. 2003. 70: 95-106.
40. International Study Group for Behçet's disease. Criteria for diagnosis of Behçet's disease. Lancet 1990. 335: 1078-1080.
41. North, R. A., Molecular physiology of P2X receptors. Physiol. Rev. 2002. 82: 1013-1067.
42. Kenneth, A., Jacobson P2X and P2Y receptors. Tocris Bioscience Scientific Reviews Series 2010, No. 33, 1-16.