Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry

Toxicology Letters

Volumn 225, Issue 2, 2014, Pages 230-239

  Wang, Hong ^a   Li, Sifan ^a   Qi, Lei ^a   Xu, Wei ^a   Zeng, Yan ^a   Hou, Yurong ^a   Zhao, Xiujuan ^a   Sun, Changhao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

DDVP; Low dose chronic exposure; Metabonomics; Quercetin; Rat urine; UPLC MS

Indexed keywords

3 HYDROXYANTHRANILIC ACID; CHOLIC ACID; CITRIC ACID; CREATINE PHOSPHATE; CRESOL; DEOXYCHOLIC ACID; DICHLORVOS; ELCATONIN; ESTRONE SULFATE; HIPPURIC ACID; INDICAN; KYNURENIC ACID; OROTIC ACID; QUERCETIN; SEBACIC ACID; SULFATE; TAURINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; FEEDING; LONG TERM EXPOSURE; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; METABOLISM; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTECTIVE EFFECT; RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; WEIGHT CHANGE;

DDVP; LOW-DOSE CHRONIC EXPOSURE; METABONOMICS; QUERCETIN; RAT URINE; UPLC/MS;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CHROMATOGRAPHY, LIQUID; DICHLORVOS; INSECTICIDES; INTESTINES; MALE; MASS SPECTROMETRY; METABOLOMICS; QUERCETIN; RATS; RATS, WISTAR; TOXICITY TESTS, CHRONIC;

EID: 84892449262     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.12.017     Document Type: Article

References (58)

1. Ajiboso S., Gbate M., Ajari O., Adeyemo S. Sub chronic inhalation toxicity studies of 2,2-dichlorovinyl dimethyl phosphate (DDVP) in albino rats. Adv. Biol. Res. 2012, 6:133-140.
2. Ajiboye T.O. Redox status of the liver and kidney of 2,2-dichlorovinyl dimethyl phosphate (DDVP) treated rats. Chem. Biol. Interact. 2010, 185:202-207.
3. An D., Zhang Q., Wu S., Wei J., Yang J., Dong F., Yan X., Guo C. Changes of metabolic profiles in urine after oral administration of quercetin in rats. Food Chem. Toxicol. 2010, 48:1521-1527.
4. Baghel S.S., Shrivastava N., Baghel R.S., Agrawal P., Rajput S. A review of quercetin: antioxidant and anticancer properties. World J. Pharm. Sci. 2012, 1:146-160.
5. Barcelos G.R.M., Grotto D., Serpeloni J.M., Angeli J.P.F., Rocha B.A., de Oliveira Souza V.C., Vicentini J.T., Emanuelli T., Bastos J.K., Antunes L.M.G. Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Arch. Toxicol. 2011, 85:1151-1157.
6. Behling E.B., Sendao M.C., Francescato H.D., Antunes L.M., Costa R.S., de Lourdes P., Bianchi M. Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys. Pharmacol. Rep. 2006, 58:526-532.
7. Buang Y. The enlargements of liver size induced by orotic acid and di (2-ethyl hexyl) phthalate occur in different metabolic pathways. J. Appl. Pharm. Sci. 2011, 1:71-75.
8. Celik I., Yilmaz Z., Turkoglu V. Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats. Environ. Toxicol. 2009, 24:128-132.
9. de Loor H., Bammens B., Evenepoel P., De Preter V., Verbeke K. Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum. Clin. Chem. 2005, 51:1535-1538.
10. Dere E., Ari F., Ugur S. The effect of dichlorvos on acetylcholinesterase activity in some tissues in rats. Acta Vet. 2010, 60:123-131.
11. Desai S., Desai P. Changes in renal clearance and renal tubular function in albino mice under the influence of dichlorvos. Pestic. Biochem. Physiol. 2008, 91:160-169.
12. Dirican E.K., Kalender Y. Dichlorvos-induced testicular toxicity in male rats and the protective role of vitamins C and E. Exp. Toxicol. Pathol. 2012, 64:821-830.
13. Du L., Wang H., Xu W., Zeng Y., Hou Y., Zhang Y., Zhao X., Sun C. Application of ultra-performance liquid chromatography/mass spectrometry-based metabonomic techniques to analyze the joint toxic action of long-term low-level exposure to a mixture of organophosphate pesticides on rat urine profile. Toxicol. Sci. 2013, 134(1):195-206.
14. Greef J.v.d., Stroobant P., Heijden R.v.d. The role of analytical sciences in medical systems biology. Curr. Opin. Chem. Biol. 2004, 8:559-565.
15. Gregersen N., Mortensen P., Koelvraa S. On the biologic origin of C6-C10-dicarboxylic and C6-C10-ω-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the ω- and ω-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver. Pediatr. Res. 1983, 17:828-834.
16. Gregory S., Kelly N. Quercetin. Altern. Med. Rev. 2011, 16:172-194.
17. Guzy J., Chovanova Z., Marekova M., Chavková Z., Tomeckova V., Mojzisova G., Kusnir J. Effect of quercetin on paracetamol-induced rat liver mitochondria dysfunction. Biologia 2004, 59:399-404.
18. Gwacham N., Wagner D.R. Acute effects of a caffeine-taurine energy drink on repeated sprint performance of American college football players. Int. J. Sport Nutr. Exerc. Metab. 2012, 22:109-116.
19. Hoek-van den Hil E.F., Keijer J., Bunschoten A., Vervoort J.J., Stankova B., Bekkenkamp M., Herreman L., Venema D., Hollman P.C., Tvrzicka E. Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice. PLoS ONE 2013, 8:e51588.
20. Imae M., Asano T., Murakami S. Potential role of taurine in the prevention of diabetes and metabolic syndrome. Amino Acids 2012, 1-8.
21. Julka D., Pal R., Gill K. Neurotoxicity of dichlorvos: effect on antioxidant defense system in the rat central nervous system. Exp. Mol. Pathol. 1992, 56:144-152.
22. Kalender Y., Kaya S., Durak D., Uzun F.G., Demir F. Protective effects of catechin and quercetin on antioxidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats. Environ. Toxicol. Pharmacol. 2012, 33:141-148.
23. Kar V., Shrivastava M., Shrivastava S., Dhankhar N., Kumar S. Azathioprine induce TCA dysfunction due to oxidative stress and protective effect of qucertin in rat hepatocytes. Int. J. Res. Pharm. Biomed. Sci. 2011, 2:1297-1302.
24. Kebieche M., Lakroun Z., Lahouel M., Bouayed J., Meraihi Z., Soulimani R. Evaluation of epirubicin-induced acute oxidative stress toxicity in rat liver cells and mitochondria, and the prevention of toxicity through quercetin administration. Exp. Toxicol. Pathol. 2009, 61:161-167.
25. Kemp G., Taylor D., Radda G. Control of phosphocreatine resynthesis during recovery from exercise in human skeletal muscle. NMR Biomed. 1993, 6:66-72.
26. Knights K.M., Sykes M.J., Miners J.O. Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acids. Exp. Opin. Drug Metab. Toxicol. 2007, 3:159-168.
27. Kobori M., Masumoto S., Akimoto Y., Oike H. Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol. Nutr. Food Res. 2011, 55:530-540.
28. Krebs H.A., Johnson W.A. The role of citric acid in intermediate metabolism in animal tissues. FEBS Lett. 1980, 117:2-10.
29. Lafontaine A., Aerts J., Jacques P. Toxicity, carcinogenic, mutagenic, teratogenic action of dichlorvos. Arch. Belg. Med. Soc. 1981, 39:159-174.
30. Li S., Ran X.Q., Xu L., Wang J.F. microRNA and mRNA expression profiling analysis of dichlorvos cytotoxicity in porcine kidney epithelial PK15 cells. DNA Cell Biol. 2011, 30:1073-1083.
31. Lugo-Huitron R., Blanco-Ayala T., Ugalde-Muniz P., Carrillo-Mora P., Pedraza-Chaverri J., Silva-Adaya D., Maldonado P., Torres I., Pinzon E., Ortiz-Islas E. On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress. Neurotoxicol. Teratol. 2011, 33:538-547.
32. Masai N., Tatebe J., Yoshino G., Morita T. Indoxyl sulfate stimulates monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells by inducing oxidative stress through activation of the NADPH oxidase-nuclear factor-κB pathway. Circ. J. 2010, 74:2216-2224.
33. Morales A.I., Vicente-Sánchez C., Jerkic M., Santiago J.M., Sánchez-González P.D., Pérez-Barriocanal F., López-Novoa J.M. Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol. Appl. Pharmacol. 2006, 210:128-135.
34. Mortensen O.H., Olsen H.L., Frandsen L., Nielsen P.E., Nielsen F.C., Grunnet N., Quistorff B. A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine. J. Biomed. Sci. 2010, 17:S38.
35. Nicholson J.K., Lindon J.C., Holmes E. Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
36. Niwa T., Ise M., Miyazaki T. Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate. Am. J. Nephrol. 1994, 14:207-212.
37. Okamura A., Kamijima M., Shibata E., Ohtani K., Takagi K., Ueyama J., Watanabe Y., Omura M., Wang H., Ichihara G. A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats. Toxicology 2005, 213:129-137.
38. Pérez-Enciso M., Tenenhaus M. Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach. Hum. Genet. 2003, 112:581-592.
39. Pennington C., Ross P., Bouchier I. Serum bile acids in the diagnosis of hepatobiliary disease. Gut 1977, 18:903-908.
40. Platia M.P., Fencl M.d., Elkind-Hirsch K.E., Canick J.A., Tulchinsky D. Estrone sulfatase activity in the human brain and estrone sulfate levels in the normal menstrual cycle. J. Steroid Biochem. 1984, 21:237-241.
41. Rassi C.M., Lieberherr M., Chaumaz G., Pointillart A., Cournot G. Modulation of osteoclastogenesis in porcine bone marrow cultures by quercetin and rutin. Cell Tissue Res. 2005, 319:383-393.
42. Safe S.H. Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach. Environ. Health Perspect. 1998, 106:1051-1058.
43. Sai Y., Kaneko Y., Ito S., Mitsuoka K., Kato Y., Tamai I., Artursson P., Tsuji A. Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Drug Metab. Dispos. 2006, 34:1423-1431.
44. Sharma P., Singh R. Dichlorvos and lindane induced oxidative stress in rat brain: protective effects of ginger. Pharmacognosy Res. 2012, 4:27-32.
45. Sokol R.J., Straka M.S., Dahl R., Devereaux M.W., Yerushalmi B., Gumpricht E., Elkins N., Everson G. Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids. Pediatr. Res. 2001, 49:519-531.
46. Sun C.-Y., Hsu H.-H., Wu M.-S. p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells. Nephrol. Dial. Transpl. 2013, 28:70-78.
47. Swamy M.S., Sivanna N., Tamatam A., Khanum F. Effect of poly phenols in enhancing the swimming capacity of rats. Funct. Foods Health Dis. 2011, 1:482-491.
48. Terawaki H., Yoshimura K., Hasegawa T., Matsuyama Y., Negawa T., Yamada K., Matsushima M., Nakayama M., Hosoya T., Era S. Oxidative stress is enhanced in correlation with renal dysfunction: examination with the redox state of albumin. Kidney Int. 2004, 66:1988-1993.
49. Uzun F.G., Demir F., Kalender S., Bas H., Kalender Y. Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats. Food Chem. Toxicol. 2010, 48:1714-1720.
50. Van der Greef J., Martin S., Juhasz P., Adourian A., Plasterer T., Verheij E., McBurney R. The art and practice of systems biology in medicine: mapping patterns of relationships. J. Proteome Res. 2007, 6:1540-1559.
51. Wang H.-P., Liang Y.-J., Long D.-X., Chen J.-X., Hou W.-Y., Wu Y.-J. Metabolic profiles of serum from rats after subchronic exposure to chlorpyrifos and carbaryl. Chem. Res. Toxicol. 2009, 22:1026-1033.
52. Watanabe H., Miyamoto Y., Honda D., Tanaka H., Wu Q., Endo M., Noguchi T., Kadowaki D., Ishima Y., Kotani S. p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase. Kidney Int. 2013, 83:582-592.
53. Wilkinson C.F., Christoph G.R., Julien E., Kelley J.M., Kronenberg J., McCarthy J., Reiss R. Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: how to cumulate?. Regul. Toxicol. Pharmacol. 2000, 31:30-43.
54. Wu I.-W., Hsu K.-H., Lee C.-C., Sun C.-Y., Hsu H.-J., Tsai C.-J., Tzen C.-Y., Wang Y.-C., Lin C.-Y., Wu M.-S. p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease. Nephrol. Dial. Transpl. 2011, 26:938-947.
55. Yang J., Sun X., Feng Z., Hao D., Wang M., Zhao X., Sun C. Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry. Toxicol. Lett. 2011, 206:306-313.
56. Zhang X., Yao W., Jia B., Sun D., Ka W., He D., Wang X., Wen Z. Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress. Clin. Hemorheol. Microcirc. 2010, 44:207-216.
57. Zhang Y., Li Y., Cao C., Cao J., Chen W., Zhang Y., Wang C., Wang J., Zhang X., Zhao X. Dietary flavonol and flavone intakes and their major food sources in Chinese adults. Nutr. Cancer 2010, 62:1120-1127.
58. Zhao L., Wu J., Yang J., Wei J., Gao W., Guo C. Dietary quercetin supplementation increases serum antioxidant capacity and alters hepatic gene expression profile in rats. Exp. Biol. Med. 2011, 236:701-706.