Application of ultraperformance liquid chromatography/mass spectrometry-based metabonomic techniques to analyze the joint toxic action of long-term low-level exposure to a mixture of organophosphate pesticides on rat urine profile

Toxicological Sciences

Volumn 134, Issue 1, 2013, Pages 195-206

  Du, Longfei ^a   Wang, Hong ^a   Xu, Wei ^a   Zeng, Yan ^a   Hou, Yurong ^a   Zhang, Yuqiu ^a   Zhao, Xiujuan ^a   Sun, Changhao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Joint toxic action; Low dose chronic exposure; Metabonomics; Organophosphate mixtures; Rat urine; UPLC MS

Indexed keywords

7 METHYLGUANINE; ACEPHATE; CHOLIC ACID; CITRIC ACID; CREATININE; DICHLORVOS; DIHYDROSPHINGOSINE C 18; DIMETHOATE; DITHIOPHOSPHORIC ACID DIMETHYL ESTER; DRINKING WATER; GENTISIC ACID; HIPPURIC ACID; INDICAN; KYNURENINE; ORGANOPHOSPHATE PESTICIDE; PHORATE; PHOSPHORIC ACID DIMETHYL ESTER; PHYTOSPHINGOSINE; PYRIDOXIC ACID; RIBOTHYMIDINE; SPHINGANINE; SUBERIC ACID; UNCLASSIFIED DRUG; URIC ACID; DRUG MIXTURE; ORGANOPHOSPHATE; PESTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CLINICAL CHEMISTRY; COMET ASSAY; CONTROLLED STUDY; DISORDERS OF LIPID METABOLISM; DNA DAMAGE; HISTOPATHOLOGY; JOINT TOXIC ACTION; LONG TERM EXPOSURE; MALE; MASS SPECTROMETRY; METABOLIC PARAMETERS; NO OBSERVED ADVERSE EFFECT LEVEL; NONHUMAN; OXIDATIVE STRESS; RAT; TOXICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; WEIGHT GAIN; ANIMAL; DEVICES; DOSE RESPONSE; DRUG EFFECTS; DRUG MIXTURE; DRUG POTENTIATION; DRUG SURVEILLANCE PROGRAM; LIQUID CHROMATOGRAPHY; METABOLOME; METABOLOMICS; ORGANOPHOSPHATE POISONING; PROCEDURES; TIME; URINE; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, LIQUID; COMPLEX MIXTURES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGANOPHOSPHATE POISONING; ORGANOPHOSPHATES; PESTICIDES; RATS; RATS, WISTAR; TIME FACTORS;

EID: 84880321322     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft091     Document Type: Article

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