Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry

Toxicology Letters

Volumn 206, Issue 3, 2011, Pages 306-313

  Yang, Jindan ^a   Sun, Xiaowei ^a   Feng, Zhijing ^a   Hao, Dongfang ^a   Wang, Maoqing ^a   Zhao, Xiujuan ^a   Sun, Changhao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Chronic exposure; Dichlorvos; Low level; Metabolomics; Toxicity; UPLC MS

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CHOLINESTERASE; CITRIC ACID; CREATININE; DICHLORVOS; ESTRONE SULFATE; LACTOBIONIC ACID; NITROGEN; UREA; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARBOHYDRATE METABOLISM; CHOLINESTERASE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FATTY ACID METABOLISM; LONG TERM EXPOSURE; MALE; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UREA NITROGEN BLOOD LEVEL;

ANIMALS; BIOLOGICAL MARKERS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, LIQUID; DICHLORVOS; DOSE-RESPONSE RELATIONSHIP, DRUG; INSECTICIDES; KIDNEY; MALE; MASS SPECTROMETRY; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; WEIGHT GAIN;

RATTUS;

EID: 80052678532     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.08.012     Document Type: Article

References (36)

1. Abe E., et al. A fatal dichlorvos poisoning: concentrations in biological specimens. J. Forensic Sci. 2008, 53:997-1000.
2. Ajiboye T.O. Redox status of the liver and kidney of 2,2-dichlorovinyl dimethyl phosphate (DDVP) treated rats. Chem. Biol. Interact. 2010, 185:202-207.
3. Akbarsha M., Latha P., Murugaian P. Retention of cytoplasmic droplet by rat cauda epididymal spermatozoa after treatment with cytotoxic and xenobiotic agents. J. Reprod. Fertil. 2000, 120:385-390.
4. Begum K., Rajini P. Monocrotophos augments the early alterations in lipid profile and organ toxicity associated with experimental diabetes in rats. Pestic. Biochem. Phys. 2010, 99:33-38.
5. Bratty M.A., et al. Metabolomic profiling of the effects of allopurinol on Drosophila melanogaster. Metabolomics 2011, (online).
6. Celik I., Tuluce Y. Determination of toxicity of subacute treatment of some plant growth regulators on rats. Environ. Toxicol. 2007, 22:613-619.
7. Celik I., Yilmaz Z., Turkoglu V. Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats. Environ. Toxicol. 2009, 24:128-132.
8. Das B., Mukherjee S. Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita (Ham.). Toxicol. Lett. 2000, 114:11-18.
9. Dere E., Ari F., Tosunoglu H. Pyruvate kinase activity in various organs of rats exposed to dinitro-o-cresol and dichlorvos. Acta Vet. 2008, 58:439-447.
10. Fulton M.H., Key P.B. Acetylcholinesterase inhibition in estuarine fish and invertebrates as an indicator of organophosphorus insecticide exposure and effects. Environ. Toxicol. Chem. 2001, 20:37-45.
11. Glantzounis G., et al. Uric acid and oxidative stress. Curr. Pharm. Des. 2005, 11:4145-4151.
12. Hutson D., Hoadley E.C. The metabolism of [14 C-methyl] dichlorvos in the rat and the mouse. Xenobiotica 1972, 2:107-116.
13. Hutson D., Hoadley E.C., Pickering B. The metabolic fate of [Vinyl-I-14C] dichlorvos in the rat after oral and inhalation exposure. Xenobiotica 1971, 1:593-611.
14. John S., et al. Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes. J. Nutr. Biochem. 2001, 12:500-504.
15. Lenz E.M., Wilson I.D. Analytical strategies in metabonomics. J. Proteome Res. 2007, 6:443-458.
16. Liao P., et al. Metabolic profiling of serum from gadolinium chloride-treated rats by 1H NMR spectroscopy. Anal. Biochem. 2007, 364:112-121.
17. Macarrn-Vicente J. Uric acid and evolution. Rheumatology 2010, 49:2010-2015.
18. Mally A., et al. Are 4-hydroxy-2 (E)-nonenal derived mercapturic acids and 1H NMR metabonomics potential biomarkers of chemically induced oxidative stress in the kidney?. Toxicology 2007, 230:244-255.
19. Mishra G.A. The effect of tobacco consumption on blood cholinesterase levels among workers exposed to organophosphorus pesticides. Toxicol. Ind. Health 2006, 22:399-403.
20. Nicholson J.K., et al. Metabonomics: a platform for studying drug toxicity and gene function. Nat. Rev. Drug Discov. 2002, 1:153-161.
21. Nicholson J.K., Lindon J.C., Holmes E. Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
22. Niwa T. Uremic toxicity of indoxyl sulfate. Nagoya J. Med. Sci. 2010, 72:1-11.
23. Ohta T., et al. Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in fischer 344 male rats. Toxicol. Pathol. 2009, 37:521-535.
24. Okamura A., et al. A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats. Toxicology 2005, 213:129-137.
25. Recio R., et al. Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy. Environ. Health Perspect. 2001, 109:1237-1240.
26. Robertson D.G., et al. Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol. Sci. 2000, 57:326-337.
27. Sasaki H., et al. Sugihiratake mushroom (Angel's wing mushroom)-induced cryptogenic encephalopathy may involve vitamin D analogues. Biol. Pharm. Bull. 2006, 29:2514-2518.
28. Schaafsma G. Lactose and lactose derivatives as bioactive ingredients in human nutrition. Int. Dairy J. 2008, 18:458-465.
29. Slim R.M., et al. Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats. Toxicol. App. Pharmacol. 2002, 183:108-116.
30. Desai S.N., Desai P.V. Changes in renal clearance and renal tubular function in albino mice under the influence of Dichlorvos. Pestic. Biochem. Physiol. 2008, 91:160-169.
31. Taofeek, Olakunle, Ajiboye Redox status of the liver and kidney of 2,2-dichlorovinyl dimethyl phosphate (DDVP) treated rats. Chem. Biol. Interact. 2010, 185:202-207.
32. Theodoridis G., Gika H.G., Wilson I.D. LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics. Trends Anal. Chem. 2008, 27:251-260.
33. van der Greef J., Stroobant P., van der Heijden R. The role of analytical sciences in medical systems biology. Curr. Opin. Chem. Biol. 2004, 8:559-565.
34. Waterfield C.J., et al. Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch Toxicol. 1993, 67:244-254.
35. 3 in rats. J. Inorg. Biochem. 2005, 99:2151-2160.
36. Zhao Y., et al. Study on of dietary pesticide residues in Chinese residents. Chin. J. Epidemiol. 2003, 24:661-664.