Rational selection and engineering of exogenous principal sigma factor (σHrdB) to increase teicoplanin production in an industrial strain of Actinoplanes teichomyceticus

Microbial Cell Factories

Volumn 13, Issue 1, 2014, Pages

  Wang, Haiyong ^a   Yang, Liu ^a   Wu, Kuo ^b   Li, Guanghui ^c  

^a QILU UNIVERSITY OF TECHNOLOGY   (China)

^b INSTITUTE OF MEDICINAL PLANTS   (China)

^c TANGSHAN NORMAL UNIVERSITY   (China)

Author keywords

Actinoplanes teichomyceticus; Exogenous principal sigma factor; Metabolic perturbation; Teicoplanin

Indexed keywords

SIGMA FACTOR; TEICOPLANIN; TRANSCRIPTION FACTOR;

ACTINOBACTERIA; ACTINOPLANES TEICHOMYCETICUS; AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM MUTANT; BIOENGINEERING; BIOSYNTHESIS; DNA BINDING; DNA SHUFFLING; DRUG SCREENING; ESCHERICHIA COLI K 12; EVOLUTION; FERMENTATION; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; MICROMONOSPORA; MICROMONOSPORA AURANTIACA; MOLECULE; MUTATION RATE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYLOGENETIC TREE; POINT MUTATION; SALINISPORA ARENICOLA; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

ACTINOBACTERIA (CLASS); ACTINOPLANES MISSOURIENSIS; ACTINOPLANES TEICHOMYCETICUS; MICROMONOSPORA AURANTIACA; SALINISPORA ARENICOLA;

BACTERIAL PROTEINS; EVOLUTION, MOLECULAR; GENETIC ENGINEERING; INDUSTRIAL MICROBIOLOGY; MICROMONOSPORACEAE; MUTAGENESIS; PHYLOGENY; SIGMA FACTOR; TEICOPLANIN;

EID: 84892420089     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-13-10     Document Type: Article

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