A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 3943-3946

  Yang, Yanhui ^a   Gao, Peng ^b   Liu, Yishuang ^a   Ji, Xinyue ^a   Gan, Maoluo ^a   Guan, Yan ^a   Hao, Xueqin ^a   Li, Zhuorong ^a   Xiao, Chunling ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Actinomycin D; Inhibitor; Mycobacterium tuberculosis; Pantothenate synthetase; Pharmacophore

Indexed keywords

DACTINOMYCIN; PANTOTHENATE SYNTHETASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; DRUG INHIBITION; DRUG MECHANISM; FLUORESCENCE; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR INTERACTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SCREENING; STRUCTURE ANALYSIS;

ANTITUBERCULAR AGENTS; DACTINOMYCIN; ENZYME ACTIVATION; ENZYME INHIBITORS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79958708761     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.021     Document Type: Article

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