A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5057-5061

  Fernandez, Maria Carmen ^a   Castaño, Ana ^a   Dominguez, Esteban ^a   Escribano, Ana ^a   Jiang, Delu ^b   Jimenez, Alma ^a   Hong, Eric ^b   Hornback, William J ^b   Nisenbaum, Eric S ^b   Rankl, Nancy ^b   Tromiczak, Eric ^b   Vaught, Grant ^b   Zarrinmayeh, Hamideh ^b   Zimmerman, Dennis M ^b  

^a ELI LILLY AND COMPANY   (Spain)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

AMPA receptor allosteric modulators; Heteroaryl carboxylic acids

Indexed keywords

AMPA RECEPTOR; AMPA RECEPTOR AGONIST; CARBOXYLIC ACID DERIVATIVE; SULFIDE;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALLOSTERIC REGULATION; CARBOXYLIC ACIDS; DRUG DESIGN; EXCITATORY AMINO ACID AGENTS; HETEROCYCLIC COMPOUNDS; HUMANS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 33747357802     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.035     Document Type: Article

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