Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: Role of ERK, c-Jun and ligand-activated PBR-independent pathways

Biochemical Pharmacology

Volumn 67, Issue 10, 2004, Pages 1927-1932

  Kletsas, Dimitris ^a   Li, Wenping ^b   Han, Zeqiu ^b   Papadopoulos, Vassilios ^a,c  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

Fibroblasts; Fibrosarcoma; PBR; PK 11195; Proliferation; siRNA

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; ISOQUINOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RO 54864; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DRUG INHIBITION; DRUG RECEPTOR BINDING; FIBROBLAST; FIBROSARCOMA; HUMAN; HUMAN CELL; LIGAND BINDING; MITOCHONDRION; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ANTINEOPLASTIC AGENTS; CELL DIVISION; FIBROBLASTS; FIBROSARCOMA; HUMANS; ISOQUINOLINES; LIGANDS; RECEPTORS, GABA-A; TUMOR CELLS, CULTURED;

EID: 2342633234     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.01.021     Document Type: Article

References (13)

1. Papadopoulos V. Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr. Rev. 14:1993;222-240
2. Gavish M., Bachman I., Shoukrun R., Katz Y., Veenman L., Weisinger G., et al. Enigma of the peripheral benzodiazepine receptor. Pharmacol. Rev. 51:1999;629-650
3. Casellas P., Galiegue S., Basile A.S. Peripheral benzodiazepine receptors and mitochondrial function. Neurochem. Int. 40:2002;475-486
4. Hardwick M., Fertikh D., Culty M., Li H., Vidic B., Papadopoulos V. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res. 59:1999;831-842
5. Brown R.C., Degenhardt B., Kotoula M., Papadopoulos V. Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis. Cancer Lett. 15:2000;125-132
6. Beinlich A., Strohmeier R., Kaufmann M., Kuhl H. Specific binding of benzodiazepines to human breast cancer cell lines. Life Sci. 20:1999;2099-2108
7. Kozikowski A.P., Kotoula M., Ma D., Boujrad N., Tuckmantel W., Papadopoulos V. Synthesis and biology of 7-nitro-2, 1, 3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor. J. Medicinal Chem. 40:1997;2435-2439
8. Han Z., Slack S.R., Li W., Papadopoulos V. Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colon and prostate tumor progression. J. Receptor Res. Signal Transduction. 23:2003;225-238
9. Hipskind R.A., Bilbe G. MAP kinase signaling cascades and gene expression in osteoblasts. Front. Biosci. 3:1998;D804-D816
10. Angel P., Karin M. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta. 1072:1991;129-157
11. Kelly-Hershkovitz E., Weizman R., Spannier H., Leschinen S., Lahav M., Weisinger G., et al. Effects of peripheral-type benzodiazepine receptor antisense knockout on MA-10 Leydig cell proliferation and steroidogenesis. J. Biol. Chem. 273:1998;5478-5483
12. Benton L., Shah L.X., Hardy M.P. Differentiation of adult Leydig cells. J. Steroid Biochem. Mol. Biol. 53:1995;61-68
13. Python C.P., Rossier M.F., Vallotton M.B., Capponi A.M. Peripheral-type benzodiazepines inhibit calcium channels and aldosterone production in adrenal glomerulosa cells. Endocrinology. 132:1993;1489-1495