Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth

Clinical Cancer Research

Volumn 20, Issue 1, 2014, Pages 199-212

  Karkare, Swagata ^a,c   Chhipa, Rishi Raj ^a   Anderson, Jane ^a   Liu, Xiaona ^a   Henry, Heather ^a   Gasilina, Anjelika ^b   Nassar, Nicholas ^b   Roychoudhury, Jayeeta ^b   Clark, Jason P ^b   Kumar, Ashish ^b   Pauletti, Giovanni M ^c   Ghosh, Pradip K ^d   Dasgupta, Biplab ^a  

^a Department of Oncology ^*  (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d MARYVILLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZADIRACHTA INDICA EXTRACT; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; NIMBOLIDE; PROTEIN BCL 2; RETINOBLASTOMA PROTEIN; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AZADIRACHTA INDICA; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EGFRVIII GENE; ENZYME INHIBITION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; ONCOGENE; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AZADIRACHTA; BRAIN NEOPLASMS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; G1 PHASE CELL CYCLE CHECKPOINTS; GLIOBLASTOMA; HUMANS; LIMONINS; MALE; MICE; MICE, NUDE; PHOSPHORYLATION; PLANT EXTRACTS; PLANT LEAVES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETINOBLASTOMA PROTEIN; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84892162119     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0762     Document Type: Article

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