메뉴 건너뛰기




Volumn 37, Issue 6, 2013, Pages 395-403

Targeting the peroxisome proliferator-activated receptor-γ to counter the inflammatory milieu in obesity

Author keywords

Diabetes; Hypoglycemic agents; Metabolic disorders; Metabolic syndrome; PPAR gamma; Protein processing, post translational; Receptors, cytoplasmic and nuclear; Review; Synthetic ligands; Thiazolidinediones

Indexed keywords

GLITAZONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; SELECTIVE PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA MODULATOR; UNCLASSIFIED DRUG;

EID: 84892152786     PISSN: 22336079     EISSN: 22336087     Source Type: Journal    
DOI: 10.4093/dmj.2013.37.6.395     Document Type: Review
Times cited : (41)

References (59)
  • 1
    • 13544253065 scopus 로고    scopus 로고
    • Metabolic syndrome: a clinical and molecular perspective.
    • Moller DE, Kaufman KD. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 2005;56:45-62.
    • (2005) Annu Rev Med , vol.56 , pp. 45-62
    • Moller, D.E.1    Kaufman, K.D.2
  • 2
    • 27444443876 scopus 로고    scopus 로고
    • Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement.
    • American Heart Association; National Heart, Lung, and Blood Institute.
    • Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-52.
    • (2005) Circulation , vol.112 , pp. 2735-2752
    • Grundy, S.M.1    Cleeman, J.I.2    Daniels, S.R.3    Donato, K.A.4    Eckel, R.H.5    Franklin, B.A.6    Gordon, D.J.7    Krauss, R.M.8    Savage, P.J.9    Smith Jr., S.C.10    Spertus, J.A.11    Costa, F.12
  • 3
    • 0842285784 scopus 로고    scopus 로고
    • Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management.
    • American Heart Association; National Heart, Lung, and Blood Institute; American Diabetes Association.
    • Grundy SM, Hansen B, Smith SC Jr, Cleeman JI, Kahn RA; American Heart Association; National Heart, Lung, and Blood Institute; American Diabetes Association. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 2004;109:551-6.
    • (2004) Circulation , vol.109 , pp. 551-556
    • Grundy, S.M.1    Hansen, B.2    Smith Jr., S.C.3    Cleeman, J.I.4    Kahn, R.A.5
  • 5
    • 0023737722 scopus 로고
    • Genetic factors in the regulation of adipose tissue distribution.
    • Bouchard C. Genetic factors in the regulation of adipose tissue distribution. Acta Med Scand Suppl 1988;723:135-41.
    • (1988) Acta Med Scand Suppl , vol.723 , pp. 135-141
    • Bouchard, C.1
  • 6
    • 33646587999 scopus 로고    scopus 로고
    • How can we implement current therapies and interventions to achieve glycemic control?
    • Gavin JR 3rd. How can we implement current therapies and interventions to achieve glycemic control? Endocr Pract 2006;12 Suppl 1:93-7.
    • (2006) Endocr Pract , vol.12 , Issue.SUPPL 1 , pp. 93-97
    • Gavin III, J.R.1
  • 7
    • 8844262660 scopus 로고    scopus 로고
    • Principles for modulation of the nuclear receptor superfamily.
    • Gronemeyer H, Gustafsson JA, Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004;3:950-64.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 950-964
    • Gronemeyer, H.1    Gustafsson, J.A.2    Laudet, V.3
  • 8
    • 0034678088 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: insight into multiple cellular functions.
    • Escher P, Wahli W. Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutat Res 2000;448:121-38.
    • (2000) Mutat Res , vol.448 , pp. 121-138
    • Escher, P.1    Wahli, W.2
  • 9
    • 1542283630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha target genes.
    • Mandard S, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 2004;61:393-416.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 393-416
    • Mandard, S.1    Muller, M.2    Kersten, S.3
  • 10
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.
    • Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990;347:645-50.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 11
    • 0026517010 scopus 로고
    • Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors.
    • Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992;68:879-87.
    • (1992) Cell , vol.68 , pp. 879-887
    • Dreyer, C.1    Krey, G.2    Keller, H.3    Givel, F.4    Helftenbein, G.5    Wahli, W.6
  • 12
    • 75449096571 scopus 로고    scopus 로고
    • Cross-talk between PPARs and the partners of RXR: a molecular perspective.
    • Chan LS, Wells RA. Cross-talk between PPARs and the partners of RXR: a molecular perspective. PPAR Res 2009;2009:925309.
    • (2009) PPAR Res , vol.2009 , pp. 925309
    • Chan, L.S.1    Wells, R.A.2
  • 13
    • 0026705751 scopus 로고
    • Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.
    • Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 1992;358:771-4.
    • (1992) Nature , vol.358 , pp. 771-774
    • Kliewer, S.A.1    Umesono, K.2    Noonan, D.J.3    Heyman, R.A.4    Evans, R.M.5
  • 14
    • 33644645013 scopus 로고    scopus 로고
    • PPAR delta: a dagger in the heart of the metabolic syndrome.
    • Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest 2006;116:590-7.
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 15
    • 0021341986 scopus 로고
    • The insulin receptor.
    • Kaplan SA. The insulin receptor. J Pediatr 1984;104:327-36.
    • (1984) J Pediatr , vol.104 , pp. 327-336
    • Kaplan, S.A.1
  • 16
    • 78149500681 scopus 로고    scopus 로고
    • Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective.
    • Wong RH, Sul HS. Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective. Curr Opin Pharmacol 2010;10:684-91.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 684-691
    • Wong, R.H.1    Sul, H.S.2
  • 17
    • 36549015742 scopus 로고    scopus 로고
    • Insulin receptor structure and its implications for the IGF-1 receptor.
    • Lawrence MC, McKern NM, Ward CW. Insulin receptor structure and its implications for the IGF-1 receptor. Curr Opin Struct Biol 2007;17:699-705.
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 699-705
    • Lawrence, M.C.1    McKern, N.M.2    Ward, C.W.3
  • 20
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
    • Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 2012;55:2565-82.
    • (2012) Diabetologia , vol.55 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 21
    • 0038809142 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 in obesity and insulin resistance.
    • Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A 2003;100:7265-70.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7265-7270
    • Sartipy, P.1    Loskutoff, D.J.2
  • 23
    • 0013880431 scopus 로고
    • Transformation of monocytes in tissue culture into macrophages, epithelioid cells, and multinucleated giant cells.
    • Sutton JS, Weiss L. Transformation of monocytes in tissue culture into macrophages, epithelioid cells, and multinucleated giant cells. An electron microscope study. J Cell Biol 1966;28:303-32.
    • (1966) An electron microscope study. J Cell Biol , vol.28 , pp. 303-332
    • Sutton, J.S.1    Weiss, L.2
  • 24
    • 0034092368 scopus 로고    scopus 로고
    • Postnatal mammary gland development requires macrophages and eosinophils.
    • Gouon-Evans V, Rothenberg ME, Pollard JW. Postnatal mammary gland development requires macrophages and eosinophils. Development 2000;127:2269-82.
    • (2000) Development , vol.127 , pp. 2269-2282
    • Gouon-Evans, V.1    Rothenberg, M.E.2    Pollard, J.W.3
  • 25
    • 33645211764 scopus 로고    scopus 로고
    • A transient microenvironment loaded mainly with macrophages in the early developing human pancreas.
    • Banaei-Bouchareb L, Peuchmaur M, Czernichow P, Polak M. A transient microenvironment loaded mainly with macrophages in the early developing human pancreas. J Endocrinol 2006;188:467-80.
    • (2006) J Endocrinol , vol.188 , pp. 467-480
    • Banaei-Bouchareb, L.1    Peuchmaur, M.2    Czernichow, P.3    Polak, M.4
  • 26
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007;117:175-84.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 27
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective.
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009;27:451-83.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 28
    • 77950899271 scopus 로고    scopus 로고
    • Saturated fatty acids and inflammation: who pays the toll?
    • Chait A, Kim F. Saturated fatty acids and inflammation: who pays the toll? Arterioscler Thromb Vasc Biol 2010;30:692-3.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 692-693
    • Chait, A.1    Kim, F.2
  • 30
    • 80055059815 scopus 로고    scopus 로고
    • Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and e.
    • Kewalramani G, Fink LN, Asadi F, Klip A. Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and e. PLoS One 2011;6:e26947.
    • (2011) PLoS One , vol.6
    • Kewalramani, G.1    Fink, L.N.2    Asadi, F.3    Klip, A.4
  • 31
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.
    • Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007;282:35279-92.
    • (2007) J Biol Chem , vol.282 , pp. 35279-92
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6    Liu-Bryan, R.7    Glass, C.K.8    Neels, J.G.9    Olefsky, J.M.10
  • 34
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997;389:610-4.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 35
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects.
    • Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 2003;278:45777-84.
    • (2003) J Biol Chem , vol.278 , pp. 45777-84
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 36
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes.
    • Senn JJ, Klover PJ, Nowak IA, Mooney RA. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 2002;51:3391-9.
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 37
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: structure, function and inhibition.
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001;357(Pt 3):593-615.
    • (2001) Biochem J , vol.357 , Issue.PART 3 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 38
    • 34748845045 scopus 로고    scopus 로고
    • Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice.
    • Tsuchiya K, Sakai H, Suzuki N, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y. Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice. Endocrinology 2007;148:4548-56.
    • (2007) Endocrinology , vol.148 , pp. 4548-4556
    • Tsuchiya, K.1    Sakai, H.2    Suzuki, N.3    Iwashima, F.4    Yoshimoto, T.5    Shichiri, M.6    Hirata, Y.7
  • 39
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle.
    • Perreault M, Marette A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 2001;7:1138-43.
    • (2001) Nat Med , vol.7 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 43
    • 0033547443 scopus 로고    scopus 로고
    • Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes.
    • Rieusset J, Auwerx J, Vidal H. Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes. Biochem Biophys Res Commun 1999;265:265-71.
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 265-271
    • Rieusset, J.1    Auwerx, J.2    Vidal, H.3
  • 44
    • 0035655245 scopus 로고    scopus 로고
    • Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats.
    • Kramer D, Shapiro R, Adler A, Bush E, Rondinone CM. Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats. Metabolism 2001;50:1294-300.
    • (2001) Metabolism , vol.50 , pp. 1294-1300
    • Kramer, D.1    Shapiro, R.2    Adler, A.3    Bush, E.4    Rondinone, C.M.5
  • 48
    • 0036090467 scopus 로고    scopus 로고
    • Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.
    • Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 2002;143:2376-84.
    • (2002) Endocrinology , vol.143 , pp. 2376-2384
    • Lecka-Czernik, B.1    Moerman, E.J.2    Grant, D.F.3    Lehmann, J.M.4    Manolagas, S.C.5    Jilka, R.L.6
  • 49
    • 79957507671 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats.
    • Stunes AK, Westbroek I, Gustafsson BI, Fossmark R, Waarsing JH, Eriksen EF, Petzold C, Reseland JE, Syversen U. The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats. BMC Endocr Disord 2011;11:11.
    • (2011) BMC Endocr Disord , vol.11 , pp. 11
    • Stunes, A.K.1    Westbroek, I.2    Gustafsson, B.I.3    Fossmark, R.4    Waarsing, J.H.5    Eriksen, E.F.6    Petzold, C.7    Reseland, J.E.8    Syversen, U.9
  • 52
    • 0035408779 scopus 로고    scopus 로고
    • A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes.
    • Rosiglitazone Clinical Trials Study Group
    • Raskin P, Rendell M, Riddle MC, Dole JF, Freed MI, Rosenstock J; Rosiglitazone Clinical Trials Study Group. A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes. Diabetes Care 2001;24:1226-32.
    • (2001) Diabetes Care , vol.24 , pp. 1226-1232
    • Raskin, P.1    Rendell, M.2    Riddle, M.C.3    Dole, J.F.4    Freed, M.I.5    Rosenstock, J.6
  • 54
    • 36349030319 scopus 로고    scopus 로고
    • Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling.
    • Sena S, Rasmussen IR, Wende AR, McQueen AP, Theobald HA, Wilde N, Pereira RO, Litwin SE, Berger JP, Abel ED. Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling. Endocrinology 2007;148:6047-53.
    • (2007) Endocrinology , vol.148 , pp. 6047-6053
    • Sena, S.1    Rasmussen, I.R.2    Wende, A.R.3    McQueen, A.P.4    Theobald, H.A.5    Wilde, N.6    Pereira, R.O.7    Litwin, S.E.8    Berger, J.P.9    Abel, E.D.10
  • 55
    • 78649852533 scopus 로고    scopus 로고
    • SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence.
    • Han L, Zhou R, Niu J, McNutt MA, Wang P, Tong T. SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res 2010;38:7458-71.
    • (2010) Nucleic Acids Res , vol.38 , pp. 7458-7471
    • Han, L.1    Zhou, R.2    Niu, J.3    McNutt, M.A.4    Wang, P.5    Tong, T.6
  • 56
    • 40849114903 scopus 로고    scopus 로고
    • Acetylation in nuclear receptor signaling and the role of sirtuins.
    • Wang C, Powell MJ, Popov VM, Pestell RG. Acetylation in nuclear receptor signaling and the role of sirtuins. Mol Endocrinol 2008;22:539-45.
    • (2008) Mol Endocrinol , vol.22 , pp. 539-545
    • Wang, C.1    Powell, M.J.2    Popov, V.M.3    Pestell, R.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.