메뉴 건너뛰기




Volumn , Issue , 2010, Pages 57-75

Animal models of scleroderma: From cellular and molecular mechanisms to novel antifibrotic strategies

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84891963686     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-84882-637-3_3     Document Type: Chapter
Times cited : (1)

References (91)
  • 1
    • 0023854176 scopus 로고
    • Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis
    • LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol. 1988;15:202-205.
    • (1988) J Rheumatol. , vol.15 , pp. 202-205
    • Le Roy, E.C.1    Black, C.2    Fleischmajer, R.3
  • 2
    • 0346727461 scopus 로고    scopus 로고
    • Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis
    • Jimenez SA, Derk CT. Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med. 2004;140:37-50.
    • (2004) Ann Intern Med. , vol.140 , pp. 37-50
    • Jimenez, S.A.1    Derk, C.T.2
  • 3
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: A prototypic multisystem fibrotic disorder
    • Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007;117:557-567.
    • (2007) J Clin Invest. , vol.117 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 4
    • 31044456861 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells
    • Distler JH, Jüngel A, Caretto D, et al. Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells. Arthritis Rheum. 2006;54:214-225.
    • (2006) Arthritis Rheum. , vol.54 , pp. 214-225
    • Distler, J.H.1    Jüngel, A.2    Caretto, D.3
  • 5
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the T (H) 1/T (H) 2 paradigm
    • Wynn TA. Fibrotic disease and the T (H) 1/T (H) 2 paradigm. Nat Rev Immunol. 2004;4:583-594.
    • (2004) Nat Rev Immunol. , vol.4 , pp. 583-594
    • Wynn, T.A.1
  • 6
    • 33746122263 scopus 로고    scopus 로고
    • Intracellular TGF-b receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo
    • Ishida W, Mori Y, Lakos G, et al. Intracellular TGF-b receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo. J Invest Dermatol. 2006;126:1733-1744.
    • (2006) J Invest Dermatol. , vol.126 , pp. 1733-1744
    • Ishida, W.1    Mori, Y.2    Lakos, G.3
  • 7
    • 0038004796 scopus 로고    scopus 로고
    • Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
    • Mori Y, Chen SJ, Varga J. Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts. Arthritis Rheum. 2003;48:1964-1978.
    • (2003) Arthritis Rheum. , vol.48 , pp. 1964-1978
    • Mori, Y.1    Chen, S.J.2    Varga, J.3
  • 8
    • 33749320619 scopus 로고    scopus 로고
    • Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma
    • Pannu J, Gardner H, Shearstone JR, Smith E, Trojanowska M. Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: a model of scleroderma. Arthritis Rheum. 2006;54:3011-3021.
    • (2006) Arthritis Rheum. , vol.54 , pp. 3011-3021
    • Pannu, J.1    Gardner, H.2    Shearstone, J.R.3    Smith, E.4    Trojanowska, M.5
  • 9
    • 33745815350 scopus 로고    scopus 로고
    • Constitutive ALK5-independent c-Jun. N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: Evidence of an autocrine endothelin loop operating through the endothelin A and B receptors
    • Shi-Wen X, Rodriguez-Pascual F, Lamas S, et al. Constitutive ALK5-independent c-Jun. N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol. 2006;26:5518-5527.
    • (2006) Mol Cell Biol. , vol.26 , pp. 5518-5527
    • Shi-Wen, X.1    Rodriguez-Pascual, F.2    Lamas, S.3
  • 10
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • Wang Y, Fan PS, Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum. 2006;54:2271-2279.
    • (2006) Arthritis Rheum. , vol.54 , pp. 2271-2279
    • Wang, Y.1    Fan, P.S.2    Kahaleh, B.3
  • 11
    • 34547758359 scopus 로고    scopus 로고
    • Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis
    • Huber LC, Distler J H W, Moritz F, et al. Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. Arthritis Rheum. 2007;56:2755-2764.
    • (2007) Arthritis Rheum. , vol.56 , pp. 2755-2764
    • Huber, L.C.1    Distler, J.H.W.2    Moritz, F.3
  • 12
    • 23644440113 scopus 로고    scopus 로고
    • Animal models in scleroderma
    • Clark SH. Animal models in scleroderma. Curr Rheumatol Rep. 2005;7:150-155.
    • (2005) Curr Rheumatol Rep. , vol.7 , pp. 150-155
    • Clark, S.H.1
  • 13
    • 27744469670 scopus 로고    scopus 로고
    • The relaxin knockout mouse: A model of progressive scleroderma
    • Samuel CS, Zhao C, Yang Q, et al. The relaxin knockout mouse: a model of progressive scleroderma. J Invest Dermatol. 2005;125:692-699.
    • (2005) J Invest Dermatol. , vol.125 , pp. 692-699
    • Samuel, C.S.1    Zhao, C.2    Yang, Q.3
  • 14
    • 20944449564 scopus 로고    scopus 로고
    • Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II transforming growth factor-b receptor (TbRIIDk)
    • Denton CP, Lindahl GE, Khan K, et al. Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II transforming growth factor-b receptor (TbRIIDk). J Biol Chem. 2005;280:16053-16065.
    • (2005) J Biol Chem. , vol.280 , pp. 16053-16065
    • Denton, C.P.1    Lindahl, G.E.2    Khan, K.3
  • 15
    • 33846247466 scopus 로고    scopus 로고
    • Postnatal induction of transforming growth factor b signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma
    • Sonnylal S, Denton CP, Zheng B, et al. Postnatal induction of transforming growth factor b signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum. 2007;56:334-344.
    • (2007) Arthritis Rheum. , vol.56 , pp. 334-344
    • Sonnylal, S.1    Denton, C.P.2    Zheng, B.3
  • 16
    • 28444477739 scopus 로고    scopus 로고
    • Scleroderma: From cell and molecular mechanisms to disease models
    • Abraham DJ, Varga J. Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol. 2005;26:587-595.
    • (2005) Trends Immunol. , vol.26 , pp. 587-595
    • Abraham, D.J.1    Varga, J.2
  • 17
    • 0032907817 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. I. Local injections of bleomycin induce sclerotic skin mimicking scleroderma
    • Yamamoto T, Takagawa S, Katayama I, et al. Animal model of sclerotic skin. I. Local injections of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol. 1999;112:456-462.
    • (1999) J Invest Dermatol. , vol.112 , pp. 456-462
    • Yamamoto, T.1    Takagawa, S.2    Katayama, I.3
  • 18
    • 31344473454 scopus 로고    scopus 로고
    • The bleomycin-induced scleroderma model: What have we learned for scleroderma pathogenesis?
    • Yamamoto T. The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis? Arch Dermatol Res. 2006;297:333-344.
    • (2006) Arch Dermatol Res. , vol.297 , pp. 333-344
    • Yamamoto, T.1
  • 19
    • 0035149214 scopus 로고    scopus 로고
    • Oxidative stress in scleroderma: Maintenance of sclerodermia fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway
    • Sambo P, Baroni SS, Luchetti M, et al. Oxidative stress in scleroderma: maintenance of sclerodermia fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum. 2001;44:1667-1676.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1667-1676
    • Sambo, P.1    Baroni, S.S.2    Luchetti, M.3
  • 20
    • 0034013109 scopus 로고    scopus 로고
    • Role of E-selectin in bleomycin induced lung fibrosis in mice
    • Azuma A, Takahashi S, Nose M, et al. Role of E-selectin in bleomycin induced lung fibrosis in mice. Thorax. 2000;55:147-152.
    • (2000) Thorax. , vol.55 , pp. 147-152
    • Azuma, A.1    Takahashi, S.2    Nose, M.3
  • 21
    • 1642575264 scopus 로고    scopus 로고
    • Possible role of apoptosis in the pathogenesis of bleomycininduced scleroderma
    • Yamamoto T, Nishioka K. Possible role of apoptosis in the pathogenesis of bleomycininduced scleroderma. J Invest Dermatol. 2004;122:44-50.
    • (2004) J Invest Dermatol. , vol.122 , pp. 44-50
    • Yamamoto, T.1    Nishioka, K.2
  • 22
    • 33846412577 scopus 로고    scopus 로고
    • Fas- and FasL-deficient mice are resistant to the induction of bleomycin-induced scleroderma
    • Yamamoto T, Tokozeki H, Nishioka K. Fas- and FasL-deficient mice are resistant to the induction of bleomycin-induced scleroderma. Arch Dermatol Res. 2007;298:465-468.
    • (2007) Arch Dermatol Res. , vol.298 , pp. 465-468
    • Yamamoto, T.1    Tokozeki, H.2    Nishioka, K.3
  • 23
    • 3042822469 scopus 로고    scopus 로고
    • Increased expression of TGF-beta1 in the sclerotic skin in bleomycin-"susceptible" mouse strains
    • Oi M, Yamamoto T, Nishioka K. Increased expression of TGF-beta1 in the sclerotic skin in bleomycin-"susceptible" mouse strains. J Med Dent Sci. 2004;51:7-17.
    • (2004) J Med Dent Sci. , vol.51 , pp. 7-17
    • Oi, M.1    Yamamoto, T.2    Nishioka, K.3
  • 24
    • 0036150358 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. V: Increased expression of alphasmooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma
    • Yamamoto T, Nishioka K. Animal model of sclerotic skin. V: increased expression of alphasmooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma. Clin Immunol. 2002;102:77-83.
    • (2002) Clin Immunol. , vol.102 , pp. 77-83
    • Yamamoto, T.1    Nishioka, K.2
  • 25
    • 14744306219 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 is elevated, but not essential, in the development of bleomycin-induced murine scleroderma
    • Matsushita M, Yamamoto T, Nishioka K. Plasminogen activator inhibitor-1 is elevated, but not essential, in the development of bleomycin-induced murine scleroderma. Clin Exp Immunol. 2005;139:429-438.
    • (2005) Clin Exp Immunol. , vol.139 , pp. 429-438
    • Matsushita, M.1    Yamamoto, T.2    Nishioka, K.3
  • 26
    • 0041842736 scopus 로고    scopus 로고
    • Sustained activation of transforming growth factor-b/mediated signalling in a murine model of scleroderma
    • Takagawa S, Lakos G, Mori Y, Yamamoto T, Nishioka K, Varga J. Sustained activation of transforming growth factor-b/mediated signalling in a murine model of scleroderma. J Invest Dermatol. 2003;121:41-50.
    • (2003) J Invest Dermatol. , vol.121 , pp. 41-50
    • Takagawa, S.1    Lakos, G.2    Mori, Y.3    Yamamoto, T.4    Nishioka, K.5    Varga, J.6
  • 27
    • 3042550759 scopus 로고    scopus 로고
    • Targeted disruption of TGF-b/smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
    • Lakos G, Takagawa S, Chen SJ, et al. Targeted disruption of TGF-b/smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol. 2004;165:203-217.
    • (2004) Am J Pathol. , vol.165 , pp. 203-217
    • Lakos, G.1    Takagawa, S.2    Chen, S.J.3
  • 28
    • 0041333160 scopus 로고    scopus 로고
    • Role of monocyte chemoattractant protein-1 and its receptor, CCR-2, in the pathogenesis of bleomycin-induced scleroderma
    • Yamamoto T, Nishioka K. Role of monocyte chemoattractant protein-1 and its receptor, CCR-2, in the pathogenesis of bleomycin-induced scleroderma. J Invest Dermatol. 2003;121:510-516.
    • (2003) J Invest Dermatol. , vol.121 , pp. 510-516
    • Yamamoto, T.1    Nishioka, K.2
  • 30
    • 11444270348 scopus 로고    scopus 로고
    • Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma
    • Matsushita M, Yamamoto T, Nishioka K. Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma. Int Arch Allergy Immunol. 2004;135:348-356.
    • (2004) Int Arch Allergy Immunol. , vol.135 , pp. 348-356
    • Matsushita, M.1    Yamamoto, T.2    Nishioka, K.3
  • 31
    • 0036787916 scopus 로고    scopus 로고
    • Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis
    • Belperio JA, Dy M, Burdick MD, et al. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2002;27:419-427.
    • (2002) Am J Respir Cell Mol Biol. , vol.27 , pp. 419-427
    • Belperio, J.A.1    Dy, M.2    Burdick, M.D.3
  • 32
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor b1
    • Lee CG, Homer RJ, Zhu Z, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor b1. J Exp Med. 2001;194:809-821.
    • (2001) J Exp Med. , vol.194 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3
  • 33
    • 33847324516 scopus 로고    scopus 로고
    • Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13
    • Aliprantis AO, Wang J, Fathman JW, et al. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci USA. 2007;104:2827-2830.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 2827-2830
    • Aliprantis, A.O.1    Wang, J.2    Fathman, J.W.3
  • 34
    • 4644225081 scopus 로고    scopus 로고
    • IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent
    • Kaviratne M, Hesse M, Leusink M, et al. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004;173:4020-4029.
    • (2004) J Immunol. , vol.173 , pp. 4020-4029
    • Kaviratne, M.1    Hesse, M.2    Leusink, M.3
  • 36
    • 0034783450 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. IV. Induction of dermal sclerosis by bleomycin is T cell independent
    • Yamamoto T, Nishioka K. Animal model of sclerotic skin. IV. Induction of dermal sclerosis by bleomycin is T cell independent. J Invest Dermatol. 2001;117:999-1001.
    • (2001) J Invest Dermatol. , vol.117 , pp. 999-1001
    • Yamamoto, T.1    Nishioka, K.2
  • 37
    • 1842629781 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. VI. Evaluation of bleomycininduced skin sclerosis in nude mice
    • Yamamoto T, Nishioka K. Animal model of sclerotic skin. VI. Evaluation of bleomycininduced skin sclerosis in nude mice. Arch Dermatol Res. 2004;295:453-456.
    • (2004) Arch Dermatol Res. , vol.295 , pp. 453-456
    • Yamamoto, T.1    Nishioka, K.2
  • 38
    • 27144458232 scopus 로고    scopus 로고
    • Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis
    • Santiago B, Gutierrez-Canas I, Dotor J, et al. Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis. J Invest Dermatol. 2005;125:450-455.
    • (2005) J Invest Dermatol. , vol.125 , pp. 450-455
    • Santiago, B.1    Gutierrez-Canas, I.2    Dotor, J.3
  • 39
    • 0742306757 scopus 로고    scopus 로고
    • Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma
    • Wu M-H, Yokozeki H, Takagawa S, et al. Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma. Gene Ther. 2004;11:170-180.
    • (2004) Gene Ther. , vol.11 , pp. 170-180
    • Wu, M.-H.1    Yokozeki, H.2    Takagawa, S.3
  • 40
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-b/SMAD signaling by the interferon-g/STAT pathway
    • Ulloa L, Doody J, Massagué J. Inhibition of transforming growth factor-b/SMAD signaling by the interferon-g/STAT pathway. Nature. 1999;397:710-713.
    • (1999) Nature. , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massagué, J.3
  • 41
    • 0030933595 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma
    • Hunzelmann N, Anders S, Fierlbeck G, et al. Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma. J Am Acad Dermatol. 1997;36:433-435.
    • (1997) J Am Acad Dermatol. , vol.36 , pp. 433-435
    • Hunzelmann, N.1    Anders, S.2    Fierlbeck, G.3
  • 42
    • 34247572897 scopus 로고    scopus 로고
    • SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta, prevents bleomycin-induced skin sclerosis in mice
    • Kimura M, Kawahito Y, Hamaguchi M, et al. SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta, prevents bleomycin-induced skin sclerosis in mice. Biomed Pharmacother. 2007;61:222-228.
    • (2007) Biomed Pharmacother. , vol.61 , pp. 222-228
    • Kimura, M.1    Kawahito, Y.2    Hamaguchi, M.3
  • 43
    • 33746968120 scopus 로고    scopus 로고
    • Adenosine A2A receptors in diffuse dermal fibrosis: Pathogenic role in human dermal fibroblasts and in a murine model of scleroderma
    • Chan ES, Fernandez P, Merchant AA, et al. Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. Arthritis Rheum. 2006;54:2632-2642.
    • (2006) Arthritis Rheum. , vol.54 , pp. 2632-2642
    • Chan, E.S.1    Fernandez, P.2    Merchant, A.A.3
  • 44
    • 33846209989 scopus 로고    scopus 로고
    • Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    • Distler JH, Jüngel A, Huber LC, et al. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum. 2007;56:311-322.
    • (2007) Arthritis Rheum. , vol.56 , pp. 311-322
    • Distler, J.H.1    Jüngel, A.2    Huber, L.C.3
  • 45
    • 0020630583 scopus 로고
    • Chronic graft-versus-host disease (GvHD) as a model for scleroderma
    • Jaffee BD, Claman HN. Chronic graft-versus-host disease (GvHD) as a model for scleroderma. Cell Immunol. 1983;77:1-12.
    • (1983) Cell Immunol. , vol.77 , pp. 1-12
    • Jaffee, B.D.1    Claman, H.N.2
  • 46
    • 0033571072 scopus 로고    scopus 로고
    • Anti-TGF-b treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: A model for human scleroderma
    • McCormick LL, Zhang Y, Tootell E, Gilliam AC. Anti-TGF-b treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol. 1999;163:5693-5699.
    • (1999) J Immunol. , vol.163 , pp. 5693-5699
    • McCormick, L.L.1    Zhang, Y.2    Tootell, E.3    Gilliam, A.C.4
  • 47
    • 0037087318 scopus 로고    scopus 로고
    • Murine sclerodermatous graftversus-host disease, a model for human scleroderma: Cutaneous cytokines, chemokines, and immune cell activation
    • Zhang Y, McCormick LL, Desai SR, Wu C, Gilliam AC. Murine sclerodermatous graftversus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation. J Immunol. 2002;168:3088-3098.
    • (2002) J Immunol. , vol.168 , pp. 3088-3098
    • Zhang, Y.1    McCormick, L.L.2    Desai, S.R.3    Wu, C.4    Gilliam, A.C.5
  • 48
    • 0141887528 scopus 로고    scopus 로고
    • Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma
    • Zhang Y, McCormick LL, Gilliam AC. Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol. 2003;121:713-719.
    • (2003) J Invest Dermatol. , vol.121 , pp. 713-719
    • Zhang, Y.1    McCormick, L.L.2    Gilliam, A.C.3
  • 49
    • 33846188950 scopus 로고    scopus 로고
    • Cutaneous gene expression by DNA microarray in murine sclerodermatous graft-versus-host disease, a model for human scleroderma
    • Zhou L, Askew D, Wu C, Gilliam AC. Cutaneous gene expression by DNA microarray in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol. 2007;127:281-292.
    • (2007) J Invest Dermatol. , vol.127 , pp. 281-292
    • Zhou, L.1    Askew, D.2    Wu, C.3    Gilliam, A.C.4
  • 50
    • 1842783757 scopus 로고    scopus 로고
    • A modified model of graft-versushost-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease
    • Ruzek MC, Jha S, Ledbetter S, Richards SM, Garman RD. A modified model of graft-versushost-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease. Arthritis Rheum. 2004;50:1319-1331.
    • (2004) Arthritis Rheum. , vol.50 , pp. 1319-1331
    • Ruzek, M.C.1    Jha, S.2    Ledbetter, S.3    Richards, S.M.4    Garman, R.D.5
  • 51
    • 0029941445 scopus 로고    scopus 로고
    • A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation
    • Siracusa LD, McGrath R, Ma Q, et al. A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res. 1996;6:300-313.
    • (1996) Genome Res. , vol.6 , pp. 300-313
    • Siracusa, L.D.1    McGrath, R.2    Ma, Q.3
  • 52
    • 0017250167 scopus 로고
    • Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton
    • Green MC, Sweet HO, Bunker LE. Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton. Am J Pathol. 1976;82:493-512.
    • (1976) Am J Pathol. , vol.82 , pp. 493-512
    • Green, M.C.1    Sweet, H.O.2    Bunker, L.E.3
  • 54
    • 25144523631 scopus 로고    scopus 로고
    • Analysis of the tight skin (Tsk1/+) mouse as a model for testing antifibrotic agents
    • Baxter RM, Crowell TP, McCrann ME, Frew EM, Gardner H. Analysis of the tight skin (Tsk1/+) mouse as a model for testing antifibrotic agents. Lab Invest. 2005;85:1199-1209.
    • (2005) Lab Invest. , vol.85 , pp. 1199-1209
    • Baxter, R.M.1    Crowell, T.P.2    McCrann, M.E.3    Frew, E.M.4    Gardner, H.5
  • 55
    • 0033206743 scopus 로고    scopus 로고
    • Genetic and immunologic features associated with sclerodermalike syndrome of TSK mice
    • Saito S, Kasturi K, Bona C. Genetic and immunologic features associated with sclerodermalike syndrome of TSK mice. Curr Rheumatol Rep. 1999;1:34-37.
    • (1999) Curr Rheumatol Rep. , vol.1 , pp. 34-37
    • Saito, S.1    Kasturi, K.2    Bona, C.3
  • 56
    • 0347719250 scopus 로고    scopus 로고
    • Fibrillin 1 abnormalities in dermal fibroblast cultures from first degree relatives of patients with systemic sclerosis (scleroderma)
    • Wallis DD, Tan FK, Kessler R, et al. Fibrillin 1 abnormalities in dermal fibroblast cultures from first degree relatives of patients with systemic sclerosis (scleroderma). Arthritis Rheum. 2004;50:329-331.
    • (2004) Arthritis Rheum. , vol.50 , pp. 329-331
    • Wallis, D.D.1    Tan, F.K.2    Kessler, R.3
  • 57
    • 0031687121 scopus 로고    scopus 로고
    • Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population
    • Tan FK, Stivers DN, Foster MW, et al. Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population. Arthritis Rheum. 1998;41:1729-1737.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1729-1737
    • Tan, F.K.1    Stivers, D.N.2    Foster, M.W.3
  • 58
    • 0025916022 scopus 로고
    • Extracellular microfibrils are increased in localized and systemic scleroderma skin
    • Fleischmajer R, Jacobs L, Schwartz E, Sakai LY. Extracellular microfibrils are increased in localized and systemic scleroderma skin. Lab Invest. 1991;64:791-798.
    • (1991) Lab Invest. , vol.64 , pp. 791-798
    • Fleischmajer, R.1    Jacobs, L.2    Schwartz, E.3    Sakai, L.Y.4
  • 59
    • 0033564969 scopus 로고    scopus 로고
    • Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin-1, in patients with scleroderma and other connective tissue diseases
    • Tan FK, Arnett FC, Antohi S, et al. Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin-1, in patients with scleroderma and other connective tissue diseases. J Immunol. 1999;163:1066-1072.
    • (1999) J Immunol. , vol.163 , pp. 1066-1072
    • Tan, F.K.1    Arnett, F.C.2    Antohi, S.3
  • 60
    • 0033009739 scopus 로고    scopus 로고
    • Characterization of mutated protein encoded by partially duplicated fibrillin-1 gene in tight skin (TSK) mice
    • Saito S, Nishimura H, Brumeanu TD, et al. Characterization of mutated protein encoded by partially duplicated fibrillin-1 gene in tight skin (TSK) mice. Mol Immunol. 1999;36:169-176.
    • (1999) Mol Immunol. , vol.36 , pp. 169-176
    • Saito, S.1    Nishimura, H.2    Brumeanu, T.D.3
  • 61
    • 1542313925 scopus 로고    scopus 로고
    • Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen
    • Lemaire R, Farina G, Kissin E, et al. Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen. Arthritis Rheum. 2004;50:915-926.
    • (2004) Arthritis Rheum. , vol.50 , pp. 915-926
    • Lemaire, R.1    Farina, G.2    Kissin, E.3
  • 62
    • 0037462678 scopus 로고    scopus 로고
    • Latent transforming growth factor b-binding protein 1 interacts with fibrillin and is a microfibril-associated protein
    • Isogai Z, Ono RN, Ushiro S, et al. Latent transforming growth factor b-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem. 2003;278:2750-2757.
    • (2003) J Biol Chem. , vol.278 , pp. 2750-2757
    • Isogai, Z.1    Ono, R.N.2    Ushiro, S.3
  • 63
    • 0035076489 scopus 로고    scopus 로고
    • Activation of a fibroblast specific enhancer of the Proa2 (I) collagen gene in tight-skin mice
    • Denton CP, Zheng B, Shiwen X, et al. Activation of a fibroblast specific enhancer of the Proa2 (I) collagen gene in tight-skin mice. Arthritis Rheum. 2001;44:712-722.
    • (2001) Arthritis Rheum. , vol.44 , pp. 712-722
    • Denton, C.P.1    Zheng, B.2    Shiwen, X.3
  • 64
    • 0043074620 scopus 로고    scopus 로고
    • Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts
    • McGaha TL, Le M, Kodera T, et al. Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts. Arthritis Rheum. 2003;48:2275-2284.
    • (2003) Arthritis Rheum. , vol.48 , pp. 2275-2284
    • McGaha, T.L.1    Le, M.2    Kodera, T.3
  • 65
    • 0035138260 scopus 로고    scopus 로고
    • Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes
    • McGaha TL, Saito S, Phelps RG, et al. Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes. J Invest Dermatol. 2001;116:136-143.
    • (2001) J Invest Dermatol. , vol.116 , pp. 136-143
    • McGaha, T.L.1    Saito, S.2    Phelps, R.G.3
  • 66
    • 0037133611 scopus 로고    scopus 로고
    • Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-b production by fibroblasts
    • Kodera T, McGaha TL, Phelps R, Paul WE, Bona CA. Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-b production by fibroblasts. Proc Natl Acad Sci USA. 2002;99:3800-3805.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , pp. 3800-3805
    • Kodera, T.1    McGaha, T.L.2    Phelps, R.3    Paul, W.E.4    Bona, C.A.5
  • 67
    • 0028292522 scopus 로고
    • A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice
    • Wallace VA, Kondo S, Kono T, et al. A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice. Eur J Immunol. 1994;24:1463-1466.
    • (1994) Eur J Immunol. , vol.24 , pp. 1463-1466
    • Wallace, V.A.1    Kondo, S.2    Kono, T.3
  • 68
    • 0031792376 scopus 로고    scopus 로고
    • The mouse tight skin (Tsk) phenotype is not dependent on the presence of mature T and B lymphocytes
    • Siracusa LD, McGrath R, Fisher JK, Jimenez SA. The mouse tight skin (Tsk) phenotype is not dependent on the presence of mature T and B lymphocytes. Mamm Genome. 1998;9:907-909.
    • (1998) Mamm Genome. , vol.9 , pp. 907-909
    • Siracusa, L.D.1    McGrath, R.2    Fisher, J.K.3    Jimenez, S.A.4
  • 69
  • 70
    • 0031712891 scopus 로고    scopus 로고
    • Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma
    • Ong D, Wong C, Roberts CR, Teh HS, Jirik FR. Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma. Eur J Immunol. 1998;128:2619-2629.
    • (1998) Eur J Immunol. , vol.128 , pp. 2619-2629
    • Ong, D.1    Wong, C.2    Roberts, C.R.3    Teh, H.S.4    Jirik, F.R.5
  • 71
    • 0036277168 scopus 로고    scopus 로고
    • The role of intravenous immunoglobulin therapy in mediating skin fibrosis in tight skin mice
    • Blank M, Levy Y, Amital H, Shoenfeld Y, Pines M, Genina O. The role of intravenous immunoglobulin therapy in mediating skin fibrosis in tight skin mice. Arthritis Rheum. 2002;46:1689-1690.
    • (2002) Arthritis Rheum. , vol.46 , pp. 1689-1690
    • Blank, M.1    Levy, Y.2    Amital, H.3    Shoenfeld, Y.4    Pines, M.5    Genina, O.6
  • 72
    • 0030019449 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice. Effect of halofuginone
    • Levi-Schaffer F, Nagler A, Slavin S, Knopov V, Pines M. Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice. Effect of halofuginone. J Invest Dermatol. 1996;106:84-88.
    • (1996) J Invest Dermatol. , vol.106 , pp. 84-88
    • Levi-Schaffer, F.1    Nagler, A.2    Slavin, S.3    Knopov, V.4    Pines, M.5
  • 73
    • 0036121027 scopus 로고    scopus 로고
    • Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-b-mediated Smad3 activation in fibroblasts
    • McGaha TL, Phelps RG, Spiera H, Bona C. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor- b-mediated Smad3 activation in fibroblasts. J Invest Dermatol. 2002;118:461-470.
    • (2002) J Invest Dermatol. , vol.118 , pp. 461-470
    • McGaha, T.L.1    Phelps, R.G.2    Spiera, H.3    Bona, C.4
  • 74
    • 41749098419 scopus 로고    scopus 로고
    • Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma
    • Iwasaki T, Imado T, Kitano S, Sano H. Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma. Arthritis Res Ther. 2006;8:R161.
    • (2006) Arthritis Res Ther. , vol.8
    • Iwasaki, T.1    Imado, T.2    Kitano, S.3    Sano, H.4
  • 75
    • 0038004791 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 3 as a mediator of fibrosis. Overexpression in systemic sclerosis and the type 1 tight-skin mouse
    • Ong VH, Evans LA, Shiwen X, et al. Monocyte chemoattractant protein 3 as a mediator of fibrosis. Overexpression in systemic sclerosis and the type 1 tight-skin mouse. Arthritis Rheum. 2003;48:1979-1991.
    • (2003) Arthritis Rheum. , vol.48 , pp. 1979-1991
    • Ong, V.H.1    Evans, L.A.2    Shiwen, X.3
  • 76
    • 0036262665 scopus 로고    scopus 로고
    • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    • Saito E, Fujimoto M, Hasegawa M, et al. CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. J Clin Invest. 2002;109:1453-1462.
    • (2002) J Clin Invest. , vol.109 , pp. 1453-1462
    • Saito, E.1    Fujimoto, M.2    Hasegawa, M.3
  • 77
    • 16544364829 scopus 로고    scopus 로고
    • The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: Systemic sclerosis as a model system
    • Tedder TF, Poe JC, Fujimoto M, Haas KM, Sato S. The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. Curr Dir Autoimm. 2005;8:55-90.
    • (2005) Curr Dir Autoimm. , vol.8 , pp. 55-90
    • Tedder, T.F.1    Poe, J.C.2    Fujimoto, M.3    Haas, K.M.4    Sato, S.5
  • 78
    • 3242810358 scopus 로고    scopus 로고
    • B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
    • Asano N, Fujimoto M, Yazawa N, et al. B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. Am J Pathol. 2004;165:641-650.
    • (2004) Am J Pathol. , vol.165 , pp. 641-650
    • Asano, N.1    Fujimoto, M.2    Yazawa, N.3
  • 79
    • 33748788266 scopus 로고    scopus 로고
    • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    • Hasegawa M, Hamaguchi Y, Yanaba K, et al. B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. Am J Pathol. 2006;169:954-966.
    • (2006) Am J Pathol. , vol.169 , pp. 954-966
    • Hasegawa, M.1    Hamaguchi, Y.2    Yanaba, K.3
  • 80
    • 45149116742 scopus 로고    scopus 로고
    • Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse
    • doi: 10.1136/ard.2007.073387
    • Komura K, Manabu F, Yanaba K, et al. Blockade of CD40-CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse. Ann Rheum Dis. 2008; doi: 10.1136/ard.2007.073387.
    • (2008) Ann Rheum Dis.
    • Komura, K.1    Manabu, F.2    Yanaba, K.3
  • 81
    • 36248941233 scopus 로고    scopus 로고
    • BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice
    • Matsushita T, Fujimoto M, Hasegawa M, et al. BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice. J Invest Dermatol. 2007;127:2772-2780.
    • (2007) J Invest Dermatol. , vol.127 , pp. 2772-2780
    • Matsushita, T.1    Fujimoto, M.2    Hasegawa, M.3
  • 82
    • 0029610915 scopus 로고
    • The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration
    • Christner PJ, Peters J, Hawkins D, Siracusa LD, Jimenez SA. The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration. Arthritis Rheum. 1995;38:1791-1798.
    • (1995) Arthritis Rheum. , vol.38 , pp. 1791-1798
    • Christner, P.J.1    Peters, J.2    Hawkins, D.3    Siracusa, L.D.4    Jimenez, S.A.5
  • 85
    • 0032948215 scopus 로고    scopus 로고
    • A syndrome resembling human systemic sclerosis (scleroderma) in MRL/lpr mice lacking interferon-gamma (IFNg) receptor (MRL/lprgR-/-)
    • Le Hir M, Martin M, Haas C. A syndrome resembling human systemic sclerosis (scleroderma) in MRL/lpr mice lacking interferon-gamma (IFNg) receptor (MRL/lprgR-/-). Clin Exp Immunol. 1999;115:281-287.
    • (1999) Clin Exp Immunol. , vol.115 , pp. 281-287
    • Le Hir, M.1    Martin, M.2    Haas, C.3
  • 86
    • 0019400724 scopus 로고
    • Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma)
    • Gershwin ME, Abplanalp H, Castles JJ, et al. Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma). J Exp Med. 1981;153:1640-1659.
    • (1981) J Exp Med. , vol.153 , pp. 1640-1659
    • Gershwin, M.E.1    Abplanalp, H.2    Castles, J.J.3
  • 87
    • 0032752728 scopus 로고    scopus 로고
    • The vascular perspective of systemic sclerosis: Of chickens, mice and men
    • Sgonc R. The vascular perspective of systemic sclerosis: of chickens, mice and men. Int Arch Allergy Immunol. 1999;120:169-176.
    • (1999) Int Arch Allergy Immunol. , vol.120 , pp. 169-176
    • Sgonc, R.1
  • 88
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    • Sgonc R, Gruschwitz MS, Dietrich H, Recheis H, Gershwin ME, Wick G. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Invest. 1996;98:785-792.
    • (1996) J Clin Invest. , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.S.2    Dietrich, H.3    Recheis, H.4    Gershwin, M.E.5    Wick, G.6
  • 89
    • 0033758304 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95
    • Sgonc R, Gruschwitz MS, Boeck G, Sepp N, Gruber J, Wick G. Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95. Arthritis Rheum. 2000;43:2550-2562.
    • (2000) Arthritis Rheum. , vol.43 , pp. 2550-2562
    • Sgonc, R.1    Gruschwitz, M.S.2    Boeck, G.3    Sepp, N.4    Gruber, J.5    Wick, G.6
  • 90
    • 0141676369 scopus 로고    scopus 로고
    • In vivo analysis of the apoptosis-inducing effect of antiendothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay
    • Worda M, Sgonc R, Dietrich H, et al. In vivo analysis of the apoptosis-inducing effect of antiendothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay. Arthritis Rheum. 2003;48:2605-2614.
    • (2003) Arthritis Rheum. , vol.48 , pp. 2605-2614
    • Worda, M.1    Sgonc, R.2    Dietrich, H.3
  • 91
    • 0033621643 scopus 로고    scopus 로고
    • Endothelial injury in internal organs of University of California at Davis line 200 (UCD 200) chickens, an animal model for systemic sclerosis (scleroderma)
    • Nguyen VA, Sgonc R, Dietrich H, Wick G. Endothelial injury in internal organs of University of California at Davis line 200 (UCD 200) chickens, an animal model for systemic sclerosis (scleroderma). J Autoimmun. 2000;14:143-149.
    • (2000) J Autoimmun. , vol.14 , pp. 143-149
    • Nguyen, V.A.1    Sgonc, R.2    Dietrich, H.3    Wick, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.