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Volumn 120, Issue 3, 1999, Pages 169-176

The vascular perspective of systemic sclerosis: Of chickens, mice and men

Author keywords

Adhesion molecules; Anti endothelial cell antibodies; Apoptosis; Cytokines; Endothelial cells; Scleroderma

Indexed keywords

ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; APOPTOSIS; CELL INFILTRATION; CHICKEN; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; HUMAN; MONONUCLEAR CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SKIN BIOPSY; SYSTEMIC SCLEROSIS; VASCULAR DISEASE;

EID: 0032752728     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024264     Document Type: Review
Times cited : (42)

References (66)
  • 1
    • 0023874792 scopus 로고
    • Systemic scleroderma. Clinical and pathophysiologic aspects
    • Krieg T, Meurer M: Systemic scleroderma. Clinical and pathophysiologic aspects. J Am Acad Dermatol 1988;18:457-481.
    • (1988) J Am Acad Dermatol , vol.18 , pp. 457-481
    • Krieg, T.1    Meurer, M.2
  • 2
    • 0025810224 scopus 로고
    • The pathogenesis of scleroderma (systemic sclerosis, SSc)
    • LeRoy EC, Trojanowska M, Smith EA: The pathogenesis of scleroderma (systemic sclerosis, SSc). Clin Exp Rheumatol 1991;9:173-177.
    • (1991) Clin Exp Rheumatol , vol.9 , pp. 173-177
    • LeRoy, E.C.1    Trojanowska, M.2    Smith, E.A.3
  • 3
    • 0027317449 scopus 로고
    • The aetiopathogenesis of systemic sclerosis
    • Black CM: The aetiopathogenesis of systemic sclerosis. J Intern Med 1993;234:3-8.
    • (1993) J Intern Med , vol.234 , pp. 3-8
    • Black, C.M.1
  • 4
    • 0023904706 scopus 로고
    • Correlates between autoantibodies to nuclear antigens and clinical features in patients with systemic sclerosis (scleroderma)
    • Reimer G, Steen VD, Penning CA, Medsger TA Jr, Tan EM: Correlates between autoantibodies to nuclear antigens and clinical features in patients with systemic sclerosis (scleroderma). Arthritis Rheum 1988;31:525-532.
    • (1988) Arthritis Rheum , vol.31 , pp. 525-532
    • Reimer, G.1    Steen, V.D.2    Penning, C.A.3    Medsger T.A., Jr.4    Tan, E.M.5
  • 6
    • 0029963412 scopus 로고    scopus 로고
    • Immunopathogenesis of systemic sclerosis
    • White B: Immunopathogenesis of systemic sclerosis. Rheum Dis Clin North Am 1996;22:695-708.
    • (1996) Rheum Dis Clin North Am , vol.22 , pp. 695-708
    • White, B.1
  • 7
    • 0030847892 scopus 로고    scopus 로고
    • In situ expression and serum levels of tumor necrosis factor-alpha receptors in patients with early stages of systemic sclerosis
    • Gruschwitz MS, Albrecht M, Vieth G, Haustein UF: In situ expression and serum levels of tumor necrosis factor-alpha receptors in patients with early stages of systemic sclerosis. J Rheumatol 1997;24:1936-1943.
    • (1997) J Rheumatol , vol.24 , pp. 1936-1943
    • Gruschwitz, M.S.1    Albrecht, M.2    Vieth, G.3    Haustein, U.F.4
  • 8
    • 0026604019 scopus 로고
    • Sequential dermal microvascular and perivascular changes in the development of scleroderma
    • Prescott RJ, Freemont AJ, Jones CJ, Hoyland J, Fielding P: Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol 1992;166:255-263.
    • (1992) J Pathol , vol.166 , pp. 255-263
    • Prescott, R.J.1    Freemont, A.J.2    Jones, C.J.3    Hoyland, J.4    Fielding, P.5
  • 9
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    • Sgonc R, Gruschwitz MS, Dietrich H, Recheis H, Gershwin ME, Wick G: Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Invest 1996;98:785-792.
    • (1996) J Clin Invest , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.S.2    Dietrich, H.3    Recheis, H.4    Gershwin, M.E.5    Wick, G.6
  • 10
    • 0021016455 scopus 로고
    • The tight-skin mouse: Is it a model for scleroderma?
    • Russell ML: The tight-skin mouse: Is it a model for scleroderma? J Rheumatol 1983;10:679-688.
    • (1983) J Rheumatol , vol.10 , pp. 679-688
    • Russell, M.L.1
  • 12
    • 0019400724 scopus 로고
    • Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma)
    • Gershwin ME, Abplanalp H, Castles RM, Ikeda J, Van De Water J, Eklund J, Haynes D: Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma). J Exp Med 1981;153:1640-1659.
    • (1981) J Exp Med , vol.153 , pp. 1640-1659
    • Gershwin, M.E.1    Abplanalp, H.2    Castles, R.M.3    Ikeda, J.4    Van De Water, J.5    Eklund, J.6    Haynes, D.7
  • 15
    • 0029610915 scopus 로고
    • The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration
    • Christner PJ, Peters J, Hawkins D, Siracusa LD, Jimenez SA: The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration. Arthritis Rheum 1995;38:1791-1798.
    • (1995) Arthritis Rheum , vol.38 , pp. 1791-1798
    • Christner, P.J.1    Peters, J.2    Hawkins, D.3    Siracusa, L.D.4    Jimenez, S.A.5
  • 17
    • 0344589510 scopus 로고    scopus 로고
    • What can we learn from an avian model for scleroderma?
    • Schoenfeld Y (ed): Amsterdam, Elsevier
    • Sgonc R, Wick G: What can we learn from an avian model for scleroderma? in Schoenfeld Y (ed): The Decade of Autoimmunity. Amsterdam, Elsevier, 1999, pp 209-217.
    • (1999) The Decade of Autoimmunity , pp. 209-217
    • Sgonc, R.1    Wick, G.2
  • 18
    • 0141738906 scopus 로고    scopus 로고
    • Autoimmune disease, spontaneous animal models
    • Delves PJ, Roitt IM (eds): London, Academic Press
    • Wick G, Sgonc R, Kroemer G: Autoimmune disease, spontaneous animal models; in Delves PJ, Roitt IM (eds): Encyclopedia of Immunology. London, Academic Press, 1998, pp 280-287.
    • (1998) Encyclopedia of Immunology , pp. 280-287
    • Wick, G.1    Sgonc, R.2    Kroemer, G.3
  • 19
    • 0025870889 scopus 로고
    • Phenotypic analysis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen cells and thymocytes in early avian scleroderma
    • Gruschwitz MS, Moormann S, Kromer G, Sgonc R, Dietrich H, Boeck G, Gershwin ME, Boyd R, Wick G: Phenotypic analysis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen cells and thymocytes in early avian scleroderma. J Autoimmun 1991;4:577-593.
    • (1991) J Autoimmun , vol.4 , pp. 577-593
    • Gruschwitz, M.S.1    Moormann, S.2    Kromer, G.3    Sgonc, R.4    Dietrich, H.5    Boeck, G.6    Gershwin, M.E.7    Boyd, R.8    Wick, G.9
  • 20
    • 0031458231 scopus 로고    scopus 로고
    • Altered procollagen mRNA expression during the progression of avian scleroderma
    • Ausserlechner MJ, Sgonc R, Dietrich H, Wick G: Altered procollagen mRNA expression during the progression of avian scleroderma. Mol Med 1997;3:654-662.
    • (1997) Mol Med , vol.3 , pp. 654-662
    • Ausserlechner, M.J.1    Sgonc, R.2    Dietrich, H.3    Wick, G.4
  • 21
    • 0028800468 scopus 로고
    • Genomic analysis of collagen and endogenous virus loci in the UCD-200 and 206 lines of chickens, animal models for scleroderma
    • Sgonc R, Dietrich H, Gershwin ME, Colombatti A, Wick G: Genomic analysis of collagen and endogenous virus loci in the UCD-200 and 206 lines of chickens, animal models for scleroderma. J Autoimmun 1995;8:763-770.
    • (1995) J Autoimmun , vol.8 , pp. 763-770
    • Sgonc, R.1    Dietrich, H.2    Gershwin, M.E.3    Colombatti, A.4    Wick, G.5
  • 22
    • 0016732764 scopus 로고
    • Pathogenesis of systemic sclerosis: A vascular hypothesis
    • Campbell PM, LeRoy EC: Pathogenesis of systemic sclerosis: A vascular hypothesis. Semin Arthritis Rheum 1975;4:351-368.
    • (1975) Semin Arthritis Rheum , vol.4 , pp. 351-368
    • Campbell, P.M.1    LeRoy, E.C.2
  • 23
    • 0019523801 scopus 로고
    • Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud's phenomenon
    • Kahaleh MB, Osborn I, LeRoy EC: Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud's phenomenon. Ann Intern Med 1981;94:482-484.
    • (1981) Ann Intern Med , vol.94 , pp. 482-484
    • Kahaleh, M.B.1    Osborn, I.2    LeRoy, E.C.3
  • 24
    • 0027426209 scopus 로고
    • Mechanisms of endothelial cell damage in systemic sclerosis and Raynaud's phenomenon
    • Blann AD, Illingworth K, Jayson MI: Mechanisms of endothelial cell damage in systemic sclerosis and Raynaud's phenomenon. J Rheumatol 1993;20:1325-1330.
    • (1993) J Rheumatol , vol.20 , pp. 1325-1330
    • Blann, A.D.1    Illingworth, K.2    Jayson, M.I.3
  • 26
    • 0027972356 scopus 로고
    • Plasma thrombomodulin as a marker of vascular injuries in collagen vascular diseases
    • Ohdama S, Takano S, Miyake S, Kubota T, Sato K, Aoki N: Plasma thrombomodulin as a marker of vascular injuries in collagen vascular diseases. Am J Clin Pathol 1994;101:109-113.
    • (1994) Am J Clin Pathol , vol.101 , pp. 109-113
    • Ohdama, S.1    Takano, S.2    Miyake, S.3    Kubota, T.4    Sato, K.5    Aoki, N.6
  • 27
    • 0026767749 scopus 로고
    • Angiotensin converting enzyme: An in vivo and in vitro marker of endothelial injury
    • Matucci Cerinic M, Jaffa A, Kahaleh B: Angiotensin converting enzyme: An in vivo and in vitro marker of endothelial injury. J Lab Clin Med 1992;120:428-433.
    • (1992) J Lab Clin Med , vol.120 , pp. 428-433
    • Matucci Cerinic, M.1    Jaffa, A.2    Kahaleh, B.3
  • 28
    • 0022632828 scopus 로고
    • Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon
    • Reilly IA, Roy L, Fitzgerald GA: Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon. Br Med J Clin Res Ed 1986;292:1037-1039.
    • (1986) Br Med J Clin Res Ed , vol.292 , pp. 1037-1039
    • Reilly, I.A.1    Roy, L.2    Fitzgerald, G.A.3
  • 29
    • 0020046233 scopus 로고
    • Elevated levels of circulating platelet aggregates and beta-thromboglobulin in scleroderma
    • Kahaleh MB, Osborn I, LeRoy EC: Elevated levels of circulating platelet aggregates and beta-thromboglobulin in scleroderma. Ann Intern Med 1982;96:610-613.
    • (1982) Ann Intern Med , vol.96 , pp. 610-613
    • Kahaleh, M.B.1    Osborn, I.2    LeRoy, E.C.3
  • 31
    • 0031127473 scopus 로고    scopus 로고
    • Mechanism of serum-mediated endothelial injury in scleroderma: Identification of a granular enzyme in scleroderma skin and sera
    • Kahaleh MB, Fan PS: Mechanism of serum-mediated endothelial injury in scleroderma: Identification of a granular enzyme in scleroderma skin and sera. Clin Immunol Immunopathol 1997;83:32-40.
    • (1997) Clin Immunol Immunopathol , vol.83 , pp. 32-40
    • Kahaleh, M.B.1    Fan, P.S.2
  • 32
    • 0008275041 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in systemic sclerosis is induced by antibody dependent cellular cytotoxicity via CD95 (abstract)
    • Sgonc R, Boeck G, Gruschwitz M, Sepp N, Wick G: Endothelial cell apoptosis in systemic sclerosis is induced by antibody dependent cellular cytotoxicity via CD95 (abstract). J Rheumatol 1998;25(suppl 52):76.
    • (1998) J Rheumatol , vol.25 , Issue.SUPPL. 52 , pp. 76
    • Sgonc, R.1    Boeck, G.2    Gruschwitz, M.3    Sepp, N.4    Wick, G.5
  • 33
    • 0024237654 scopus 로고
    • The effects of scleroderma serum on human microvascular entothelial cells. Induction of antibody-dependent cellular cytotoxicity
    • Marks RM, Czerniecki M, Andrews BS, Penny R: The effects of scleroderma serum on human microvascular entothelial cells. Induction of antibody-dependent cellular cytotoxicity. Arthritis Rheum 1988;31:1524-1534.
    • (1988) Arthritis Rheum , vol.31 , pp. 1524-1534
    • Marks, R.M.1    Czerniecki, M.2    Andrews, B.S.3    Penny, R.4
  • 34
    • 0024351623 scopus 로고
    • Antibody-dependent cellular cytotoxicity of vascular endothelium: Characterization and pathogenic associations in systemic sclerosis
    • Holt CM, Lindsey N, Moult J, Malia RG, Greaves M, Hume A, Rowell NR, Hughes P: Antibody-dependent cellular cytotoxicity of vascular endothelium: characterization and pathogenic associations in systemic sclerosis. Clin Exp Immunol 1989;78:359-365.
    • (1989) Clin Exp Immunol , vol.78 , pp. 359-365
    • Holt, C.M.1    Lindsey, N.2    Moult, J.3    Malia, R.G.4    Greaves, M.5    Hume, A.6    Rowell, N.R.7    Hughes, P.8
  • 35
    • 0029092295 scopus 로고
    • Expression of extracellular matrix genes in adult human dermal microvascular endothelial cells and their regulation by heparin and endothelial cell mitogens
    • Hitraya EG, Tan EM, Rudnicka L, Jimenez SA: Expression of extracellular matrix genes in adult human dermal microvascular endothelial cells and their regulation by heparin and endothelial cell mitogens. Lab Invest 1995;73:393-402.
    • (1995) Lab Invest , vol.73 , pp. 393-402
    • Hitraya, E.G.1    Tan, E.M.2    Rudnicka, L.3    Jimenez, S.A.4
  • 42
    • 0030031147 scopus 로고    scopus 로고
    • IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines
    • Carvalho D, Savage CO, Black CM, Pearson JD: IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. J Clin Invest 1996;97:111-119.
    • (1996) J Clin Invest , vol.97 , pp. 111-119
    • Carvalho, D.1    Savage, C.O.2    Black, C.M.3    Pearson, J.D.4
  • 43
    • 0026749372 scopus 로고
    • Expression of adhesion proteins involved in cell-cell and cell-matrix interactions in the skin of patients with progressive systemic sclerosis
    • Gruschwitz M, von den Driesch P, Kellner I, Hornstein OP, Sterry W: Expression of adhesion proteins involved in cell-cell and cell-matrix interactions in the skin of patients with progressive systemic sclerosis. J Am Acad Dermatol 1992;27:169-177.
    • (1992) J Am Acad Dermatol , vol.27 , pp. 169-177
    • Gruschwitz, M.1    Von Den Driesch, P.2    Kellner, I.3    Hornstein, O.P.4    Sterry, W.5
  • 44
    • 0026515116 scopus 로고
    • Elevated expression of beta 1 and beta 2 integrins, intercellular adhesion molecule 1, and endothelial leukocyte adhesion molecule 1 in the skin of patients with systemic sclerosis of recent onset
    • Sollberg S, Peltonen J, Uitto J, Jimenez SA: Elevated expression of beta 1 and beta 2 integrins, intercellular adhesion molecule 1, and endothelial leukocyte adhesion molecule 1 in the skin of patients with systemic sclerosis of recent onset. Arthritis Rheum 1992;35:290-298.
    • (1992) Arthritis Rheum , vol.35 , pp. 290-298
    • Sollberg, S.1    Peltonen, J.2    Uitto, J.3    Jimenez, S.A.4
  • 45
    • 0032954179 scopus 로고    scopus 로고
    • IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner
    • Carvalho D, Savage CO, Isenberg D, Pearson JD: IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner. Arthritis Rheum 1999;42:631-640.
    • (1999) Arthritis Rheum , vol.42 , pp. 631-640
    • Carvalho, D.1    Savage, C.O.2    Isenberg, D.3    Pearson, J.D.4
  • 46
    • 0030936758 scopus 로고    scopus 로고
    • Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage
    • Gruschwitz MS, Vieth G: Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage. Arthritis Rheum 1997;40:540-550.
    • (1997) Arthritis Rheum , vol.40 , pp. 540-550
    • Gruschwitz, M.S.1    Vieth, G.2
  • 48
    • 0026316776 scopus 로고
    • Endothelial and fibroblastic activation in scleroderma. The myth of the 'uninvolved skin'
    • Claman HN, Giorno RC, Seibold JR: Endothelial and fibroblastic activation in scleroderma. The myth of the 'uninvolved skin'. Arthritis Rheum 1991;34:1495-1501.
    • (1991) Arthritis Rheum , vol.34 , pp. 1495-1501
    • Claman, H.N.1    Giorno, R.C.2    Seibold, J.R.3
  • 50
    • 0031684385 scopus 로고    scopus 로고
    • T cell interaction with ICAM-1-deficient endothelium in vitro: Essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells
    • Reiss Y, Hoch G, Deutsch U, Engelhardt B: T cell interaction with ICAM-1-deficient endothelium in vitro: Essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells. Eur J Immunol 1998;28:3086-3099.
    • (1998) Eur J Immunol , vol.28 , pp. 3086-3099
    • Reiss, Y.1    Hoch, G.2    Deutsch, U.3    Engelhardt, B.4
  • 51
    • 0023666065 scopus 로고
    • Integrins: A family of cell surface receptors
    • Hynes RO: Integrins: A family of cell surface receptors. Cell 1987;48:549-554.
    • (1987) Cell , vol.48 , pp. 549-554
    • Hynes, R.O.1
  • 53
    • 0028837027 scopus 로고
    • Correlation of soluble adhesion molecules in the peripheral blood of scleroderma patients with their in situ expression and with disease activity
    • Gruschwitz MS, Hornstein OP, von den Driesch P: Correlation of soluble adhesion molecules in the peripheral blood of scleroderma patients with their in situ expression and with disease activity. Arthritis Rheum 1995; 38:184-189.
    • (1995) Arthritis Rheum , vol.38 , pp. 184-189
    • Gruschwitz, M.S.1    Hornstein, O.P.2    Von Den Driesch, P.3
  • 55
    • 0025836185 scopus 로고
    • Endothelin, an endothelial-dependent vascoconstrictor in scleroderma. Enhanced production and profibrotic action
    • Kahaleh MB: Endothelin, an endothelial-dependent vascoconstrictor in scleroderma. Enhanced production and profibrotic action. Arthritis Rheum 1991;34:978-983.
    • (1991) Arthritis Rheum , vol.34 , pp. 978-983
    • Kahaleh, M.B.1
  • 57
    • 0025092082 scopus 로고
    • Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: A mediator of fibrosis?
    • Gruschwitz M, Muller PU, Sepp N, Hofer E, Fontana A, Wick G: Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: A mediator of fibrosis? J Invest Dermatol 1990; 94:197-203.
    • (1990) J Invest Dermatol , vol.94 , pp. 197-203
    • Gruschwitz, M.1    Muller, P.U.2    Sepp, N.3    Hofer, E.4    Fontana, A.5    Wick, G.6
  • 58
    • 0027429490 scopus 로고
    • Immunohistochemical localization of intracellular and extracellular associated TGF beta in the skin of patients with systemic sclerosis (scleroderma) and primary Raynaud's phenomenon
    • Gabrielli A, Di Loreto C, Taborro R, Candela M, Sambo P, Nitti C, Danieli MG, DeLustro F, Dasch JR, Danieli G: Immunohistochemical localization of intracellular and extracellular associated TGF beta in the skin of patients with systemic sclerosis (scleroderma) and primary Raynaud's phenomenon. Clin Immunol Immunopathol 1993;68:340-349.
    • (1993) Clin Immunol Immunopathol , vol.68 , pp. 340-349
    • Gabrielli, A.1    Di Loreto, C.2    Taborro, R.3    Candela, M.4    Sambo, P.5    Nitti, C.6    Danieli, M.G.7    DeLustro, F.8    Dasch, J.R.9    Danieli, G.10
  • 59
    • 0023623241 scopus 로고
    • TGF-beta inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression
    • Takehara K, LeRoy EC, Grotendorst GR: TGF-beta inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression. Cell 1987;49:415-422.
    • (1987) Cell , vol.49 , pp. 415-422
    • Takehara, K.1    LeRoy, E.C.2    Grotendorst, G.R.3
  • 61
    • 0023631004 scopus 로고
    • Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts
    • Varga J, Rosenbloom J, Jimenez SA: Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 1987;247:597-604.
    • (1987) Biochem J , vol.247 , pp. 597-604
    • Varga, J.1    Rosenbloom, J.2    Jimenez, S.A.3
  • 62
    • 0025260903 scopus 로고
    • Interleukin-6: An overview
    • Van Snick J: Interleukin-6: An overview. Annu Rev Immunol 1990;8:253-278.
    • (1990) Annu Rev Immunol , vol.8 , pp. 253-278
    • Van Snick, J.1
  • 63
    • 0025989368 scopus 로고
    • Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6
    • Duncan MR, Berman B: Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6. J Invest Dermatol 1991;97:686-692.
    • (1991) J Invest Dermatol , vol.97 , pp. 686-692
    • Duncan, M.R.1    Berman, B.2
  • 64
    • 0025734094 scopus 로고
    • Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)
    • Lotz M, Guerne PA: Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 1991;266:2017-2020.
    • (1991) J Biol Chem , vol.266 , pp. 2017-2020
    • Lotz, M.1    Guerne, P.A.2
  • 65
    • 0032974438 scopus 로고    scopus 로고
    • Augmented production of chemokines monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1-alpha) and MIP-1-(beta) in patients with systemic sclerosis: MCP-1 and MIP-1-alpha may be involved in the development of pulmonary fibrosis
    • Hasegawa M, Sato S, Takehara K: Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1-alpha) and MIP-1-(beta) in patients with systemic sclerosis: MCP-1 and MIP-1-alpha may be involved in the development of pulmonary fibrosis. Clin Exp Immunol 1999;117:159-165.
    • (1999) Clin Exp Immunol , vol.117 , pp. 159-165
    • Hasegawa, M.1    Sato, S.2    Takehara, K.3


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